Title: The Response of Thyrotropin and Triiodothyronine to Various Doses of Thyrotropin Releasing Hormone in Normal Man
Abstract:Abstract. The relationship between serum thyrotropin (TSH) and serum triiodothyronine (T 3 ) before and after injection of different doses of thyrotropin releasing hormone (TRH), given as single injec...Abstract. The relationship between serum thyrotropin (TSH) and serum triiodothyronine (T 3 ) before and after injection of different doses of thyrotropin releasing hormone (TRH), given as single injections or as multiple injections with short intervals, was investigated in normal men. A positive correlation between prestimulated serum TSH and serum T 3 levels and between the increase in the serum TSH and the serum T 3 levels after TRH was found when repeated tests were performed in the same individual. There was a dose dependent TSH and T 3 response to TRH. The smallest dose that produced a maximal response of both TSH and T 3 was only 30 μg TRH. After six injections of 30 μg TRH with an interval of 30 minutes the increase in TSH was two times and the increase in T 3 was three times as high as the maximal increase after single injections of TRH. This test with multiple injections of TRH may prove to be of clinical value in the measurement of both pituitary and thyroid function in selected patients. The close positive correlation between the serum TSH and serum T 3 levels in basal conditions, demonstrated in four normal subjects in this study, probably reflects the steady state level determined by the hypothalamus from which the feedback control of TSH secretion operates.Read More
Publication Year: 1975
Publication Date: 1975-11-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 9
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