Title: Factors influencing methoxsalen phototoxicity in vitiliginous skin
Abstract: • A series of experiments were conducted to determine the optimum conditions required to induce methoxsalen phototoxicity in vitiliginous skin. The results revealed that optimum phototoxicity could be obtained only when a lapse of at least 15 minutes was allowed between the application of the drug and exposure to long-wave ultraviolet light (UVA). The duration of methoxsalen's phototoxic potentiality, after its application to skin, varied in direct proportion to chemical concentration. Although a high chemical concentration and low dosage of UVA was a less time-consuming method of inducing phototoxicity, our results indicate that lower concentration and longer UVA exposure were less likely to induce undesirable blistering reactions. (<i>Arch Dermatol</i>112:327-332, 1976)
Publication Year: 1976
Publication Date: 1976-03-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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