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2041, 2047, 2063, 2076, 2153, 2178, 2185, 2219, 2221, 2239, 2251, 2261, 2267, 2293, 2408, 2437, 2467, 2534, 2596, 2605, 2610, 2617, 2665, 2674, 2683, 2704, 2738, 2742, 2775, 2785, 2841, 2861, 2868, 2882, 2895, 2912, 2936, 2941, 2991, 2997, 3001, 3138, 3144, 3158, 3167, 3179, 3186, 3204, 3232, 3239, 3263, 3279, 3284, 3310, 3319, 3326, 3336, 3341, 3352, 3373, 3378, 3404, 3413, 3420, 3430, 3435, 3446, 3450, 3535, 3547, 3555, 3588, 3602, 3607, 3626, 3660, 3665, 3730, 3779, 3854, 3900, 3912, 3919, 3948, 3955, 4012, 4059, 4107, 4158], '∼3': [63], 'years': [64, 1308, 2296], '5-year': [67], 'only': [70, 1071, 3678], '∼25%': [71], '[2.Cardoso': [72, 141], 'Spence': [74, 143], 'D.': [75, 144, 375], 'Mertz': [76, 145], 'S.': [77, 146, 2082], 'et': [78, 107, 147, 246, 276, 380, 786, 825, 1863, 2087, 2122, 3621, 3808, 3982, 4050], 'al.Global': [79, 148], 'analysis': [80, 149, 489], 'advanced/metastatic': [82, 151], 'cancer:': [84, 153, 4056], 'decade': [85, 154, 419, 3801], 'report': [86, 155], '(2005–2015).Breast.': [87, 156], '2018;': [88, 157, 366], '39:': [89, 158], '131-138Abstract': [90, 159], '(126)': [98, 167], 'Scholar,': [100, 239, 269, 373, 1856, 2115, 4009, 4043, 4075], '3.N': [101], 'Howlader,': [102], 'AM': [103], 'Noone,': [104], 'M': [105], 'Krapcho': [106], 'al': [108], '(eds).': [109], 'SEER': [110, 125, 131], 'Statistics': [112], 'Review,': [113], '1975–2013.': [114], 'Bethesda,': [115], 'MD:': [116], 'National': [117], 'Institute.': [119], 'http://seer.cancer.gov/csr/1975_2013/,': [120], 'based': [121, 603, 880], 'on': [122, 251, 566, 604, 873, 881, 906, 935, 1043, 1304, 1324, 1334, 1363, 1497, 2707, 2849, 3148, 3515, 3532, 3814, 3898], 'November': [123, 568], '2015': [124], 'data': [126, 488, 884, 993, 2059, 2759, 2848, 3463], 'submission,': [127], 'posted': [128], 'to': [129, 195, 203, 320, 335, 338, 464, 472, 490, 498, 509, 530, 613, 629, 632, 773, 848, 895, 933, 957, 966, 997, 1024, 1058, 1274, 1383, 1428, 1436, 1501, 1583, 1755, 1816, 1894, 1968, 2014, 2197, 2247, 2356, 2371, 2396, 2404, 2447, 2454, 2463, 2486, 2496, 2502, 2565, 2593, 2601, 2627, 2637, 2640, 2731, 2734, 2752, 2760, 2806, 2834, 2907, 3010, 3016, 3030, 3056, 3060, 3069, 3081, 3103, 3236, 3251, 3477, 3494, 3501, 3526, 3565, 3570, 3598, 3636, 3711, 3713, 3722, 3741, 3764, 3866, 3890, 4150, 4174], 'the': [130, 252, 291, 321, 401, 425, 434, 441, 445, 484, 500, 504, 512, 531, 536, 539, 588, 595, 605, 625, 692, 703, 714, 717, 724, 729, 735, 745, 756, 763, 856, 863, 874, 887, 922, 953, 976, 987, 991, 1012, 1019, 1034, 1045, 1100, 1129, 1145, 1182, 1194, 1262, 1305, 1339, 1389, 1433, 1445, 1479, 1520, 1548, 1575, 1584, 1603, 1639, 1709, 1753, 1760, 1788, 1805, 1812, 1954, 1961, 1989, 2022, 2039, 2042, 2045, 2048, 2061, 2064, 2217, 2249, 2252, 2263, 2306, 2350, 2359, 2405, 2465, 2497, 2532, 2556, 2594, 2603, 2641, 2663, 2723, 2802, 2862, 2866, 2893, 2900, 2903, 2909, 2934, 2956, 2963, 2971, 2974, 2998, 3046, 3067, 3101, 3142, 3145, 3165, 3177, 3180, 3183, 3205, 3290, 3384, 3465, 3472, 3478, 3496, 3533, 3556, 3567, 3586, 3589, 3600, 3605, 3612, 3627, 3653, 3658, 3683, 3691, 3694, 3728, 3737, 3749, 3774, 3777, 3795, 3799, 3888, 3894, 3917, 3940, 3945, 3949, 3952, 3964, 3969, 4105, 4120], 'web': [132], 'site,': [133], 'April': [134], '2016.Google': [135], 'The': [137, 310, 417, 477, 552, 634, 695, 731, 1021, 1884, 1918, 1965, 2242, 3169, 3448], 'Decade': [139], 'Report': [140], 'Scholar]': [169, 845, 2148], 'shows': [170], 'that': [171, 1065, 1110, 1197, 1920, 2070, 2276, 2283, 2719, 2754, 3261, 3523, 3536, 3681], 'progress': [172], 'has': [173, 420, 3784, 3887], 'been': [174, 3785], 'slow': [175], 'in': [176, 199, 205, 222, 315, 327, 424, 462, 563, 618, 691, 961, 975, 1011, 1116, 1388, 1444, 1488, 1519, 1574, 1614, 1636, 1684, 1706, 1787, 1802, 1951, 1960, 2074, 2098, 2129, 2149, 2189, 2297, 2305, 2358, 2440, 2450, 2512, 2531, 2631, 2685, 2696, 2722, 2777, 2787, 2821, 2876, 2924, 2985, 3045, 3077, 3234, 3244, 3287, 3356, 3381, 3468, 3709, 3852, 3882, 4022, 4113, 4164], 'terms': [177, 2075, 3549], 'improved': [179], 'outcomes,': [180], 'quality': [181, 2552, 3351, 3445], 'life': [183, 2883, 3027], '(QoL),': [184], 'awareness': [185], 'information': [187, 2319, 2335, 2439, 3175], 'regarding': [188, 2060, 3944], 'ABC.': [189, 1797], 'More': [190, 452, 2745], 'recently,': [191], 'some': [192, 2057, 2284, 2298, 3212, 3469, 3560, 3833], 'studies': [193, 1252], 'seem': [194], 'indicate': [196], 'improvement': [198, 423], 'OS,': [200], 'mostly': [201], 'due': [202, 628, 956, 1893], 'advances': [204], 'human': [206, 1651, 1721], 'epidermal': [207, 1652, 1722], 'growth': [208, 1653, 1723, 2951, 3675], 'factor': [209, 1654, 1724], 'receptor': [210, 1795], '2': [211, 1307, 1341], '(HER2)-positive': [212], 'ABC': [213, 333, 435, 558, 598, 635, 696, 739, 864, 877, 926, 1063, 1096, 1117, 1183, 1217, 1225, 1451, 1540, 1578, 1622, 1691, 1766, 2179, 2277, 2289, 2324, 2391, 2491, 2577, 2686, 2778, 2809, 2869, 2930, 3111, 3157, 3209, 3242, 3270, 3363, 3455, 3540, 3568, 3654, 3834, 3871, 3883, 3909, 4114], '[4.Sundquist': [214], 'M.': [215, 245, 343, 3618], 'Brudin': [216], 'Tejler': [218], 'G.': [219], 'Improved': [220], '1985–2016.Breast.': [226], '2017;': [227, 297, 409, 794, 833, 1878, 3640, 3819, 4095], '31:': [228, 1879, 4069], '46-50Abstract': [229], '(107)': [237], '5.Kobayashi': [240], 'K.': [241], 'Ito': [242], 'Y.': [243, 2121], 'Matsuura': [244], 'al.Impact': [247], 'immunohistological': [249], 'subtypes': [250], 'long-term': [253, 3946], 'prognosis': [254, 3178, 3947], 'patients': [256, 285, 1412, 1453, 1537, 1792, 1810, 2131, 2223, 2285, 2325, 2367, 2416, 2426, 2446, 2462, 2578, 2600, 2655, 2687, 2762, 2786, 2987, 3053, 3089, 3112, 3240, 3724, 3754, 3835, 4023, 4054], 'cancer.Surg': [260], 'Today.': [261], '2016;': [262, 2108], '46:': [263], '821-826Crossref': [264], '(28)': [267], '6.Fietz': [270], 'T.': [271], 'Tesch': [272], 'H.': [273, 2119], 'Rauh': [274], 'J.': [275, 785, 824, 3616], 'al.Palliative': [277], 'systemic': [278, 382], 'therapy': [279, 1581, 1588], '1,395': [284], 'cancer—results': [289], 'from': [290, 400, 440, 574, 643, 1140, 2561, 3453, 3794], 'prospective': [292], 'German': [293], 'TMK': [294], 'cohort': [295], 'study.Breast.': [296], '34:': [298], '122-130Abstract': [299], '(26)': [307, 414], 'better': [311, 510, 2661], 'is': [313, 587, 742, 1007, 1239, 1260, 1299, 1329, 1367, 1472, 1478, 1486, 1528, 1780, 1811, 1908, 1923, 1935, 1941, 1948, 2037, 2180, 2214, 2278, 2804, 2859, 2983, 3135, 3247, 3503, 3604, 3744, 3849, 3877, 3904, 3916], 'seen': [314, 421], 'environment': [317], 'access': [319, 631, 2395, 2495, 3500], 'best': [322, 1966, 3479, 3497], 'available': [323, 882, 1122, 1172, 1209, 1229, 1661, 1731, 3339, 3433, 3461, 3480, 3721], 'care': [324, 2212, 2231, 2268, 2402, 2420, 2452, 2540, 2571, 2676, 2776, 2949, 3000, 3673, 3743], 'particularly': [326, 1284, 2923, 3756, 3905], 'de': [328, 353, 677], 'novo': [329, 354], 'ABC,': [330, 517, 1322, 1361, 1694, 2222, 2262, 2989, 3366], 'while': [331, 1303, 1323, 1333, 1362], 'recurrent': [332, 356], 'seems': [334], 'become': [336, 494], 'harder': [337], 'manage': [339], '[7.Malmgren': [340], 'J.A.': [341], 'Mayer': [342], 'Atwood': [344], 'M.K.': [345], 'Kaplan': [346], 'H.G.': [347], 'Differential': [348], 'presentation': [349], 'over': [360, 1547, 1563], 'time:': [361], '1990–2010.Breast': [362], 'Res': [364, 406, 2139], 'Treat.': [365, 2140], '167:': [367], '579-590Crossref': [368], '(72)': [371], '8.Hölzel': [374], 'Eckel': [376], 'R.': [377, 3620, 3981], 'Bauerfeind': [378], 'I.': [379], 'al.Improved': [381], 'treatment': [383, 615, 1220, 1287, 1789, 2026, 2128, 2265, 2382, 2399, 2428, 2533, 2611, 2658, 2714, 2766, 2918, 2940, 3014, 3019, 3047, 3084, 3485, 3529, 3664, 3720, 3993], 'early': [385, 448, 2135, 2548, 2672], 'improves': [388], 'cure': [389], 'rates,': [390], 'modifies': [391], 'pattern': [393], 'shortens': [395], 'post-metastatic': [396], 'survival:': [397], '35-year': [398], 'results': [399, 2073], 'Munich': [402], 'Registry.J': [404], 'Clin': [407, 4066], 'Oncol.': [408, 793, 832, 3996, 4067], '143:': [410], '1701-1712Crossref': [411], 'last': [418, 3800], 'levels': [426, 1975, 1979], 'evidence': [428, 482, 608], '(LoEs)': [429], 'used': [430, 612, 847, 1487], 'many': [432, 619, 2986, 4169], 'recommendations,': [436], 'however,': [437, 2056], 'still': [438, 3457, 4171], 'far': [439], 'LoEs': [442], 'existing': [443], 'majority': [446, 537, 2040, 3449], 'guidelines.': [451], 'better,': [454, 2757], 'more': [455, 1280, 3723, 3850, 4156], 'innovatively': [456], 'designed': [457], 'trials': [458, 2152, 2693, 2791, 2798, 2815, 2831, 4157], 'are': [459, 543, 602, 637, 648, 813, 1056, 1228, 1409, 1996, 2771, 2799, 3256, 3265, 3492, 3524, 3550, 3562, 3582], 'urgently': [460], 'needed,': [461], 'particular': [463, 963, 3634], 'address': [465], 'clinically': [466, 3108], 'important': [467, 495, 1270, 2817, 3249], 'questions,': [468, 937], 'not': [469, 544, 949, 995, 1041, 1067, 1075, 1261, 1293, 1386, 1473, 1936, 1997, 2195, 2825, 4124], 'necessarily': [470, 1387], 'related': [471, 1023, 3525], 'specific': [474, 1438, 2711, 2715], 'therapeutic': [475, 533, 1617], 'agent.': [476], 'use': [478, 1461, 1604, 1761, 2046, 2062, 2595, 2630, 2700, 2894, 2935, 3231, 3606, 3659], 'real': [480, 2846, 2910], 'world': [481, 2847], 'application': [485], 'big': [487], 'oncology': [491, 3194, 3235, 3637], 'may': [492, 1891, 3216], 'soon': [493], 'additional': [496, 1414, 1770, 1819], 'pathways': [497], 'acquire': [499], 'necessary': [501, 626], 'LoEs.': [502], 'At': [503], 'research': [505, 541, 1006], 'level,': [506], 'efforts': [507, 3561], 'continue': [508, 2833, 3763], 'understand': [511], 'biology': [513], 'heterogeneity': [515], 'as': [518, 520, 639, 1134, 1201, 1241, 1245, 1301, 1331, 1369, 1411, 2011, 2235, 2411, 2422, 2484, 2613, 2899, 3095, 3459, 3482, 3484, 3574], 'well': [519, 1998, 3483], 'mechanisms': [521], 'tumour': [523], 'resistance': [524, 1298, 1328], 'biomarkers': [526], 'predictive': [527], 'response': [529], 'different': [532, 620, 630, 3507, 3571, 4108], 'options.': [534], 'However,': [535, 3499, 3960], 'recent': [540, 2058], 'highlights': [542], 'yet': [545], 'ready': [546, 3009], 'routine': [548, 2237, 2999], 'clinical': [549, 1276, 2618, 2632, 2769, 2814, 2819, 4062], 'practice': [550, 4063], 'implementation.': [551], '4th': [553], 'Conference': [556, 698, 757, 3812], '(ABC': [559, 1873], '4)': [560], 'took': [561], 'place': [562], 'Lisbon,': [564], 'Portugal': [565], '2–4': [567], '2017,': [569], 'bringing': [570], 'together': [571], '1300': [572], 'participants': [573], '88': [575], 'countries,': [576, 3213], 'including': [577, 2522, 2572], 'health': [578], 'professionals,': [579], 'patient': [580, 2310, 2351, 2392, 2479, 2492, 2803, 3886, 3941, 3970, 4090], 'advocates': [581], 'journalists.': [583], 'Its': [584], 'primary': [585, 2424], 'aim': [586], 'development': [589, 2434, 2965, 3685], 'international': [591], 'consensus': [592, 693, 753, 923, 1046, 1185], 'guidelines': [593, 601, 636, 736, 889, 1097, 1137, 1146, 1226, 3466, 3522, 3591], 'management': [596, 875, 1025, 2177, 2526, 3238], 'patients.': [599, 1917, 2173, 3003, 3210, 3872, 3884], 'These': [600, 891, 2620], 'most': [606, 2498], 'up-to-date': [607, 2332, 2499], 'can': [610, 1454, 2286, 2377, 3836, 4115], 'be': [611, 984, 1199, 1294, 1455, 1495, 1508, 1823, 1914, 2162, 2225, 2245, 2270, 2274, 2303, 2321, 2327, 2354, 2369, 2372, 2448, 2542, 2583, 2591, 2623, 2638, 2689, 2732, 2750, 2793, 2835, 2874, 2954, 2959, 2995, 3008, 3043, 3121, 3130, 3151, 3202, 3217, 3706, 3733, 3765, 3867, 3891, 3973, 4116], 'guide': [614, 2888], 'decision': [616, 2456, 3966, 4153], 'making': [617, 1425, 2457, 3719], 'healthcare': [621, 2460, 3228], 'settings': [622], 'globally,': [623], 'adaptations': [627], 'care.': [633, 2241, 2619], 'developed': [638, 737], 'joint': [641], 'effort': [642, 1754], 'ESO': [644], 'ESMO': [646, 764, 888, 1136, 3613, 3987], 'endorsed': [649], 'by': [650, 855, 900, 1053, 1080, 1084, 1247, 1609, 1903, 2374, 2517, 2585, 2660, 2865, 2915, 2970, 3219, 3486, 3690, 3767], 'EUSOMA': [651], '(European': [652, 659], 'Society': [653, 660, 687, 3278, 3314, 3372, 3408, 3629, 4014, 4058], 'Specialists),': [657], 'ESTRO': [658], 'Radiation': [662], 'Oncology),': [663], 'UICC': [664], '(Union': [665], 'Control),': [669], 'SIS': [670], '(Senologic': [671], 'Society)': [673], 'Flam': [675], '(FederatiónLatinoAmericana': [676], 'Mastologia).': [678], 'There': [679, 2054], 'was': [680, 699, 771, 846, 915, 973, 2002, 2009], 'also': [681, 700, 2749, 3129, 3172, 3745, 3869], 'official': [682], 'representation': [683], 'ASCO': [685, 2904], '(American': [686], 'Clinical': [689, 767, 789, 828, 2830, 3280, 3320, 3374, 3414, 3988, 4060], 'Oncology)': [690], 'panel.': [694], '4': [697, 740, 865, 1184, 1623, 1678, 1692, 1748, 1767, 2051, 3271, 3364], 'organised': [701], 'under': [702, 1033], 'auspices': [704], 'OECI': [706], '(Organization': [707], 'European': [709, 775, 3300, 3304, 3313, 3394, 3398, 3407, 3628, 3796], 'Institutes)': [711], 'support': [715, 2347, 2378, 2388, 2575], 'BCRF': [718], '(Breast': [719], 'Research': [721, 3307, 3401], 'Foundation)': [722], 'Susan': [725], 'G': [726], 'Komen': [727], 'Cure.': [730], 'present': [732], 'manuscript': [733], 'summarises': [734], 'at': [738, 755, 1123, 1173, 1210, 1231, 1289, 1398, 2362, 2505, 2546], 'supported': [743], 'LoEs,': [746], 'grades': [747], 'recommendation': [749, 871, 1807], '(GoRs),': [750], 'percentages': [751], 'reached': [754], 'supporting': [759], 'references.': [760], 'In': [761, 1688, 3211, 3360, 3538, 3609, 3772], 'addition,': [762], 'Magnitude': [765, 3318, 3412], 'Benefit': [768, 3321, 3415], 'Scale': [769], '(ESMO-MCBS)': [770], 'applied': [772], 'new': [774, 811, 852, 970, 1130, 1686, 2843, 2917, 3358, 3462], 'Medicines': [776, 3301, 3395], 'Agency': [777], '(EMA)-approved': [778], 'drugs': [779, 4121], '[9.Cherny': [780, 819], 'N.I.': [781, 820], 'Dafni': [782, 821], 'U.': [783, 822], 'Bogaerts': [784, 823], 'al.ESMO-Magnitude': [787, 826], 'BenefitScale': [790, 829], 'version': [791, 816, 830], '1.1.Ann': [792, 831], '28:': [795, 834], '2340-2366Abstract': [796, 835], '(325)': [804, 843], 'Scholar],': [806, 3652], 'ESMO-MCBS': [808, 815, 2901], 'scores': [809, 850], 'therapies/indications': [812, 853], 'included.': [814], '1.1': [817], '(v1.1)': [818], 'calculate': [849], 'approved': [854, 1115, 2960], 'EMA': [857, 2972, 3692], 'since': [858, 1285], '1': [859], 'January': [860], '2016.': [861], 'Before': [862], 'Conference,': [866], 'set': [868, 912], 'preliminary': [870], 'statements': [872, 1015, 1022, 1227], 'were': [878, 893, 931, 994, 1016, 1040, 1074, 1078, 1111], 'prepared,': [879], 'published': [883], 'following': [886], 'methodology.': [890], 'recommendations': [892, 914, 1064, 1105, 1439, 3452, 3793], 'circulated': [894], 'all': [896, 936, 1081, 1095, 1104, 1179, 1224, 1431, 1532, 2186, 2363, 2666, 2877, 3154, 3460, 3539, 3752], '42': [897], 'panel': [898, 929, 988, 1082, 1186, 1634, 1704, 2006, 2043, 3285, 3379], 'members': [899, 930, 939, 1083, 1180, 1635, 1705, 3286, 3380], 'email': [901, 1085], 'comments': [903], 'corrections': [905], 'content': [907], 'wording.': [909], 'A': [910, 969, 2551, 3873], 'final': [911, 3965], 'presented,': [916], 'discussed': [917, 1049, 1801, 1915, 3152, 3868], 'voted': [919, 1042, 1113], 'upon': [920], 'during': [921, 1018, 1044, 2021], 'session': [924], '4.': [927, 1118], 'All': [928, 3521], 'instructed': [932, 965], 'vote': [934, 967, 998], 'potential': [942, 1203, 2264, 3184, 3895, 3953], 'conflict': [943, 1204, 4088], 'interest': [945], 'or': [946, 1000, 1070, 1312, 1343, 1352, 1420, 1465, 1777, 1889, 1977, 2346, 2647, 2717, 2902, 2973, 2976, 3058, 3223, 3545, 3693, 3700, 3857, 3914, 3927, 4128], 'who': [947, 2376, 3054, 3761, 3843], 'did': [948, 1066], 'feel': [950], 'comfortable': [951], 'answering': [952], 'question': [954], '(e.g.': [955, 1416, 2384, 3188], 'lack': [958], 'expertise': [960], 'field)': [964], "'abstain'.": [968], 'possible': [971, 1434, 3197, 3596], 'answer': [972], 'included': [974, 1032], 'Precision': [977], 'Medicine': [978, 4017], 'statements:': [979], "'Insufficient": [980], "data',": [981], 'which': [982, 1817], 'should': [983, 1493, 1822, 1913, 2224, 2269, 2273, 2302, 2320, 2326, 2353, 2368, 2541, 2582, 2590, 2622, 2688, 2699, 2748, 2832, 2873, 2886, 2994, 3006, 3042, 3065, 3099, 3120, 3128, 3150, 3201, 3705, 3732, 3937, 3972], 'selected': [985, 2172], 'if': [986, 1525, 1943, 2349, 3107, 3928, 4119], 'member': [989], 'believes': [990], 'existent': [992], 'enough': [996], "'yes'": [999], "'no',": [1001], 'highlighting': [1002, 1108], 'area': [1004], 'where': [1005, 3910], 'needed.': [1008], 'Additional': [1009], 'changes': [1010, 1073], 'wording': [1013], 'made': [1017, 2875, 3564], 'session.': [1020], 'side': [1027, 1608, 1610, 2524, 2608], 'effects': [1028, 2525, 2609, 3021], 'difficult': [1030, 1427], 'symptoms,': [1031, 1250], 'Supportive': [1035], 'Palliative': [1037], 'Care': [1038], 'section,': [1039], 'session,': [1047], 'but': [1048, 1077, 1268, 1337, 1784, 1939, 2194, 2280, 3580, 3755, 4131], 'unanimously': [1051], 'agreed': [1052], 'email,': [1054], 'considered': [1057, 2163], 'have': [1059, 1102, 2394, 2756, 3066, 3100, 3863, 4133], '100%': [1060], 'agreement.': [1061], 'Previous': [1062], 'require': [1068, 1541], 'update': [1069], 'minor': [1072], 're-voted': [1076], 'reviewed': [1079], 'remain': [1087], 'valid.': [1088], 'To': [1089, 2953], 'provide': [1090], 'full': [1092, 3962], 'overview': [1093], 'currently': [1098], 'approved,': [1099], 'authors': [1101], 'listed': [1103], 'per': [1106, 1135], 'subject,': [1107], 'those': [1109, 3679, 3842], 'discussed,': [1112], 'supplementary': [1119, 1169, 1207], 'Table': [1120, 1170], 'S1,': [1121], 'Annals': [1124, 1174, 1211], 'Oncology': [1126, 1176, 1213, 3317, 3411, 4061], 'online,': [1127, 1177, 1214], 'describes': [1128], 'grading': [1131], 'system': [1132], 'used,': [1133, 2038, 2955, 3551], 'methodology,': [1138], 'adapted': [1139], '[10.Dykewicz': [1141], 'C.A.': [1142], 'Summary': [1143], 'preventing': [1148], 'opportunistic': [1149], 'infections': [1150], 'among': [1151, 2005], 'hematopoietic': [1152], 'stem': [1153], 'cell': [1154], 'transplant': [1155], 'recipients.Clin': [1156], 'Infect': [1157], 'Dis.': [1158], '2001;': [1159], '33:': [1160], '139-144Crossref': [1161], '(422)': [1164], 'Scholar];': [1166], 'see': [1167], 'http://www.esmo.org/Guidelines/ESMO-Guidelines-Methodology.': [1168], 'S2,': [1171], 'lists': [1178], 'their': [1188, 2240, 2337, 2343, 2418, 2451, 2459, 2469, 2473, 2580, 2629, 2657, 3078, 3162], 'disclosures': [1189], 'any': [1191, 3957], 'relationships': [1192], 'pharmaceutical': [1195], 'industry': [1196], 'could': [1198], 'perceived': [1200], 'interest.': [1206], 'Figures,': [1208], 'features': [1215], 'updated': [1216], 'diagnostic': [1218], 'algorithms.': [1221], 'Slides': [1222], 'online': [1230], 'http://www.abc-lisbon.org/': [1232], 'http://oncologypro.esmo.org/Guidelines/ESMO-Consensus-Conferences/Breast-Cancer.': [1234], 'Tabled': [1235, 2174], '1Guideline': [1236, 2175], 'statementLoE/GoRConsensusVisceral': [1237], 'crisis': [1238, 1259], 'defined': [1240, 1300, 1330, 1368, 1410, 2412], 'severe': [1242], 'organ': [1243], 'dysfunction': [1244], 'assessed': [1246], 'signs': [1248], 'laboratory': [1251], 'rapid': [1254], 'progression': [1255, 1290], 'disease.': [1257, 3860], 'Visceral': [1258], 'mere': [1263], 'presence': [1264, 1521], 'visceral': [1266, 1271], 'metastases': [1267], 'implies': [1269], 'compromise': [1272], 'leading': [1273], 'indication': [1277], 'rapidly': [1281], 'efficacious': [1282], 'therapy,': [1283], 'another': [1286, 3224], 'option': [1288, 1911, 2166, 3102, 3250], 'will': [1291], 'probably': [1292], 'possible.Expert': [1295], 'opinion/n/a95%Primary': [1296], 'endocrine': [1297, 1327, 1533, 1644, 1714, 1820], 'relapse': [1302, 1332, 1344], 'first': [1306, 1315, 1340], 'adjuvant': [1310, 1335, 1350], 'ET,': [1311, 1351, 1643, 1713], 'PD': [1313, 1353], 'within': [1314, 1345, 2472, 3510], '6': [1316, 1355], 'months': [1317, 1347, 1356, 2024], 'first-line': [1319], 'ET': [1320, 1336, 1359, 1590], 'ET.Expert': [1325, 1364], 'opinion/n/a67%Secondary': [1326], 'after': [1338, 1357, 1591, 2839, 2961, 3961], 'years,': [1342, 3840], '12': [1346], 'completing': [1349], '≥': [1354], 'initiating': [1358], 'opinion/n/a67%Oligometastatic': [1365], 'low': [1370], 'volume': [1371], 'limited': [1375, 2927], 'number': [1376], 'size': [1378], 'lesions': [1381], '(up': [1382], '5': [1384], 'same': [1390], 'organ),': [1391], 'potentially': [1392, 1556], 'amenable': [1393], 'local': [1395], 'treatment,': [1396, 2566, 2844], 'aimed': [1397], 'achieving': [1399], 'complete': [1401, 3846], 'remission': [1402], 'status.Expert': [1403], 'opinion/n/a78%Patients': [1404], 'multiple': [1406], 'chronic': [1407, 3031], 'conditions': [1408], 'comorbidities': [1415], 'cardiovascular,': [1417], 'impaired': [1418], 'renal': [1419], 'liver': [1421], 'function,': [1422], 'autoimmune': [1423], 'disease)': [1424], 'it': [1426, 1492, 1940], 'account': [1429, 2478], 'extrapolations': [1435], 'develop': [1437, 2464], 'care.Expert': [1441, 2489], 'opinion/n/a100%Adequate': [1442], 'OFS': [1443, 1449, 1506, 1888, 3913], 'context': [1446, 1576], 'ABC:Adequate': [1448], 'pre-menopausal': [1452, 1536, 1791, 2099, 2130], 'obtained': [1456], 'through': [1457, 1467, 1512, 2433], 'bilateral': [1458], 'ovariectomy,': [1459], 'continuous': [1460, 3083], 'LHRH': [1463, 1484, 2031, 2035], 'agonists': [1464], 'OFA': [1466, 1890, 3915], 'pelvic': [1468], 'RT': [1469], '(this': [1470], 'latter': [1471], 'always': [1474, 1937, 2887], 'effective': [1475], 'therefore': [1477, 3007, 3864], 'least': [1480], 'preferred': [1481], 'option).I/A85%If': [1482], 'agonist': [1485, 2036], 'this': [1489, 1970, 2697, 2822, 3214, 3593], 'age': [1490, 3160], 'group,': [1491], 'usually': [1494, 3762], 'given': [1496, 1949, 2592, 2639], 'q4w': [1499, 2049], 'basis': [1500], 'guarantee': [1502], 'optimal': [1503, 2397, 2487], 'OFS.II/B85%Efficacy': [1504], 'must': [1507, 2244, 2393, 2792, 2958, 3171], 'initially': [1509], 'confirmed': [1510], 'analytically': [1511], 'serial': [1513, 2016], 'evaluations': [1514], 'serum': [1516, 2019], 'oestradiol,': [1517], 'even': [1518, 2838], 'amenorrhoea,': [1523], 'especially': [1524, 3841, 4118], 'AI': [1527, 2029], 'administered.Expert': [1529], 'opinion/': [1530, 1571], 'B85%As': [1531], 'interventions': [1534, 2234], 'endocrine-responsive': [1539], 'indefinite': [1542], 'OFS,': [1543, 1669, 1739], 'choosing': [1544, 2764], 'one': [1545], 'method': [1546, 1885], 'other': [1549, 2977, 3701], 'requires': [1550], 'balance': [1551], "patient's": [1553, 1895], 'wish': [1554], 'preserving': [1557], 'fertility,': [1558], 'compliance': [1559], 'frequent': [1561, 3851], 'injections': [1562], 'long': [1565, 3786], 'period': [1566], 'time': [1568, 2218, 2294], 'cost.Expert': [1570], 'B85%Maintenance': [1572], 'therapy:': [1573], 'Guidelines,': [1579], 'maintenance': [1580], 'refers': [1582], 'continuation': [1585], 'anti-HER2': [1587], 'and/or': [1589, 3474], 'discontinuation': [1592], 'ChT.Expert': [1594], 'opinion/n/a100%Integrative': [1595], 'medicine:': [1596], 'complementary': [1597, 1606], 'integrative': [1599], 'medicine': [1600], '(CIM)': [1601], 'represents': [1602], 'treatments': [1607, 2500, 3502, 4112], 'conventional': [1612], 'approaches': [1613], 'proper': [1616], 'environment.Expert': [1618], 'opinion/n/a100%In': [1619], 'green,': [1620, 1689, 3268, 3361], 'NEW': [1621, 1690, 3269, 3362], 'statements.ABC,': [1624, 3272], 'cancer;': [1627, 1697, 3275, 3369], 'AI,': [1628, 1698], 'aromatase': [1629, 1699, 1945], 'inhibitor;': [1630, 1700], 'Consensus,': [1631, 1701, 3282, 3376], 'percentage': [1632, 1702, 3283, 3377], 'agreement': [1637, 1707, 3288, 3382], 'statement;': [1640, 1710, 3291, 3385], 'ChT,': [1641, 1711], 'chemotherapy;': [1642, 1712], 'therapy;': [1645, 1715], 'GoR,': [1646, 1716, 3334, 3428], 'grade': [1647, 1717, 3335, 3429], 'recommendation;': [1649, 1719, 3337, 3431], 'HER2,': [1650, 1720], '2;': [1655, 1725], 'LHRH,': [1656, 1726], 'luteinising': [1657, 1727, 1930, 1981], 'hormone-releasing': [1658, 1728, 1931], 'hormone;': [1659, 1729], 'LoE,': [1660, 1730, 3338, 3432], 'level': [1662, 1732, 3340, 3434], 'evidence;': [1664, 1734, 3342, 3436], 'OFA,': [1665, 1735], 'ovarian': [1666, 1670, 1736, 1740, 1773, 1921], 'function': [1667, 1671, 1737, 1741, 1774, 1922], 'ablation;': [1668, 1738], 'suppression;': [1672, 1742], 'PD,': [1673, 1743], 'progression;': [1675, 1745], 'q4w,': [1676, 1746], 'every': [1677, 1747], 'weeks;': [1679, 1749], 'RT,': [1680, 1750], 'radiotherapy.': [1681, 1751], 'Open': [1682, 3354], 'table': [1683, 3355], 'tab': [1687, 3359], 'statements.': [1693, 3365], 'Following': [1752], 'standardise': [1756], 'definitions': [1757], 'homogenise': [1759], 'certain': [1763, 3528], 'medical': [1764, 2857, 4093], 'terms,': [1765], 'provides': [1768], 'three': [1769], 'definitions.': [1771], 'Adequate': [1772], 'suppression': [1775], '(OFS)': [1776], 'ablation': [1778], '(OFA)': [1779], 'somewhat': [1782], 'controversial': [1783], 'crucial': [1785, 3493], 'issue': [1786, 3601, 3876], 'oestrogen': [1794], '(ER)-positive': [1796], 'As': [1798], 'already': [1799], 'extensively': [1800], 'previous': [1803, 3454], 'editions,': [1804], 'main': [1806, 3590], 'these': [1809, 1958, 3002, 3581], 'induction': [1813, 3911], 'OFS/OFA,': [1815], 'agent': [1821], 'added': [1824], '11.Cardoso': [1857], 'Senkus': [1861], 'E.': [1862], 'al.ESO-ESMO': [1864], '3rd': [1865], '3).Simultaneous': [1874], 'in:': [1876], 'Breast.': [1877], '244-259Scopus': [1880], '(157)': [1881], 'inducing': [1887], 'vary': [1892], 'preferences,': [1896, 2480], 'logistical': [1897], 'financial': [1899, 3063], 'issues.': [1900, 3520], 'Bilateral': [1901], 'salpingo-oophorectomy': [1902], 'minimal': [1905], 'invasive': [1906], 'approach': [1907, 2243], 'reasonable': [1910, 3075], 'confirmation': [1919, 1971, 1994, 2260], 'adequately': [1924], 'suppressed': [1925], 'when': [1926, 2167, 2763, 3133, 3253, 3542], 'chemically': [1927], 'induced': [1928], '[i.e.': [1929, 1972], 'hormone': [1932, 1982, 1986], '(LHRH)': [1933], 'agonist]': [1934], 'straightforward': [1938], 'indispensable': [1942], 'inhibitor': [1946], '(AI)': [1947], 'concomitantly,': [1950], 'view': [1952], 'oestrogen-inducing': [1955], 'effect': [1956], 'agents': [1959], 'absence': [1962], 'OFS.': [1964], 'way': [1967, 3597], 'obtain': [1969], 'testing': [1973], 'oestradiol': [1974, 2020], 'without': [1978], '(LH)': [1983], 'follicle-stimulating': [1985], '(FSH)]': [1987], 'timing': [1990, 2737], 'frequency': [1992], 'tests': [1995], 'established': [1999], 'there': [2001, 3134], 'substantial': [2003], 'discussion': [2004, 3170, 3936], 'members.': [2007], 'It': [2008], 'decided,': [2010], 'compromise,': [2013], 'recommend': [2015, 2892], 'measures': [2017], 'initial': [2023], '+': [2030], 'agonist.': [2032], 'When': [2033, 2365], 'recommends': [2044], '(every': [2050], 'weeks)': [2052], 'regimen.': [2053], 'are,': [2055], '3-monthly': [2065, 2094, 2125], 'regimen': [2066], 'concurrent': [2068], 'tamoxifen': [2069, 2170], 'yielded': [2071], 'similar': [2072], 'pharmacodynamic': [2077], 'safety': [2079], 'profiles': [2080], '[12.Noguchi': [2081], 'Kim': [2083], 'H.J.': [2084], 'Jesena': [2085], 'al.Phase': [2088], '3,': [2089], 'open-label,': [2090], 'randomized': [2091], 'study': [2092], 'comparing': [2093], 'monthly': [2096], 'goserelin': [2097, 2126], 'women': [2100, 3155], 'estrogen': [2102, 2133], 'receptor-positive': [2103, 2134], 'cancer.Breast': [2106, 2137], 'Cancer.': [2107, 3818], '771-779Crossref': [2110], '(16)': [2113], '13.Masuda': [2116], 'N.': [2117], 'Iwata': [2118], 'Rai': [2120], 'al.Monthly': [2123], 'versus': [2124], 'acetate': [2127], '2011;': [2141], '126:': [2142], '443-451Crossref': [2143], '(22)': [2146], 'two': [2150], 'randomised': [2151], '222': [2154], '170': [2156], 'patients,': [2157, 3760], 'respectively,': [2158], 'may,': [2160], 'therefore,': [2161, 2183], 'valid': [2165], 'combined': [2168], 'statementLoE/GoRConsensusThe': [2176], 'complex': [2181, 3906], 'and,': [2182, 3467], 'involvement': [2184], 'appropriate': [2187, 2227, 2444, 2781, 3174], 'specialties': [2188], 'multidisciplinary': [2191, 2520, 3206, 3490, 3742], 'team': [2192, 2521, 3207, 3491], '(including': [2193], 'restricted': [2196], 'medical,': [2198], 'radiation,': [2199], 'surgical': [2200], 'oncologists,': [2201], 'imaging': [2202, 3119, 3127], 'experts,': [2203], 'pathologists,': [2204], 'gynaecologists,': [2205], 'psycho-oncologists,': [2206], 'social': [2207, 3040], 'workers,': [2208], 'nurses': [2209, 3195], 'palliative': [2211, 2539, 2570], 'specialists),': [2213], 'crucial.Expert': [2215], 'opinion/A100%From': [2216], 'diagnosis': [2220, 2564], 'offered': [2226, 2328, 2545, 4122], 'psychosocial': [2228], 'care,': [2229, 2410, 2432, 3037], 'supportive': [2230, 2401, 2431, 2675, 2948, 3672], 'symptom-related': [2233], 'part': [2238, 2616, 2996, 3203], 'personalised': [2246], 'meet': [2248], 'needs': [2250, 2483, 2636, 2730, 3032], 'individual': [2253], 'patient.Expert': [2254], 'opinion/A100%Following': [2255], 'thorough': [2257, 3935], 'assessment': [2258], 'goals': [2266], 'discussed.': [2271, 3558], 'Patients': [2272, 4136], 'told': [2275], 'live': [2287, 3838], 'extended': [2291], 'periods': [2292], '(many': [2295], 'circumstances).Expert': [2299], 'opinion/A97%This': [2300], 'conversation': [2301], 'conducted': [2304], 'accessible': [2307, 2506], 'language,': [2308], 'respecting': [2309], 'privacy': [2311], 'cultural': [2313], 'differences,': [2314], 'whenever': [2316, 2796], 'possible,': [2317, 2366], 'written': [2318], 'provided.Expert': [2322], 'opinion/A97%All': [2323], 'comprehensive,': [2329], 'culturally': [2330, 2443], 'sensitive,': [2331], 'easy-to-understand': [2334], 'about': [2336, 2427, 3176, 3893, 4104, 4145], 'its': [2340, 2850], 'management.I/A97%Patients': [2341], '(and': [2342], 'families,': [2344], 'caregivers': [2345], 'network,': [2348], 'agrees)': [2352], 'invited': [2355], 'participate': [2357], 'decision-making': [2360], 'process': [2361], 'times.': [2364], 'encouraged': [2370], 'accompanied': [2373], 'persons': [2375], 'them': [2379], 'share': [2381, 2455], 'decisions': [2383, 2872], 'family': [2385, 3036], 'members,': [2386], 'caregivers,': [2387, 2581], 'network).Expert': [2389], 'opinion/A100%Every': [2390, 2490], 'according': [2403], 'highest': [2406], 'standards': [2407, 2774], 'patient-centred': [2409], 'by:•Open': [2413], 'communication': [2414, 2653], 'between': [2415, 2654, 2765, 3506, 4089], 'teams': [2421, 2659], 'goal.•Educating': [2425], 'options': [2429], 'dissemination': [2436], 'evidence-based': [2438], 'clear,': [2442], 'form.•Encouraging': [2445], 'proactive': [2449], 'providers.•Empowering': [2461], 'capability': [2466], 'improving': [2468, 2984], 'own': [2470], 'QoL': [2471, 2684, 2695, 4166], 'experience.•Always': [2475], 'taking': [2476], 'into': [2477], 'values': [2481], 'essential': [2485], 'should:•': [2493], 'Have': [2494], 'innovative': [2503], 'therapies': [2504, 3147, 3481, 4160], 'Units/Centres.Expert': [2508], 'opinion/A100%•': [2509], 'Be': [2510], 'treated': [2511, 3094], 'Specialist': [2513], 'Units/Centres/Services': [2515, 3782], '(SBUs)': [2516, 3783], 'specialised': [2519, 2523, 3198, 3227, 3488], 'nurse': [2529], 'experienced': [2530, 2612], 'ABC.I/A•': [2535], 'Survivorship': [2536, 3861], 'issues': [2537, 2993, 3262, 3862], 'addressed': [2543], 'stage.Expert': [2549], 'opinion/A•': [2550], 'assurance': [2553], 'programme': [2554], 'covering': [2555], 'entire': [2557], 'pathway': [2560], 'screening': [2562, 3117], 'rehabilitation,': [2567], 'follow-up': [2568], 'services': [2573, 2677], 'implemented': [2584], 'SBUs.Expert': [2586], 'opinion/BGeneral:': [2587], 'QoLStrong': [2588], 'consideration': [2589, 2990], 'validated': [2597], 'PROMs': [2598, 2621], 'record': [2602], 'symptoms': [2604], 'regular': [2615], 'simple': [2624], 'user-friendly': [2626], 'facilitate': [2628, 2652], 'practice,': [2633], 'thought': [2635], 'easiest': [2642], 'collection': [2643, 2735], 'platform,': [2644], 'e.g.': [2645], 'tablets': [2646], 'smartphones.': [2648], 'Systematic': [2649], 'monitoring': [2650], 'would': [2651, 2670], 'characterising': [2662], 'toxicities': [2664], 'anticancer': [2667, 3146, 3901, 4111], 'therapies.': [2668, 3902], 'This': [2669, 3848, 3903], 'permit': [2671], 'intervention': [2673], 'enhancing': [2678], 'QoL.I/C87%Specific': [2679], 'tools': [2680], 'evaluation': [2682], 'developed.Expert': [2690], 'opinion/A100%Until': [2691], 'then,': [2692], 'evaluating': [2694], 'setting': [2698], 'standardised': [2701], 'PROs': [2702], '(instead': [2703], 'focusing': [2705], 'exclusively': [2706], 'CTCAEs)': [2708], 'incorporate': [2710], 'site': [2712], 'modules': [2716], 'subscales': [2718], 'exist': [2720], 'EORTC': [2724], 'FACT': [2726], 'systems.Expert': [2727], 'opinion/A100%Additionally,': [2728], 'attention': [2729], 'paid': [2733], 'methods,': [2736], 'assessments': [2739], 'handling': [2741], 'missing': [2743], 'data.': [2744], 'sophisticated': [2746], 'statistics': [2747], 'employed': [2751], 'ensure': [2753], 'clinicians': [2755], 'reliable': [2758, 4143], 'help': [2761, 2920, 3237], 'options.Expert': [2767], 'opinion/A100%General:': [2768, 2855], 'trialsThere': [2770], 'few': [2772], 'proven': [2773], 'management.': [2779], 'After': [2780], 'informed': [2782, 3892], 'consent,': [2783], 'inclusion': [2784], 'well-designed,': [2788], 'prospective,': [2789], 'independent': [2790], 'priority': [2795], 'such': [2797, 2898, 3573], 'available,': [2800], 'willing': [2805], 'participate.Expert': [2807], 'opinion/A100%The': [2808], 'community': [2810, 2858, 2931, 3655], 'strongly': [2811, 2891, 2932, 3656], 'calls': [2812], 'addressing': [2816], 'unanswered': [2818], 'questions': [2820], 'setting,': [2823], 'just': [2826], 'regulatory': [2828], 'purposes.': [2829], 'carried': [2836, 3131], 'out,': [2837], 'approval': [2840], 'providing': [2845], 'performance,': [2851], 'efficacy': [2852], 'toxicity.Expert': [2854], 'affordability/cost-effectivenessThe': [2856], 'aware': [2860], 'problems': [2863], 'raised': [2864], 'cost': [2867, 3603], 'treatment.': [2870, 3168, 3537], 'Balanced': [2871], 'instances;': [2878], "patients'": [2879, 3024], 'well-being,': [2880], 'length': [2881], 'preferences': [2885], 'decisions.Expert': [2889], 'opinion/A100%We': [2890], 'objective': [2896], 'scales,': [2897], 'Value': [2905], 'Framework,': [2906], 'evaluate': [2908], 'magnitude': [2911], 'benefit': [2913], 'provided': [2914, 3260], 'prioritise': [2921], 'funding,': 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