Abstract: To the Editor: We appreciate the comment by Mennini et al. The authors would have preferred a study wherein only asymptomatic patients had been investigated; however, a substantial proportion of the screen-detected patients experience unrecognized clinical symptoms (1–3), and who are really asymptomatic? Such a group may be highly selected. We agree that long-term studies are needed, as well as comparisons among children, adolescents, and adults. Meanwhile, we recommend active case finding by screening for celiac disease in at-risk groups in children. On the contrary, we do not advocate mass screening.