Abstract: The nuclear lamina is a network of proteins within the nucleus that provides structural support to the nuclear membrane, and helps organize the arrangement of interphase chromatin. There is a wealth of information on the proteins that comprise the nuclear lamina, but our understanding of how these proteins physically contact and regulate the membrane and interphase chromatin is incomplete. What is clear is that there are subtle differences in the nuclear lamina in different cell types and tissues, and that mutations in genes that encode nuclear lamina proteins can lead to human disease.
Publication Year: 2021
Publication Date: 2021-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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