Title: ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
Abstract: In this article (Cancer Cell 7, pp. 275–286), the name of one of the authors was listed incorrectly. The author incorrectly listed as "R. Boomi Nathan" is actually named R. Boominathan. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agentGumireddy et al.Cancer CellMarch, 2005In BriefElevated expression of polo-like kinase1 (Plk1) has been reported in many human tumors, and inhibition of Plk1 activity results in their mitotic arrest and apoptosis. Here we describe the profile of ON01910, a small molecule inhibitor of Plk1 activity, which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis. This compound was not ATP-competitive, but competed for the substrate binding site of the enzyme. In vivo, this compound did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models. Full-Text PDF Open Archive