Abstract: DiabetesSerum response factor (c-fos serum response element-binding transcription factor; SRF)Studies in patient samples and in mice suggest that inhibiting SRF could help treat type 2 diabetes.In muscle tissue samples, SRF target genes were upregulated in diabetic and insulin-resistant patients compared with healthy controls.In obese mice on a high-fat diet, the SRF transcription inhibitor CCG-1423 improved glucose tolerance and normalized insulin levels compared with vehicle control.Next steps include additional studies of SRF activity in cell-based and mouse models.