Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4238320793', 'doi': 'https://doi.org/10.1128/mcb.8.1.210-225.1988', 'title': 'Two DNA-Binding Factors Recognize Specific Sequences at Silencers, Upstream Activating Sequences, Autonomously Replicating Sequences, and Telomeres in <i>Saccharomyces cerevisiae</i>', 'display_name': 'Two DNA-Binding Factors Recognize Specific Sequences at Silencers, Upstream Activating Sequences, Autonomously Replicating Sequences, and Telomeres in <i>Saccharomyces cerevisiae</i>', 'publication_year': 1988, 'publication_date': '1988-01-01', 'ids': {'openalex': 'https://openalex.org/W4238320793', 'doi': 'https://doi.org/10.1128/mcb.8.1.210-225.1988', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3275867'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/mcb.8.1.210-225.1988', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014325188', 'display_name': 'Andrew R. Buchman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew R. Buchman', 'raw_affiliation_strings': ['Department of Cell Biology, Stanford University School of Medicine, Stanford, California 94305'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Stanford University School of Medicine, Stanford, California 94305', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088879477', 'display_name': 'William J. Kimmerly', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William J. Kimmerly', 'raw_affiliation_strings': ['Department of Cell Biology, Stanford University School of Medicine, California 94305.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Stanford University School of Medicine, California 94305.', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038166405', 'display_name': 'Jasper Rine', 'orcid': 'https://orcid.org/0000-0003-2297-9814'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jasper Rine', 'raw_affiliation_strings': ['Department of Cell Biology, Stanford University School of Medicine, California 94305.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Stanford University School of Medicine, California 94305.', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049465163', 'display_name': 'Roger D. Kornberg', 'orcid': 'https://orcid.org/0000-0002-2425-7519'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roger D. Kornberg', 'raw_affiliation_strings': ['Department of Cell Biology, Stanford University School of Medicine, Stanford, California 94305'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Stanford University School of Medicine, Stanford, California 94305', 'institution_ids': ['https://openalex.org/I97018004']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.882, 'has_fulltext': False, 'cited_by_count': 170, 'citation_normalized_percentile': {'value': 0.948874, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '8', 'issue': '1', 'first_page': '210', 'last_page': '225'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11927', 'display_name': 'Plant Reproductive Biology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11237', 'display_name': 'Plant Gene Expression Analysis', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dna-binding-site', 'display_name': 'DNA binding site', 'score': 0.4973419}, {'id': 'https://openalex.org/keywords/conserved-sequence', 'display_name': 'Conserved sequence', 'score': 0.4382031}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.9151248}, {'id': 'https://openalex.org/C2777576037', 'wikidata': 'https://www.wikidata.org/wiki/Q719725', 'display_name': 'Saccharomyces cerevisiae', 'level': 3, 'score': 0.76651454}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.72344804}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5658946}, {'id': 'https://openalex.org/C3662595', 'wikidata': 'https://www.wikidata.org/wiki/Q5205743', 'display_name': 'DNA binding site', 'level': 5, 'score': 0.4973419}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.4947326}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.46964854}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.45368257}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.44262075}, {'id': 'https://openalex.org/C199216141', 'wikidata': 'https://www.wikidata.org/wiki/Q4995178', 'display_name': 'Conserved sequence', 'level': 4, 'score': 0.4382031}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.23107275}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.19308558}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.11739272}], 'mesh': [{'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002875', 'descriptor_name': 'Chromosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002875', 'descriptor_name': 'Chromosomes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072235', 'descriptor_name': 'Mating Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009838', 'descriptor_name': 'Oligodeoxyribonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009838', 'descriptor_name': 'Oligodeoxyribonucleotides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/mcb.8.1.210-225.1988', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3275867', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 83, 'referenced_works': ['https://openalex.org/W1417166419', 'https://openalex.org/W1513717105', 'https://openalex.org/W1519549458', 'https://openalex.org/W1538101859', 'https://openalex.org/W1584093684', 'https://openalex.org/W168383662', 'https://openalex.org/W1825047037', 'https://openalex.org/W1855382658', 'https://openalex.org/W1926757795', 'https://openalex.org/W1964262489', 'https://openalex.org/W1964876650', 'https://openalex.org/W1965267927', 'https://openalex.org/W1968916548', 'https://openalex.org/W1970099353', 'https://openalex.org/W1972187528', 'https://openalex.org/W1978172752', 'https://openalex.org/W1978617734', 'https://openalex.org/W1982741134', 'https://openalex.org/W1992675473', 'https://openalex.org/W1997986439', 'https://openalex.org/W1998498650', 'https://openalex.org/W1999685455', 'https://openalex.org/W2003893812', 'https://openalex.org/W2004563262', 'https://openalex.org/W2004812565', 'https://openalex.org/W2005115290', 'https://openalex.org/W2006945555', 'https://openalex.org/W2009310436', 'https://openalex.org/W2012819319', 'https://openalex.org/W2013545053', 'https://openalex.org/W2015669100', 'https://openalex.org/W2026642300', 'https://openalex.org/W2029377254', 'https://openalex.org/W2034300701', 'https://openalex.org/W2036708429', 'https://openalex.org/W2037164528', 'https://openalex.org/W2040193953', 'https://openalex.org/W2045251366', 'https://openalex.org/W2045583364', 'https://openalex.org/W2046328458', 'https://openalex.org/W2047371315', 'https://openalex.org/W2048500913', 'https://openalex.org/W2049481106', 'https://openalex.org/W2063638237', 'https://openalex.org/W2068477468', 'https://openalex.org/W2068764665', 'https://openalex.org/W2070637617', 'https://openalex.org/W2074057410', 'https://openalex.org/W2074231493', 'https://openalex.org/W2074237669', 'https://openalex.org/W2080139629', 'https://openalex.org/W2081260355', 'https://openalex.org/W2083065209', 'https://openalex.org/W2085492596', 'https://openalex.org/W2087777628', 'https://openalex.org/W2093315295', 'https://openalex.org/W2109290075', 'https://openalex.org/W2110033538', 'https://openalex.org/W2114217399', 'https://openalex.org/W2122078632', 'https://openalex.org/W2157724881', 'https://openalex.org/W2162598032', 'https://openalex.org/W2165512566', 'https://openalex.org/W2166801871', 'https://openalex.org/W2173106494', 'https://openalex.org/W2189220566', 'https://openalex.org/W2314952974', 'https://openalex.org/W302511345', 'https://openalex.org/W4211016615', 'https://openalex.org/W4231758439', 'https://openalex.org/W4233226164', 'https://openalex.org/W4233287369', 'https://openalex.org/W4234424100', 'https://openalex.org/W4234704602', 'https://openalex.org/W4235502788', 'https://openalex.org/W4236790131', 'https://openalex.org/W4242869219', 'https://openalex.org/W4246026706', 'https://openalex.org/W4248505698', 'https://openalex.org/W4248792141', 'https://openalex.org/W4252096174', 'https://openalex.org/W4255865936', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W2617836174', 'https://openalex.org/W2236968607', 'https://openalex.org/W2165899269', 'https://openalex.org/W2153561273', 'https://openalex.org/W2152664145', 'https://openalex.org/W2146393977', 'https://openalex.org/W2122429294', 'https://openalex.org/W2090848290', 'https://openalex.org/W2079197459', 'https://openalex.org/W2036927633'], 'abstract_inverted_index': {'Two': [0, 154], 'DNA-binding': [1, 205], 'factors': [2, 206], 'from': [3, 170], 'Saccharomyces': [4], 'cerevisiae': [5], 'have': [6], 'been': [7], 'characterized,': [8], 'GRFI': [9, 27, 82, 99, 199, 236], '(general': [10], 'regulatory': [11, 34], 'factor': [12, 17], 'I)': [13], 'and': [14, 45, 48, 139, 142, 148, 164, 190, 200, 207, 237], 'ABFI': [15, 156, 186, 201, 238], '(ARS-binding': [16], 'I),': [18], 'that': [19, 174, 234], 'recognize': [20], 'specific': [21], 'sequences': [22, 30, 88, 124, 183], 'within': [23, 242], 'diverse': [24], 'genetic': [25], 'elements.': [26], 'bound': [28, 83], 'to': [29, 49, 87, 105, 121, 180, 192, 211], 'at': [31, 68, 93, 126], 'the': [32, 38, 50, 59, 90, 101, 108, 130, 149, 162, 196, 215, 225, 243], 'negative': [33], 'elements': [35, 128], '(silencers)': [36], 'of': [37, 58, 107, 129, 195, 224], 'silent': [39, 131, 226], 'mating': [40, 132, 227], 'type': [41, 133, 228], 'loci': [42, 134], 'HML': [43, 140], 'E': [44, 47], 'HMR': [46, 135, 137], 'upstream': [51], 'activating': [52], 'sequence': [53], '(UAS)': [54], 'required': [55, 221], 'for': [56, 98, 222], 'transcription': [57], 'MAT': [60], 'alpha': [61], 'genes.': [62], 'A': [63], 'putative': [64], 'conserved': [65], 'UAS': [66], 'located': [67, 119], 'genes': [69], 'involved': [70], 'in': [71], 'translation': [72], '(RPG': [73], 'box)': [74], 'was': [75], 'also': [76], 'recognized': [77, 184], 'by': [78, 185, 214], 'GRFI.': [79], 'In': [80], 'addition,': [81], 'with': [84, 89, 100, 145], 'high': [85], 'affinity': [86, 103], '(C1-3A)-repeat': [91], 'region': [92], 'yeast': [94], 'telomeres.': [95], 'Binding': [96], 'sites': [97, 117, 158, 176], 'highest': [102], 'appeared': [104, 191], 'be': [106, 193, 212], 'form': [109], "5'-(A/G)(A/C)ACCCANNCA(T/C)(T/C)-3',": [110], 'where': [111], 'N': [112], 'is': [113], 'any': [114, 171], 'nucleotide.': [115], 'ABFI-binding': [116, 175], 'were': [118, 143, 159, 202], 'next': [120], 'autonomously': [122], 'replicating': [123], '(ARSs)': [125], 'controlling': [127], 'E,': [136], 'I,': [138], 'I': [141], 'associated': [144], 'ARS1,': [146], 'ARS2,': [147], '2': [150], 'micron': [151], 'plasmid': [152], 'ARS.': [153], 'tandem': [155], 'binding': [157], 'found': [160], 'between': [161], 'HIS3': [163], 'DED1': [165], 'genes,': [166, 217], 'several': [167], 'kilobase': [168], 'pairs': [169], 'ARS,': [172], 'indicating': [173], 'are': [177, 220], 'not': [178, 209], 'restricted': [179], 'ARSs.': [181], 'The': [182], 'showed': [187], 'partial': [188], 'dyad-symmetry': [189], 'variations': [194], 'consensus': [197], "5'-TATCATTNNNNACGA-3'.": [198], 'both': [203, 235], 'abundant': [204], 'did': [208], 'appear': [210], 'encoded': [213], 'SIR': [216], 'whose': [218], 'products': [219], 'repression': [223], 'loci.': [229], 'Together,': [230], 'these': [231], 'results': [232], 'indicate': [233], 'play': [239], 'multiple': [240], 'roles': [241], 'cell.': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4238320793', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-07T21:20:18.176149', 'created_date': '2022-05-12'}