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[1326], 'MR:': [1327], 'psychiatric': [1332], 'genetics.': [1333], 'Psychol': [1334], 'Med': [1335], '2007;': [1336, 1500], '37:163–180Google': [1337], 'Scholar3.': [1338], 'Wong': [1339], 'AHC,': [1340], 'Petronis': [1343], 'A:': [1344, 1365], 'Phenotypic': [1345], 'differences': [1346], 'identical': [1349, 1378], 'organisms:': [1350], 'epigenetic': [1352], 'perspective.': [1353], 'Hum': [1354], 'Mol': [1355], 'Genet': [1356], '2005;': [1357], '14(review': [1358], '1):R11–R18Google': [1360], 'Scholar4.': [1361], 'Bertelsen': [1364], 'Confirming': [1366], 'unexpressed': [1367], 'genotypes': [1368], 'schizophrenia:': [1370, 1483], 'risks': [1371], "Fischer's": [1376], 'Danish': [1377], 'fraternal': [1380], 'Arch': [1383, 1447], 'Gen': [1384, 1448], '1989;': [1386], '46:867–872Google': [1387], 'Scholar5.': [1388], 'Torrey': [1389, 1431], 'EF,': [1390, 1432], 'Taylor': [1391], 'EH,': [1392], 'Bracha': [1393], 'HS,': [1394], 'Bowler': [1395], 'AE,': [1396], 'McNeil': [1397], 'TF,': [1398], 'Rawlings': [1399], 'RR,': [1400], 'Quinn': [1401], 'PO,': [1402], 'Bigelow': [1403, 1435], 'LB,': [1404, 1436], 'Rickler': [1405], 'K,': [1406, 1408], 'Sjostrom': [1407], 'al:': [1410], 'Prenatal': [1411], 'origin': [1412], 'subgroup': [1417], 'Schizophr': [1422, 1498], 'Bull': [1423, 1499], '1994;': [1424], '20:423–432Google': [1425], 'Scholar6.': [1426], 'Goldberg': [1427], 'TE,': [1428], 'Ragland': [1429], 'JD,': [1430], 'Gold': [1433], 'JM,': [1434], 'Weinberger': [1437], 'DR:': [1438], 'Neuropsychological': [1439], 'assessment': [1440], '1990;': [1450], '47:1066–1072Google': [1451], 'Scholar7.': [1452], 'Jarvik': [1453], 'LF,': [1454], 'Deckard': [1455], 'BS:': [1456], 'Odyssean': [1458], 'personality:': [1459], 'survival': [1461], 'carriers': [1464], 'predisposing': [1467], 'schizophrenia?': [1469], 'Neuropsychobiology': [1470], '1977;': [1471], '3:179–191Google': [1472], 'Scholar8.': [1473], 'DL,': [1475], 'R,': [1477], 'NJ,': [1479], 'II:': [1481], 'Deconstructing': [1482], 'overview': [1485], 'use': [1488], 'order': [1492], 'understand': [1494], 'disorder.': [1497], '33:21–32Google': [1501], 'Scholar': [1502], 'FiguresReferencesCited': [1503], 'byDetailsCited': [1504], 'ByToxicity': [1505], 'testing': [1506], 'natural': [1508], 'products': [1509], 'zebrafish': [1512], 'systemSensory': [1514], 'gating': [1515], 'positive': [1519], 'disorganised': [1521], 'schizotypy': [1522], 'contrast': [1524], 'smooth': [1526], 'pursuit': [1527], 'eye': [1528], 'movements': [1529], 'latent': [1531], 'inhibitionNeuropsychologia,': [1532], 'Vol.': [1533, 1556, 1569, 1576, 1578, 1587, 1592, 1597, 1724, 1728, 1732, 1734, 1747, 1752, 1758], '161White': [1534], 'Matter': [1535], 'Alterations': [1536], 'Goal-Directed': [1539], 'System': [1540], 'Patients': [1542], 'With': [1543], 'Obsessive-Compulsive': [1544], 'Disorder': [1545], 'Their': [1547], 'Unaffected': [1548], 'First-Degree': [1549], 'RelativesBiological': [1550], 'Psychiatry:': [1551], 'Cognitive': [1552], 'Neuroscience': [1553], 'Neuroimaging,': [1555], '6,': [1557, 1579], 'No.': [1558, 1571, 1580, 1589, 1594, 1599, 1726, 1730, 1736, 1749, 1754, 1760], '10Érosion': [1559], 'prématurée': [1560], 'des': [1561], 'télomères': [1562], 'schizophrénies': [1564], ':': [1565], 'synthèse': [1566], "hypothèsesL'Encéphale,": [1568], '47,': [1570], '4Neuroscience': [1572], '&': [1573, 1744], 'Biobehavioral': [1574], 'Reviews,': [1575], '105Medicines,': [1577], '2Modeling': [1581], 'Gene–Gene': [1582], 'Interactions': [1583], 'SchizophreniaSchizophrenia': [1585], 'Research,': [1586, 1591], '170,': [1588, 1725], '1Schizophrenia': [1590], '174,': [1593], '1-3PLoS': [1595], 'ONE,': [1596], '9,': [1598], '2Genome-Wide': [1600], 'Linkage': [1601], 'Analyses': [1602], '12': [1604], 'From': [1608], 'Consortium': [1610], 'Genetics': [1613], 'SchizophreniaTiffany': [1615], 'A.': [1616, 1691, 1709], 'Greenwood,': [1617], 'Ph.D.,': [1618, 1623, 1628, 1636, 1647, 1651, 1655, 1659, 1669, 1673, 1677, 1685, 1689, 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