Title: A comparison of the analgesic effects of pentazocine and morphine in patients with cancer
Abstract: A double‐blind crossover evaluation of the relative analgesic potency of graded intramuscular doses of pentazocine and morphine was carried out in patients with chronic pain due to cancer. The analgesic potency of pentazocine, based on “total” effect, is estimated to be approximately one sixth that of morphine. An analysis of the analgesic response of patients in relation to their prior narcotic experience suggests that cross‐tolerance between pentazocine and narcotics is low. Doses of from 10 to 80 mg. of pentazocine preCipitated acute narcotic withdrawal reactions in some patients with substantial prior narcotic experience. Other adverse effects produced by pentazocine were qualitatively similar to those of morphine.
Publication Year: 1966
Publication Date: 1966-11-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 61
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