Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4235923312', 'doi': 'https://doi.org/10.1002/(sici)1097-4547(19970215)47:4<416::aid-jnr7>3.3.co;2-8', 'title': 'N‐methyl‐D‐aspartate‐mediated glutamate toxicity in the developing rabbit retina', 'display_name': 'N‐methyl‐D‐aspartate‐mediated glutamate toxicity in the developing rabbit retina', 'publication_year': 1997, 'publication_date': '1997-02-15', 'ids': {'openalex': 'https://openalex.org/W4235923312', 'doi': 'https://doi.org/10.1002/(sici)1097-4547(19970215)47:4<416::aid-jnr7>3.3.co;2-8'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4547(19970215)47:4<416::aid-jnr7>3.3.co;2-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053350450', 'display_name': 'Michael Haberecht', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael F. Haberecht', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061884784', 'display_name': 'Cheryl K. Mitchell', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheryl K. Mitchell', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087631439', 'display_name': 'Garrett J. Lo', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Garrett J. Lo', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001853695', 'display_name': 'Dianna A. Redburn', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dianna A. Redburn', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Houston', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.210943, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 66}, 'biblio': {'volume': '47', 'issue': '4', 'first_page': '416', 'last_page': '426'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10691', 'display_name': 'Molecular Mechanisms of Retinal Degeneration and Regeneration', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12236', 'display_name': 'Optogenetics in Neuroscience and Biophysics Research', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutamate-receptors', 'display_name': 'Glutamate Receptors', 'score': 0.508762}, {'id': 'https://openalex.org/keywords/nmda-receptors', 'display_name': 'NMDA Receptors', 'score': 0.501899}], 'concepts': [{'id': 'https://openalex.org/C67018056', 'wikidata': 'https://www.wikidata.org/wiki/Q414896', 'display_name': 'NMDA receptor', 'level': 3, 'score': 0.809929}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.78936577}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.62691057}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.61715174}, {'id': 'https://openalex.org/C2777093970', 'wikidata': 'https://www.wikidata.org/wiki/Q169342', 'display_name': 'Retina', 'level': 2, 'score': 0.5286862}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.5245662}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.51283795}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.47533134}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.42166764}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.366062}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35632175}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.30829355}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26675034}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.153813}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.12949085}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.08973467}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4547(19970215)47:4<416::aid-jnr7>3.3.co;2-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W750390717', 'https://openalex.org/W2952941127', 'https://openalex.org/W2362796209', 'https://openalex.org/W2094568064', 'https://openalex.org/W2036743046', 'https://openalex.org/W2025958644', 'https://openalex.org/W2019163442', 'https://openalex.org/W1994090017', 'https://openalex.org/W1986936937', 'https://openalex.org/W190756422'], 'abstract_inverted_index': {'Journal': [0], 'of': [1, 24, 30, 47, 53, 70, 76, 95, 101, 106, 109, 112, 134, 140, 157, 163, 180, 186, 205, 211, 216, 219, 222, 263, 273, 286, 297, 315, 349, 361, 387, 410, 455, 487, 490, 508, 515], 'Neuroscience': [2], 'ResearchVolume': [3], '47,': [4], 'Issue': [5], '4': [6], 'p.': [7], '416-426': [8, 576], 'N-methyl-D-aspartate-mediated': [9], 'glutamate': [10, 317, 353, 450], 'toxicity': [11, 354, 430, 501], 'in': [12, 321, 340, 383, 484, 499, 552], 'the': [13, 279, 289, 322, 341, 347, 358, 373, 411, 417, 433, 452, 456, 476, 479, 485, 495, 513, 520, 557], 'developing': [14, 323], 'rabbit': [15, 324], 'retina': [16, 325, 481], 'Michael': [17, 20, 127, 130], 'F.': [18, 21, 128, 131], 'Haberecht,': [19, 129], 'Haberecht': [22, 132], 'Department': [23, 46, 69, 94, 133, 156, 179, 204], 'Ophthalmology': [25, 48, 71, 96, 135, 158, 181, 206], 'and': [26, 49, 72, 97, 136, 159, 182, 207, 261, 265, 277, 284, 303, 333, 369, 372, 389, 397, 399, 439, 464, 540], 'Visual': [27, 50, 73, 98, 137, 160, 183, 208], 'Sciences,': [28, 51, 74, 99, 138, 161, 184, 209], 'University': [29, 52, 75, 100, 111, 139, 162, 185, 210, 221], 'Texas': [31, 54, 77, 102, 141, 164, 187, 212], 'Medical': [32, 55, 78, 103, 142, 165, 188, 213], 'School,': [33, 56, 79, 104, 143, 166, 189, 214], 'HoustonSearch': [34, 57, 80, 144, 167, 190], 'for': [35, 58, 81, 121, 145, 168, 191, 231, 445], 'more': [36, 59, 82, 122, 146, 169, 192, 232], 'papers': [37, 60, 83, 123, 147, 170, 193, 233], 'by': [38, 61, 84, 124, 148, 171, 194, 234, 462], 'this': [39, 62, 85, 125, 149, 172, 195, 235, 298, 538], 'authorCheryl': [40, 150], 'K.': [41, 44, 151, 154], 'Mitchell,': [42, 152], 'Cheryl': [43, 153], 'Mitchell': [45, 155], 'authorGarrett': [63, 173], 'J.': [64, 67, 174, 177, 561], 'Lo,': [65, 175], 'Garrett': [66, 176], 'Lo': [68, 178], 'authorDianna': [86, 196], 'A.': [87, 92, 197, 202], 'Redburn,': [88, 198], 'Corresponding': [89, 199], 'Author': [90, 200], 'Dianna': [91, 201], 'Redburn': [93, 203], 'HoustonDepartment': [105, 215], 'Ophthalmology,': [107, 217], 'College': [108, 218], 'Medicine,': [110, 220], 'Tennessee,': [113, 223], 'Memphis,': [114, 118, 224, 228], '855': [115, 225], 'Monroe': [116, 226], 'Street,': [117, 227], 'TN': [119, 229], '38163Search': [120, 230], 'author': [126, 236], 'First': [237], 'published:': [238], '07': [239], 'December': [240], '1998': [241], 'https://doi.org/10.1002/(SICI)1097-4547(19970215)47:4<416::AID-JNR7>3.0.CO;2-HCitations:': [242], '23AboutPDF': [243], 'ToolsRequest': [244], 'permissionExport': [245], 'citationAdd': [246], 'to': [247, 269, 292, 329, 345, 352, 404, 428, 432, 475, 482], 'favoritesTrack': [248], 'citation': [249], 'ShareShare': [250], 'Give': [251], 'accessShare': [252, 255], 'full': [253], 'text': [254], 'full-text': [256, 271, 295], 'accessPlease': [257], 'review': [258], 'our': [259, 541], 'Terms': [260, 283], 'Conditions': [262, 285], 'Use': [264], 'check': [266], 'box': [267], 'below': [268, 291], 'share': [270, 293], 'version': [272, 296], 'article.I': [274], 'have': [275], 'read': [276], 'accept': [278], 'Wiley': [280], 'Online': [281], 'Library': [282], 'UseShareable': [287], 'LinkUse': [288], 'link': [290], 'a': [294, 309, 505], 'article': [299], 'with': [300, 394, 401, 504], 'your': [301], 'friends': [302], 'colleagues.': [304], 'Learn': [305], 'more.Copy': [306], 'URL': [307], 'Share': [308], 'linkShare': [310], 'onFacebookTwitterLinkedInRedditWechat': [311], 'Abstract': [312], 'Extracellular': [313], 'levels': [314, 489], 'endogenous': [316, 491], 'are': [318, 549], 'relatively': [319], 'high': [320, 488], 'but': [326], 'nonetheless': [327], 'appear': [328], 'promote': [330], 'cell': [331], 'survival': [332], 'developmental': [334, 497], 'processes': [335], 'at': [336, 528, 537], 'concentrations': [337], 'considered': [338], 'toxic': [339], 'adult.': [342, 434], 'We': [343], 'wished': [344], 'examine': [346], 'development': [348], 'retinal': [350, 385, 447], 'susceptibility': [351, 454], 'as': [355, 357], 'well': [356], 'protective': [359], 'effects': [360], 'two': [362, 471], 'N-methyl-D-aspartate': [363], '(NMDA)': [364], 'antagonists,': [365, 398], '2-amino-5-phosphono-5-valeric': [366], 'acid': [367], '(APV)': [368], 'dextromethorphan': [370], '(Dex),': [371], 'nitric': [374], 'oxide': [375], 'synthase': [376], '(NOS)': [377], 'inhibitor,': [378], 'NG-methyl-L-arginine': [379], '(metARG).': [380], 'One': [381], 'day': [382], 'vitro': [384], 'explants': [386], 'adult': [388, 446], 'neonatal': [390, 480], 'rabbits': [391], 'were': [392, 423], 'incubated': [393], 'various': [395], 'agonists': [396], 'stained': [400], 'trypan': [402], 'blue': [403], 'visualize': [405], 'necrotic': [406, 412], 'cells.': [407, 518], 'The': [408], 'density': [409], 'cells': [413, 548], 'was': [414, 459], 'analyzed': [415], 'using': [416], 'Zeiss': [418], 'Videoplan': [419], '2.': [420], 'Immature': [421], 'neurons': [422, 448], 'approximately': [424], '10-fold': [425, 496], 'less': [426], 'sensitive': [427], 'NMDA': [429, 437, 500], 'compared': [431], 'Although': [435], 'both': [436], 'antagonists': [438], 'met': [440], 'ARG': [441], 'provided': [442], 'marked': [443], 'protection': [444], 'against': [449], 'toxicity,': [451], 'modest': [453], 'immature': [457], 'neuron': [458], 'blocked': [460], 'only': [461], 'Dex': [463], 'not': [465, 525, 550], 'APV': [466], 'or': [467, 478], 'metARG.': [468], 'At': [469], 'least': [470], 'factors': [472], 'may': [473, 524], 'contribute': [474], 'ability': [477], 'survive': [483], 'presence': [486], 'extracellular': [492, 509], 'glutamate.': [493], 'First,': [494], 'increase': [498], 'occurs': [502], 'simultaneously': [503], '12–15-fold': [506], 'downregulation': [507], 'glutamate,': [510], 'probably': [511], 'through': [512], 'actions': [514], 'maturing': [516], 'Muller': [517], 'Second,': [519], 'NMDA/NO': [521], 'excitotoxic': [522], 'pathway': [523], 'be': [526], 'active': [527], 'birth': [529], 'since': [530], 'an': [531], 'NOS': [532], 'inhibitor': [533], 'had': [534], 'little': [535], 'effect': [536], 'stage': [539], 'previous': [542], 'morphological': [543], 'data': [544], 'demonstrate': [545], 'that': [546], 'NOS-containing': [547], 'present': [551], 'their': [553], 'mature': [554], 'configuration': [555], 'until': [556], 'second': [558], 'postnatal': [559], 'week.': [560], 'Neurosci.': [562], 'Res.': [563], '47:416–426,': [564], '1997.': [565], '©': [566], '1997': [567], 'Wiley-Liss,': [568], 'Inc.': [569], 'Citing': [570], 'Literature': [571], 'Volume47,': [572], 'Issue415': [573], 'February': [574], '1997Pages': [575], 'RelatedInformation': [577]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4235923312', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-10T21:45:10.790174', 'created_date': '2022-05-12'}