Publication Information

{'id': 'https://openalex.org/W4235907291', 'doi': 'https://doi.org/10.1161/01.str.0000154880.49901.73', 'title': 'Response:', 'display_name': 'Response:', 'publication_year': 2005, 'publication_date': '2005-02-10', 'ids': {'openalex': 'https://openalex.org/W4235907291', 'doi': 'https://doi.org/10.1161/01.str.0000154880.49901.73'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.str.0000154880.49901.73', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.STR.0000154865.32282.8e', 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.STR.0000154865.32282.8e', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033410318', 'display_name': 'F. Cipollone', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'F. Cipollone', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5033410318'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': None, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': None, 'topics': [], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9393958}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.str.0000154880.49901.73', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.STR.0000154865.32282.8e', 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.str.0000154880.49901.73', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.STR.0000154865.32282.8e', 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1592471891', 'https://openalex.org/W1970170869', 'https://openalex.org/W1985974471', 'https://openalex.org/W1987764829', 'https://openalex.org/W1995449196', 'https://openalex.org/W2052794493', 'https://openalex.org/W2055009731', 'https://openalex.org/W2063147924', 'https://openalex.org/W2064182395', 'https://openalex.org/W2070426582', 'https://openalex.org/W2091771395', 'https://openalex.org/W2111017968', 'https://openalex.org/W2111089169', 'https://openalex.org/W2111814427', 'https://openalex.org/W2126597767', 'https://openalex.org/W2128571597', 'https://openalex.org/W2133355468', 'https://openalex.org/W2133784818', 'https://openalex.org/W2149172315', 'https://openalex.org/W2162661261', 'https://openalex.org/W2529190803', 'https://openalex.org/W4367480688'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2148612803', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'HomeStrokeVol.': [0], '36,': [1, 1635], 'No.': [2], '3Circulating': [3], 'Transforming': [4, 27], 'Growth': [5, 28], 'Factor-β1': [6, 29], 'Levels': [7, 30], 'in': [8, 31, 148, 166, 177, 196, 215, 252, 282, 294, 412, 439, 541, 579, 596, 607, 616, 631, 674, 705, 766, 830, 868, 876, 893, 899, 905, 926, 939, 963, 1027, 1037, 1067, 1112, 1194, 1251, 1321, 1356, 1373, 1423, 1472, 1511, 1518, 1544], 'Asymptomatic': [9, 32], 'Carotid': [10, 33], 'Plaques': [11, 34], 'Free': [12], 'AccessLetterPDF/EPUBAboutView': [13], 'PDFView': [14], 'EPUBSections': [15], 'ToolsAdd': [16], 'to': [17, 164, 223, 229, 266, 405, 425, 505, 514, 609, 625, 641, 647, 666, 695, 725, 1092, 1127, 1209, 1214, 1270, 1343, 1377, 1417, 1430, 1435, 1467, 1502, 1537, 1550, 1565, 1576, 1580, 1585], 'favoritesDownload': [18], 'citationsTrack': [19], 'citationsPermissions': [20], 'ShareShare': [21], 'onFacebookTwitterLinked': [22], 'InMendeleyReddit': [23], 'Jump': [24], 'toFree': [25], 'AccessLetterPDF/EPUBCirculating': [26], 'Patrizia': [35, 48], 'Ferroni': [36, 50, 856, 932, 1202, 1287, 1326], 'Salvatore': [37, 63], 'Novo,': [38], 'Valentina': [39, 75], 'Davì': [40, 47, 77, 113], 'and': [41, 55, 86, 182, 199, 239, 260, 370, 602, 645, 717, 827, 846, 919, 1147, 1228, 1242, 1304, 1307, 1429, 1475, 1492, 1514, 1528, 1554, 1560, 1600, 1619], 'Giuseppina': [42, 87], 'Novo': [43, 65, 89, 1590, 1601], 'Stefania': [44, 98], 'Basili': [45, 100, 815], 'Giovanni': [46, 111], 'FerroniPatrizia': [49], 'Department': [51, 66, 78, 90, 101, 315], 'of': [52, 67, 79, 91, 102, 143, 151, 207, 227, 242, 269, 287, 290, 316, 319, 336, 341, 344, 362, 397, 430, 433, 444, 455, 497, 527, 538, 551, 594, 619, 628, 650, 700, 703, 714, 758, 820, 863, 896, 917, 923, 957, 971, 974, 989, 1008, 1030, 1046, 1050, 1061, 1064, 1070, 1078, 1082, 1096, 1103, 1108, 1122, 1134, 1139, 1143, 1154, 1173, 1179, 1190, 1223, 1232, 1254, 1259, 1262, 1275, 1294, 1318, 1338, 1352, 1365, 1368, 1382, 1398, 1421, 1427, 1447, 1490, 1540, 1607, 1613, 1623], 'Experimental': [53], 'Medicine': [54, 318], 'Pathology,': [56], 'Rome': [57, 105], 'University': [58, 106, 322], '"La': [59, 107], 'Sapienza",': [60, 108], 'Rome,': [61, 109], 'Italy': [62, 73, 85, 97, 110, 120], 'NovoSalvatore': [64], 'Clinical': [68, 80, 92], 'Medicine,': [69, 81, 93, 1625], 'Palermo': [70, 82, 94, 321], 'University,': [71, 83, 95, 118], 'Palermo,': [72, 84, 96], ',': [74], 'DavìValentina': [76], 'NovoGiuseppina': [88], 'BasiliStefania': [99], 'Medical': [103], 'Therapy,': [104], 'DavìGiovanni': [112], '"G.': [114, 727], 'd\'Annunzio"': [115, 728], 'Foundation,': [116, 729], 'Chieti': [117], 'Chieti,': [119], 'Originally': [121, 1643], 'published1': [122], 'Mar': [123], '2005https://doi.org/10.1161/01.STR.0000154865.32282.8eStroke.': [124], '2005;36:525–526To': [125], 'the': [126, 134, 141, 149, 236, 267, 279, 288, 314, 320, 342, 431, 442, 524, 575, 580, 597, 617, 648, 669, 698, 726, 853, 860, 887, 894, 914, 920, 972, 987, 1028, 1044, 1062, 1068, 1076, 1085, 1094, 1101, 1109, 1119, 1128, 1131, 1137, 1151, 1183, 1188, 1197, 1201, 1211, 1220, 1226, 1229, 1252, 1260, 1284, 1291, 1335, 1344, 1349, 1366, 1369, 1396, 1419, 1424, 1432, 1440, 1448, 1459, 1473, 1503, 1541, 1545, 1566, 1610], 'Editor:It': [127], 'was': [128, 190, 355, 908, 1167], 'with': [129, 170, 173, 192, 271, 297, 387, 409, 441, 464, 531, 549, 555, 679, 823, 851, 870, 947, 960, 986, 998, 1013, 1015, 1052, 1150, 1170, 1205, 1341, 1358, 1384], 'great': [130], 'interest': [131, 852], 'we': [132, 585, 633, 880], 'read': [133, 850], 'report': [135], 'by': [136, 378, 686, 709, 792, 1257], 'Cipollone': [137, 211, 445, 731], 'et': [138, 212, 446, 857, 933, 1288, 1327], 'al1': [139], 'on': [140, 1290, 1301, 1556], 'role': [142, 1022, 1063, 1420], 'transforming': [144, 759, 864], 'growth': [145, 605, 760, 865], 'factor-β1': [146, 761, 866], '(TGF-β1)': [147, 867], 'process': [150, 251, 895, 1069, 1253], 'plaque': [152, 197, 208, 363, 897, 1255], 'stabilization.': [153], 'The': [154, 942, 992, 1040, 1072], 'authors': [155, 1160], 'demonstrate': [156], 'that': [157, 565, 588, 635, 668, 882, 945, 980, 996, 1043, 1075, 1162, 1379], 'TGF-β': [158], 'mRNA': [159], 'levels': [160, 226, 241, 375, 396, 533, 557, 578, 637, 672, 862, 922, 956, 1002, 1099, 1231, 1606], 'are': [161, 590, 1115, 1392, 1476, 1485, 1495, 1500, 1508, 1515, 1535], 'increased': [162, 576, 626, 670], 'up': [163], '3-fold': [165], 'asymptomatic': [167, 298, 388, 465, 871, 949], 'as': [168, 357, 599, 762, 1213, 1314, 1410, 1434, 1458, 1552], 'compared': [169, 408, 548, 959, 1012], 'symptomatic': [171, 1053], 'plaques,': [172], 'a': [174, 193, 204, 232, 249, 257, 283, 307, 331, 453, 469, 545, 591, 622, 687, 763, 910, 1005, 1021, 1047, 1058, 1079, 1140, 1216, 1273, 1315, 1363, 1380, 1411, 1442, 1478, 1578], 'parallel': [175], 'increase': [176, 195], 'protein': [178], 'expression': [179, 189, 238, 570, 757, 916, 1222, 1367], 'at': [180, 313, 345, 1165, 1176], 'immunocytochemistry': [181], 'Western': [183], 'blot': [184], 'analyses.1': [185], 'In': [186, 582, 874, 1117, 1235, 1265, 1282, 1347, 1575], 'addition,': [187], 'TGF-β1': [188, 228, 374, 398, 498, 532, 556, 577, 595, 636, 671, 704, 883, 918, 958, 982, 1001, 1017, 1025, 1066, 1083, 1098, 1163, 1185, 1224, 1237, 1268, 1313, 1400, 1428, 1437], 'associated': [191, 624, 985, 1169], 'comparable': [194], 'procollagen': [198], 'collagen': [200], 'content,': [201], 'thus': [202, 978, 1019, 1181], 'providing': [203, 1481], 'tangible': [205], 'mechanism': [206], 'stabilization.1': [209], 'As': [210], 'al': [213, 858, 934, 1289, 1328], 'acknowledge': [214], 'their': [216, 940, 1148], 'discussion,': [217], 'one': [218], 'important': [219, 937, 1454], 'issue': [220, 699, 904, 1513], 'would': [221, 247], 'be': [222, 417, 572, 684, 693, 968, 984, 1271, 1415, 1439, 1522, 1531, 1548, 1563], 'measure': [224], 'systemic': [225, 250, 981, 1024, 1399, 1425], 'verify': [230], 'whether': [231, 909, 1215, 1436], 'correlation': [233, 246, 911, 1149, 1217], 'exist': [234, 1036], 'between': [235, 913, 1219], 'localized': [237, 915, 1221], 'circulating': [240, 861, 921, 1000, 1065, 1097, 1152, 1184, 1230, 1267], 'this': [243, 245, 459, 583, 706, 906, 924, 930, 1038, 1113, 1158, 1233, 1295, 1323], 'cytokine;': [244], 'suggest': [248, 564, 1378], 'these': [253, 490], 'patients': [254, 270, 296, 463, 491, 530, 554, 678, 869, 946, 997, 1014, 1051, 1357], 'rather': [255, 1277], 'than': [256, 518, 568, 1278, 1525], 'local': [258, 569], 'phenomenon,': [259], 'probably': [261, 1362], 'might': [262, 571, 683], 'add': [263], 'prognostic': [264], 'information': [265, 1333], 'management': [268], 'carotid': [272, 300, 337, 352, 390, 681, 872, 950], 'plaques.We': [273], 'have': [274], 'only': [275, 1300, 1530], 'recently': [276, 1470], 'completed': [277], 'reviewing': [278], 'data': [280, 1303], 'collected': [281], '10-year': [284], 'prospective': [285], 'study': [286, 907, 1114, 1203], 'incidence': [289, 627, 1007, 1172], 'major': [291, 592], 'cardiovascular': [292, 348, 434, 629, 975, 1174, 1192, 1620], 'events': [293, 1175], '42': [295], 'low-grade': [299, 358, 389, 466, 680], 'stenosis.': [301], 'Patients': [302, 386], 'were': [303, 376, 449, 638], 'consecutively': [304], 'enrolled': [305], 'over': [306], '1-year': [308], 'period': [309, 1087, 1121], 'from': [310, 677, 711, 855, 929, 1200, 1239, 1286], 'those': [311, 519], 'presenting': [312], 'Internal': [317], 'Hospital': [323], 'for': [324, 452, 574, 1023, 1395, 1453, 1480, 1487, 1616], 'ultrasound': [325], 'evaluation': [326], '(high-resolution': [327], 'B-mode': [328], 'ultrasonography': [329], 'using': [330, 1157, 1406], '7.5-MHz': [332], 'duplex-type': [333], 'probe;': [334], 'Toshiba)': [335], 'atherosclerotic': [338, 768, 888, 990, 1031], 'involvement': [339], 'because': [340, 361], 'presence': [343, 432, 973], 'least': [346], '1': [347], 'risk': [349, 435, 976, 1189, 1276], 'factor.': [350], 'Percent': [351], 'lumen': [353, 359], 'stenosis': [354, 360, 391, 467, 682, 951], 'graded': [356], '>15%': [364], 'but': [365], '<50%': [366], '(intima-media': [367], 'thickness': [368], '>0.85': [369], '<1.5': [371], 'mm).': [372], 'Plasma': [373], 'determined': [377], 'enzyme': [379], 'immunoassay': [380], '(R&D': [381], 'Systems': [382], 'Inc,': [383], 'Minneapolis,': [384], 'Minn).': [385], 'had': [392, 492, 952], 'markedly': [393, 953], 'higher': [394, 494, 954, 1006, 1171, 1385], 'baseline': [395, 495, 955], '(median,': [399, 499], '3.7': [400], 'pg/mL;': [401, 421, 427, 516], 'interquartile': [402, 422, 502, 511], 'range,': [403, 423, 503, 512], '0.5': [404, 420, 424, 513], '10.8': [406, 506], 'pg/mL)': [407], 'control': [410, 542, 961, 1048], 'subjects': [411], 'whom': [413, 964], 'no': [414, 965, 1523], 'lesion': [415, 966], 'could': [416, 967, 1438], 'detected': [418, 969], '(mean,': [419], '4.8': [426], 'P<0.0001)': [428], 'independently': [429, 639, 970], 'factors,': [436, 977], 'which': [437, 632], 'is': [438, 663, 890, 944, 995, 1042, 1074, 1246], 'agreement': [440], 'finding': [443], 'al.1All': [447], 'patient': [448], 'longitudinally': [450], 'followed-up': [451], 'median': [454], '8.8': [456, 1177], 'years.': [457], 'During': [458], 'period,': [460], '14': [461], '(33%)': [462], 'experienced': [468, 544], 'hard': [470, 546, 1009, 1144], 'endpoint': [471, 547], '(nonfatal': [472], 'myocardial': [473], 'infarction,': [474], 'n=4;': [475, 481], 'stroke,': [476], 'n=2;': [477, 484], 'transient': [478], 'ischemic': [479], 'attack,': [480], 'intermittent': [482], 'claudication,': [483], 'percutaneous': [485], 'revascularization': [486], 'procedure,': [487], 'n=2).': [488], 'Surprisingly,': [489], 'significantly': [493], 'values': [496, 539], '7.2': [500], 'pg/mL,': [501, 510], '0.8': [504], 'versus': [507], 'median,': [508], '2.4': [509], '10.6': [515], 'P<0.02)': [517], 'who': [520], 'remained': [521], 'event-free': [522], 'during': [523, 1100], 'follow-up.': [525], 'Nine': [526], '19': [528], '(47%)': [529], '>4.8': [534], 'pg/mL': [535], '(upper': [536], 'quartile': [537], 'observed': [540, 634, 1161], 'subjects)': [543], '5': [550], '23': [552], '(22%)': [553], '<4.8': [558], '(log-rank': [559], 'test': [560], '1.9;': [561], 'P=0.06).These': [562], 'results': [563, 1285], 'mechanism(s)': [566], 'other': [567], 'responsible': [573, 1394, 1452], 'circulation.': [581], 'respect,': [584], 'must': [586], 'consider': [587], 'platelets': [589, 1383, 1422], 'source': [593], 'circulation': [598], 'they': [600, 1391], 'release': [601, 702], 'activate': [603], 'latent': [604], 'factor': [606, 765], 'response': [608], 'activation.2': [610], 'This': [611, 1581], 'has': [612], 'been': [613], 'clearly': [614], 'demonstrated': [615, 881], 'setting': [618], 'visceral': [620], 'obesity,': [621], 'condition': [623], 'events,': [630, 1621], 'related': [640], 'prothrombin': [642], 'fragment': [643], 'F1+23': [644], 'correlate': [646], 'rate': [649], 'urinary': [651], 'thromboxane': [652], 'metabolite': [653], 'excretion': [654], '(Rho=0.37;': [655], 'P<0.05)': [656], '(G.': [657], 'Davì,': [658], 'unpublished': [659, 1482], 'observation,': [660], '2003).': [661], 'It': [662], 'therefore': [664, 1308], 'conceivable': [665], 'hypothesize': [667], 'found': [673], 'plasma': [675, 1605], 'samples': [676], 'caused': [685], 'procoagulant': [688], 'state.': [689], 'Specific': [690], 'trials': [691], 'should': [692, 1465, 1521, 1562], 'designed': [694], 'directly': [696], 'address': [697], 'platelet': [701, 1292, 1319, 1354, 1450], 'clinical': [707, 1455], 'setting.Supported': [708], 'grants': [710], 'Italian': [712], 'Ministry': [713], 'Research': [715], '(40%': [716], 'Fondo': [718], 'per': [719], 'gli': [720], 'Investimenti': [721], 'Recerca': [722], 'di': [723], 'Base)': [724], 'Chieti.1': [730], 'F,': [732, 746, 751, 1597], 'Fazia': [733], 'M,': [734, 749, 802, 812, 1595], 'Mincione': [735], 'G,': [736, 782, 806, 1591], 'Iezzi': [737], 'A,': [738, 753, 778, 810, 1593], 'Pini': [739], 'B,': [740], 'Cuccurullo': [741, 750], 'C,': [742], 'Ucchino': [743], 'S,': [744, 808, 816], 'Spigonardo': [745], 'Di': [747], 'Nisio': [748], 'Mezzetti': [752, 847], 'Porreca': [754], 'E.': [755], 'Increased': [756], 'stabilizing': [764], 'human': [767], 'plaques.': [769, 873], 'Stroke.': [770], '2004;': [771, 797], '35:': [772], '2253–2257.LinkGoogle': [773], 'Scholar2': [774], 'Blakytny': [775], 'R,': [776], 'Ludlow': [777], 'Martin': [779], 'GE,': [780], 'Ireland': [781], 'Lund': [783], 'LR,': [784], 'Ferguson': [785], 'MW,': [786], 'Brunner': [787], 'G.': [788, 818], 'Latent': [789], 'TGF-beta1': [790], 'activation': [791, 829], 'platelets.': [793], 'J': [794, 834], 'Cell': [795], 'Physiol.': [796], '199:': [798], '67–76.CrossrefMedlineGoogle': [799], 'Scholar3': [800], 'Romano': [801], 'Guagnano': [803], 'MT,': [804], 'Pacini': [805], 'Vigneri': [807], 'Falco': [809], 'Marinopiccoli': [811], 'Manigrasso': [813], 'MR,': [814], 'Davi': [817], 'Association': [819], 'inflammation': [821], 'markers': [822], 'impaired': [824], 'insulin': [825], 'sensitivity': [826], 'coagulative': [828], 'obese': [831], 'healthy': [832], 'women.': [833], 'Clin': [835], 'Endocrinol': [836], 'Metab.': [837], '2003;': [838], '88:': [839], '5321–5326.CrossrefMedlineGoogle': [840], 'ScholarstrokeahaStrokeStrokeStroke0039-24991524-4628Lippincott': [841], 'Williams': [842], '&': [843], 'WilkinsResponse:Cipollone': [844], 'Francesco,': [845], 'Andrea,': [848], '01032005We': [849], 'letter': [854], 'about': [859, 1334], 'fact,': [875, 1236, 1283, 1348], 'our': [877, 1206], 'recent': [878, 1350], 'study,1': [879], 'generated': [884, 1238], 'locally': [885], 'within': [886, 1225], 'plaques': [889, 1032, 1054, 1227], 'actively': [891], 'involved': [892, 1250], 'stabilization': [898, 1256], 'humans.': [900], 'However,': [901], 'an': [902, 1247, 1279, 1468, 1512], 'unresolved': [903], 'exists': [912, 1218], 'cytokine': [925], 'high-risk': [927, 1195], 'patients.Starting': [928], 'point,': [931], 'provide': [935, 1331], '2': [936, 1372], 'observations': [938, 1306, 1351], 'study.': [941, 1039], 'first': [943, 1041], 'proved': [948], 'subjects,': [962], 'suggesting': [979, 1020, 1182], 'may': [983, 1003, 1186, 1388], 'development': [988], 'damage.': [991], 'second': [993, 1073, 1080], 'observation': [994, 1123, 1138], 'high': [999], 'experience': [1004], 'end': [1010, 1145], 'point': [1011], 'low': [1016], 'levels,': [1018], 'also': [1026, 1393], 'evolution': [1029], 'developing': [1033], 'complications.Some': [1034], 'limitations': [1035], 'absence': [1045, 1077], 'group': [1049], 'does': [1055, 1088], 'not': [1056, 1089, 1330, 1477, 1496, 1509, 1516], 'permit': [1057, 1090], 'complete': [1059], 'interpretation': [1060], 'atherothrombosis.': [1071], 'measurement': [1081], 'after': [1084], 'follow-up': [1086], 'us': [1091], 'know': [1093], 'modifications': [1095], 'progression': [1102], 'vessel': [1104], 'damage.Nevertheless,': [1105], 'some': [1106], 'aspects': [1107], 'methodology': [1110], 'adopted': [1111], 'noteworthy.': [1116], 'particular,': [1118], 'long-term': [1120], '(8.8': [1124], 'years)': [1125], 'permitted': [1126], 'authors,': [1129], 'despite': [1130, 1297], 'limited': [1132, 1536], 'number': [1133, 1142], 'studied': [1135], 'patients,': [1136, 1339], 'fair': [1141], 'points': [1146], 'level': [1153, 1164], 'TGF-β1.': [1155], 'Thus,': [1156, 1403], 'approach,': [1159], 'enrollment': [1166], 'positively': [1168], 'years': [1178], 'follow-up,': [1180], 'predict': [1187], 'future': [1191, 1617], 'complications': [1193], 'patients.Therefore,': [1196], 'evidence': [1198], 'rising': [1199], 'together': [1204], 'own': [1207], 'seems': [1208], 'resolve': [1210], 'question': [1212, 1433], 'cytokine.': [1234], 'tissue': [1240], 'macrophages': [1241], 'smooth': [1243], 'muscle': [1244], 'cells': [1245], 'active': [1248, 1280], 'player': [1249], 'modulation': [1258], 'turnover': [1261], 'extracellular': [1263], 'matrix.': [1264], 'contrast,': [1266], 'appears': [1269], 'simply': [1272], 'marker': [1274, 1317, 1446], 'mediator.': [1281], 'origin': [1293], 'mediator,': [1296], 'being': [1298], 'based': [1299], 'correlative': [1302], 'indirect': [1305], 'fairly': [1309], 'speculative,': [1310], 'nevertheless': [1311], 'identified': [1312], 'potential': [1316], 'reactivity': [1320, 1387, 1451], 'humans.In': [1322], 'light,': [1324], 'unfortunately': [1325], 'did': [1329], 'any': [1332], 'pharmacological': [1336, 1412], 'treatment': [1337], 'particularly': [1340], 'respect': [1342], 'antiplatelet': [1345, 1408], 'therapy.': [1346], 'aspirin-insensitive': [1353, 1370], 'activity': [1355], 'acute': [1359], 'vascular': [1360], 'events,2,3,4': [1361], 'consequence': [1364], 'cyclooxygenase': [1371], 'young': [1374], 'platelets,5,6': [1375], 'seem': [1376], 'subgroup': [1381], '(aspirin-insensitive)': [1386], 'exist.': [1389], 'Whether': [1390], 'generation': [1397, 1426], 'remains': [1401], 'unknown.': [1402], 'further': [1404], 'studies': [1405], 'different': [1407], 'strategies': [1409], 'tool': [1413], 'will': [1414, 1529, 1547], 'necessary': [1416], 'confirm': [1418], 'answer': [1431], '(for': [1441], 'long': [1443], 'time': [1444], 'searched)': [1445], 'abnormal': [1449], 'conditions,': [1456], 'such': [1457], 'so': [1460], 'called': [1461], '"aspirin-resistance': [1462], 'phenomenon."7': [1463], 'eLetters(0)eLetters': [1464], 'relate': [1466], 'article': [1469, 1542], 'published': [1471, 1510], 'journal': [1474, 1504], 'forum': [1479], 'data.': [1483], 'Comments': [1484, 1494, 1507, 1520], 'reviewed': [1486], 'appropriate': [1488], 'use': [1489], 'tone': [1491], 'language.': [1493], 'peer-reviewed.': [1497], 'Acceptable': [1498], 'comments': [1499], 'posted': [1501, 1532], 'website': [1505], 'only.': [1506], 'indexed': [1517], 'PubMed.': [1519], 'longer': [1524], '500': [1526], 'words': [1527], 'online.': [1533], 'References': [1534], '10.': [1538], 'Authors': [1539], 'cited': [1543], 'comment': [1546], 'invited': [1549], 'reply,': [1551], 'appropriate.Comments': [1553], 'feedback': [1555], 'AHA/ASA': [1557, 1567], 'Scientific': [1558], 'Statements': [1559], 'Guidelines': [1561], 'directed': [1564], 'Manuscript': [1568], 'Oversight': [1569], 'Committee': [1570], 'via': [1571], 'its': [1572], 'Correspondence': [1573], 'page.Sign': [1574], 'Submit': [1577], 'Response': [1579], 'Article': [1582, 1639], 'Previous': [1583], 'Back': [1584], 'top': [1586], 'Next': [1587], 'FiguresReferencesRelatedDetailsCited': [1588], 'By': [1589], 'Sansone': [1592], 'Rizzo': [1594], 'Guarneri': [1596], 'Pernice': [1598], 'C': [1599], 'S': [1602], '(2014)': [1603], 'High': [1604], 'endothelin-1': [1608], 'enhance': [1609], 'predictive': [1611], 'value': [1612], 'preclinical': [1614], 'atherosclerosis': [1615], 'cerebrovascular': [1618], 'Journal': [1622], 'Cardiovascular': [1624], '10.2459/JCM.0000000000000121,': [1626], '15:9,': [1627], '(696-701),': [1628], 'Online': [1629], 'publication': [1630], 'date:': [1631], '1-Sep-2014.': [1632], 'March': [1633], '2005Vol': [1634], 'Issue': [1636], '3': [1637], 'Advertisement': [1638, 1649], 'InformationMetrics': [1640], 'https://doi.org/10.1161/01.STR.0000154865.32282.8ePMID:': [1641], '15738573': [1642], 'publishedMarch': [1644], '1,': [1645], '2005': [1646], 'PDF': [1647], 'download': [1648]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4235907291', 'counts_by_year': [], 'updated_date': '2024-12-14T04:42:05.319959', 'created_date': '2022-05-12'}