Publication Information

{'id': 'https://openalex.org/W4235850766', 'doi': 'https://doi.org/10.3389/conf.fimmu.2015.05.00027', 'title': 'Human T lymphotropic virus type 1 (HTLV-1) provirus decreases IL-4 and IL-17A production in HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP)', 'display_name': 'Human T lymphotropic virus type 1 (HTLV-1) provirus decreases IL-4 and IL-17A production in HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP)', 'publication_year': 2015, 'publication_date': '2015-01-01', 'ids': {'openalex': 'https://openalex.org/W4235850766', 'doi': 'https://doi.org/10.3389/conf.fimmu.2015.05.00027'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.fimmu.2015.05.00027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2595292759', 'display_name': 'Frontiers in Immunology', 'issn_l': '1664-3224', 'issn': ['1664-3224'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 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'abstract_inverted_index': {'Event': [0, 4], 'Abstract': [1, 884, 886, 958], 'Back': [2, 960], 'to': [3, 91, 170, 201, 352, 358, 736, 761, 870, 961, 975], 'Human': [5, 417, 461, 678], 'T': [6, 462, 679], 'lymphotropic': [7, 680], 'virus': [8, 681], 'type': [9, 682], '1': [10, 39, 421, 683], '(HTLV-1)': [11, 684], 'provirus': [12, 348, 685], 'decreases': [13, 686], 'IL-4': [14, 288, 310, 362, 382, 687], 'and': [15, 36, 59, 125, 156, 229, 247, 287, 315, 343, 357, 363, 370, 383, 392, 399, 404, 430, 438, 474, 485, 492, 499, 511, 519, 532, 538, 548, 588, 599, 609, 674, 688, 743, 764, 806, 813, 823, 830, 875], 'IL-17A': [16, 275, 316, 689], 'production': [17, 360, 690], 'in': [18, 98, 270, 273, 296, 299, 331, 424, 455, 460, 542, 576, 602, 691, 729, 768, 889, 953, 969, 973], 'HTLV-associated': [19, 692], 'myelopathy/tropical': [20, 693], 'spastic': [21, 694], 'paraparesis': [22, 695], '(HAM/TSP)': [23], 'Giovanni': [24, 847, 891, 906, 922, 937], 'M.': [25], 'Lopez1*,': [26], 'Soraya': [27, 526, 894, 909, 925, 940], 'Menezes2,': [28], 'Michael': [29, 896, 911, 927, 942], 'Talledo3,': [30], 'Carolina': [31, 898, 913, 929, 944], 'Alvarez3,': [32], 'Johan': [33, 900, 915, 931, 946], 'Van': [34, 671, 901, 916, 932, 947], 'Weyenbergh2': [35], 'Eduardo': [37, 903, 918, 934, 949], 'Gotuzzo3': [38], 'Universidad': [40, 63, 850], 'Peruana': [41, 64, 851], 'Cayetano': [42, 65, 852], 'Heredia,': [43, 66, 853], 'Instituto': [44, 67, 854], 'de': [45, 68, 638, 642, 715, 719, 855], 'Medicina': [46, 69, 856], 'Tropical': [47, 70, 857], '“Alexander': [48, 71, 858], 'von': [49, 72, 859], 'Humboldt",': [50, 73, 860], 'Peru': [51, 74], '2': [52], 'University': [53], 'of': [54, 57, 96, 140, 158, 183, 188, 361, 381, 416, 434, 442, 552, 586, 607, 628, 633, 705, 710, 777, 793, 817], 'Leuven,': [55], 'Department': [56], 'Microbiology': [58], 'Immunology,': [60], 'Belgium': [61], '3': [62], 'Background:': [75], 'Cytokine': [76, 266, 293, 521], 'have': [77, 732], 'mainly': [78], 'focused': [79], 'on': [80, 980], 'T-cell': [81], 'subsets': [82], 'activation': [83], 'during': [84, 138], 'HTLV-1': [85, 112, 220, 493, 543, 563], 'infection.': [86], 'B': [87, 132, 389, 458, 534, 603, 621], 'lymphocytes': [88, 390], 'are': [89, 744, 750, 795, 825], 'known': [90], 'be': [92, 809, 814, 871], 'an': [93, 374], 'important': [94, 375], 'source': [95], 'cytokines': [97, 204, 249, 356], 'chronic': [99], 'inflammatory': [100, 118, 355], 'diseases': [101], '(Vazquez-Tello': [102], 'et': [103, 121, 127, 143, 147, 195, 410, 448, 528, 559, 595], 'al.': [104, 122, 128, 144, 148, 196, 411, 449, 529, 560, 596], '2012).': [105], 'Studies': [106], 'provide': [107], 'evidence': [108], 'that': [109, 325, 367], 'a': [110, 257, 387, 566, 759, 798], 'higher': [111, 259, 269, 330, 344], 'proviral': [113, 304, 327, 345], 'load': [114, 305, 328], '(PVL)': [115], 'detonate': [116], 'intense': [117], 'response': [119, 396], '(Primo': [120], '2009)': [123], '(Gessain': [124], 'Mahieux': [126], '2012)': [129], 'where': [130], 'circulating': [131], 'cell': [133], 'could': [134], 'lose': [135], 'their': [136], 'signals': [137], 'pathogenesis': [139], 'HAM/TSP': [141, 226, 333], '(Furukawa': [142], '2000)': [145], '(Menezes': [146], '2014).': [149], 'We': [150], 'explored': [151], 'this': [152, 730, 981], 'hypothesis': [153], 'comparing:': [154], 'PVL': [155, 172, 177, 246, 260], 'levels': [157, 267], 'plasma': [159], 'Th1/Th2/Th17': [160, 203], 'cytokines.': [161], 'Methods:': [162], 'Peripheral': [163, 456], 'blood': [164], 'mononuclear': [165], 'cells': [166, 622], '(PBMC)': [167], 'were': [168, 236, 251, 268, 294], 'isolated': [169], 'measure': [171, 202], 'by': [173, 205, 747, 774], 'Sybr-Green': [174], 'quantitative': [175], 'PCR.': [176], 'was': [178, 199, 214, 329], 'determined': [179], 'as': [180, 536, 758, 788, 790], 'the': [181, 217, 239, 245, 248, 326, 332, 350, 378, 394, 629, 706, 754, 769, 775, 791, 815, 821, 978], 'number': [182], 'tax': [184], 'copies': [185], '/': [186], '(number': [187], 'ERV-3': [189], 'copies/2)': [190], 'x': [191], '104': [192], 'PBMCs': [193], '(Adaui': [194], '2006).': [197], 'Plasma': [198], 'obtained': [200], 'Fluorescent': [206], 'Bead': [207], 'Immunoassay': [208], '-': [209, 625, 635, 651, 702, 712], 'Flow': [210], 'Cytometry.': [211], 'The': [212, 727, 766, 887], 'comparison': [213], 'made': [215, 751], 'between': [216, 244], 'groups:': [218], '(1)': [219], 'asymptomatic': [221], 'carriers': [222], '[AC]': [223], '(n=7);': [224], '(2)': [225], '[TSP]': [227], '(n=19)': [228], 'healthy': [230], 'controls': [231], '[HC]': [232], '(n=5).': [233], 'Non-parametric': [234], 'tests': [235], 'used': [237], 'for': [238, 377, 568], 'statistical': [240], 'analysis.': [241], 'Correlation': [242], 'analysis': [243], 'evaluated': [250], 'also': [252], 'performed.': [253], 'Results:': [254], 'TSP': [255, 300], 'had': [256, 349], 'significantly': [258], 'than': [261, 272], 'AC': [262, 271, 338], '[2700±1620SD': [263, 289], 'vs.1301±1256SD]': [264, 290], '[p=0.025].': [265, 291], 'TSP:': [274], '[40.68±72.92SD': [276], 'vs.13.96±28.33SD]': [277], '[p=0.022],': [278], 'IL-2': [279], '[443.9±294.1SD': [280], 'vs.275.0±407.5SD]': [281], '[p=0.033],': [282], 'IL-1β': [283], '[58.22±24.77SD': [284], 'vs.37.54±50.89SD]': [285], '[p=0.005]': [286], 'Inflammatory': [292], 'undetectable': [295], 'ND.': [297], 'Interestingly': [298], 'patients,': [301], 'we': [302], 'found': [303], 'correlated': [306], 'negatively': [307], 'both': [308, 386], 'with': [309, 337, 427, 578, 582, 873], '[Spearman': [311, 317], 'r': [312, 318], '=-0.501,': [313], 'p=0.005]': [314], '=-0.4256,': [319], 'p=0.030].': [320], 'Conclusion:': [321], 'Our': [322], 'findings': [323], 'showed': [324], 'group': [334], 'when': [335], 'compared': [336], 'group,': [339], 'correlating': [340], 'disease': [341], 'progression': [342], 'load.': [346], 'Moreover,': [347], 'potential': [351], 'produce': [353], 'various': [354], 'regularly': [359], 'IL-17A.': [364], 'Overall,': [365], 'suggesting': [366], 'viral': [368], 'persistence': [369], 'pro-inflammatory': [371], 'state': [372], 'play': [373], 'role': [376], 'down': [379], 'regulation': [380], 'IL-17A,': [384, 618], 'causing': [385], 'cytokine-stimulated': [388], 'defect': [391], 'impaired': [393], 'host': [395], 'against': [397], 'bacterial': [398], 'fungal': [400], 'infections': [401], '(Gu,': [402], 'Wu,': [403, 510], 'Li': [405], '2013).': [406], 'References': [407], 'Adaui,': [408], 'Vanessa': [409], '2006.': [412], '“SYBR': [413], 'Green-Based': [414], 'Quantitation': [415], 'T-Lymphotropic': [418], 'Virus': [419, 465], 'Type': [420, 466], 'Proviral': [422, 564, 619], 'Load': [423], 'Peruvian': [425], 'Patients': [426, 577], 'Neurological': [428], 'Disease': [429], 'Asymptomatic': [431], 'Carriers:': [432], 'Influence': [433], 'Clinical': [435, 473], 'Status,': [436], 'Sex,': [437], 'Familial': [439], 'Relatedness.”': [440], 'Journal': [441, 551, 585], 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