Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing

Name: Work Video:
Duration: 3 min 30 s
Karen L. Wright; Norio Ozaki; Mark Feeney; J J T Tate; Duncan A. Robertson; Melanie J. Welham; Stephen G. Ward
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531, 1006], 'termed': [7, 242], 'CB1': [8, 21, 65, 197, 243, 256, 300, 432, 776, 838, 1230, 1313, 1436, 1638, 2380, 2528, 2720, 2873, 3034, 3407], 'and': [9, 14, 23, 40, 55, 66, 86, 91, 115, 135, 141, 205, 211, 244, 249, 258, 275, 290, 301, 321, 326, 350, 370, 376, 440, 446, 491, 502, 552, 582, 597, 629, 643, 659, 749, 877, 897, 907, 911, 913, 982, 988, 1010, 1044, 1080, 1083, 1096, 1102, 1126, 1188, 1226, 1276, 1344, 1398, 1495, 1628, 1710, 1749, 1781, 1902, 1918, 1972, 2043, 2068, 2072, 2098, 2106, 2247, 2263, 2274, 2303, 2507, 2572, 2585, 2591, 2620, 2764, 2846, 2918, 2933, 3035, 3041, 3049, 3062, 3165, 3172, 3185, 3188, 3192, 3195, 3209, 3217, 3238, 3244, 3257, 3270, 3280, 3283, 3308, 3314, 3357, 3408, 3460, 3515, 3543, 3556, 3572, 3589, 3632, 3671, 3692, 3735, 3760, 3778, 3800, 3851, 3861, 3886, 3896, 3911, 4016, 4033, 4087, 4113], 'CB2,': [10, 245], 'have': [11, 246, 537, 626, 1207, 2840, 2940], 'been': [12, 38, 247, 273, 538, 627, 1024, 1072, 2430, 2518, 2703, 2829, 2841, 2941], 'identified': [13, 248, 3499], 'several': [15, 250, 1218, 1505], 'mammalian': [16, 251, 1506], 'enteric': [17, 252, 1214, 1243], 'nervous': [18, 253, 1215, 1244], 'systems': [19, 254], 'express': [20, 255, 1229], 'receptors': [22, 51, 68, 96, 198, 257, 286, 303, 331, 433, 625, 744, 1314, 1437, 1702, 2058, 2101, 2169, 2193, 2273, 2571, 2763, 2826, 2874, 2910, 2939, 3037, 3056], 'produce': [24, 259], 'endocannabinoids.': [25, 260], 'An': [26, 261, 1834], 'immunomodulatory': [27, 227, 262, 462, 2245], 'role': [28, 228, 263, 463, 2258, 3081], 'for': [29, 119, 264, 354, 610, 623, 879, 946, 1026, 1038, 2125, 2163, 2471, 2489, 2779, 3004, 3078, 3236, 3334, 3382, 3399, 3457, 3466, 3642, 3655, 3679, 3711, 3741, 3764, 3773, 3829, 3954, 4030, 4111, 4128], 'the': [30, 46, 95, 136, 150, 165, 265, 281, 330, 371, 385, 400, 488, 493, 586, 774, 837, 1011, 1018, 1030, 1048, 1131, 1155, 1159, 1213, 1221, 1241, 1273, 1316, 1347, 1351, 1357, 1501, 1567, 1704, 1750, 1921, 1925, 1931, 1996, 2004, 2010, 2037, 2122, 2129, 2133, 2164, 2195, 2202, 2253, 2275, 2318, 2324, 2337, 2379, 2406, 2424, 2534, 2726, 2780, 2805, 2812, 2816, 2832, 2912, 2934, 2948, 3001, 3024, 3030, 3052, 3106, 3126, 3138, 3141, 3196, 3230, 3335, 3339, 3351, 3445, 3488, 3501, 3520, 3695, 3712, 3716, 3779, 3808, 3939, 4034, 4045, 4057, 4065], 'endocannabinoid': [31, 266, 1020, 1609, 1747, 1883, 2977, 3002], 'system': [32, 267, 1216, 1748, 2267, 2814, 3003, 3233], 'in': [33, 52, 69, 89, 112, 120, 129, 149, 164, 183, 201, 219, 268, 287, 304, 324, 347, 355, 364, 384, 399, 418, 436, 454, 558, 649, 688, 728, 1014, 1087, 1104, 1130, 1192, 1240, 1272, 1315, 1350, 1356, 1401, 1438, 1477, 1500, 1535, 1537, 1564, 1665, 1703, 1756, 1784, 1843, 1924, 1930, 1975, 2003, 2036, 2102, 2128, 2139, 2194, 2230, 2259, 2363, 2618, 2657, 2708, 2785, 2815, 2831, 2843, 2875, 2911, 2943, 3038, 3071, 3082, 3161, 3167, 3296, 3371, 3388, 3393, 3417, 3453, 3462, 3519, 3561, 3566, 3619, 3673, 3715, 3754, 3783, 3832, 3876, 3938, 3967, 4121, 4126, 4137], 'gastrointestinal': [34, 269, 1156, 1533, 1782, 2228, 2786, 3503], 'inflammatory': [35, 172, 221, 270, 407, 456, 3042], 'disorders': [36, 271, 1040], 'has': [37, 272, 1023, 1071, 2187, 2429, 2517, 2702, 2827], 'proposed': [39, 274], 'this': [41, 276, 3297], 'study': [42, 277, 2186, 3026, 3298], 'sought': [43, 278], 'to': [44, 56, 97, 213, 279, 291, 332, 448, 693, 1075, 1362, 1632, 1936, 2200, 2321, 2432, 2533, 2595, 2705, 2710, 2725, 2807, 2999, 3012, 3028, 3050, 3066, 3097, 3227, 3610, 3729, 3909, 4038, 4083, 4092, 4115], 'determine': [45, 280, 3029, 3807], 'location': [47, 63, 282, 298, 3031], 'of': [48, 64, 94, 167, 171, 283, 299, 329, 402, 406, 483, 505, 509, 523, 532, 554, 578, 585, 606, 645, 683, 773, 828, 853, 874, 909, 953, 1033, 1047, 1099, 1120, 1152, 1158, 1183, 1217, 1236, 1267, 1310, 1346, 1353, 1433, 1474, 1504, 1532, 1540, 1611, 1634, 1662, 1699, 1707, 1753, 1778, 1804, 1885, 1920, 1927, 1995, 1998, 2009, 2031, 2070, 2096, 2135, 2166, 2204, 2222, 2252, 2265, 2277, 2297, 2317, 2326, 2329, 2350, 2399, 2405, 2423, 2438, 2493, 2536, 2569, 2608, 2638, 2682, 2728, 2761, 2783, 2824, 2870, 2907, 2915, 2936, 2950, 2979, 3023, 3032, 3054, 3140, 3229, 3338, 3362, 3404, 3437, 3494, 3512, 3622, 3698, 3752, 3787, 3810, 3814, 3823, 3864, 3926, 3941, 4078], 'both': [49, 84, 284, 319, 743, 2596, 2937, 3033, 3039, 3060], 'human': [53, 70, 203, 220, 288, 305, 438, 455, 1227, 1439, 1583, 1708, 2103, 2300, 2833, 2844, 2876, 2916, 2945, 3046], 'colon': [54, 204, 289, 439, 3120], 'investigate': [57, 292], 'epithelial': [58, 79, 107, 177, 216, 293, 314, 342, 412, 451, 3073, 3083, 3551], 'receptor': [59, 194, 294, 429, 557, 581, 609, 648, 726, 1238, 1270, 1349, 1393, 1569, 1923, 1967, 2409, 2474, 2530, 2722, 3198], 'function.': [60, 295], 'Methods:': [61, 296], 'The': [62, 297, 470, 521, 1181, 1492, 1746, 2420, 2527, 2636, 2719, 2822, 3021, 3325, 3625, 3767], 'CB2': [67, 155, 160, 302, 390, 395, 2057, 2136, 2192, 3036, 3409], 'colonic': [71, 78, 106, 131, 168, 206, 306, 313, 341, 366, 403, 441, 1475, 1663, 3047, 3072, 3089, 3115, 3133, 3550], 'tissue': [72, 169, 224, 307, 404, 459, 3048, 3342, 3563, 3639], 'was': [73, 101, 127, 144, 156, 162, 308, 336, 362, 379, 391, 397, 804, 2132, 3027, 3128, 3286, 3332, 3367, 3440, 3482, 3490, 3538, 3601, 3627, 3769, 3781, 3907, 3921, 3936, 4023, 4036, 4054, 4081, 4103], 'determined': [74, 102, 309, 337, 3937, 4063], 'by': [75, 103, 310, 338, 528, 862, 933, 2001, 2208, 2403, 2435, 2481, 2613, 2648, 2686, 2689, 3057, 3444, 3500, 3733, 3750, 3951, 4025], 'immunohistochemistry.': [76, 311], 'Primary': [77, 312], 'cells': [80, 148, 315, 383, 2064, 3497, 3509, 3633, 3661, 3753], 'were': [81, 110, 316, 345, 3101, 3159, 3175, 3201, 3211, 3234, 3247, 3260, 3273, 3346, 3353, 3386, 3421, 3431, 3451, 3470, 3498, 3558, 3577, 3615, 3634, 3662, 3669, 3684, 3722, 3731, 3748, 3825, 3949, 3965, 4062, 4090, 4119], 'treated': [82, 317, 3685], 'with': [83, 185, 318, 420, 833, 970, 3355, 3472, 3579, 3603, 3686, 3694, 3857, 3915, 3923, 4064, 4132], 'synthetic': [85, 320, 3063], 'endogenous': [87, 322, 685, 724, 771, 801, 1008, 1835, 1999, 3061, 3189, 3231], 'cannabinoids': [88, 323, 1184, 2002, 2322, 3064, 3194, 3811], 'vitro,': [90, 325], 'biochemical': [92, 327, 3068], 'coupling': [93, 328], 'known': [98, 333, 1025, 3067], 'signaling': [99, 334, 2510], 'events': [100, 335], 'immunoblotting.': [104, 339], 'Human': [105, 340, 3088, 3549], 'cell': [108, 343, 3552, 4021], 'lines': [109, 344, 3553], 'used': [111, 346, 3295, 3333, 3441, 3908, 4055], 'cannabinoid-binding': [113, 348], 'studies': [114, 349, 1206, 2839, 3948], 'as': [116, 351, 865, 1042, 1471, 1659, 2378, 2789, 3240, 3442, 3484, 3611, 3709, 3724], 'a': [117, 189, 352, 424, 555, 579, 607, 646, 722, 829, 863, 1538, 2490, 2592, 3079, 3360, 3414, 3434, 3473, 3492, 3784, 3897, 4039, 4106], 'model': [118, 353, 1539, 2492], 'vitro': [121, 356, 1430, 2867], 'wound-healing': [122, 357], 'experiments.': [123, 358], 'Results:': [124, 359], 'CB1-receptor': [125, 360, 1529], 'immunoreactivity': [126, 161, 361, 396, 1239, 1271], 'evident': [128, 363], 'normal': [130, 202, 365, 437, 2260, 2944, 3040, 3119, 3513], 'epithelium,': [132, 367], 'smooth': [133, 368], 'muscle,': [134, 369], 'submucosal': [137, 372], 'myenteric': [138, 373, 1278, 2005], 'plexus.': [139, 374], 'CB1-': [140, 375, 3542], 'CB2-receptor': [142, 217, 377, 452, 3544], 'expression': [143, 218, 378, 453, 584, 2127], 'present': [145, 157, 380, 392, 687, 1499, 3025], 'on': [146, 158, 232, 381, 393, 467, 1123, 1154, 1185, 2033, 2062, 2170, 2226, 2299, 2811, 3348, 3812, 4105], 'plasma': [147, 382], 'lamina': [151, 386, 3521], 'propria,': [152, 387], 'whereas': [153, 388], 'only': [154, 389, 2123], 'macrophages.': [159, 394], 'seen': [163, 398], 'epithelium': [166, 207, 401, 442], 'characteristic': [170, 405, 3511], 'bowel': [173, 222, 408, 457, 3043, 3514], 'disease.': [174, 409], 'Cannabinoids': [175, 410, 2243, 2563, 2755], 'enhanced': [176, 411], 'wound': [178, 413, 3084], 'closure': [179, 414], 'either': [180, 415, 3699], 'alone': [181, 416], 'or': [182, 417, 860, 939, 2483, 2652, 3433, 3645, 3649, 3652, 3702, 3706], 'combination': [184, 419], 'lysophosphatidic': [186, 421], 'acid': [187, 191, 422, 426, 935, 985, 3301], 'through': [188, 423, 857, 1637, 1786, 3359, 3369], 'CB1—lysophosphatidic': [190, 425], '1': [192, 427, 1395, 1969, 3400, 3796, 3830, 3833, 3847, 3942, 3990, 3994, 4031], 'heteromeric': [193, 428], 'complex.': [195, 430], 'Conclusions:': [196, 431], 'are': [199, 434, 525, 1498, 2059, 2323, 2998, 3510, 3517], 'expressed': [200, 435], 'is': [208, 443, 487, 492, 793, 2269, 2531, 2646, 2723, 2818, 3010, 3086], 'responsive': [209, 444], 'biochemically': [210, 445], 'functionally': [212, 447], 'cannabinoids.': [214, 449], 'Increased': [215, 450], 'disease': [223, 458, 3044], 'implies': [225, 460], 'an': [226, 461, 506, 684, 770, 800, 2209, 2436, 3620], 'that': [229, 464, 691, 1029, 1212, 2191, 3507], 'may': [230, 465, 855], 'impact': [231, 466, 2810], 'mucosal': [233, 468], 'immunity.': [234, 469], 'plant': [471], 'Cannabis': [472, 1034, 2784], 'sativa': [473], 'contains': [474], 'more': [475], 'than': [476], '60': [477], 'aromatic': [478], 'hydrocarbon': [479], 'compounds': [480], 'called': [481], 'cannabinoids,': [482, 3701], 'which': [484, 533, 2808, 3117], '▵9-tetrahydrocannabinol': [485], '(▵9-THC)': [486], 'most': [489], 'abundant': [490], 'main': [494], 'psychotropic': [495], 'constituent.1Gaoni': [496], 'Y.': [497, 901], 'Mechoulam': [498, 765], 'R.': [499, 662, 766, 1303, 1512, 1820, 2212], 'Isolation,': [500], 'structure': [501], 'partial': [503], 'synthesis': [504], 'active': [507], 'constituent': [508], 'hashish.J': [510], 'Am': [511], 'Chem': [512], 'Soc.': [513], '1964;': [514], '86:': [515], '1646-1647Crossref': [516], 'Scopus': [517, 593, 616, 701, 737, 788, 847, 893, 929, 966, 1001, 1141, 1165, 1200, 1252, 1286, 1326, 1374, 1447, 1488, 1549, 1578, 1624, 1676, 1721, 1797, 1854, 1898, 1948, 2019, 2053, 2115, 2180, 2239, 2286, 2312, 2373, 2416, 2502, 2545, 2628, 2667, 2697, 2737, 2884, 2929, 2992], '(1906)': [518], 'Google': [519, 565, 595, 618, 656, 703, 739, 790, 849, 895, 931, 968, 1003, 1113, 1143, 1167, 1202, 1254, 1288, 1328, 1376, 1449, 1490, 1551, 1580, 1626, 1678, 1723, 1762, 1799, 1856, 1900, 1950, 2021, 2055, 2117, 2182, 2241, 2288, 2314, 2375, 2418, 2504, 2547, 2581, 2630, 2669, 2699, 2739, 2773, 2886, 2931, 2994], 'Scholar': [520, 596, 619, 657, 740, 791, 850, 896, 932, 969, 1004, 1068, 1203, 1491, 1581, 1627, 1800, 1857, 1901, 2056, 2118, 2183, 2242, 2315, 2376, 2419, 2505, 2582, 2700, 2774, 2804, 2932, 2995, 3534], 'effects': [522, 1098, 2030], '▵9-THC': [524, 1070], 'mediated': [526, 1530, 2040, 2688], 'primarily': [527], '2': [534, 3383, 4129], 'so': [535], 'far': [536], 'identified:': [539], 'CB12Devane': [540], 'W.A.': [541, 632], 'Dysarz': [542, 633], '3rd,': [543, 634], 'F.A.': [544, 635], 'Johnson': [545, 636], 'M.R.': [546, 637], 'Melvin': [547, 638], 'L.S.': [548, 639, 1091], 'Howlett': [549, 640], 'A.C.': [550, 574, 641, 806], 'Determination': [551, 642], 'characterization': [553, 605, 644], 'rat': [559, 650, 1132, 1277, 2196], 'brain.Mol': [560, 651], 'Pharmacol.': [561, 652, 696, 1136, 1195, 1321, 1442, 1544, 1792, 2014, 2048, 2175, 2234, 2879], '1988;': [562, 653], '34:': [563, 654, 1715, 2923], '605-613PubMed': [564, 655], 'Scholar,': [566, 704, 1054, 1114, 1144, 1168, 1255, 1289, 1329, 1377, 1409, 1450, 1552, 1679, 1724, 1763, 1951, 1983, 2022, 2289, 2548, 2631, 2670, 2740, 2887], '3Matsuda': [567], 'L.A.': [568], 'Lolait': [569], 'S.J.': [570], 'Brownstein': [571], 'M.J.': [572, 814], 'Young': [573], 'Bonner': [575], 'T.I.': [576], 'Structure': [577], 'functional': [583, 1210, 1311, 1431, 2189, 2838, 2868], 'cloned': [587], 'cDNA.Nature.': [588], '1990;': [589], '346:': [590], '561-564Crossref': [591], 'PubMed': [592, 615, 700, 736, 787, 846, 892, 928, 965, 1000, 1140, 1164, 1199, 1251, 1285, 1325, 1373, 1446, 1487, 1548, 1577, 1623, 1675, 1720, 1796, 1853, 1897, 1947, 2018, 2052, 2114, 2179, 2238, 2285, 2311, 2372, 2415, 2501, 2544, 2580, 2627, 2666, 2696, 2736, 2772, 2883, 2928, 2991], '(4357)': [594], 'CB2.4Munro': [598], 'S.': [599, 664, 676, 708, 712, 754, 903, 1265, 1295, 1426, 1694, 2075, 2077, 2157, 2443, 2863, 2902], 'Thomas': [600], 'K.L.': [601], 'Abu-Shaar': [602], 'M.': [603, 668, 1174, 1379, 1419, 1602, 1687, 1765, 1769, 1876, 1953, 1985, 2087, 2382, 2392, 2441, 2449, 2451, 2526, 2678, 2718, 2856, 2895, 2970], 'Molecular': [604], 'peripheral': [608, 2099, 2171], 'cannabinoids.Nature.': [611], '1993;': [612, 2624], '365:': [613], '61-65Crossref': [614], '(4308)': [617], 'Endogenous': [620], 'lipid': [621], 'ligands': [622], 'these': [624, 3015, 3055, 3508], 'isolated': [628], 'identified.': [630], 'Anandamide2Devane': [631], '(AEA)': [658], '2-arachidonoyl': [660, 1496], 'glycerol5Mechoulam': [661], 'Ben-Shabat': [663], 'Hanus': [665], 'L.': [666, 752, 1056, 1307, 1413, 1452, 1516, 1592, 1640, 1681, 1734, 1776, 1822, 1866, 2445, 2792, 2850, 2889, 2960], 'Ligumsky': [667], 'Kaminski': [669], 'N.E.': [670], 'Schatz': [671], 'A.R.': [672], 'Gopher': [673], 'A.': [674, 710, 714, 718, 758, 783, 1232, 1293, 1381, 1585, 1730, 1732, 1740, 1810, 1816, 1826, 1859, 1955, 1991, 2554, 2746, 2953], 'Almog': [675], 'Martin': [677], 'B.R.': [678], 'Compton': [679], 'D.R.': [680, 1234, 1462, 1650, 2674], 'et': [681], 'al.Identification': [682], '2-monoglyceride,': [686], 'canine': [689], 'gut,': [690], 'binds': [692], 'receptors.Biochem': [695], '1995;': [697, 733, 2111, 2369, 2412, 2693], '50:': [698], '83-90Crossref': [699], '(2425)': [702], '6Sugiura': [705], 'T.': [706, 899, 1411, 1458, 1514, 1518, 1587, 1646, 1683, 1767, 1812, 1861, 2522, 2714, 2848, 2891, 2955], 'Kondo': [707], 'Sukagawa': [709], 'Nakane': [711], 'Shinoda': [713], 'Itoh': [715], 'K.': [716, 720, 905, 1261, 1338, 1340, 1460, 1648, 1912, 1914], 'Yamashita': [717], 'Waku': [719, 904], '2-arachidonoylglycerol': [721, 876, 912], 'possible': [723, 915], 'ligand': [727], 'brain.Biochem': [729], 'Biophys': [730], 'Res': [731], 'Commun.': [732], '215:': [734], '89-97Crossref': [735], '(1887)': [738], 'can': [741, 1035], 'bind': [742], 'at': [745, 795, 836, 2947, 3105, 3121, 3379, 3413, 3424, 3491, 3617, 3737, 3744, 3762, 3771, 3776, 3802, 3827, 4027, 4098], 'physiologically': [746], 'relevant': [747], 'concentrations': [748, 1125, 3863, 4061], 'noladin': [750], 'ether7Hanus': [751], 'Abu-Lafi': [753], 'Fride': [755], 'E.': [756, 1989, 2550, 2742], 'Breuer': [757], 'Vogel': [759], 'Z.': [760], 'Shalev': [761], 'D.E.': [762], 'Kustanovich': [763], 'I.': [764, 1589, 1604, 1818, 1863, 1878, 2957, 2972], '2-arachidonyl': [767], 'glyceryl': [768], 'ether,': [769], 'agonist': [772, 2470], 'receptor.Proc': [777], 'Natl': [778], 'Acad': [779], 'Sci': [780], 'U': [781], 'S': [782], '2001;': [784, 1545, 2049], '98:': [785], '3662-3665Crossref': [786], '(674)': [789], '(NE)': [792], 'CB1-specific': [794], 'low': [796], 'nanomolar': [797], 'concentrations.': [798], 'Recently,': [799], 'antagonist,': [802], 'virodhamine,': [803, 832], 'characterized.8Porter': [805], 'Sauer': [807], 'J.M.': [808, 2552, 2744], 'Knierman': [809], 'M.D.': [810, 1334, 1908, 2291], 'Becker': [811], 'G.W.': [812], 'Berna': [813], 'Bao': [815], 'J.': [816, 1150, 1758, 2079, 2411, 2459, 2540, 2560, 2623, 2732, 2752], 'Nomikos': [817], 'G.G.': [818], 'Carter': [819], 'P.': [820, 1297, 1738, 2085, 2094, 2355, 2397, 2466, 2606, 2635, 2676], 'Bymaster': [821], 'F.P.': [822], 'Leese': [823], 'A.B.': [824], 'Felder': [825], 'C.C.': [826], 'Characterization': [827], 'novel': [830], 'endocannabinoid,': [831], 'antagonist': [834, 3199], 'activity': [835], 'receptor.J': [839], 'Pharmacol': [840, 1571], 'Exp': [841, 1572], 'Ther.': [842, 1109, 1573], '2002;': [843, 886, 922, 959, 994, 1282, 1479, 1667, 1714, 1759, 1793, 2015, 2308, 2577, 2769, 2922], '301:': [844], '1020-1024Crossref': [845], '(506)': [848], 'Cellular': [851, 872], 'uptake': [852], 'endocannabinoids': [854, 1493, 2809], 'be': [856, 1036, 2433, 2706], 'facilitated': [858], 'diffusion': [859], 'transport': [861, 873, 1355, 1929], 'specific,': [864], 'yet': [866], 'unknown,': [867], 'protein9Fowler': [868], 'C.J.': [869, 1172], 'Jacobsson': [870], 'S.O.': [871], 'anandamide,': [875], 'palmitoylethanolamide—targets': [878], 'drug': [880], 'development?.Prostaglandins': [881], 'Leukot': [882, 918, 955, 990], 'Essent': [883, 919, 956, 991], 'Fatty': [884, 920, 957, 992], 'Acids.': [885, 921, 958, 993], '66:': [887, 923, 960, 995], '193-200Abstract': [888], 'Full': [889, 925, 962, 997, 1482, 1484, 1618, 1620, 1670, 1672, 1717, 1848, 1850, 1892, 1894, 2663, 2925, 2986, 2988], 'Text': [890, 926, 963, 998, 1483, 1485, 1619, 1621, 1671, 1673, 1718, 1849, 1851, 1893, 1895, 2664, 2926, 2987, 2989], 'PDF': [891, 927, 964, 999, 1486, 1622, 1674, 1719, 1852, 1896, 2665, 2927, 2990], '(64)': [894], 'inactivation10Sugiura': [898], 'Kobayashi': [900], 'Oka': [902], 'Biosynthesis': [906], 'degradation': [908], 'anandamide': [910, 2032], 'their': [914, 1007, 1015, 1189, 2126, 2257], 'physiological': [916, 1472, 1660], 'significance.Prostaglandins': [917], '173-192Abstract': [924], '(302)': [930], 'fatty': [934, 984], 'amide': [936], 'hydrolase': [937], '(FAAH)': [938], 'monoacylglyceride': [940], 'lipase.': [941], 'Other': [942, 3293], 'metabolic': [943], 'pathways': [944, 3070], 'exist': [945], 'endocannabinoids,11Kozak': [947], 'K.R.': [948], 'Marnett': [949], 'L.J.': [950], 'Oxidative': [951], 'metabolism': [952, 987], 'endocannabinoids.Prostaglandins': [954], '211-220Abstract': [961], '(140)': [967], 'some': [971, 1027, 2837], 'metabolites': [972], 'having': [973], 'cannabimimetic': [974], 'activities.12Schmid': [975], 'H.H.': [976, 1558], 'Berdyshev': [977], 'E.V.': [978, 2271], 'Cannabinoid': [979, 1005, 1392, 1528, 1966, 2272], 'receptor-inactive': [980], 'N-acylethanolamines': [981], 'other': [983, 3005, 3219], 'amides': [986], 'function.Prostaglandins': [989], '363-376Abstract': [996], '(101)': [1002], 'ligands,': [1009], 'enzymes': [1012], 'involved': [1013], 'inactivation': [1016], 'constitute': [1017], 'so-called': [1019], 'system.': [1021], 'It': [1022], 'time': [1028], 'medicinal': [1031], 'use': [1032], 'beneficial': [1037], 'digestive': [1039, 1502, 2130], 'such': [1041, 2377, 2788], 'pain': [1043], 'diarrhea.13Merck': [1045], 'Manual': [1046], 'materia': [1049], 'medica.': [1050], 'Merck,': [1051], 'Rahway,': [1052], 'NJ1899Google': [1053], '14Grinspoon': [1055], 'Bakalar': [1057, 2793], 'J.B.': [1058, 2794], 'Marijuana—the': [1059, 2795], 'forbidden': [1060, 2796], 'medicine.': [1061, 2797], 'Yale': [1062, 2798], 'University': [1063, 2799], 'Press,': [1064, 2800], 'New': [1065, 2801, 3320], 'Haven,': [1066, 2802], 'CT1997Google': [1067, 2803], 'Plant-derived': [1069], 'shown': [1073, 2431, 2704], 'previously': [1074], 'inhibit': [1076], 'peristalsis,': [1077], 'reduce': [1078], 'gastric': [1079, 1779], 'intestinal': [1081, 1186, 1541, 1635, 1787, 2205], 'secretions,': [1082], 'protect': [1084], 'against': [1085], 'ulcers': [1086], 'rodents.15Dewey': [1088], 'W.L.': [1089], 'Harris': [1090], 'Kennedy': [1092], 'J.S.': [1093, 2218], 'Some': [1094], 'pharmacological': [1095], 'toxicological': [1097], '1-trans-': [1100], '8': [1101], '1-trans-9-tetrahydrocannabinol': [1103], 'laboratory': [1105], 'rodents.Arch': [1106], 'Int': [1107], 'Pharmacodyn': [1108], '1972;': [1110], '196:': [1111], '133-145PubMed': [1112], '16Coupar': [1115], 'I.M.': [1116], 'Taylor': [1117], 'D.A.': [1118, 2672], 'Effect': [1119, 1151], 'delta': [1121], '9-tetrahydrocannabinol': [1122], 'prostaglandin': [1124], 'fluid': [1127, 1841], 'absorption': [1128], 'rates': [1129], 'small': [1133], 'intestine.J': [1134], 'Pharm': [1135], '1983;': [1137], '35:': [1138], '392-394Crossref': [1139], '(3)': [1142], '17Sofia': [1145], 'R.D.': [1146], 'Diamantis': [1147], 'W.': [1148, 2214], 'Edelson': [1149], 'delta9-tetrahydrocannabinol': [1153], 'tract': [1157, 2131], 'rat.Pharmacology.': [1160], '1978;': [1161], '17:': [1162], '79-82Crossref': [1163], '(10)': [1166], '18Chesher': [1169], 'G.B.': [1170], 'Dahl': [1171], 'Everingham': [1173], 'Jackson': [1175], 'D.M.': [1176], 'Marchant-Williams': [1177], 'H.': [1178, 2028], 'Starmer': [1179], 'G.A.': [1180], 'effect': [1182, 1191, 3809], 'motility': [1187, 1534, 1636, 2206], 'antinociceptive': [1190], 'mice.Br': [1193], 'J': [1194, 1320, 1365, 1404, 1441, 1543, 1791, 1939, 1978, 2013, 2047, 2109, 2174, 2233, 2878], '1973;': [1196], '49:': [1197], '588-594Crossref': [1198], '(91)': [1201], 'More': [1204], 'recent': [1205], 'provided': [1208, 2188], 'good': [1209], 'evidence': [1211, 1432, 2124, 2190, 2778, 2869, 3077], 'mammals,': [1219], 'including': [1220, 1582, 2065], 'mouse,': [1222], 'rat,': [1223], 'guinea': [1224, 1274, 1358, 1932], 'pig,': [1225], 'beings,': [1228], 'receptors.19Kulkarni-Narla': [1231], 'Brown': [1233, 1461, 1649], 'Localization': [1235], 'CB1-cannabinoid': [1237], 'porcine': [1242], 'system.Cell': [1245], 'Tissue': [1246, 3157], 'Res.': [1247], '2000;': [1248, 2282, 2541, 2733], '302:': [1249], '73-80Crossref': [1250], '(117)': [1253], '20Coutts': [1256], 'A.A.': [1257, 1454, 1508, 1642, 1728, 1806], 'Irving': [1258], 'A.J.': [1259], 'Mackie': [1260, 1339, 1913], 'Pertwee': [1262, 2160], 'R.G.': [1263, 2161], 'Anavi-Goffer': [1264], 'Localisation': [1266], 'CB(1)': [1269, 1789], 'pig': [1275, 1359, 1933], 'plexus.J': [1279], 'Comp': [1280], 'Neurol.': [1281], '448:': [1283], '410-422Crossref': [1284], '(134)': [1287], '21Casu': [1290], 'M.A.': [1291, 1301], 'Porcella': [1292], 'Ruiu': [1294], 'Saba': [1296], 'Marchese': [1298], 'G.': [1299, 1383, 1415, 1424, 1428, 1520, 1598, 1600, 1692, 1696, 1774, 1814, 1872, 1874, 1957, 2092, 2143, 2395, 2464, 2524, 2556, 2716, 2748, 2852, 2861, 2865, 2900, 2904, 2966, 2968], 'Carai': [1300], 'Reali': [1302], 'Gessa': [1304], 'G.L.': [1305], 'Pani': [1306], 'Differential': [1308, 2029], 'distribution': [1309, 2823], 'mouse': [1317, 1402, 1976], 'gastroenteric': [1318], 'tract.Eur': [1319], '2003;': [1322, 1574, 1615, 1845, 1889, 2983], '459:': [1323], '97-105Crossref': [1324], '(82)': [1327], '22MacNaughton': [1330], 'W.K.': [1331, 1905], 'Van': [1332, 1906], 'Sickle': [1333, 1907], 'Keenan': [1335, 1909], 'C.M.': [1336, 1910], 'Cushing': [1337, 1911], 'Sharkey': [1341, 1915, 2219], 'K.A.': [1342, 1916, 2220], 'Distribution': [1343, 1917], 'function': [1345, 1919, 2302], 'cannabinoid-1': [1348, 1922], 'modulation': [1352, 1926], 'ion': [1354, 1928], 'ileum': [1360, 1709, 1934, 2039, 2845, 2917], 'relationship': [1361, 1935], 'capsaicin-sensitive': [1363, 1937], 'nerves.Am': [1364, 1938], 'Physiol': [1366, 1940], 'Gastrointest': [1367, 1941], 'Liver': [1368, 1712, 1942, 2920], 'Physiol.': [1369, 1405, 1943, 1979, 2368], '2004;': [1370, 1406, 1944, 1980, 2235], '286:': [1371, 1407, 1945, 1981], 'G863-G871Crossref': [1372, 1946], '(61)': [1375, 1949], '23Storr': [1378, 1952], 'Sibaev': [1380, 1954], 'Marsicano': [1382, 1813, 1956], 'Lutz': [1384, 1827, 1958], 'B.': [1385, 1828, 1959, 2386, 2390, 2455], 'Schusdziarra': [1386, 1960], 'V.': [1387, 1467, 1525, 1596, 1607, 1655, 1745, 1833, 1870, 1881, 1961, 2964, 2975], 'Timmermans': [1388, 1962], 'J.P.': [1389, 1421, 1689, 1771, 1963, 2461, 2858, 2897], 'Allescher': [1390, 1964], 'H.D.': [1391, 1965], 'type': [1394, 1968], 'modulates': [1396, 1970], 'excitatory': [1397, 1971], 'inhibitory': [1399, 1973], 'neurotransmission': [1400, 1974], 'colon.Am': [1403, 1977], 'G110-G117Google': [1408, 1982], '24Croci': [1410], 'Manara': [1412, 1775, 2849], 'Aureggi': [1414, 2851], 'Guagnini': [1416, 1684, 2853, 2892], 'F.': [1417, 1469, 1510, 1527, 1657, 1685, 1742, 1808, 1824, 2453, 2457, 2558, 2750, 2854, 2893], 'Rinaldi-Carmona': [1418, 1686, 1768, 2391, 2448, 2855, 2894], 'Maffrand': [1420, 1688, 1770, 2460, 2857, 2896], 'Le': [1422, 1690, 1772, 2090, 2393, 2462, 2859, 2898], 'Fur': [1423, 1691, 1773, 2091, 2394, 2463, 2860, 2899], 'Mukenge': [1425, 1693, 2862, 2901], 'Ferla': [1427, 1695, 2864, 2903], 'In': [1429, 2866, 3075, 3113, 3595], 'neuronal': [1434, 1700, 2871, 2908], 'ileum.Br': [1440, 2012, 2877], '1998;': [1443, 2880], '125:': [1444, 1616, 1846, 1890, 2881, 2984], '1393-1395Crossref': [1445, 2882], '(141)': [1448, 2885], '25Pinto': [1451], 'Izzo': [1453, 1641, 1727], 'Cascio': [1455, 1593, 1643, 1735, 1867, 2961], 'M.G.': [1456, 1594, 1644, 1736, 1868, 2962], 'Bisogno': [1457, 1513, 1586, 1645, 1811, 1860, 2954], 'Hospodar-Scott': [1459, 1647], 'Mascolo': [1463, 1521, 1651, 1829], 'N.': [1464, 1522, 1652, 1726, 1830, 1987], 'Di': [1465, 1523, 1605, 1653, 1743, 1831, 1879, 2973], 'Marzo': [1466, 1524, 1606, 1654, 1744, 1832, 1880, 2974], 'Capasso': [1468, 1511, 1526, 1656, 1741, 1807, 1819], 'Endocannabinoids': [1470, 1561, 1658], 'regulators': [1473, 1661], 'propulsion': [1476, 1664], 'mice.Gastroenterology.': [1478, 1666, 1844], '123:': [1480, 1668], '227-234Abstract': [1481, 1669], '(162)': [1489, 1677], 'AEA': [1494], 'glycerol': [1497], 'tracts': [1503], 'species,26Izzo': [1507], 'Fezza': [1509], 'Pinto': [1515, 1733, 1821], 'Iuvone': [1517], 'Esposito': [1519], 'regulation': [1531, 2276], 'mice': [1536], 'inflammation.Br': [1542], '134:': [1546, 2050], '563-570Crossref': [1547], '(238)': [1550], '27McVey': [1553], 'D.C.': [1554], 'Schmid': [1555, 1557], 'P.C.': [1556], 'Vigna': [1559], 'S.R.': [1560, 2145], 'induce': [1562], 'ileitis': [1563], 'rats': [1565, 1785], 'via': [1566, 2041, 2511], 'capsaicin': [1568], '(VR1).J': [1570], '304:': [1575], '713-722Crossref': [1576], '(114)': [1579], 'beings,28Ligresti': [1584], 'Matias': [1588, 1817, 1862, 2956], 'De': [1590, 1864, 2958], 'Petrocellis': [1591, 1865, 2959], 'Cosenza': [1595, 1869, 2963], "D'Argenio": [1597, 1871, 2965], 'Scaglione': [1599, 1873, 2967], 'Bifulco': [1601, 1875, 2969], 'Sorrentini': [1603, 1877, 2971], 'Possible': [1608, 1882, 2976], 'control': [1610, 1803, 1884, 2978, 3427], 'colorectal': [1612, 1886, 2980], 'cancer': [1613, 1887, 2981], 'growth.Gastroenterology.': [1614, 1888, 2982], '677-687Abstract': [1617, 1891, 2985], '(266)': [1625, 1899, 2993], 'functions': [1629, 2319], 'largely': [1630], 'relate': [1631], 'retardation': [1633], 'receptors,25Pinto': [1639], '29Manara': [1680, 2888], 'Croci': [1682, 1766, 2890], 'Functional': [1697, 2905, 3528], 'assessment': [1698, 2906], 'muscular': [1705, 2913], 'layers': [1706, 2914], 'colon.Dig': [1711, 2919], 'Dis.': [1713, 2921], '262-269Abstract': [1716, 2924], '(52)': [1722, 2930], '30Mascolo': [1725], 'Ligresti': [1729, 1815], 'Costagliola': [1731, 1809], 'Maffia': [1737], 'Cecio': [1739, 1825], 'molecular': [1751], 'basis': [1752], 'paralytic': [1754], 'ileus': [1755], 'mice.FASEB': [1757], '16:': [1760], '1973-1975PubMed': [1761], '31Landi': [1764], 'Modulation': [1777, 1994], 'emptying': [1780], 'transit': [1783, 2229], 'receptors.Eur': [1790], '450:': [1794], '77-83Crossref': [1795], '(71)': [1798], 'but': [1801], 'include': [1802], 'secretion,32Izzo': [1805], 'Borrelli': [1823], 'tone': [1837], 'attenuates': [1838], 'cholera': [1839], 'toxin-induced': [1840], 'accumulation': [1842], '765-774Abstract': [1847], '(125)': [1855], 'proliferation,28Ligresti': [1858], 'neurotransmitter': [1903], 'release.22MacNaughton': [1904], '33Begg': [1984], 'Dale': [1986], 'Llaudet': [1988], 'Molleman': [1990], 'Parsons': [1992], 'M.E.': [1993], 'release': [1997, 2035], 'adenosine': [2000], 'plexus-longitudinal': [2006], 'muscle': [2007, 2645], 'preparation': [2008], 'guinea-pig': [2011, 2038, 2140], '137:': [2016], '1298-1304Crossref': [2017], '(39)': [2020], '34Mang': [2023], 'C.F.': [2024], 'Erbelding': [2025], 'D.': [2026, 2081, 2083, 2089, 2153], 'Kilbinger': [2027], 'acetylcholine': [2034], 'vanilloid': [2042], 'non-CB1': [2044], 'receptors.Br': [2046], '161-167Crossref': [2051], '(92)': [2054], 'found': [2060, 2942], 'mainly': [2061], 'immune': [2063, 2104, 2261, 2266, 2278, 2301, 2813], 'neutrophils,': [2066], 'macrophages,': [2067, 3478], 'subtypes': [2069], 'B': [2071, 2514], 'T': [2073], 'cells,35Galiegue': [2074], 'Mary': [2076], 'Marchand': [2078], 'Dussossoy': [2080], 'Carriere': [2082], 'Carayon': [2084], 'Bouaboula': [2086], 'Shire': [2088, 2152], 'Casellas': [2093, 2396, 2465], 'Expression': [2095], 'central': [2097, 2407, 2472], 'tissues': [2105], 'leukocyte': [2107], 'subpopulations.Eur': [2108], 'Biochem.': [2110], '232:': [2112], '54-61Crossref': [2113], '(1435)': [2116], 'and,': [2119], 'until': [2120, 3664, 3804], 'recently,': [2121], 'detection': [2134], 'messenger': [2137, 2951], 'RNA': [2138], 'whole': [2141], 'gut.36Griffin': [2142], 'Fernando': [2144], 'Ross': [2146], 'R.A.': [2147], 'McKay': [2148], 'N.G.': [2149], 'Ashford': [2150], 'M.L.': [2151], 'Huffman': [2154], 'J.W.': [2155], 'Yu': [2156], 'Lainton': [2158], 'J.A.': [2159], 'Evidence': [2162, 2488], 'presence': [2165, 2935, 3940], 'CB2-like': [2167], 'nerve': [2172], 'terminals.Eur': [2173], '1997;': [2176, 2498], '339:': [2177], '53-61Crossref': [2178], '(164)': [2181], 'A': [2184, 2467, 3867], 'new': [2185, 2491, 2615], 'intestine': [2197], 'could': [2198], 'contribute': [2199], 'reducing': [2201], 'increase': [2203], 'induced': [2207], 'endotoxic': [2210], 'inflammation.37Mathison': [2211], 'Ho': [2213], 'Pittman': [2215], 'Q.J.': [2216], 'Davison': [2217], 'Effects': [2221, 2296], 'receptor-2': [2224], 'activation': [2225, 2328, 2479, 2535, 2727], 'accelerated': [2227], 'lipopolysaccharide-treated': [2231], 'rats.Br': [2232], '142:': [2236], '1247-1254Crossref': [2237], '(131)': [2240], 'exhibit': [2244], 'properties': [2246], 'influence': [2248], 'almost': [2249], 'every': [2250, 3629], 'component': [2251], 'immune-response': [2254], 'machinery,': [2255], 'although': [2256, 2836], 'homeostasis': [2262], 'development': [2264], 'disorder': [2268], 'unresolved.38Berdyshev': [2270], 'response.Chem': [2279], 'Phys': [2280, 2306], 'Lipids.': [2281, 2307], '108:': [2283], '169-190Crossref': [2284], '(236)': [2287], '39Roth': [2290], 'Baldwin': [2292], 'G.C.': [2293], 'Tashkin': [2294], 'D.P.': [2295], 'delta-9-tetrahydrocannabinol': [2298], 'host': [2304], 'defense.Chem': [2305], '121:': [2309], '229-239Crossref': [2310], '(76)': [2313], 'Many': [2316], 'attributed': [2320], 'result': [2325], 'receptor-mediated': [2327], 'common': [2330, 2594], 'signal': [2332], 'transduction': [2333], 'pathways.': [2334], 'For': [2335, 3426, 4042, 4073], 'example,': [2336], 'extracellular-regulated': [2338], 'kinases': [2339, 2402], '(ERK)': [2340], '1/2': [2341], 'mitogen-activated': [2342, 2360, 2400, 2425, 2476], 'protein': [2343, 2361, 2401, 2426, 2477, 2512, 2537, 2655, 2690, 2729, 4093], 'kinase': [2344, 2362, 2427, 2478, 2513, 2538, 2616, 2651, 2691, 2730], '(MAPK)': [2345], 'pathway': [2346], 'results': [2347], 'from': [2348, 2642, 2776, 3092, 3103, 3125, 3130, 3177, 3202, 3212, 3222, 3248, 3261, 3274, 3287, 3304, 3316, 3546, 3946], 'stimulation': [2349, 2404, 2422], 'receptors40Bhat': [2352], 'N.R.': [2353], 'Zhang': [2354], 'Hogan': [2356], 'E.L.': [2357], 'Thrombin': [2358], 'activates': [2359], 'primary': [2364, 3405, 3429, 4133], 'astrocyte': [2365], 'cultures.J': [2366], 'Cell': [2367, 3169, 3317], '165:': [2370], '417-424Crossref': [2371], '(25)': [2374], 'receptor.41Bouaboula': [2381], 'Poinot-Chazel': [2383], 'C.': [2384, 2562, 2602, 2633, 2754], 'Bourrie': [2385], 'Canat': [2387, 2446], 'X.': [2388, 2447], 'Calandra': [2389, 2454], 'Activation': [2398], 'CB1.Biochem': [2410], '312:': [2413], '637-641Crossref': [2414], '(468)': [2417], 'cannabinoid-induced': [2421, 2508], 'cascade': [2428], 'prevented': [2434], 'inhibitor': [2437], 'phosphatidylinositol': [2439], '3-kinase42Bouaboula': [2440], 'Perrachon': [2442], 'Milligan': [2444], 'Portier': [2450], 'Barth': [2452], 'Pecceu': [2456], 'Lupker': [2458], 'selective': [2468], 'inverse': [2469], 'inhibits': [2475], 'stimulated': [2480, 3693], 'insulin': [2482, 2619, 2687], 'insulin-like': [2484], 'growth': [2485], 'factor': [2486], '1.': [2487], 'receptor/ligand': [2494], 'interactions.J': [2495], 'Biol': [2496], 'Chem.': [2497], '272:': [2499], '22330-22339Crossref': [2500], '(426)': [2503], '(PI3K),': [2506], 'PI3K': [2509], '(PKB)': [2515], 'also': [2516], 'proposed.43Gomez': [2519], 'del': [2520, 2712], 'Pulgar': [2521, 2713], 'Velasco': [2523, 2715], 'Guzman': [2525, 2717], 'coupled': [2532, 2724, 4091], 'B/Akt.Biochem': [2539, 2731], '347:': [2542, 2734], '369-373Crossref': [2543, 2735], '(222)': [2546, 2738], '44Molina-Holgado': [2549, 2741], 'Vela': [2551, 2743], 'Arevalo-Martin': [2553, 2745], 'Almazan': [2555, 2747], 'Molina-Holgado': [2557, 2749], 'Borrell': [2559, 2751], 'Guaza': [2561, 2753], 'promote': [2564, 2756], 'oligodendrocyte': [2565, 2757], 'progenitor': [2566, 2758], 'survival': [2567, 2759], 'involvement': [2568, 2760], 'phosphatidylinositol-3': [2573, 2765], 'kinase/Akt': [2574, 2766], 'signaling.J': [2575, 2767], 'Neurosci.': [2576, 2768], '22:': [2578, 2770], '9742-9753Crossref': [2579, 2771], 'Activated': [2583], 'ERK': [2584], 'PKB': [2586], 'phosphorylate': [2587], 'many': [2588], 'intracellular': [2589], 'substrates': [2590], 'target': [2593], 'effectors,': [2597], 'namely': [2598], 'glycogen': [2599, 2609, 2639, 2683], 'synthase': [2600, 2610, 2640, 2684], 'kinase45Sutherland': [2601], 'Leighton': [2603], 'I.A.': [2604], 'Cohen': [2605, 2634, 2675], 'Inactivation': [2607], 'kinase-3': [2611, 2641, 2685], 'beta': [2612], 'phosphorylation': [2614], 'connections': [2617], 'growth-factor': [2621], 'signalling.Biochem': [2622], '296:': [2625], '15-19Crossref': [2626], '(785)': [2629], '46Sutherland': [2632], 'alpha-isoform': [2637], 'rabbit': [2643], 'skeletal': [2644], 'inactivated': [2647], 'p70': [2649], 'S6': [2650], 'MAP': [2653], 'kinase-activated': [2654], 'kinase-1': [2656], 'vitro.FEBS': [2658], 'Lett.': [2659], '1994;': [2660], '338:': [2661], '37-42Abstract': [2662], '(200)': [2668], '47Cross': [2671], 'Alessi': [2673], 'Andjelkovich': [2677], 'Hemmings': [2679], 'B.A.': [2680], 'Inhibition': [2681], 'B.Nature.': [2692], '378:': [2694], '785-789Crossref': [2695], '(4491)': [2698], '(GSK)-3α/β,': [2701], 'phosphorylated': [2707], 'response': [2709], 'cannabinoids.43Gomez': [2711], 'Apart': [2775], 'anecdotal': [2777], 'therapeutic': [2781, 3006], 'benefit': [2782], 'pathologies': [2787], "Crohn's": [2790], 'disease,14Grinspoon': [2791], 'extent': [2806], 'gut': [2817, 3019], 'not': [2819, 2828], 'well': [2820], 'understood.': [2821], 'investigated': [2830], 'large': [2834], 'intestine,': [2835], 'performed': [2842, 3483], 'colon24Croci': [2847], 'mucosa': [2946], 'level': [2949], 'RNA.28Ligresti': [2952], 'If': [2996], 'we': [2997], 'exploit': [3000], 'uses,': [3007], 'then': [3008, 3450, 3461], 'it': [3009], 'important': [3011], 'know': [3013], 'how': [3014], 'drugs': [3016], 'might': [3017], 'affect': [3018], 'homeostasis.': [3020], 'purpose': [3022], '(IBD)': [3045], 'confirm': [3051], 'functionality': [3053], 'establishing': [3058], 'whether': [3059], 'couple': [3065], 'effector': [3069], 'cells.': [3074], 'addition,': [3076, 3114, 3596], 'healing': [3085], 'presented.': [3087], 'biopsy': [3090], 'specimens': [3091], 'routine': [3093], 'colonoscopy,': [3094], 'histopathologically': [3095], 'assessed': [3096], 'exclude': [3098], 'microscopic': [3099], 'inflammation,': [3100], 'retrieved': [3102], 'files': [3104], 'Royal': [3107, 3147], 'United': [3108, 3111, 3148, 3155], 'Hospital,': [3109], 'Bath,': [3110], 'Kingdom.': [3112, 3156], 'tissue,': [3116], 'included': [3118, 3299], 'least': [3122], '20–25': [3123], 'cm': [3124], 'tumor,': [3127], 'removed': [3129, 4024], 'patients': [3131], 'undergoing': [3132], 'resections.': [3134], 'This': [3135], 'procedure': [3136], 'had': [3137], 'approval': [3139], 'Bath': [3142, 3150], 'local': [3143], 'research': [3144], 'ethics': [3145], 'committee,': [3146], 'Hospital': [3149], 'National': [3151], 'Health': [3152], 'Service': [3153], 'Trust,': [3154], 'blocks': [3158], 'fixed': [3160], '4%': [3162], '(wt/vol)': [3163, 4123], 'formaldehyde': [3164], 'embedded': [3166], 'paraffin.': [3168], 'culture': [3170, 3564, 3640], 'media': [3171], 'plastic': [3173], 'ware': [3174], 'purchased': [3176, 3235], 'Invitrogen': [3178], '(Paisley,': [3179], 'UK).': [3180, 3205, 3225, 3324, 3933, 4072], 'Synthetic': [3181], '(arachidonylcyclopropylamide,': [3182], 'JWH': [3183], '133,': [3184], 'WIN': [3186], '55,212-2,)': [3187], '(AEA,': [3190], 'methanadamide,': [3191], 'NE)': [3193], '(AM251)': [3200], 'Tocris': [3203], '(Bristol,': [3204], 'Enzyme': [3206], 'inhibitors': [3207], 'LY294002': [3208], 'PD98059': [3210], 'Merck': [3213], 'Biosciences': [3214], '(Nottingham,': [3215], 'UK)': [3216, 3331, 3895, 3906], 'all': [3218], 'chemicals': [3220], 'came': [3221], 'Sigma-Aldrich': [3223], '(Dorset,': [3224], 'Antibodies': [3226], 'components': [3228], 'immunohistochemistry': [3237], 'immunoblotting': [3239], 'follows:': [3241], 'anti-CB1': [3242, 3255, 3268, 4079], '(PA1-743)': [3243], 'anti-CB2': [3245, 3258, 3271], '(PA1-744)': [3246], 'Affinity': [3249], 'BioReagents': [3250], '(Cambridge': [3251], 'BioScience,': [3252], 'Cambridge,': [3253], 'UK);': [3254, 3267], '(sc20754)': [3256, 4080], '(sc25494)': [3259], 'Santa': [3262, 3547], 'Cruz': [3263], '(Autogen': [3264], 'Bioclear,': [3265], 'Wiltshire,': [3266], '(101500)': [3269], '(101550)': [3272], 'Cayman': [3275], 'Chemical': [3276], '(IDS': [3277], 'Ltd,': [3278], 'Tyne': [3279], 'Wear,': [3281], 'UK),': [3282, 3307], 'anti-FAAH': [3284], '(11-A)': [3285], 'Alpha': [3288], 'Diagnostic': [3289], '(San': [3290, 3961], 'Antonio,': [3291], 'TX).': [3292], 'antibodies': [3294, 3410, 3430, 3545], 'anti—lysophosphatidic': [3300], '(LPA)1': [3302], '(Edg2)': [3303], 'Upstate': [3305], '(Dundee,': [3306], 'anti-ERK,': [3309], 'anti—phospho-ERK1/2,': [3310], 'anti-PKB,': [3311], 'anti—phospho-PKB,': [3312], 'anti—phospho-GSK3α/β,': [3313], 'anti-GSK3β': [3315], 'Signaling': [3318], 'Technology,': [3319], 'England': [3321], 'Biolabs': [3322], '(Hertfordshire,': [3323], 'DAKO': [3326], 'ChemMate': [3327], 'System': [3328], 'kit': [3329], '(Cambridgeshire,': [3330], 'immunohistochemical': [3336, 3536], 'staining': [3337, 3481], 'sections.': [3340], 'Briefly,': [3341], 'sections': [3343, 3352], '(3–5': [3344], 'μm)': [3345], 'mounted': [3347], 'slides.': [3349], 'After': [3350], 'deparaffinized': [3354], 'xylene': [3356], 'rehydrated': [3358], 'series': [3361], 'graded': [3363], 'alcohol,': [3364], 'antigen': [3365], 'retrieval': [3366], 'achieved': [3368], 'boiling': [3370], '.01': [3372], 'mol/L': [3373, 3882], 'sodium': [3374, 3992, 3996], 'citrate': [3375], 'buffer,': [3376], 'pH': [3377, 3397, 3419, 3493, 3758, 3791, 3842, 3884, 3974], '6.0,': [3378], 'high': [3380], 'pressure': [3381], 'minutes.': [3384, 3468, 3766], 'Sections': [3385, 3449, 3469], 'blocked': [3387, 4120], '5%': [3389, 3590, 3623, 4122], 'bovine': [3390, 3593, 3677, 3689, 3854, 3888], 'serum': [3391, 3678, 3855, 3889], 'albumin': [3392, 3890], 'Tris-buffered': [3394], 'saline': [3395], '(TBS),': [3396], '9.0,': [3398, 3420], 'hour': [3401, 3831], 'before': [3402], 'application': [3403], 'antibodies.': [3406], '(Cayman': [3411, 3447], 'Chemical)': [3412], '1:1000': [3415], 'dilution': [3416], 'TBS,': [3418], 'incubated': [3422, 3452, 3826], 'overnight': [3423], '4°C.': [3425, 3745], 'slides,': [3428], 'omitted': [3432], '10-fold': [3435], 'excess': [3436], 'blocking': [3438], 'peptide': [3439], 'suggested': [3443], 'manufacturer': [3446], 'Chemical).': [3448], 'rabbit-specific': [3454], 'secondary': [3455], 'antibody': [3456, 4134], '25': [3458], 'minutes': [3459, 3743, 3775], '3,3′-diaminobenzidine': [3463], 'tetrahydrochloride': [3464], '(DAKO)': [3465], '5': [3467, 3755, 3765, 3793, 3844, 3986, 4076], 'counterstained': [3471], 'progressive': [3474], 'hematoxylin.': [3475], 'To': [3476, 3806], 'identify': [3477], 'anti-human': [3479], 'CD68': [3480], 'described': [3485, 3714, 3725], 'earlier,': [3486], 'except': [3487], 'TBS': [3489, 4127], '7.6.': [3495], 'Plasma': [3496], 'consultant': [3502], 'histopathologist,': [3504], 'who': [3505], 'confirmed': [3506], 'always': [3516], 'located': [3518], 'propria.48Wheater': [3522], 'P.R.': [3523], 'Burkitt': [3524], 'H.G.': [3525], 'Daniels': [3526], 'V.G.': [3527], 'histology.': [3529], 'Churchill': [3530], 'Livingstone,': [3531], 'London,': [3532], 'UK1979Google': [3533], 'Further': [3535], 'validation': [3537], 'undertaken': [3539], 'taken': [3540], 'using': [3541, 3871, 3957], 'Cruz.': [3548], 'HT-29,': [3554], 'Caco2,': [3555], 'DLD1': [3557], 'cultured': [3559, 3672], 'routinely': [3560], '80-cm2': [3562, 3638], 'flasks': [3565, 3641], "McCoy's": [3567], '5A,': [3568], "Dulbecco's": [3569, 3597], 'modified': [3570, 3598], 'Eagle,': [3571], 'RPMI': [3573], 'media,': [3574], 'respectively.': [3575], 'Media': [3576], 'supplemented': [3578, 3602], 'penicillin': [3580], '(10': [3581, 3584], 'U/mL),': [3582], 'streptomycin': [3583], 'μg/mL),': [3585, 3588], 'fungizone': [3586], '(.5': [3587], '(vol/vol)': [3591], 'fetal': [3592, 3676, 3688], 'serum.': [3594], 'Eagle': [3599], 'medium': [3600, 3626, 3674, 3691], '1×': [3604], 'nonessential': [3605], 'amino': [3606], 'acids': [3607], '(Sigma)': [3608], '(referred': [3609], 'complete': [3612], 'medium).': [3613], 'Cultures': [3614], 'maintained': [3616], '37°C': [3618], 'atmosphere': [3621], 'CO2.': [3624], 'changed': [3628], '2–3': [3630], 'days': [3631], 'passaged': [3635], 'weekly': [3636], 'into': [3637, 3646], 'further': [3643], 'culture,': [3644], '6-,': [3647], '24-,': [3648], '96-well': [3650], 'plates': [3651], 'Petri': [3653], 'dishes': [3654], 'experimental': [3656], 'protocols.': [3657], 'Unless': [3658], 'otherwise': [3659], 'stated,': [3660], 'grown': [3663, 3728], 'confluent.': [3665], 'Before': [3666], 'experiments,': [3667], 'monolayers': [3668], 'washed': [3670], 'without': [3675], '24': [3680], 'hours.': [3681, 4130], 'Growth-arrested': [3682], 'cultures': [3683], 'fresh': [3687], 'serum—free': [3690], 'appropriate': [3696], 'doses': [3697], 'drugs,': [3700], 'vehicle': [3703], 'controls': [3704], '(ethanol': [3705], 'dimethyl': [3707], 'sulfoxide,': [3708], 'appropriate)': [3710], 'times': [3713], 'Results': [3717], 'section.': [3718], 'Total': [3719], 'cellular': [3720], 'proteins': [3721], 'extracted': [3723], 'later.': [3726], 'Cells': [3727, 3964], 'confluence': [3730], 'collected': [3732], 'scraping': [3734], 'spun': [3736], '200': [3738], '×': [3739], 'g': [3740], '10': [3742, 3998, 4005, 4008, 4013], 'Crude': [3746], 'membranes': [3747, 3820, 3914], 'prepared': [3749], 'homogenization': [3751], 'mmol/L': [3756, 3789, 3794, 3797, 3840, 3845, 3848, 3972, 3984, 3987, 3991, 3995, 3999], 'Tris-HCl,': [3757, 3790, 3841, 3883, 3973], '7.5,': [3759, 3792, 3975], 'centrifugation': [3761, 4026], '1000g': [3763], 'supernatant': [3768, 4035], 'centrifuged': [3770], '40,000g': [3772], '40': [3774, 4001], '4°C,': [3777], 'pellet': [3780], 'resuspended': [3782], 'buffer': [3785, 3838, 3879, 3970], 'consisting': [3786], '50': [3788], 'MgCl2,': [3795, 3846], 'ethylenediaminetetraacetic': [3798, 3849, 3988], 'acid,': [3799, 3850, 3989], 'stored': [3801], '−80°C': [3803], 'use.': [3805], 'displacement': [3813], '[3H]-CP-55,940': [3815, 3860], '(a': [3816], 'nonselective': [3817], 'agonist),': [3819], '(50': [3821, 3839, 3971], 'μg': [3822], 'protein)': [3824], '30°C': [3828], 'mL': [3834, 3925], '(final': [3835], 'volume)': [3836], 'binding': [3837, 3935], '7.7,': [3843, 3885], '.5%': [3852], '[wt/vol]': [3853], 'albumin)': [3856], '.2': [3858], 'nmol/L': [3859], 'increasing': [3862], 'unlabeled': [3865], 'cannabinoid.': [3866], 'rapid': [3868], 'filtration': [3869, 3899], 'technique': [3870], 'Whatman': [3872], 'GF/B': [3873], 'filters': [3874], '(soaked': [3875], 'cold': [3877, 3916], 'wash': [3878, 3917], 'containing': [3880], '.05': [3881], '.25%': [3887], 'buffer;': [3891], 'Fisher': [3892], 'Scientific,': [3893], 'Loughborough,': [3894], '12-well': [3898], 'apparatus': [3900], '(Brandel;': [3901], 'SEMAT': [3902], 'Technical,': [3903], 'St.': [3904], 'Albans,': [3905], 'harvest': [3910], 'rinse': [3912], 'labeled': [3913], 'buffer.': [3918], 'Filter-bound': [3919], 'radioactivity': [3920], 'counted': [3922], '4': [3924], 'biofluor': [3927], 'liquid': [3928], 'scintillator': [3929], '(Perkin': [3930], 'Elmer,': [3931], 'Beaconsfield,': [3932], 'Nonspecific': [3934], 'μmol/L': [3943], 'CP-55,940.': [3944], 'Data': [3945], 'competition': [3947, 3956], 'analyzed': [3950], 'nonlinear': [3952], 'regression': [3953], '2-site': [3955], 'GraphPad': [3958], 'Prism': [3959], 'software': [3960], 'Diego,': [3962], 'CA).': [3963], 'lysed': [3966], 'ice-cold': [3968], 'solubilization': [3969], '10%': [3976], '[vol/vol]': [3977, 3980], 'glycerol,': [3978], '1%': [3979], 'Nonidet': [3981], 'P-40,': [3982], '150': [3983], 'NaCl,': [3985], 'vanadate,': [3993], 'molybdate,': [3997], 'NaF,': [4000], 'μg/mL': [4002, 4006, 4009, 4014, 4018], 'phenymethylsulphonyl': [4003], 'fluoride,': [4004], 'aprotinin,': [4007], 'soybean': [4010], 'trypsin': [4011], 'inhibitor,': [4012], 'leupeptin,': [4015], '.7': [4017], 'pepstatin).': [4019], 'Insoluble': [4020], 'debris': [4022], 'full': [4028], 'speed': [4029], 'minute': [4032], 'transferred': [4037, 4114], 'clean': [4040], 'tube.': [4041], 'fractionation': [4043], 'studies,': [4044, 4075], 'Calbiochem': [4046], '(Merck': [4047], 'Biosciences)': [4048], 'Subcellular': [4049], 'Proteome': [4050], 'Extraction': [4051], 'Kit': [4052], '(539790)': [4053], 'per': [4056], "manufacturer's": [4058], 'instructions.': [4059], 'Protein': [4060, 4067, 4100], 'Bio-Rad': [4066], 'Assay': [4068], 'reagent': [4069], '(Bio-Rad,': [4070], 'Hertfordshire,': [4071], 'immunoprecipitation': [4074], 'μL': [4077], 'added': [4082], 'lysates': [4084], '(1': [4085, 4096], 'mg/mL)': [4086], 'immunocomplexes': [4088], 'subsequently': [4089], 'G-sepharose': [4094], 'beads': [4095], 'h': [4097], '4°C).': [4099], '(20': [4101], 'μg)': [4102], 'resolved': [4104], '7.5%': [4107], 'polyacrylamide': [4108], 'gel': [4109], '(12%,': [4110], 'immunoprecipitates)': [4112], 'nitrocellulose': [4116], 'membranes.': [4117], 'Membranes': [4118], 'nonfat': [4124], 'milk': [4125], 'Immunoblotting': [4131], 'diluted': [4135], '1:5': [4136], 'bl': [4138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4234676427', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-16T07:41:04.160040', 'created_date': '2022-05-12'}
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