Title: THE INFLUENCE OF IPRONIAZID AND PYROGALLOL ON THE THERMOGENIC EFFECTS OF NORADRENALINE
Abstract: The effects of administering a monoamine oxidase inhibitor (iproniazid) or an inhibitor of catechol-O-methyl transferase (pyrogallol) on the calorigenic response produced by injecting noradrenaline intravenously or subcutaneously to Wistar rats are described. The influence of isoniazid on the calorigenic response to subcutaneously administered noradrenaline was also studied. The effects of syrosingopine and tetrabenazine, with and without inhibitors, and of dl-normetanephrine, were also observed. Inhibition of monoamine oxidase increased and prolonged the calorigenic response to exogenous noradrenaline or to noradrenaline released endogenously. Isoniazid, chemically related to iproniazid but not an inhibitor of monoamine oxidase, or pyrogallol, caused little change in the calorigenic response. Thus oxidative deamination appears to be the primary reaction responsible for the termination of the calorigenic response.
Publication Year: 1962
Publication Date: 1962-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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