Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4234050115', 'doi': 'https://doi.org/10.1007/s10147-018-1359-3', 'title': 'Palbociclib in combination with fulvestrant in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: PALOMA-3 subgroup analysis of Japanese patients', 'display_name': 'Palbociclib in combination with fulvestrant in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: PALOMA-3 subgroup analysis of Japanese patients', 'publication_year': 2018, 'publication_date': '2018-11-03', 'ids': {'openalex': 'https://openalex.org/W4234050115', 'doi': 'https://doi.org/10.1007/s10147-018-1359-3', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30392115'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10147-018-1359-3', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s10147-018-1359-3.pdf', 'source': {'id': 'https://openalex.org/S103913600', 'display_name': 'International Journal of Clinical Oncology', 'issn_l': '1341-9625', 'issn': ['1341-9625', '1437-7772'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s10147-018-1359-3.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067189124', 'display_name': 'Norikazu Masuda', 'orcid': 'https://orcid.org/0000-0002-7302-0278'}, 'institutions': [{'id': 'https://openalex.org/I4210090372', 'display_name': 'Osaka National Hospital', 'ror': 'https://ror.org/00b6s9f18', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210090372', 'https://openalex.org/I4210137409']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Norikazu Masuda', 'raw_affiliation_strings': ['National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuou-ku, Osaka-City, 540-0006, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuou-ku, Osaka-City, 540-0006, Japan', 'institution_ids': ['https://openalex.org/I4210090372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100785002', 'display_name': 'Kenichi Inoue', 'orcid': 'https://orcid.org/0000-0003-2686-8732'}, 'institutions': [{'id': 'https://openalex.org/I4210123465', 'display_name': 'Saitama Cancer Center', 'ror': 'https://ror.org/03a4d7t12', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123465']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenichi Inoue', 'raw_affiliation_strings': ['Saitama Cancer Center, 780 Komuro, Inamachi Kitaadachi-gun, Saitama, 362-0806, Japan'], 'affiliations': [{'raw_affiliation_string': 'Saitama Cancer Center, 780 Komuro, Inamachi Kitaadachi-gun, Saitama, 362-0806, Japan', 'institution_ids': ['https://openalex.org/I4210123465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087402935', 'display_name': 'Rikiya Nakamura', 'orcid': 'https://orcid.org/0000-0002-4349-9046'}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Rikiya Nakamura', 'raw_affiliation_strings': ['Chiba Cancer Center, 666-2 Nitona-Cho, Chuo-ku, Chiba, 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Chiba Cancer Center, 666-2 Nitona-Cho, Chuo-ku, Chiba, 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042574154', 'display_name': 'Yoshiaki Rai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115833', 'display_name': 'National Sagamihara Hospital', 'ror': 'https://ror.org/01gvfxs59', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115833', 'https://openalex.org/I4210137409']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshiaki Rai', 'raw_affiliation_strings': ['Sagara Hospital, 3-28 Tenokuchi-cho, Kagoshima City, 892-0845, Japan'], 'affiliations': [{'raw_affiliation_string': 'Sagara Hospital, 3-28 Tenokuchi-cho, Kagoshima City, 892-0845, Japan', 'institution_ids': ['https://openalex.org/I4210115833']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089829213', 'display_name': 'Hirofumi Mukai', 'orcid': 'https://orcid.org/0000-0002-9292-5128'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirofumi Mukai', 'raw_affiliation_strings': ['National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba, 277-8577, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba, 277-8577, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056628460', 'display_name': 'Shinji Ohno', 'orcid': 'https://orcid.org/0000-0003-2093-3353'}, 'institutions': [{'id': 'https://openalex.org/I4210137039', 'display_name': 'The Cancer Institute Hospital', 'ror': 'https://ror.org/03md8p445', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137039']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shinji Ohno', 'raw_affiliation_strings': ['The Cancer Institute Hospital of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan'], 'affiliations': [{'raw_affiliation_string': 'The Cancer Institute Hospital of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan', 'institution_ids': ['https://openalex.org/I4210137039']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025769245', 'display_name': 'Fumikata Hara', 'orcid': 'https://orcid.org/0000-0001-8025-3494'}, 'institutions': [{'id': 'https://openalex.org/I4210141613', 'display_name': 'Shikoku Cancer Center', 'ror': 'https://ror.org/03yk8xt33', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4210141613']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumikata Hara', 'raw_affiliation_strings': ['National Hospital Organization Shikoku Cancer Center, 160 Kou, Minamiumemoto-machi, Matsuyama, Ehime, 791-0280, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Hospital Organization Shikoku Cancer Center, 160 Kou, Minamiumemoto-machi, Matsuyama, Ehime, 791-0280, Japan', 'institution_ids': ['https://openalex.org/I4210141613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031871407', 'display_name': 'Yuko Mori', 'orcid': 'https://orcid.org/0000-0003-1919-2463'}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuko Mori', 'raw_affiliation_strings': ['Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089050410', 'display_name': 'Satoshi Hashigaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Hashigaki', 'raw_affiliation_strings': ['Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060456584', 'display_name': 'Yasuaki Muramatsu', 'orcid': 'https://orcid.org/0009-0005-4339-2280'}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuaki Muramatsu', 'raw_affiliation_strings': ['Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051179799', 'display_name': 'Takashi Nagasawa', 'orcid': 'https://orcid.org/0000-0002-1600-1062'}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Nagasawa', 'raw_affiliation_strings': ['Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080897827', 'display_name': 'Yoshiko Umeyama', 'orcid': 'https://orcid.org/0000-0003-4967-0382'}, 'institutions': [{'id': 'https://openalex.org/I4210148786', 'display_name': 'Pfizer (Japan)', 'ror': 'https://ror.org/05pm71w80', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I4210148786']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshiko Umeyama', 'raw_affiliation_strings': ['Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pfizer Japan Inc, 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan', 'institution_ids': ['https://openalex.org/I4210148786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075134210', 'display_name': 'Xin Huang', 'orcid': 'https://orcid.org/0000-0003-3285-365X'}, 'institutions': [{'id': 'https://openalex.org/I180857899', 'display_name': 'Pfizer (United States)', 'ror': 'https://ror.org/01xdqrp08', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I180857899']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xin Huang', 'raw_affiliation_strings': ['Pfizer Oncology, 10555 Science Center Dr, San Diego, CA, 92121, USA'], 'affiliations': [{'raw_affiliation_string': 'Pfizer Oncology, 10555 Science Center Dr, San Diego, CA, 92121, USA', 'institution_ids': ['https://openalex.org/I180857899']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008549101', 'display_name': 'Hiroji Iwata', 'orcid': 'https://orcid.org/0000-0002-0242-4718'}, 'institutions': [{'id': 'https://openalex.org/I4210133851', 'display_name': 'Aichi Cancer Center', 'ror': 'https://ror.org/03kfmm080', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133851']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroji Iwata', 'raw_affiliation_strings': ['Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan'], 'affiliations': [{'raw_affiliation_string': 'Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan', 'institution_ids': ['https://openalex.org/I4210133851']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 10, 'corresponding_author_ids': ['https://openalex.org/A5067189124'], 'corresponding_institution_ids': ['https://openalex.org/I4210090372'], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.231, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.903319, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '24', 'issue': '3', 'first_page': '262', 'last_page': '273'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12829', 'display_name': 'Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12829', 'display_name': 'Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.9867, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fulvestrant', 'display_name': 'Fulvestrant', 'score': 0.8411813}, {'id': 'https://openalex.org/keywords/surgical-oncology', 'display_name': 'Surgical oncology', 'score': 0.6588264}, {'id': 'https://openalex.org/keywords/palbociclib', 'display_name': 'Palbociclib', 'score': 0.557203}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.527284}, {'id': 'https://openalex.org/keywords/tumor-suppression', 'display_name': 'Tumor Suppression', 'score': 0.508968}, {'id': 'https://openalex.org/keywords/subgroup-analysis', 'display_name': 'Subgroup analysis', 'score': 0.48376915}], 'concepts': [{'id': 'https://openalex.org/C2779744173', 'wikidata': 'https://www.wikidata.org/wiki/Q15269707', 'display_name': 'Palbociclib', 'level': 5, 'score': 0.90860444}, {'id': 'https://openalex.org/C2780482068', 'wikidata': 'https://www.wikidata.org/wiki/Q5508491', 'display_name': 'Fulvestrant', 'level': 5, 'score': 0.8411813}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8043057}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.7248148}, {'id': 'https://openalex.org/C2780140570', 'wikidata': 'https://www.wikidata.org/wiki/Q3545481', 'display_name': 'Surgical oncology', 'level': 2, 'score': 0.6588264}, {'id': 'https://openalex.org/C2908728163', 'wikidata': 'https://www.wikidata.org/wiki/Q415271', 'display_name': 'Human Epidermal Growth Factor Receptor 2', 'level': 4, 'score': 0.6397732}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6336467}, {'id': 'https://openalex.org/C23589133', 'wikidata': 'https://www.wikidata.org/wiki/Q412005', 'display_name': 'Hormone receptor', 'level': 4, 'score': 0.6301801}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.5038139}, {'id': 'https://openalex.org/C187960798', 'wikidata': 'https://www.wikidata.org/wiki/Q7631152', 'display_name': 'Subgroup analysis', 'level': 3, 'score': 0.48376915}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.39957643}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38600215}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.24539146}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.23508042}, {'id': 'https://openalex.org/C95190672', 'wikidata': 'https://www.wikidata.org/wiki/Q815382', 'display_name': 'Meta-analysis', 'level': 2, 'score': 0.11800024}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D044466', 'descriptor_name': 'Asians', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077267', 'descriptor_name': 'Fulvestrant', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000077267', 'descriptor_name': 'Fulvestrant', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000077267', 'descriptor_name': 'Fulvestrant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009503', 'descriptor_name': 'Neutropenia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D009503', 'descriptor_name': 'Neutropenia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010919', 'descriptor_name': 'Placebos', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10147-018-1359-3', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s10147-018-1359-3.pdf', 'source': {'id': 'https://openalex.org/S103913600', 'display_name': 'International Journal of Clinical Oncology', 'issn_l': '1341-9625', 'issn': ['1341-9625', '1437-7772'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6399170', 'pdf_url': 'https://europepmc.org/articles/pmc6399170?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30392115', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10147-018-1359-3', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s10147-018-1359-3.pdf', 'source': {'id': 'https://openalex.org/S103913600', 'display_name': 'International Journal of Clinical Oncology', 'issn_l': '1341-9625', 'issn': ['1341-9625', '1437-7772'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [{'funder': 'https://openalex.org/F4320307765', 'funder_display_name': 'Pfizer', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1464936406', 'https://openalex.org/W1961026612', 'https://openalex.org/W2123618524', 'https://openalex.org/W2142405101', 'https://openalex.org/W2144790402', 'https://openalex.org/W2153985422', 'https://openalex.org/W2154626333', 'https://openalex.org/W2290950904', 'https://openalex.org/W2298692973', 'https://openalex.org/W2415372857', 'https://openalex.org/W2474699717', 'https://openalex.org/W2552099557', 'https://openalex.org/W2605489431', 'https://openalex.org/W2719623628', 'https://openalex.org/W2783341375', 'https://openalex.org/W2790211645'], 'related_works': ['https://openalex.org/W4232409591', 'https://openalex.org/W4206711305', 'https://openalex.org/W3216407617', 'https://openalex.org/W3161515104', 'https://openalex.org/W3012234284', 'https://openalex.org/W2947864495', 'https://openalex.org/W2897446380', 'https://openalex.org/W2892043300', 'https://openalex.org/W2605489431', 'https://openalex.org/W2182070232'], 'abstract_inverted_index': {'In': [0], 'the': [1, 43, 91, 110, 141, 153, 208], 'double-blind,': [2], 'phase': [3], '3': [4, 74], 'PALOMA-3': [5, 215], 'study,': [6], 'palbociclib-fulvestrant': [7, 121, 143], 'significantly': [8], 'prolonged': [9], 'progression-free': [10, 131], 'survival': [11, 132], 'versus': [12, 109], 'placebo-fulvestrant': [13, 126, 154], 'in': [14, 52, 56, 106, 140, 152, 162, 214, 226], 'patients': [15, 54, 164, 197, 213, 228], 'with': [16, 59, 229], 'hormone': [17], 'receptor-positive': [18], '(HR+),': [19], 'human': [20], 'epidermal': [21], 'growth': [22], 'factor': [23], 'receptor': [24], '2-negative': [25], '(HER2-)': [26], 'metastatic': [27], 'breast': [28], 'cancer': [29], '(MBC)': [30], 'whose': [31, 232], 'disease': [32, 233], 'had': [33, 234], 'progressed': [34, 235], 'on': [35, 236], 'prior': [36, 237], 'endocrine': [37, 238], 'therapy.': [38], 'The': [39, 156], 'present': [40], 'study': [41], 'evaluated': [42], 'efficacy,': [44], 'safety,': [45, 98], 'and': [46, 69, 99, 145, 195, 202, 211, 223], 'pharmacokinetics': [47, 100], 'of': [48, 114], 'palbociclib': [49, 71, 187, 218], 'plus': [50, 219], 'fulvestrant': [51, 66, 220], 'Japanese': [53, 107, 116, 142, 163, 191, 212, 227], 'enrolled': [55], 'PALOMA-3.Pre/peri/postmenopausal': [57], 'women': [58, 108, 117], 'HR+/HER2-': [60], 'MBC': [61, 231], 'were': [62, 118, 172, 188], 'randomized': [63, 119], '2:1': [64], 'to': [65, 120, 174], '(500': [67], 'mg)': [68], 'either': [70], '(125': [72], 'mg/day;': [73], 'weeks': [75], 'on/1': [76], 'week': [77], 'off;': [78], 'n': [79], '=': [80, 85, 123, 128], '347)': [81], 'or': [82, 125], 'placebo': [83], '(n': [84, 122, 127], '174).': [86], 'Prespecified': [87], 'exploratory': [88], 'analyses': [89], 'compared': [90], 'efficacy': [92], '(data': [93, 101], 'cutoff:': [94, 102], 'October': [95], '23,': [96], '2015),': [97], 'December': [103], '5,': [104], '2014)': [105], 'overall': [111, 209], 'population.A': [112], 'total': [113], '35': [115], '27)': [124], '8).': [129], 'Median': [130], 'was': [133, 165, 221], '13.6': [134], 'months': [135, 147], '(95%': [136, 148], 'CI,': [137, 149], '7.5-not': [138], 'estimable)': [139, 151], 'group': [144], '11.2': [146], '5.6-not': [150], 'group.': [155], 'most': [157], 'common': [158], 'adverse': [159], 'event': [160], '(AE)': [161], 'neutropenia': [166], '(all': [167], 'grades,': [168], '93%);': [169], 'no': [170], 'discontinuations': [171], 'due': [173], 'an': [175], 'AE.': [176], 'Geometric': [177], 'mean': [178, 183], 'trough': [179], 'concentration': [180], 'values': [181], '(within-subject': [182], 'steady': [184], 'state)': [185], 'for': [186, 190, 207], 'similar': [189], 'Asian': [192], '(excluding': [193], 'Japanese),': [194], 'non-Asian': [196], '(84.4': [198], 'ng/mL,': [199, 201, 204], '86.3': [200], '74.8': [203], 'respectively).The': [205], 'results': [206], 'population': [210], 'suggest': [216], 'that': [217], 'effective': [222], 'well': [224], 'tolerated': [225], 'HR+/HER2‒': [230], 'therapy': [239], '(Pfizer;': [240], 'NCT01942135).': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4234050115', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}], 'updated_date': '2024-08-08T14:55:07.237292', 'created_date': '2022-05-12'}