Title: Treatments That Block Proteins Involved in Cell Communication
Abstract: This chapter first provides a general introduction to how cells communicate. It then describes how various communication pathways operate, what goes wrong with them in cancer cells, and how these defects are targeted using treatments such as monoclonal antibodies and kinase inhibitors. Many of the treatments described in this chapter block cell surface receptors called epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2). Drugs that target EGFR can be split into two groups: Monoclonal antibodies; and kinase inhibitors. The goal of all these treatments is to block the receptor and prevent it from activating any internal signaling pathways. As well as EGFR and HER2, many other growth factor receptors are found on the surface of cancer cells and on other cells in their immediate environment. Growth factor receptors such as insulin-like growth factor receptor (IGF1R) and many others have also been implicated in various cancers.
Publication Year: 2018
Publication Date: 2018-05-11
Language: en
Type: other
Indexed In: ['crossref']
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Cited By Count: 1
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