Title: A Comparison of Protoporphyrin IX and Protoporphyrin IX Dimethyl Ester as a Photosensitizer in Poorly Differentiated Human Nasopharyngeal Carcinoma Cells¶
Abstract: Protoporphyrin IX dimethyl ester (PME), a dimethyl esterification of protoporphyrin IX (PpIX), exhibits higher intracellular uptake into NPC/CNE2 cells, a poorly differentiated human nasopharyngeal carcinoma, than does PpIX. Phototoxicity studies reveal PME to be a more potent photosensitizer than is PpIX, at the early and late incubation time points. Correlating phototoxicity with subcellular localization indicates that PME is a more potent photosensitizer when its primary target of photodamage is mitochondria. Also, additional targeting of lysosome enhances phototoxicity.
Publication Year: 2007
Publication Date: 2007-05-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 2
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