Title: Renal Effects of the Non-Ionic Contrast Medium Iopentol after Intravenous Injection in Healthy Volunteers
Abstract:AbstractRenal effects of the new non-ionic contrast medium iopentol in increasing doses were assessed and compared with the effects of physiologic saline. Twenty-four healthy male volunteers, allocate...AbstractRenal effects of the new non-ionic contrast medium iopentol in increasing doses were assessed and compared with the effects of physiologic saline. Twenty-four healthy male volunteers, allocated to three dose groups, were given iopentol intravenously in doses of 0.3, 0.6, and 1.2 g I/kg body weight, respectively. The highest dose group was also given physiologic saline separately as a control. The diuresis increased in all groups, most in the highest dose group, and with a concomitant fall of urine osmolality and increase in osmolar clearance. A slight decrease of serum osmolality, creatinine and urea occurred at 3 hours due to hemodilution. The glomerular filtration rate was unaffected by iopentol. The urinary excretion of albumin and β2-microglobulin was unchanged. However, urinary N-acetyl-β-glucosaminidase and alkaline phosphatase increased significantly, most in the highest dose group. All changes were reversible.Key Words: Iopentolcontrast mediaglomerular filtration rate, nephrotoxicity, enzymuriaRead More
Publication Year: 1990
Publication Date: 1990-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 4
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