Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4232351203', 'doi': 'https://doi.org/10.18632/oncotarget.15513', 'title': 'Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer', 'display_name': 'Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer', 'publication_year': 2017, 'publication_date': '2017-02-19', 'ids': {'openalex': 'https://openalex.org/W4232351203', 'doi': 'https://doi.org/10.18632/oncotarget.15513', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28423564'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15513', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15513&path%5B%5D=49567', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15513&path%5B%5D=49567', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058751728', 'display_name': 'Yao-fei Pei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131061', 'display_name': "Zhejiang Provincial People's Hospital", 'ror': 'https://ror.org/03k14e164', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131061']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yao-fei Pei', 'raw_affiliation_strings': ["Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province 310014, PR China"], 'affiliations': [{'raw_affiliation_string': "Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province 310014, PR China", 'institution_ids': ['https://openalex.org/I4210131061']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100458593', 'display_name': 'Yajing Zhang', 'orcid': 'https://orcid.org/0000-0003-4226-8024'}, 'institutions': [{'id': 'https://openalex.org/I4210119028', 'display_name': 'Beijing Anzhen Hospital', 'ror': 'https://ror.org/02h2j1586', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119028']}, {'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ya-jing Zhang', 'raw_affiliation_strings': ['Department of General Surgery, Bejing Anzhen Hospital, Capital Medical University, Beijing 100000, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Bejing Anzhen Hospital, Capital Medical University, Beijing 100000, PR China', 'institution_ids': ['https://openalex.org/I4210119028', 'https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103272418', 'display_name': 'Yao Lei', 'orcid': 'https://orcid.org/0000-0002-4299-8011'}, 'institutions': [{'id': 'https://openalex.org/I4210147389', 'display_name': "Hunan Provincial People's Hospital", 'ror': 'https://ror.org/03wwr4r78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147389']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yao Lei', 'raw_affiliation_strings': ["Department of Interventional Therapy and Vascular Surgery, Hunan Provincial People's Hospital, Changsha, Hunan Province 410005, PR China"], 'affiliations': [{'raw_affiliation_string': "Department of Interventional Therapy and Vascular Surgery, Hunan Provincial People's Hospital, Changsha, Hunan Province 410005, PR China", 'institution_ids': ['https://openalex.org/I4210147389']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008779602', 'display_name': 'Ding-Wei Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131061', 'display_name': "Zhejiang Provincial People's Hospital", 'ror': 'https://ror.org/03k14e164', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131061']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ding-wei Wu', 'raw_affiliation_strings': ["Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province 310014, PR China"], 'affiliations': [{'raw_affiliation_string': "Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province 310014, PR China", 'institution_ids': ['https://openalex.org/I4210131061']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047730128', 'display_name': 'Tonghui Ma', 'orcid': 'https://orcid.org/0000-0002-5414-0522'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tong-hui Ma', 'raw_affiliation_strings': ['Genetron Health (Beijing) Technology, Co. Ltd., Changping, Beijing 100000, PR China'], 'affiliations': [{'raw_affiliation_string': 'Genetron Health (Beijing) Technology, Co. Ltd., Changping, Beijing 100000, PR China', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100721002', 'display_name': 'Xiqiang Liu', 'orcid': 'https://orcid.org/0000-0002-0845-2242'}, 'institutions': [{'id': 'https://openalex.org/I4210131061', 'display_name': "Zhejiang Provincial People's Hospital", 'ror': 'https://ror.org/03k14e164', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131061']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xi-qiang Liu', 'raw_affiliation_strings': ["Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province 310014, PR China"], 'affiliations': [{'raw_affiliation_string': "Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province 310014, PR China", 'institution_ids': ['https://openalex.org/I4210131061']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.037, 'has_fulltext': False, 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.813541, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '8', 'issue': '14', 'first_page': '23155', 'last_page': '23166'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13157', 'display_name': 'Protein Arginine Methylation in Mammals', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13157', 'display_name': 'Protein Arginine Methylation in Mammals', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Role of Long Noncoding RNAs in Cancer and Development', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.476131}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.66358316}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.63640076}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.5759917}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.57384515}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.56274}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5423932}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.47732645}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47607723}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.44069257}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.43306762}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3648644}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3449637}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.19368151}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17778605}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.14758924}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0733619}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15513', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15513&path%5B%5D=49567', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5410293', 'pdf_url': 'https://europepmc.org/articles/pmc5410293?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410293', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28423564', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.15513', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15513&path%5B%5D=49567', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty', 'score': 0.6}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1122451631', 'https://openalex.org/W1569447426', 'https://openalex.org/W1899124983', 'https://openalex.org/W1985916142', 'https://openalex.org/W1993953064', 'https://openalex.org/W2011956567', 'https://openalex.org/W2036387692', 'https://openalex.org/W2051925478', 'https://openalex.org/W2066390334', 'https://openalex.org/W2068498905', 'https://openalex.org/W2119342433', 'https://openalex.org/W2137805919', 'https://openalex.org/W2176794756', 'https://openalex.org/W2178762141', 'https://openalex.org/W2179096514', 'https://openalex.org/W2179513915', 'https://openalex.org/W2180738906', 'https://openalex.org/W2186401139', 'https://openalex.org/W2187491702', 'https://openalex.org/W2189655283', 'https://openalex.org/W2195188759', 'https://openalex.org/W2204932515', 'https://openalex.org/W2217825891', 'https://openalex.org/W2218362260', 'https://openalex.org/W2254075920', 'https://openalex.org/W2409359560', 'https://openalex.org/W2412080175', 'https://openalex.org/W2414441303', 'https://openalex.org/W2418379008', 'https://openalex.org/W2471851188', 'https://openalex.org/W2472950311', 'https://openalex.org/W841006940'], 'related_works': ['https://openalex.org/W4205189596', 'https://openalex.org/W3183179750', 'https://openalex.org/W3116479654', 'https://openalex.org/W2982360817', 'https://openalex.org/W2916964185', 'https://openalex.org/W2422815049', 'https://openalex.org/W2098584395', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597', 'https://openalex.org/W2019551003'], 'abstract_inverted_index': {'//': [0], 'Yao-fei': [1], 'Pei': [2], '1,': [3], '*': [4, 9, 86], ',': [5, 10, 14, 18, 22, 196], 'Ya-jing': [6], 'Zhang': [7], '2,': [8], 'Yao': [11], 'Lei': [12], '3': [13, 56], 'Ding-wei': [15], 'Wu': [16], '1': [17, 25, 26], 'Tong-hui': [19], 'Ma': [20], '4': [21, 74], 'Xi-qiang': [23, 96], 'Liu': [24], 'Department': [27, 42, 57], 'of': [28, 43, 58, 132, 144, 219, 230], 'Hepatobiliary-Pancreatic': [29], 'Surgery,': [30, 45, 63], 'Zhejiang': [31, 36], 'Provincial': [32, 65], 'People’s': [33, 66], 'Hospital,': [34, 48, 67], 'Hangzhou,': [35], 'Province': [37, 70], '310014,': [38], 'PR': [39, 54, 72, 84], 'China': [40, 55, 73, 85], '2': [41], 'General': [44], 'Bejing': [46], 'Anzhen': [47], 'Capital': [49], 'Medical': [50], 'University,': [51], 'Beijing': [52, 82], '100000,': [53, 83], 'Interventional': [59], 'Therapy': [60], 'and': [61, 157, 162, 177, 192, 203, 212, 232, 256], 'Vascular': [62], 'Hunan': [64, 69], 'Changsha,': [68], '410005,': [71], 'Genetron': [75], 'Health': [76], '(Beijing)': [77], 'Technology,': [78], 'Co.': [79], 'Ltd.,': [80], 'Changping,': [81], 'These': [87], 'authors': [88], 'contributed': [89], 'equally': [90], 'to': [91, 153, 236], 'this': [92], 'work': [93], 'Correspondence': [94], 'to:': [95], 'Liu,': [97], 'email:': [98], '[email protected]': [99], 'Keywords:': [100], 'CHRDL1,': [101], 'EMT,': [102], 'gastric': [103, 174, 224], 'cancer,': [104, 225], 'methylation,': [105], 'Wnt': [106], 'Received:': [107], 'December': [108], '08,': [109], '2016 ': [110], 'Accepted:': [111], 'February': [112, 116], '07,': [113], '2017 ': [114], 'Published:': [115], '19,': [117], '2017': [118], 'ABSTRACT': [119], 'CHRDL1': [120, 168, 190, 197, 221, 231, 245], '(Chordin-like': [121], '1)': [122], 'is': [123, 158], 'a': [124, 139, 185, 248], 'secreted': [125], 'protein': [126, 135], 'that': [127, 167, 244], 'acts': [128], 'as': [129, 141, 247], 'an': [130, 142], 'antagonist': [131], 'bone': [133], 'morphogenetic': [134], '(BMP).': [136], 'BMP': [137, 145], 'plays': [138], 'role': [140], 'activator': [143], 'receptor': [146], 'II': [147, 207], '(BMPR': [148], 'II),': [149], 'which': [150, 226], 'mediates': [151], 'extracellular': [152], 'intracellular': [154], 'signal': [155], 'transmission': [156], 'involved': [159], 'in': [160, 173, 223, 240, 252], 'carcinogenesis': [161], 'metastasis.': [163, 193, 257], 'Herein,': [164], 'we': [165, 215], 'report': [166], 'expression': [169, 191, 229], 'was': [170], 'significantly': [171], 'down-regulated': [172], 'cancer': [175], 'tissues': [176], 'associated': [178], 'with': [179], 'poor': [180], 'survival.': [181], 'Clinic-pathological': [182], 'parameters': [183], 'demonstrated': [184], 'close': [186], 'relationship': [187], 'between': [188], 'low': [189, 228], 'In': [194], 'vitro': [195], 'knockdown': [198], 'promoted': [199], 'tumor': [200, 249, 254], 'cell': [201], 'proliferation': [202], 'migration': [204], 'through': [205], 'BMPR': [206], 'by': [208], 'activating': [209], 'Akt,': [210], 'Erk': [211], 'β-catenin.': [213], 'Furthermore,': [214], 'observed': [216], 'the': [217, 220, 237], 'hypermethylation': [218], 'promoter': [222], 'induced': [227], 'decreased': [233], 'its': [234], 'secretion': [235], 'supernatant.': [238], 'Finally,': [239], 'vivo': [241], 'experiments': [242], 'confirmed': [243], 'acted': [246], 'suppressor': [250], 'gene': [251], 'suppressing': [253], 'growth': [255]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4232351203', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-09-19T09:32:49.180795', 'created_date': '2022-05-12'}