Title: Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation-a prospective multi-centre observation study
Abstract: Transplant InternationalVolume 17, Issue 5 p. 256-260 Free to Read Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation—a prospective multi-centre observation study Herwig Pokorny, Corresponding Author Herwig Pokorny Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaE-mail: [email protected], Tel.: +43-1-404005621, Fax: +43-1-404006872Search for more papers by this authorSusanne Rasoul-Rockenschaub, Susanne Rasoul-Rockenschaub Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorFelix Langer, Felix Langer Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorThomas Windhager, Thomas Windhager Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorAndreas Rosenstingl, Andreas Rosenstingl Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorReinhard Lange, Reinhard Lange Department of Surgery, University Clinic of Essen, Essen, GermanySearch for more papers by this authorAlfred Königsrainer, Alfred Königsrainer Department of Transplant Surgery, University Hospital of Innsbruck, Innsbruck, AustriaSearch for more papers by this authorBurckhardt Ringe, Burckhardt Ringe Department of Transplant Surgery, University Clinic of Göttingen, Göttingen, GermanySearch for more papers by this authorFerdinand Mühlbacher, Ferdinand Mühlbacher Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorRudolf Steininger, Rudolf Steininger Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this author Herwig Pokorny, Corresponding Author Herwig Pokorny Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaE-mail: [email protected], Tel.: +43-1-404005621, Fax: +43-1-404006872Search for more papers by this authorSusanne Rasoul-Rockenschaub, Susanne Rasoul-Rockenschaub Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorFelix Langer, Felix Langer Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorThomas Windhager, Thomas Windhager Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorAndreas Rosenstingl, Andreas Rosenstingl Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorReinhard Lange, Reinhard Lange Department of Surgery, University Clinic of Essen, Essen, GermanySearch for more papers by this authorAlfred Königsrainer, Alfred Königsrainer Department of Transplant Surgery, University Hospital of Innsbruck, Innsbruck, AustriaSearch for more papers by this authorBurckhardt Ringe, Burckhardt Ringe Department of Transplant Surgery, University Clinic of Göttingen, Göttingen, GermanySearch for more papers by this authorFerdinand Mühlbacher, Ferdinand Mühlbacher Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this authorRudolf Steininger, Rudolf Steininger Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18–20, 1090 Vienna, AustriaSearch for more papers by this author First published: 11 March 2005 https://doi.org/10.1111/j.1432-2277.2004.tb00439.xCitations: 56AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Abstract Based on experimental work and clinical small studies, histidine-tryptophan-ketoglutarate (HTK) solution was found to be suitable not only for heart and kidney preservation but also for liver preservation. We decided, therefore, to use this preservation solution for clinical liver preservation in a prospective multi-centre trial. Enrolment to the study was from 1996 to 1999 in four European centres, and the results of 214 patients with HTK-preserved organs were analysed. Analysis showed a primary dysfunction (PDF) rate of 8.8%, with a primary non-function (PNF) rate of 2.3% and initial poor function (IPF) in 6.5%. Patient survival rate at 1 year was 83% and 1-year graft survival rate was 80%. In a univariate and a multivariate analysis PDF, early surgical complications and tendentiously severe infections (septicaemia, pneumonia, cholangitis) were identified as independent risk factors for graft and patient survival. Preservation with HTK can be regarded as an established alternative to preservation with University of Wisconsin (UW) solution when preservation times are short. Definitive assessment of the efficacy of preservation solutions requires further prospective randomised clinical trials that compare HTK and UW. References 1 Wahlberg J, Southard JH, Belzer FO. Development of a cold storage solution for pancreas preservation. Cryobiology 1986; 23: 477. 2 Jamieson NV, Sundberg R, Lindell S, et al. Preservation of the canine liver for 24–48 hours using simple cold storage with UW solution. Transplantation 1988; 46: 517. 3 Kalayoglu M, Sollinger HW, Stratta RJ, et al. Extended preservation of the liver for clinical transplantation. 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