Title: Phototesting in Lupus Erythematosus Tumidus-Review of 60 Patients¶
Abstract: Photochemistry and PhotobiologyVolume 73, Issue 5 p. 532-536 Phototesting in Lupus Erythematosus Tumidus—Review of 60 Patients¶ Annegret Kuhn, Corresponding Author Annegret Kuhn Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany *To whom correspondence should be addressed at: Institute of Cell Biology, ZMBE, Westfälische Wilhelms-University, Von-Esmarch-Strasse 56, D-48149 Münster, Germany. Fax: 49-251-8352236;[email protected] for more papers by this authorMonika Sonntag, Monika Sonntag Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorDagmar Richter-Hintz, Dagmar Richter-Hintz Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorClaudia Oslislo, Claudia Oslislo Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorMosaad Megahed, Mosaad Megahed Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorThomas Ruzicka, Thomas Ruzicka Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorPercy Lehmann, Percy Lehmann Department of Dermatology, University of Witten-Herdecke, Wuppertal, GermanySearch for more papers by this author Annegret Kuhn, Corresponding Author Annegret Kuhn Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany *To whom correspondence should be addressed at: Institute of Cell Biology, ZMBE, Westfälische Wilhelms-University, Von-Esmarch-Strasse 56, D-48149 Münster, Germany. Fax: 49-251-8352236;[email protected] for more papers by this authorMonika Sonntag, Monika Sonntag Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorDagmar Richter-Hintz, Dagmar Richter-Hintz Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorClaudia Oslislo, Claudia Oslislo Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorMosaad Megahed, Mosaad Megahed Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorThomas Ruzicka, Thomas Ruzicka Department of Dermatology, Heinrich-Heine-University, Düsseldorf, GermanySearch for more papers by this authorPercy Lehmann, Percy Lehmann Department of Dermatology, University of Witten-Herdecke, Wuppertal, GermanySearch for more papers by this author First published: 01 May 2007 https://doi.org/10.1562/0031-8655(2001)0730532PILETR2.0.CO2Citations: 13 ¶ Posted on the website on 28 February 2001. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat ABSTRACT Photosensitivity is an important characteristic feature of several forms of lupus erythematosus (LE), and induction of skin lesions by UV-A and UV-B irradiation has been proved to be an optimal model for evaluating light sensitivity in patients with this disease. Because lupus erythematosus tumidus (LET) has rarely been documented in the literature and is often difficult to differentiate from other photodermatoses such as polymorphous light eruption, we performed photoprovocation tests in 60 patients with LET according to a standardized protocol. Areas of uninvolved skin on the upper back were irradiated with single doses of UV-A (100 J/cm2) and/or UV-B (1.5 minimal erythema dose) daily for three consecutive days. Interestingly, patients with LET are more photosensitive than those with subacute cutaneous lupus erythematosus, and in our study experimental phototesting revealed characteristic skin lesions in 43 patients (72%). Because of the latency period in developing positive phototest reactions, it might be difficult for these patients to link sun exposure with their skin lesions. Furthermore, our data revealed a positive correlation of antinuclear antibodies and positive provocative phototest reactions in these patients as seen for other forms of LE. In conclusion, the high incidence of positive phototest reactions in correlation with the clinical findings, history of photosensitivity and antinuclear antibodies enable the classification of LET as the most photosensitive type of LE. Citing Literature Volume73, Issue5May 2001Pages 532-536 RelatedInformation
Publication Year: 2007
Publication Date: 2007-05-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 5
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