Publication Information

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2073, 2099, 2149, 2469, 2513, 2523, 2739, 2785, 2803, 2814, 2920, 2983, 3008, 3097, 3164, 3174, 3186, 3337, 3369, 3423, 3452, 3526, 3633, 3657, 3707, 3715, 3748, 3778, 3869, 3878, 3891, 3970, 4154, 4207, 4229, 4263, 4273, 4276, 4308, 4486, 4495, 4543, 4554], 'with': [332, 639, 647, 915, 1034, 1107, 1114, 1142, 1278, 1504, 1606, 1853, 1952, 2098, 2348, 2522, 2754, 2823, 2857, 3117, 3241, 3248, 3256, 3340, 3349, 3417, 3510, 3593, 3703, 3871, 3881, 3973, 3983, 4030, 4087, 4124, 4173, 4336, 4362, 4526, 4601], 'your': [333], 'friends': [334], 'colleagues.': [336], 'Learn': [337], 'more.Copy': [338], 'URL': [339], 'Share': [340], 'linkShare': [342], 'onFacebookTwitterLinkedInRedditWechat': [343], 'Summary': [344], 'uses': [347], 'system': [352, 557, 3051], 'inject': [354], 'protein': [355, 393, 803, 836, 929, 1090, 1356, 1508, 2026, 2031, 2325, 2958, 3457, 3640, 4071, 4472, 4545], 'effectors': [356, 1248, 1431, 4225], 'into': [357, 430, 563, 983, 1221, 1360, 1550, 1698, 3964], 'targeted': [359, 567, 3855], 'host': [360, 367, 568, 1223, 1410], 'cell.': [361, 4633], 'Effector': [362, 4358], 'is': [364, 373, 379, 394, 411, 457, 501, 508, 518, 586, 606, 664, 668, 688, 705, 1178, 1256, 1372, 1482, 1489, 1547, 1556, 1569, 1611, 1665, 1996, 2027, 2033, 2079, 2105, 2138, 2254, 2327, 2421, 2446, 2462, 2661, 2684, 2713, 2729, 2821, 2941, 2993, 3029, 3075, 3096, 3326, 3384, 3391, 3938, 4072, 4105, 4176, 4379, 4423, 4447, 4462, 4473, 4477, 4509, 4542], 'triggered': [365, 1557, 1636, 2314, 2574], 'cell': [368, 377, 671, 692, 697, 1213, 1224, 1292, 1462, 1629, 1764, 2250, 2400, 2492, 2717, 4249], 'contact.': [369, 2401], 'How': [370, 685], 'prevented': [374, 689, 3488], 'prior': [375, 690, 1290, 1460, 1627, 2490], 'contact': [378, 672, 698, 897, 1293, 1463, 1765, 2493, 2718], 'not': [380, 439, 519, 706, 1324, 1922, 2080, 2175, 2447, 2994, 3031, 3387, 3505, 3520, 3669, 4106, 4366, 4547, 4576, 4605], 'well': [381, 707, 1246, 1532, 2192, 2354], 'understood.': [382], 'In': [383, 1649, 1734, 1804, 2563, 2646, 3884], 'all': [384, 1854, 2141, 2651], 'systems': [386], 'studied': [387, 725, 1478], 'date,': [389], 'needle': [391, 405, 421, 433, 712, 801, 834, 907, 953, 985, 1028, 1032, 1056, 1073, 1109, 1139, 1144, 1159, 1218, 1234, 1280, 1379, 1417, 1588, 1738, 1773, 1783, 1789, 1847, 1865, 2029, 2056, 2064, 2471, 2537, 3542, 3828, 4363, 4530], 'tip': [392, 406, 422, 434, 713, 802, 835, 882, 908, 954, 986, 1033, 1057, 1074, 1110, 1145, 1160, 1235, 1281, 1380, 1418, 1589, 1739, 2030, 2057, 2065, 2472, 3543, 3829, 4364], 'required': [395, 520, 1453, 2107, 2422, 2448, 2500, 3392, 4480], 'controlling': [397, 505, 3831, 4521], 'secretion,': [399, 1540, 2453, 2825, 4133], 'but': [400, 2454, 3006, 3504], 'mechanism': [402], 'which': [404, 495, 889, 1014, 1425, 1451, 1775, 2526, 3095, 3154, 3459, 3480, 3718, 4279, 4290, 4313], 'control': [408, 524, 540, 721, 934, 1331, 1538, 1720, 2059, 2111, 2343, 2376, 2426, 2459, 2633, 3394, 3447, 3579, 3620, 3694, 3808, 3823, 3861, 4131, 4144, 4360, 4384, 4428, 4484], 'unclear.': [412], 'Here': [413, 869, 1692], 'we': [414, 2365, 2416, 2826, 2967, 3471, 4035, 4406, 4552], 'present': [415, 491], 'data': [416, 531, 1939, 4438], 'that': [417, 462, 493, 511, 665, 828, 873, 909, 930, 978, 988, 1069, 1132, 1154, 1179, 1231, 1545, 1612, 1621, 1661, 1785, 1819, 1868, 1944, 1967, 1993, 2032, 2104, 2171, 2180, 2198, 2237, 2321, 2385, 2418, 2439, 2456, 2533, 2914, 2991, 3113, 3280, 3376, 3404, 3594, 3610, 3672, 3912, 3943, 3976, 4022, 4093, 4102, 4137, 4164, 4460, 4470, 4588], 'P.': [419, 732, 1288, 1318, 2038, 2084, 2381, 2564, 2625, 2647, 3150, 3999, 4099, 4430], 'protein,': [423, 1424, 2699, 3470, 3497, 4326], 'PcrV,': [424, 2505, 4540], 'controls': [425, 464, 1740, 2182, 2506, 3406], 'assembling': [429, 3825], 'functional': [432, 2470, 4075], 'complex.': [435, 2473], 'likely': [437, 3030, 3076], 'does': [438, 1323], 'simply': [440, 1156], 'obstruct': [441], 'channel': [444, 1365, 1664, 1701], 'because': [445, 2485, 4485], 'pore-forming': [447, 844, 1088, 1242, 1272, 1314], 'translocator': [448, 845, 1089, 1315, 1622, 1711, 1726, 2486], 'can': [450, 496, 1263, 1624, 2312, 2572, 2799, 2867, 3041, 3428, 3914], 'still': [451, 1860, 1911, 4491], 'be': [452, 1135, 1264, 1492, 1625, 1686, 1696, 1950, 2155, 2313, 2413, 2573, 2800, 2911, 3043, 3122, 3278, 3442, 3854, 3957, 4025, 4059, 4085, 4141, 4160, 4180, 4518], 'secreted': [453, 2489, 2698, 3506, 4548, 4669], 'while': [454, 2499], 'repressed.': [458], 'This': [459, 585, 1680, 2078, 2931, 3037, 3330, 3906, 4475], 'finding': [460], 'suggests': [461, 1068, 1620, 4469], 'affecting': [468, 1744], 'conformation': [470, 1675, 1784, 1793, 1879, 3837], 'apparatus,': [473, 2261, 2736], 'shifting': [474], 'it': [475, 870, 1128, 1180, 1541, 1657, 1990, 2152, 2181, 2234, 3925, 4410, 4516], 'from': [476, 949, 1615, 1902, 2259, 2509, 2539, 2580, 2725, 2750, 2982, 3185, 3864, 3926, 4089, 4272], 'default,': [478, 2541], "'on'": [481, 1878, 1907, 2544], 'conformation,': [482, 1705, 2545], "'off'": [487, 2550], 'conformation.': [488, 2551], 'We': [489, 2383, 2615, 3435, 3797, 3929, 3941, 3986, 4018, 4413, 4503], 'also': [490, 502, 587, 931, 947, 1199, 1685, 1721, 2106, 3331, 3519, 3576, 4159, 4306], 'evidence': [492, 1067, 1614, 4464], 'PcrG,': [494, 2498, 3872], 'bind': [497, 2763], 'involved': [503, 4519], 'in': [504, 570, 608, 645, 700, 718, 722, 731, 735, 739, 744, 806, 809, 848, 901, 905, 926, 964, 1013, 1030, 1076, 1147, 1184, 1193, 1201, 1227, 1317, 1326, 1415, 1434, 1672, 1702, 1728, 1748, 1767, 1771, 1776, 1779, 1782, 1815, 1821, 1874, 1899, 1964, 2003, 2072, 2075, 2133, 2140, 2185, 2188, 2309, 2315, 2340, 2375, 2392, 2396, 2423, 2495, 2512, 2525, 2559, 2567, 2575, 2595, 2598, 2621, 2720, 2745, 2842, 2855, 2887, 2892, 2913, 2985, 3026, 3045, 3082, 3115, 3128, 3153, 3183, 3274, 3292, 3336, 3368, 3399, 3411, 3432, 3444, 3458, 3476, 3479, 3617, 3641, 3684, 3717, 3752, 3775, 3851, 3868, 3897, 3949, 3993, 4011, 4027, 4056, 4098, 4188, 4206, 4212, 4233, 4275, 4278, 4289, 4385, 4399, 4411, 4429, 4434, 4444, 4453, 4466, 4511, 4520, 4524, 4559, 4565, 4572, 4609, 4631], 'export,': [507, 3603], 'cytoplasmic': [509, 1391, 2139, 2244, 4090, 4544], 'interaction': [513, 1503, 2201, 2441, 3416, 3880, 3972, 3979, 4029, 4104, 4167, 4368, 4374, 4391, 4422], 'between': [514, 1926, 2006, 2202, 4369, 4375], 'either': [526, 1188, 1910, 2926, 2978, 3224, 3704, 3961, 3988, 4211], 'protein.': [527, 1487, 4064], 'Taken': [528, 2516], 'together,': [529], 'these': [530, 1151, 1480, 1840, 2232, 2518, 2619, 3027, 3511, 4573], 'allow': [532, 1001, 1861], 'us': [533, 2436, 4136], 'propose': [535], 'working': [537], 'model': [538, 857, 864, 976, 1012, 1177, 1262, 1349, 1572, 1716, 1736, 2273, 2524], 'PcrV.': [547, 4185], 'Introduction': [548], 'Many': [549], 'Gram-negative': [550], 'pathogens': [551], 'use': [552], '(T3SS)': [558], 'deliver': [560], 'cytoplasm': [565, 2187, 2511, 3413, 3866], 'cells': [569, 2851, 3789], 'order': [571, 2424, 3445, 3618, 3852, 4057, 4512], 'promote': [573], 'infection': [574, 613, 3794], '(Troisfontaines': [575, 2041], 'Cornelis,': [577, 579, 2043], '2005;': [578, 630, 680, 750, 1297, 1754, 1758, 1828, 1832, 1883, 1980, 2704, 2708, 3069], '2006;': [580, 1061], 'Galan': [581], 'Wolf-Watz,': [583], '2006).': [584, 710, 1041, 1171, 2017], 'case': [589, 1651, 2082], 'opportunistic': [592], 'pathogen': [593], '(Yahr': [596], 'et': [597, 615, 619, 623, 627, 632, 651, 655, 674, 678, 682, 748, 752, 756, 777, 781, 785, 815, 819, 823, 866, 938, 1007, 1039, 1059, 1063, 1093, 1097, 1121, 1125, 1169, 1252, 1295, 1299, 1333, 1337, 1341, 1367, 1465, 1469, 1473, 1515, 1563, 1597, 1601, 1638, 1642, 1646, 1677, 1752, 1756, 1760, 1826, 1830, 1881, 1885, 1935, 1978, 1982, 1986, 2015, 2088, 2092, 2113, 2117, 2126, 2158, 2166, 2194, 2227, 2334, 2604, 2608, 2612, 2677, 2702, 2706, 2773, 2777, 2781, 2877, 3063, 3067, 3071, 3092, 3296, 3355, 3492, 3560, 3564, 3568, 3903, 4402, 4500], 'al.,': [598, 616, 620, 624, 628, 633, 652, 656, 675, 679, 683, 749, 753, 757, 778, 782, 786, 816, 820, 824, 867, 939, 1008, 1040, 1060, 1064, 1094, 1098, 1122, 1126, 1170, 1253, 1296, 1300, 1334, 1338, 1342, 1368, 1466, 1470, 1474, 1516, 1564, 1598, 1602, 1639, 1643, 1647, 1678, 1753, 1757, 1761, 1827, 1831, 1882, 1886, 1936, 1979, 1983, 1987, 2016, 2089, 2093, 2114, 2118, 2127, 2159, 2167, 2195, 2228, 2335, 2605, 2609, 2613, 2678, 2703, 2707, 2774, 2778, 2782, 2878, 3064, 3068, 3072, 3093, 3297, 3356, 3493, 3561, 3565, 3569, 3904, 4403, 4501], '1996;': [599, 676], 'Hauser,': [600], '2009),': [601], 'where': [602, 794, 1215, 1353, 1579, 2148, 3047], 'critical': [607], 'several': [609], 'animal': [610], 'models': [611, 1044, 1206, 2360, 3398], '(Hauser': [614], '1998;': [617, 1561], 'Kurahashi': [618], '1999;': [621, 3562], 'Pukatzki': [622], '2002;': [625, 2090, 2124, 2606, 2775, 3065], '2003;': [629, 1339, 1517, 1599], 'Miyata': [631], '2003),': [634, 3094, 4404], 'has': [636, 990, 1129, 1350, 1357, 1407, 1542, 1581, 1634, 1658, 1968, 2919, 3052, 3160, 4139, 4396], 'been': [637, 716, 1020, 1046, 1130, 1275, 1351, 1358, 1543, 1582, 1635, 1659, 1812, 1969, 2304, 2586, 3053, 3161, 3464, 4286, 4315, 4397], 'correlated': [638], 'severe': [642, 2922], 'disease': [643], 'outcome': [644], 'patients': [646], 'ventilator-associated': [648], 'pneumonia': [649], '(Roy-burman': [650], '2001;': [653, 1640, 2119, 2123, 2160, 2164, 2214, 3566], 'Hauser': [654], '2002).': [657, 787, 2128], 'One': [658, 1604], 'hallmarks': [661], 'T3SSs': [663], 'upregulated': [669, 2255, 2714, 4300], '(Pettersson': [673], 'Enninga': [677], 'Schlumberger': [681], '2005).': [684, 940, 1565, 1937, 2044, 2094, 2614, 3073], 'contact,': [693, 1214, 1630, 2251], 'or': [694, 839, 1190, 1287, 1320, 1905, 1916, 1930, 2389, 2592, 2858, 2980, 3058, 3179, 3230, 3306, 3714, 3757, 3873, 3890, 3968, 3990, 4170, 4194, 4199, 4215, 4240, 4262, 4352, 4581], 'indeed': [695], 'how': [696, 1259, 2055], 'results': [699, 805, 847, 925, 1192, 1200, 1226, 1433, 1766, 1778, 2071, 2132, 2391, 2519, 2558, 2594, 2744, 3367], 'triggering': [701, 1208, 1945, 2687], 'understood': [708], '(Cornelis,': [709], 'However,': [711, 2045, 2169, 3106, 3652, 4147], 'implicated': [717], 'every': [723], 'organism': [724], 'date': [727], '[these': [728], 'include': [729], 'aeruginosa,': [733, 2565, 2648], 'LcrV': [734, 1018, 2025, 2049, 2096, 2203, 2222, 2252, 2283, 3405, 3487, 3895, 3913, 4378], 'Yersinia': [736, 792, 1285, 1484, 2023, 2095, 2310, 2568, 3401, 4388, 4445], 'sp.,': [737, 793, 2569], 'IpaD': [738, 874, 924, 961, 973, 980, 1081], 'Shigella': [740, 832, 1185, 1816, 1904], 'sp.': [741, 746, 2024, 4446], 'SipD': [743], 'Salmonella': [745, 1283], '(Mueller': [747, 1294], 'Sani': [751], '2007;': [754, 758, 1095, 1123, 1301, 1644], 'Veenendaal': [755, 1096], 'Lara-Tejero': [759, 1302], 'Galan,': [761, 1304], '2009)].': [762], 'Deletion': [763, 2129, 2553], 'corresponding': [766], 'genes': [767, 2655, 2791, 4297], 'most': [768, 2034], 'commonly': [769], 'leads': [770], 'upregulation': [772, 1194, 2207, 2281, 2888, 3021, 3040, 3088], '(Menard': [776, 865], '1993;': [779], 'Kaniga': [780], '1995a;': [783], 'Mccaw': [784], 'The': [788, 826, 975, 1172, 1476, 1566, 1713, 2680, 3017, 3136, 3206, 3236, 3260, 3495, 3571, 3625, 3730, 3763, 4118, 4219, 4373, 4390], 'notable': [789], 'exception': [790, 2053], 'being': [791], 'deletion': [795, 829, 918, 1186, 1311, 2068, 2386, 2409, 2589, 2881, 3481, 3516, 3574, 3628, 3699, 3709, 3954], 'gene': [798, 837, 841, 2819, 2834, 3083, 3104], 'encoding': [799], 'LcrV,': [804, 2352, 3421, 3427], 'defect': [808, 2074, 2924, 3774], '(see': [812], 'below)': [813], '(Bergman': [814], '1991;': [817, 821, 1467, 2671], 'Price': [818], 'Nilles': [822], '1997).': [825], 'observation': [827, 2932, 3907], 'flexneri': [833, 1072], 'ipaD,': [838], 'IpaB,': [846], 'deregulation': [849, 2404, 3371, 3898, 4012], 'led': [853], 'first': [856, 2832], 'control,': [861, 1578, 2364, 2873, 3608], "'plug'": [863], '1993).': [868], 'was': [871, 1991, 2235, 2933, 3143, 3181, 3195, 3221, 3239, 3265, 3290, 3502, 3518, 3599, 3630, 3701, 3745, 3782, 3908, 4226, 4243, 4298, 4490, 4575, 4623, 4664], 'proposed': [872, 1544, 1583, 1660, 1857, 1992, 2236, 3344, 3351, 3378], 'IpaB': [876, 1091, 1105, 1133, 1167, 1220], 'form': [877, 2468, 3425, 3546, 3893], 'structure': [879, 958, 987, 1016], 'at': [880, 994, 1022, 2242, 3540, 3632, 3656, 3826, 4528], 'needle,': [888, 1959], 'physically': [890], 'blocks': [891, 2239], 'via': [893, 1500, 2731, 3877], 'needle.': [895], 'Cell': [896], 'would': [898, 1695], 'then': [899, 2848], 'result': [900, 1325, 1820, 3033, 3078, 3667], 'conformational': [903, 1229, 1413, 1746, 1769, 1955], 'change': [904, 1230, 1414, 1747, 1770, 1781, 1956, 1963], 'opens': [910, 1232], 'channel.': [913], 'Consistent': [914, 3509], 'model,': [917, 1656, 1808], 'signal': [922, 1995, 3461, 3572, 3589, 3616, 3626, 3692, 3850, 4112, 4268], 'non-secreted': [928, 3424, 3892, 4184, 4487], 'fails': [932], '(Picking': [937], 'Some': [941], 'support': [942, 1805], 'plug': [945, 1348], 'hypothesis': [946], 'comes': [948], 'modelling': [950], 'based': [955], 'on': [956, 1212, 2231, 2943, 3473, 3535, 3820, 4221, 4248], 'an': [960, 1398, 1427, 1525, 1673, 1703, 2530, 2751, 2995, 3613, 3689, 3965, 3994, 4044, 4319, 4584, 4599], 'dimer': [962], 'found': [963, 1104], 'one': [965, 1084, 1202, 3813], 'crystals': [968], 'used': [969, 2801, 4624], 'solve': [971], 'structure.': [974], 'predicts': [977], 'five': [979], 'monomers': [981], 'assemble': [982], 'only': [989, 1103], 'small': [992, 999, 1506, 2100, 2695, 4555], 'aperture': [993, 1037], 'its': [995, 1382, 1534, 2177, 2349, 2465, 2540, 2765, 3415, 3489, 3818, 3848, 3947, 4028], 'centre,': [996], 'much': [997], 'too': [998, 4177], 'passage': [1003], '(Johnson': [1006, 1092], '2007).': [1009, 1099, 1254, 1836, 1887, 2709, 3494], 'An': [1010], 'earlier': [1011], 'had': [1019, 2585, 3463, 4285, 4314], 'inserted': [1021, 1359, 1549, 1697, 3751, 4232], 'top': [1024], 'T3SS': [1027, 1406, 1552, 2789, 4603], 'resulted': [1029, 2886, 3896, 4010], 'large': [1036], '(Deane': [1038, 1058, 2014], 'These': [1042, 1938], 'two': [1043, 1670, 2628, 3012, 3799, 4095], 'interpreted': [1047, 3909], 'represent': [1049], "'open'": [1050], "'closed'": [1052], 'versions': [1053, 4081], 'Blocker': [1062, 1759, 1981], '2008).': [1065, 1343, 1369, 1648, 1762, 1988, 2168, 2196, 2879, 3357, 4502], 'Recent': [1066], 'S.': [1071, 1321], 'may': [1075, 1134], 'fact': [1077], 'consist': [1078], 'four': [1080, 3309], 'molecules': [1082], 'molecule': [1085, 1444], 'While': [1100, 1837, 2271, 4450, 4551], 'some': [1101, 1838, 2275], 'associated': [1106, 1141, 1277, 1951], 'after': [1111, 3790, 4334], 'treating': [1112], 'bacteria': [1113, 2841], 'agents': [1115], 'such': [1116, 1441, 3055], 'as': [1117, 1245, 1247, 1531, 1533, 2046, 2191, 2353, 2355, 2529, 2566, 2802, 3056, 3213, 4148, 4257, 4356], 'bile': [1118], 'salts': [1119], '(Olive': [1120], 'Stensrud': [1124], '2008),': [1127], 'argued': [1131], 'queued': [1136], 'within': [1137], 'even': [1146, 2395, 2494, 3042, 3422], 'absence': [1149, 1730, 2398, 2844, 4152, 4216, 4582], 'treatments': [1152], 'bile-salts': [1155], 'reconfigure': [1157], 'display': [1162], 'larger': [1164], 'portion': [1165, 1384, 2150], '(Espina': [1168], 'great': [1173], 'attraction': [1174], 'immediately': [1181], 'explains': [1182, 2274], 'why': [1183], 'ipaB': [1189], 'ipaD': [1191], 'secretion.': [1197, 2061, 2077, 2136, 2428, 3036, 4146], 'It': [1198, 1255, 3074, 3276], 'clearest': [1205], 'insertion': [1216], 'tip-associated': [1219], 'membrane': [1225, 4561, 4672], 'allows': [1237], 'second': [1241, 2811, 3879], 'translocator,': [1243], 'IpaC,': [1244], 'commence': [1250], '(Veenendaal': [1251], 'unclear,': [1257], 'however,': [1258, 1610, 1920, 4479, 4536], 'far': [1260], 'applied': [1265], 'other': [1267, 2063, 3843], 'T3SSs.': [1268], 'For': [1269], 'one,': [1270], 'no': [1271, 2322], 'translocators': [1273], 'detected': [1276, 1970, 4553], 'typhimurium,': [1284], 'enterocolitica': [1286, 4458], 'Broz': [1298], '2009;': [1305, 2779], 'A.,': [1307], 'unpublished': [1308], 'observation).': [1309], 'Moreover,': [1310, 2306, 2402], 'typhimurium': [1322], 'loss': [1327], '(Kaniga': [1332], '1995b;': [1335], 'Broms': [1336], 'Cisz': [1340, 1645], 'Another': [1344], 'variation': [1345], 'proposed,': [1352], "'sensor'": [1355], '(Blocker': [1366], 'Its': [1370], 'inhibited': [1373], 'C-terminal': [1383, 1502], 'binds': [1385], 'part': [1388, 2290], 'face': [1392, 2245], 'T3SS,': [1395, 4586], 'effectively': [1396], 'occluding': [1397], 'acceptor': [1399, 1428], 'site': [1400, 1429, 3379], 'proteins.': [1403, 1712], 'Once': [1404], 'encountered': [1408], 'cell,': [1411, 4650], 'permits': [1419], 'sensor': [1423, 1443, 1690, 1694], 'frees': [1426], 'export.': [1436, 1733, 1803, 2809], 'A': [1437, 2474, 3216, 3697, 4532, 4616], 'possible': [1438, 3800], 'candidate': [1439], 'are': [1445, 1452, 1850, 2289, 2296, 2488, 2520, 3204, 4642], 'YopN/MxiC': [1449], 'family,': [1450], 'preventing': [1455], '(Forsberg': [1464], 'Sundin': [1468, 2607], '2004;': [1471, 2610], 'Botteaux': [1472], '2009).': [1475, 1603, 1679, 2783], 'best': [1477], 'pestis': [1485, 2190, 4468], 'YopN': [1486, 1488, 1523, 1546], 'thought': [1490], 'tethered': [1493], 'base': [1496, 1592, 1796], 'apparatus': [1499, 1595, 1750, 1799, 1873, 2480, 2657, 3859, 3975, 4175], 'regulatory': [1507, 2923, 3013, 3050, 3111, 4166], 'TyeA': [1509], '(Cheng': [1510], 'Schneewind,': [1512], '2000;': [1513], 'Day': [1514], 'Sundberg': [1518], 'Forsberg,': [1520], '2003).': [1521, 2679], 'Because': [1522], 'requires': [1524, 3612, 3688], 'intact': [1526, 3614, 3690, 4585], 'signal,': [1530, 3501], 'chaperone,': [1536, 2102], 'partially': [1548], 'before': [1553, 1631], '(Day': [1558], 'Plano,': [1560], 'Ferracci': [1562], 'analogy': [1567], 'here': [1568], 'ruler': [1571, 1655], 'needle-length': [1577], 'YscP': [1580, 1654], 'connect': [1585], 'growing': [1587, 1613, 2839], '(Journet': [1596], 'Wagner': [1600], 'problem': [1605, 1724], 'plug/sensor': [1608], 'models,': [1609, 1858], 'variety': [1617], 'organisms': [1619], 'exported': [1626, 2156, 2730, 3443, 4142, 4510], '(Lee': [1637, 2226, 3902], 'Olive': [1641], 'wide': [1666], 'enough': [1667], 'accommodate': [1669], 'extended': [1674, 1687, 1704], '(Wagner': [1676], 'line': [1681], 'reasoning': [1683], 'could': [1684, 1921, 3816, 3846, 3956, 4024, 4084, 4158, 4517], 'model.': [1691], 'allowing': [1706, 2760], 'simultaneous': [1708], 'third,': [1714], "'allosteric',": [1715], 'circumvents': [1722], '(Kenjale': [1751, 1825, 1880], 'Torruellas': [1755, 1829], 'Here,': [1763], 'tip,': [1774, 1848, 1866], 'turn': [1777], 'propagates': [1786], 'down': [1787], 'changes': [1791, 2002, 3081], 'permit': [1801], 'needle-protein': [1809], 'mutations': [1810, 1841, 1870, 2410], 'isolated': [1813, 1901], 'both': [1814, 2935, 3231], 'Yersinia,': [1818, 2144], 'deregulated': [1822], 'Davis': [1833], 'Mecsas,': [1835], 'disrupt': [1842], 'assembly': [1844, 1862], 'therefore': [1851, 4414], 'compatible': [1852], 'others': [1859], 'suggesting': [1867, 2179, 2320, 3375, 3671, 4587], 'lock': [1871], 'Zhang': [1884], 'Analysis': [1888], 'helical': [1891], 'pitch': [1892], 'axial': [1894], 'rise': [1895], 'needle-subunits': [1898, 2013], 'needles': [1900, 1929, 1933], 'wild-type': [1903, 1928, 2496, 3175, 3639, 3705, 3889, 3981, 3989, 3996, 4004, 4171, 4208], 'locked': [1906], 'mutants': [1908, 2430, 3046, 3061], '(that': [1909], 'responded': [1912], 'Congo': [1914, 1918], 'red': [1915], 'were': [1917, 1940, 2968, 3723, 4204, 4270, 4341, 4635], 'red-insensitive),': [1919], 'discern': [1923], 'difference': [1925], 'mutant': [1932, 2278, 2918, 2974, 2988, 3004, 3134, 3220, 3496, 3517, 3529, 3575, 3629, 3680, 3700, 3710, 3743, 3781, 3955, 4009, 4264, 4498], '(Cordes': [1934, 1977], 'taken': [1941], 'mean': [1943, 3911], 'cannot': [1949, 3121, 3677], 'large-scale': [1954], 'akin': [1960], 'flagellar': [1965], 'packing': [1966], 'upon': [1971], 'changing': [1972], 'direction': [1974], 'rotation': [1976], '2008;': [1984], 'Mueller': [1985], 'Instead,': [1989], 'propagated': [1997], 'subtle': [1999], 'and/or': [2000, 3141], 'rapid': [2001], 'interactions': [2005], 'head': [2007], 'tail': [2009], 'portions': [2010], 'adjacent': [2012], 'Among': [2018], 'well-studied': [2020], 'T3SSs,': [2021], 'closely': [2035], 'related': [2036, 2685, 2790], 'mentioned': [2047, 4149, 4433], 'above,': [2048, 4150], 'represents': [2050, 4590], 'curious': [2052], 'Unlike': [2062], 'proteins,': [2066], 'lcrV': [2070, 2288], '(Mccaw': [2087, 2603, 2772, 3062], 'interacts': [2097], 'LcrG,': [2103], '(Nilles': [2112], '1997;': [2115], 'Debord': [2116], 'Matson': [2120, 2161], 'Nilles,': [2122, 2163, 2213, 2217], 'Lawton': [2125], 'lcrG': [2131, 4496], 'constitutive': [2134], 'LcrG': [2137, 2205, 2238, 2258, 2268, 2285, 3922, 4376, 4443, 4461], 'species': [2142], 'except': [2145], 'Y.': [2146, 2189, 3477, 3885, 4454, 4457, 4467], 'pestis,': [2147], 'appears': [2153, 2411, 2909], '(Debord': [2157], 'Reina': [2165], 'fusions': [2170], 'prevent': [2172, 2199, 2206], 'do': [2174], 'abolish': [2176], 'activity,': [2178], '(Reina': [2193, 4499], 'Mutations': [2197], '(Matson': [2211], 'Hamad': [2215], '2007)': [2218], 'overexpression': [2220, 3887, 3934, 4002, 4121], 'stimulates': [2223], '2000).': [2229, 3298, 3905], 'Based': [2230], 'data,': [2233, 2279, 3512], 'T3SS.': [2248, 3985, 4389], 'Upon': [2249], 'expression': [2253, 2649, 2820, 2835, 3024, 3084, 3513, 3676, 4291], 'titrates': [2257], 'thereby': [2262, 2759], 'negating': [2263], 'block': [2265, 2476, 2868, 3917], 'imposed': [2266, 3920], '(titration': [2269], 'model).': [2270], 'differential': [2280], 'over': [2284], '(lcrG': [2286], 'lcrGVHyopBD': [2293], 'operon': [2294], 'coordinately': [2297], 'expressed)': [2298], 'has,': [2299], 'knowledge,': [2302], 'never': [2303], 'demonstrated.': [2305], 'pseudotuberculosis': [2311, 3478, 4455], 'presence': [2317, 2600, 2894, 3108, 3537, 4214, 4349, 4569, 4580], 'chloramphenicol,': [2319], 'de': [2323], 'novo': [2324], 'synthesis': [2326], 'needed': [2328], 'upregulate': [2330, 2833, 3429], '(Lloyd': [2333], '2001).': [2336], 'Given': [2337], 'differences': [2339], 'when': [2346, 3409], 'compared': [2347], 'nearest': [2350], 'relative,': [2351], 'wealth': [2357], 'competing': [2359], 'decided': [2366, 2616, 3436, 3930, 4504], 'examine': [2368], 'role': [2370], 'aeruginosa.': [2382, 4000, 4431], 'confirmed': [2384, 4244], 'pcrG': [2388, 2555, 2591, 2883, 2906, 2981, 3131, 3140, 3178, 3226, 3237, 3286, 3325, 3345, 3382, 4041], 'pcrV': [2390, 2557, 2593, 2885, 2908, 2979, 3133, 3142, 3180, 3228, 3246, 3527, 3698, 3708, 3741, 3779, 4284], 'caused': [2405], 'individual': [2408], 'additive.': [2414], 'Next': [2415], 'determined': [2417], 'Specific': [2429], 'allowed': [2435], 'determine': [2438, 2862, 4418, 4514, 4626], 'regulation': [2450], 'rather': [2455, 3007, 4597], 'tied': [2463], 'ability': [2466, 3731, 3764], 'physical': [2475], 'seems': [2483], 'unlikely,': [2484], 'bacteria.': [2497], 'efficient': [2502], 'PcrV-independent': [2514], 'manner.': [2515], 'together': [2517, 4123], 'consistent': [2521], 'acts': [2528], 'allosteric': [2531], 'regulator': [2532, 2666, 2757, 2948, 3099], 'helps': [2534], 'shift': [2535], 'complex': [2538, 2753, 3870, 3967], 'Results': [2552], 'premature': [2560], 'vitro': [2576, 4400], 'removing': [2578, 2723], 'calcium': [2579, 2602, 2724, 2846, 2860, 2866, 2872, 2896], 'growth': [2582], 'medium.': [2583], 'As': [2584, 2784, 2818, 4432], 'previously': [2587], 'reported,': [2588], 'test': [2618, 3438, 3932, 4506], 'phenotypes': [2620, 2975], 'strain': [2623, 3530, 3997, 4209, 4277, 4305], 'using': [2627, 2962, 3267, 3747, 4228, 4637, 4666], 'assays:': [2629], 'indirectly,': [2630], 'monitoring': [2632, 2937, 2952, 3785], 'exoS': [2635, 2938, 2964, 3023, 3159, 3270, 3722, 3754, 4235], 'transcription,': [2636], 'directly,': [2638], 'assaying': [2640], 'blot.': [2645], 'secretion-related': [2654], '(both': [2656], 'genes)': [2660], 'controlled': [2662, 4665], 'master': [2665], 'ExsA': [2667, 2683, 2749, 2761], '(Frank': [2668], 'Iglewski,': [2670], 'Yahr': [2672], 'Frank,': [2674], '1994;': [2675], 'Wolfgang': [2676], 'activity': [2681, 3148], 'virtue': [2692], 'ExsE': [2700, 2728], '(Rietsch': [2701], 'Urbanowski': [2705, 3070], 'When': [2710], '(either': [2715], 'or,': [2719], 'vitro,': [2721], 'medium),': [2727], 'which,': [2737], 'through': [2738, 3414], 'series': [2740], 'protein–protein': [2742], 'interactions,': [2743], 'release': [2747], 'inactive': [2752, 3966], 'negative': [2756, 2947, 3959, 4156], 'ExsD,': [2758], 'cognate': [2766], 'promoters': [2767], 'activate': [2770], 'transcription': [2771, 2787, 2939], 'Brutinel': [2776], 'Thibault': [2780], 'result,': [2786], '(in': [2792], 'case,': [2794], 'gene,': [2797], 'exoS)': [2798], 'convenient': [2804], 'readout': [2805], 'detecting': [2807], 'Our': [2810], 'assay': [2812, 3760], 'involves': [2813], 'modified': [2815, 4036, 4316], 'assay.': [2817, 3199], 'co-regulated': [2822], 'designed': [2827], 'experiment': [2830, 3643, 3655], '(and': [2836], 'secretion)': [2837], 'pelleting': [2849], 'resuspending': [2853], 'them': [2854], 'medium': [2856], 'without': [2859], 'if': [2863, 3933, 3944, 4419, 4515], 're-addition': [2864], '(reestablishing': [2871], 'RECC': [2874, 3198, 3759], 'assay)': [2875], '(Cisz': [2876], 'Both': [2880, 4080, 4328], '(Fig.': [2897, 3015, 3328, 3507, 3531, 3582, 3623, 4016, 4116, 4549], '1A': [2898], 'B).': [2900, 3585], 'Interestingly,': [2901], 'effect': [2903, 2998, 3137, 4220], 'deleting': [2905, 3139], 'additive,': [2912], 'pcrGV': [2916, 3001, 3254], 'double': [2917, 3002, 3218], 'than': [2925, 3637, 4598], 'single': [2929, 2973], 'mutants.': [2930], 'evident': [2934], '(which': [2940], 'dependent': [2942, 3020, 3087], 'ExsE)': [2949], 'ExoT': [2959, 3194], 'directly.': [2960], 'Indeed,': [2961, 3358], 'transcriptional': [2965], 'reporter,': [2966], 'able': [2969, 3521, 3600, 4060], 'recapitulate': [2971], 'expressing': [2977, 3225, 3451], 'plasmid': [2984, 3187, 3238, 3247, 3255, 4274], 'ΔpcrGV': [2987, 3217], 'background,': [2989], 'indicating': [2990], 'aberrant': [2996], 'side': [2997], 'null': [3003, 3060, 3219, 3528, 3742, 3780, 4497], 'strain,': [3005], 'property': [3009], '1C).': [3016], 'remaining': [3018], 'low-calcium': [3019, 3086], 'seen': [3025, 3044], 'experiments': [3028, 3474, 4451], 'increased': [3035], 'secretion-dependent': [3049], 'inactivated,': [3054], 'exsE': [3057], 'exsD': [3059], 'global': [3080], '[e.g.': [3085], 'cAMP': [3090], '(Wolfgang': [3091], 'positive': [3098], 'expression].': [3105], 'additional': [3110], 'factors': [3112], 'work': [3114], 'conjunction': [3116, 4525], 'ruled': [3123], 'out': [3124, 4416], 'entirely.': [3125], 'Figure': [3126, 3682, 4186, 4607], '1Open': [3127], 'figure': [3129, 3685, 4189, 4610], 'viewerPowerPoint': [3130, 3686, 4190, 4611], 'phenotype.A.': [3135], 'assayed': [3144, 3783], 'measuring': [3146], 'β-galactosidase': [3147], 'PAO1': [3152], 'chromosomal': [3156, 3269, 4038, 4281, 4309], 'copy': [3157, 3176, 4039, 4282, 4310], 'replaced': [3162], 'tandem': [3165], 'set': [3166, 4415], 'translationally': [3168], 'coupled': [3169], 'reporters': [3170], '(GFP-lacZ).': [3171], 'Where': [3172, 4302], 'indicated,': [3173, 4303], 'supplied': [3182], 'trans': [3184], '(vec': [3188], '=': [3189, 4648, 4652, 4655, 4658, 4661], 'vector': [3190], 'control).B.': [3191], 'Export': [3192], 'measured': [3196], 'Supernatant': [3200], 'pellet': [3202], 'fractions': [3203, 4333, 4564, 4574], 'indicated.': [3205, 4357], 'RNA': [3207], 'polymerase': [3208], 'alpha': [3209], 'subunit': [3210], '(RpoA)': [3211], 'served': [3212, 4256], 'fractionation': [3214, 4534], 'control.C.': [3215], 'complemented': [3222, 3702], 'alone,': [3227], 'alone': [3229], 'open': [3232, 3287, 3735, 3768], 'reading': [3233, 3288, 3736, 3769], 'frames': [3234, 3770], 'together.': [3235], 'induced': [3240], '10': [3242, 3257, 3645], 'µM': [3243, 3250, 3258, 3646], 'IPTG,': [3244], '125': [3249], 'IPTG': [3251, 3647, 3661], 'IPTG.': [3259], 'success': [3261], 'complementation': [3264], 'monitored': [3266, 3746, 4227], 'reporter': [3271, 3750, 4231], 'fusion': [3272, 3716, 4489], 'described': [3273], 'A.': [3275, 4197], 'should': [3277], 'noted': [3279], 'start': [3282, 3334], 'codon': [3283, 3323, 3335], 'frame': [3289, 3737], 'mis-annotated': [3291], 'genome': [3294], '(Stover': [3295], 'Selective': [3299], 'inactivation': [3300], 'annotated': [3303, 3314], 'ATG': [3304, 3308, 3315], '(ATG1)': [3305], 'codons': [3310, 3712, 3719, 3726], 'downstream': [3311], '(ATG2)': [3316], 'demonstrated': [3317, 4398, 4409, 4537], 'that,': [3318, 4538], 'correct': [3320, 3385], 'translation': [3321], 'initiation': [3322], 'ATG2': [3327], 'S1).': [3329], 'places': [3332], 'better': [3338], 'context': [3339], 'regard': [3341], 'promoter': [3346, 3383], '(ATG1': [3347], 'overlaps': [3348], '–10': [3352], 'box)': [3353], '(Brutinel': [3354], 'mutating': [3359], 'ATG1': [3360], 'GGG': [3362], '(as': [3363], 'opposed': [3364], 'ATC)': [3366], 'slight': [3370], 'system,': [3374], '(data': [3386, 3668, 4604], 'shown).': [3388, 4606], 'Current': [3397], 'field': [3402], 'suggest': [3403], 'located': [3410], 'LcrG.': [3418], 'Overexpression': [3419, 4191, 4237], 'organism.': [3434], 'whether': [3439, 4507], 'must': [3441], 'truncated': [3453], 'sequence': [3462, 3573, 3590, 3627, 4113], 'deleted,': [3465], 'PcrV(Δ3–21).': [3466, 3810], 'To': [3467, 4032], 'create': [3468], 'relied': [3472], 'performed': [3475, 4452], 'amino': [3483], 'acids': [3484], '3–20': [3485], '(Broms': [3491], 'lacking': [3498, 3711, 4265], 'expressed': [3503, 3631, 4271], '2B).': [3508], 'restore': [3523, 3602], 'cytotoxicity': [3524, 3604, 3776], '2C).': [3532], 'Cytotoxicity': [3533], 'relies': [3534], 'help': [3545], 'presumably': [3548], 'dock': [3549], 'translocation': [3552], 'pore': [3553], 'formed': [3554], 'PopB': [3556], 'PopD': [3558], '(Sawa': [3559], 'Dacheux': [3563], 'Goure': [3567], '2004).': [3570], 'failed': [3577], '2A': [3583], 'Replacement': [3586], 'ExoS': [3598], 'demonstrating': [3609, 4092], '2).': [3624], 'somewhat': [3634, 4448], 'lower': [3635], 'level': [3636, 3674], '(with': [3644], 'induction': [3648], 'across': [3649], 'board).': [3651], 'performing': [3653], 'higher': [3658], 'concentration': [3659], '(25': [3662], 'µM)': [3663], 'yielded': [3664], 'same': [3666], 'shown),': [3670], 'explain': [3678, 3803], 'phenotype.': [3681], '2Open': [3683], 'export.A.': [3696], 'pcrV,': [3706], '3–21,': [3713], '1–21': [3720], 'fused': [3724], '22–294': [3727], 'pcrV.': [3729], 'indicated': [3734, 3767, 4643], 'complement': [3739, 3772], 'phenotype': [3744, 4157], 'lacZ': [3749, 4230], 'locus': [3755], '(A)': [3756], '(B).': [3761], 'C.': [3762], 'rounding': [3786], 'A549': [3788], '5': [3791], 'h': [3792], '(moi': [3795], '10).': [3796], 'considered': [3798, 4019], 'scenarios': [3801], 'lack': [3805, 4119], 'On': [3811, 3841], 'hand,': [3814, 3844], 'exert': [3817], 'influence': [3819, 3948], '(perhaps': [3830, 3867], 'influencing': [3835], 'apparatus).': [3840, 3883], 'require': [3847], 'independently': [3874], 'enterocolitica,': [3886], 'relieve': [3915], 'titrating': [3924, 3962], 'apparatus.': [3928], 'signal-sequenceless': [3936, 3991, 4008, 4128, 4201], 'dominant': [3939, 3958, 4155], 'negative.': [3940], 'reasoned': [3942], 'exerts': [3946], 'cytoplasm,': [3951, 4656], 'signal-sequence': [3953], 'forming': [3969], 'non-productive': [3971], 'precludes': [3977], 'overexpressed': [3987, 4205], 'otherwise': [3995], 'Neither': [4001], 'nor': [4006], '3).': [4017], 'possibility': [4021], 'PcrV(Δ3–21)': [4023, 4203], 'defective': [4026], 'PcrG.': [4031, 4615], 'end': [4034], 'express': [4043, 4318], 'internally': [4045, 4320], 'VSV-G': [4046, 4321], '(Vesicular': [4047], 'Stomatitis': [4048], 'Virus': [4049], 'G-protein': [4050], 'epitope)': [4051], 'tagged': [4052, 4067, 4322], 'track': [4062], 'Importantly': [4065], 'essentially': [4073], 'fully': [4074], '(94%': [4076], 'active,': [4077], 'Fig.': [4078], 'S2).': [4079], 'co-precipitated': [4086], 'extracts,': [4091], 'interact': [4097], 'perturbed': [4107, 4181], 'removal': [4109], '3C).': [4117], 'phenotype,': [4122], 'inability': [4126], 'suggested': [4134], 'explained': [4161], 'arguing': [4163], 'strong': [4178], 'excess': [4183], '3Open': [4187], '(Δ3–21).': [4196], 'background': [4210], 'calcium.': [4218], 'locus.': [4236], '(Δ3–21)': [4242, 4269], 'blot': [4247], 'pellets': [4250], 'overexpressing': [4252], 'strains': [4253], '(B,': [4254], 'RpoA': [4255], 'loading': [4258], 'control).C.': [4259], 'Wild-type': [4260], 'deleted': [4287], 'uniformly': [4299], '(ΔexsE).': [4301], 'harboured': [4307], 'pcrG,': [4312], 'PcrG(i3VG).': [4327], 'input': [4329], 'cell-lysates': [4330], 'output': [4332], 'immunoprecipitation': [4335], 'anti-VSV-G': [4338], 'tag': [4339], 'antibody': [4340], 'separated': [4342], 'SDS-PAGE': [4344], 'probed': [4346], 'VSV-G-tagged': [4354, 4618], 'correlates': [4361], 'function,': [4365], 'crucial': [4380], 'homologous': [4387], '(Nanao': [4401], 'now': [4408], 'vivo.': [4412], 'PcrG–PcrV': [4421], 'important': [4424], 'introduction,': [4436], 'regarding': [4439], 'localization': [4441, 4613, 4628], 'confusing.': [4449], 'demonstrate': [4459], 'cytoplasmic,': [4463], 'gathered': [4465], 'exported.': [4474], 'not,': [4478], 'Gal4-LcrG': [4488], 'capable': [4492], 'complementing': [4494], 'tip.': [4531], 'standard': [4533], 'experiment,': [4535, 4567], 'unlike': [4539], '4).': [4550], 'amount': [4556], 'periplasmic': [4563], 'affected': [4577], 'resolution': [4592], 'limit': [4593], 'technique': [4596], 'association': [4600], '4Open': [4608], 'Subcellular': [4612], 'functional,': [4617], '[PcrG(i3VG)]': [4622], 'Bacteria': [4634], 'fractionated': [4636], 'lysozyme/EDTA': [4639], 'method.': [4640], 'Fractions': [4641], 'above': [4644], 'each': [4645], 'lane': [4646], '(wc': [4647], 'whole': [4649], 'S': [4651], 'supernatant,': [4653], 'C': [4654], 'P': [4657], 'periplasm,': [4659], 'M': [4660], 'membrane).': [4662], 'Fractionation': [4663], 'markers': [4667], '(PcrV),': [4671], '(Op': [4674]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4230283440', 'counts_by_year': [], 'updated_date': '2024-12-09T08:25:25.311072', 'created_date': '2022-05-11'}