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{'複合スフィンゴ脂質は、真核細胞の膜の主要構成成分であり、多くの生理的に重要なイベントにおいて必須な役割を持つ。哺乳動物においてスフィンゴ糖脂質は100種類を超える糖鎖構造を持ち、この構造多様性はスフィンゴ糖脂質の多様な生物機能と密接に関連すると考えられている。出芽酵母Saccharomyces': [0], 'cerevisiaeにおいて、複合スフィンゴ脂質はヒドロキシ化の状態によって異なる5種類のセラミド構造と、イノシトールリン酸とマンノースで構成される3種類の親水性頭部を持つ。このためS.': [1], 'cerevisiaeの複合スフィンゴ脂質は15種類のサブタイプに分類される。このような限定された分子種のため、S.': [2], 'cerevisiaeの複合スフィンゴ脂質の構造多様性は、哺乳動物よりもシンプルである。S.': [3], 'cerevisiaeにおいて複合スフィンゴ脂質のすべてが消失すると強力な生育阻害がおきる。一方で、セラミド部分へのヒドロキシ基の付加や親水性頭部の伸長反応は、生育には必須ではない。しかしながら、近年の研究によって、複合スフィンゴ脂質のこれらの構造修飾は、多くの細胞機能において重要であることが示されている。本レビューは、S.': [4], 'cerevisiae及びその他の酵母における複合スフィンゴ脂質の微細構造及び構造多様性の重要性に焦点を当てる。': [5]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4229920640', 'counts_by_year': [], 'updated_date': '2024-09-19T16:21:05.467261', 'created_date': '2022-05-11'}