Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4229053620', 'doi': 'https://doi.org/10.1210/endocr/bqac060', 'title': 'Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice', 'display_name': 'Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice', 'publication_year': 2022, 'publication_date': '2022-05-07', 'ids': {'openalex': 'https://openalex.org/W4229053620', 'doi': 'https://doi.org/10.1210/endocr/bqac060', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35524739'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/endocr/bqac060', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/163/7/bqac060/43892852/bqac060.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://academic.oup.com/endo/article-pdf/163/7/bqac060/43892852/bqac060.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044135900', 'display_name': 'Mahmoud-Sobhy Elkhwanky', 'orcid': 'https://orcid.org/0000-0003-0805-1040'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}, {'id': 'https://openalex.org/I2799272722', 'display_name': 'Oulu University Hospital', 'ror': 'https://ror.org/045ney286', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799272722']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Mahmoud-Sobhy Elkhwanky', 'raw_affiliation_strings': ['Biocenter Oulu, University of Oulu , Oulu , Finland', 'Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland', 'Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu , Oulu , Finland'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234', 'https://openalex.org/I2799272722']}, {'raw_affiliation_string': 'Biocenter Oulu, University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234']}, {'raw_affiliation_string': 'Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051892061', 'display_name': 'Outi Kummu', 'orcid': 'https://orcid.org/0000-0003-0327-3496'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}, {'id': 'https://openalex.org/I2799272722', 'display_name': 'Oulu University Hospital', 'ror': 'https://ror.org/045ney286', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799272722']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Outi Kummu', 'raw_affiliation_strings': ['Biocenter Oulu, University of Oulu , Oulu , Finland', 'Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland', 'Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu , Oulu , Finland'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234', 'https://openalex.org/I2799272722']}, {'raw_affiliation_string': 'Biocenter Oulu, University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234']}, {'raw_affiliation_string': 'Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028225786', 'display_name': 'Jukka Hakkola', 'orcid': 'https://orcid.org/0000-0001-5048-4363'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}, {'id': 'https://openalex.org/I2799272722', 'display_name': 'Oulu University Hospital', 'ror': 'https://ror.org/045ney286', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799272722']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Jukka Hakkola', 'raw_affiliation_strings': ['Biocenter Oulu, University of Oulu , Oulu , Finland', 'Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland', 'Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu , Oulu , Finland'], 'affiliations': [{'raw_affiliation_string': 'Biocenter Oulu, University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234']}, {'raw_affiliation_string': 'Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234', 'https://openalex.org/I2799272722']}, {'raw_affiliation_string': 'Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu , Oulu , Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5028225786'], 'corresponding_institution_ids': ['https://openalex.org/I98381234', 'https://openalex.org/I2799272722'], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'fwci': 1.02, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.72537, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 83}, 'biblio': {'volume': '163', 'issue': '7', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11967', 'display_name': 'Electrolyte and hormonal disorders', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hydroxylation', 'display_name': 'Hydroxylation', 'score': 0.47126198}], 'concepts': [{'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.87667656}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8593057}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.7785566}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.5818211}, {'id': 'https://openalex.org/C124490489', 'wikidata': 'https://www.wikidata.org/wiki/Q7936963', 'display_name': 'Vitamin D and neurology', 'level': 2, 'score': 0.50391}, {'id': 'https://openalex.org/C2776940978', 'wikidata': 'https://www.wikidata.org/wiki/Q34956', 'display_name': 'Vitamin', 'level': 2, 'score': 0.48519614}, {'id': 'https://openalex.org/C2781109383', 'wikidata': 'https://www.wikidata.org/wiki/Q898497', 'display_name': 'Hydroxylation', 'level': 3, 'score': 0.47126198}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42083877}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36007166}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.12911037}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.090419054}], 'mesh': [{'descriptor_ui': 'D053493', 'descriptor_name': 'Cholestanetriol 26-Monooxygenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015090', 'descriptor_name': '25-Hydroxyvitamin D3 1-alpha-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015090', 'descriptor_name': '25-Hydroxyvitamin D3 1-alpha-Hydroxylase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015090', 'descriptor_name': '25-Hydroxyvitamin D3 1-alpha-Hydroxylase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053493', 'descriptor_name': 'Cholestanetriol 26-Monooxygenase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D053493', 'descriptor_name': 'Cholestanetriol 26-Monooxygenase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053493', 'descriptor_name': 'Cholestanetriol 26-Monooxygenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006900', 'descriptor_name': 'Hydroxylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014808', 'descriptor_name': 'Vitamin D Deficiency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014808', 'descriptor_name': 'Vitamin D Deficiency', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014815', 'descriptor_name': 'Vitamins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014815', 'descriptor_name': 'Vitamins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/endocr/bqac060', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/163/7/bqac060/43892852/bqac060.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://urn.fi/urn:nbn:fi-fe2022122974072', 'pdf_url': 'http://jultika.oulu.fi/files/nbnfi-fe2022122974072.pdf', 'source': {'id': 'https://openalex.org/S4306400284', 'display_name': 'University of Oulu Repository (University of Oulu)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98381234', 'host_organization_name': 'University of Oulu', 'host_organization_lineage': ['https://openalex.org/I98381234'], 'host_organization_lineage_names': ['University of Oulu'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155637', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35524739', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/endocr/bqac060', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/163/7/bqac060/43892852/bqac060.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320317611', 'funder_display_name': 'Fondazione Diabete Ricerca', 'award_id': None}, {'funder': 'https://openalex.org/F4320321108', 'funder_display_name': 'Academy of Finland', 'award_id': '323706'}], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1880207624', 'https://openalex.org/W1917138589', 'https://openalex.org/W1947853286', 'https://openalex.org/W2020435820', 'https://openalex.org/W2032874870', 'https://openalex.org/W2035737992', 'https://openalex.org/W2038469606', 'https://openalex.org/W2041956619', 'https://openalex.org/W2063321649', 'https://openalex.org/W2065188188', 'https://openalex.org/W2071115739', 'https://openalex.org/W2074252273', 'https://openalex.org/W2086684784', 'https://openalex.org/W2093611015', 'https://openalex.org/W2110646769', 'https://openalex.org/W2162258804', 'https://openalex.org/W2164904685', 'https://openalex.org/W2188217851', 'https://openalex.org/W2254563264', 'https://openalex.org/W2604498431', 'https://openalex.org/W2616730536', 'https://openalex.org/W2618205203', 'https://openalex.org/W2737599529', 'https://openalex.org/W2788945338', 'https://openalex.org/W2811470971', 'https://openalex.org/W2916822805', 'https://openalex.org/W2918589819', 'https://openalex.org/W2980008083', 'https://openalex.org/W2982335678', 'https://openalex.org/W2993709105', 'https://openalex.org/W3016704539', 'https://openalex.org/W3044791914', 'https://openalex.org/W3133746044'], 'related_works': ['https://openalex.org/W2370045143', 'https://openalex.org/W2365080244', 'https://openalex.org/W2145190142', 'https://openalex.org/W2121080036', 'https://openalex.org/W2115434474', 'https://openalex.org/W2114227454', 'https://openalex.org/W2104333948', 'https://openalex.org/W2090878228', 'https://openalex.org/W2042420352', 'https://openalex.org/W1965456255'], 'abstract_inverted_index': {'Abstract': [0], 'Vitamin': [1], 'D': [2, 8, 48, 70, 140, 161, 167, 177, 219, 224, 235], 'deficiency': [3], '[ie,': [4], 'low': [5], 'plasma': [6, 175], '25-hydroxyvitamin': [7], '(25-OH-D)]': [9], 'associates': [10], 'with': [11], 'the': [12, 22, 39, 44, 53, 64, 80, 83, 86, 92, 97, 104, 117, 138, 146, 149, 155, 165, 171, 174, 200], 'prevalence': [13], 'of': [14, 55, 59, 66, 82, 107, 111, 135, 148, 154, 184, 203, 208, 232], 'metabolic': [15, 36], 'diseases': [16, 37], 'including': [17], 'type': [18, 60, 204], '1': [19, 61, 205], 'diabetes;': [20], 'however,': [21], 'molecular': [23], 'mechanisms': [24], 'are': [25], 'incompletely': [26], 'understood.': [27], 'Recent': [28], 'studies': [29], 'have': [30], 'indicated': [31], 'that': [32, 74, 198], 'both': [33, 187], 'fasting': [34], 'and': [35, 68, 125, 132, 173, 222], 'suppress': [38], 'cytochrome': [40], 'P450': [41], '(CYP)': [42], '2R1,': [43], 'major': [45], 'hepatic': [46, 209, 217], 'vitamin': [47, 69, 139, 160, 166, 218, 223, 234], '25-hydroxylase.': [49], 'We': [50, 72], 'specifically': [51], 'studied': [52], 'effect': [54], 'a': [56], 'mouse': [57, 201], 'model': [58, 202], 'diabetes': [62, 76, 206], 'on': [63], 'regulation': [65, 110], 'Cyp2r1': [67, 84, 112, 156, 210], 'status.': [71], 'show': [73], 'streptozotocin-induced': [75], 'in': [77, 85, 96, 116, 127, 145, 170, 199, 215, 238], 'mice': [78], 'suppresses': [79], 'expression': [81, 169, 211], 'liver.': [87], 'While': [88], 'insulin': [89], 'therapy': [90], 'normalized': [91, 189], 'blood': [93], 'glucose': [94], 'levels': [95], 'diabetic': [98, 150], 'mice,': [99, 151], 'it': [100], 'did': [101], 'not': [102, 123, 213], 'rescue': [103], 'diabetes-induced': [105], 'suppression': [106, 207], 'Cyp2r1.': [108], 'Similar': [109], 'was': [113, 122, 143], 'observed': [114], 'also': [115], 'kidney.': [118], 'Plasma': [119], '25-OH-D': [120], 'level': [121, 178], 'decreased': [124], 'was,': [126], 'contrast,': [128], 'higher': [129, 180], 'after': [130, 181, 190], '4': [131, 182], '8': [133], 'weeks': [134, 183], 'diabetes.': [136, 241], 'Furthermore,': [137], '25-hydroxylase': [141, 162, 220, 236], 'activity': [142, 221], 'increased': [144], 'livers': [147], 'suggesting': [152], 'compensation': [153], 'repression': [157], 'by': [158], 'other': [159, 233], 'enzymes.': [163], 'Cyp27b1,': [164], '1α-hydroxylase,': [168], 'kidney': [172], '1α,25-dihydroxyvitamin': [176], 'were': [179, 188], 'diabetes,': [185], 'while': [186], '13': [191], 'weeks.': [192], 'In': [193], 'summary,': [194], 'these': [195], 'results': [196], 'indicate': [197], 'does': [212], 'result': [214], 'reduced': [216], 'deficiency.': [225], 'This': [226], 'may': [227], 'be': [228], 'due': [229], 'to': [230, 240], 'induction': [231], 'enzymes': [237], 'response': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4229053620', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-12-17T09:13:26.262256', 'created_date': '2022-05-08'}