Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4225375626', 'doi': 'https://doi.org/10.1021/acsmedchemlett.2c00123', 'title': 'Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity', 'display_name': 'Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity', 'publication_year': 2022, 'publication_date': '2022-05-03', 'ids': {'openalex': 'https://openalex.org/W4225375626', 'doi': 'https://doi.org/10.1021/acsmedchemlett.2c00123', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35571875'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acsmedchemlett.2c00123', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00123', 'source': {'id': 'https://openalex.org/S191852912', 'display_name': 'ACS Medicinal Chemistry Letters', 'issn_l': '1948-5875', 'issn': ['1948-5875'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00123', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029783700', 'display_name': 'Maria Giulia Nizi', 'orcid': 'https://orcid.org/0000-0001-6317-3687'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria Giulia Nizi', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061817209', 'display_name': 'Leentje Persoons', 'orcid': 'https://orcid.org/0000-0002-7898-0868'}, 'institutions': [{'id': 'https://openalex.org/I24156275', 'display_name': 'Rega Institute for Medical Research', 'ror': 'https://ror.org/03w5j8p12', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I24156275']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Leentje Persoons', 'raw_affiliation_strings': ['Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium', 'institution_ids': ['https://openalex.org/I24156275', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056464448', 'display_name': 'Angela Corona', 'orcid': 'https://orcid.org/0000-0002-6630-8636'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Angela Corona', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001818513', 'display_name': 'Tommaso Felicetti', 'orcid': 'https://orcid.org/0000-0001-9369-8564'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Tommaso Felicetti', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077113911', 'display_name': 'Giada Cernicchi', 'orcid': 'https://orcid.org/0000-0002-3591-0210'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giada Cernicchi', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054053277', 'display_name': 'Serena Massari', 'orcid': 'https://orcid.org/0000-0002-9992-6318'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Serena Massari', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020731665', 'display_name': 'Giuseppe Manfroni', 'orcid': 'https://orcid.org/0000-0003-0207-3927'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Manfroni', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037780048', 'display_name': 'Laura Vangeel', 'orcid': 'https://orcid.org/0000-0001-8820-6617'}, 'institutions': [{'id': 'https://openalex.org/I24156275', 'display_name': 'Rega Institute for Medical Research', 'ror': 'https://ror.org/03w5j8p12', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I24156275']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Laura Vangeel', 'raw_affiliation_strings': ['Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium', 'institution_ids': ['https://openalex.org/I24156275', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013762333', 'display_name': 'Maria Letizia Barreca', 'orcid': 'https://orcid.org/0000-0003-3530-5042'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria Letizia Barreca', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101683201', 'display_name': 'Francesca Esposito', 'orcid': 'https://orcid.org/0000-0001-9725-7977'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Esposito', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073105044', 'display_name': 'Dirk Jochmans', 'orcid': 'https://orcid.org/0000-0002-9265-6028'}, 'institutions': [{'id': 'https://openalex.org/I24156275', 'display_name': 'Rega Institute for Medical Research', 'ror': 'https://ror.org/03w5j8p12', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I24156275']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Dirk Jochmans', 'raw_affiliation_strings': ['Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium', 'institution_ids': ['https://openalex.org/I24156275', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009869800', 'display_name': 'Jessica Milia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Jessica Milia', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043864360', 'display_name': 'Violetta Cecchetti', 'orcid': 'https://orcid.org/0000-0001-8558-7004'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Violetta Cecchetti', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023796496', 'display_name': 'Dominique Schols', 'orcid': 'https://orcid.org/0000-0003-3256-5850'}, 'institutions': [{'id': 'https://openalex.org/I24156275', 'display_name': 'Rega Institute for Medical Research', 'ror': 'https://ror.org/03w5j8p12', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I24156275']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Dominique Schols', 'raw_affiliation_strings': ['Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium', 'institution_ids': ['https://openalex.org/I24156275', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089010495', 'display_name': 'Johan Neyts', 'orcid': 'https://orcid.org/0000-0002-0033-7514'}, 'institutions': [{'id': 'https://openalex.org/I24156275', 'display_name': 'Rega Institute for Medical Research', 'ror': 'https://ror.org/03w5j8p12', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I24156275']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Johan Neyts', 'raw_affiliation_strings': ['Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium', 'institution_ids': ['https://openalex.org/I24156275', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037425032', 'display_name': 'Enzo Tramontano', 'orcid': 'https://orcid.org/0000-0002-4849-0980'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Enzo Tramontano', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09124 Cagliari, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057923752', 'display_name': 'Stefano Sabatini', 'orcid': 'https://orcid.org/0000-0003-0971-3536'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Stefano Sabatini', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030947556', 'display_name': 'Steven De Jonghe', 'orcid': 'https://orcid.org/0000-0002-3872-6558'}, 'institutions': [{'id': 'https://openalex.org/I24156275', 'display_name': 'Rega Institute for Medical Research', 'ror': 'https://ror.org/03w5j8p12', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I24156275']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Steven De Jonghe', 'raw_affiliation_strings': ['Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium', 'institution_ids': ['https://openalex.org/I24156275', 'https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010835490', 'display_name': 'Oriana Tabarrini', 'orcid': 'https://orcid.org/0000-0003-2693-5675'}, 'institutions': [{'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Oriana Tabarrini', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5057923752', 'https://openalex.org/A5030947556', 'https://openalex.org/A5010835490'], 'corresponding_institution_ids': ['https://openalex.org/I27483092', 'https://openalex.org/I24156275', 'https://openalex.org/I99464096', 'https://openalex.org/I27483092'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.842, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.999876, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '13', 'issue': '5', 'first_page': '855', 'last_page': '864'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10274', 'display_name': 'Synthesis and biological activity', 'score': 0.9879, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9774, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ec50', 'display_name': 'EC50', 'score': 0.5090794}, {'id': 'https://openalex.org/keywords/coronavirus', 'display_name': 'Coronavirus', 'score': 0.47862735}], 'concepts': [{'id': 'https://openalex.org/C3007834351', 'wikidata': 'https://www.wikidata.org/wiki/Q82069695', 'display_name': 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)', 'level': 5, 'score': 0.5594426}, {'id': 'https://openalex.org/C96529984', 'wikidata': 'https://www.wikidata.org/wiki/Q286136', 'display_name': 'EC50', 'level': 3, 'score': 0.5090794}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.49153385}, {'id': 'https://openalex.org/C2777648638', 'wikidata': 'https://www.wikidata.org/wiki/Q57751738', 'display_name': 'Coronavirus', 'level': 5, 'score': 0.47862735}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47851884}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.4376646}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.42697737}, {'id': 'https://openalex.org/C116073593', 'wikidata': 'https://www.wikidata.org/wiki/Q864491', 'display_name': 'Biological activity', 'level': 3, 'score': 0.41663045}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.38431692}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.38232726}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3330487}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.321738}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.28849685}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28848195}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23965576}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acsmedchemlett.2c00123', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00123', 'source': {'id': 'https://openalex.org/S191852912', 'display_name': 'ACS Medicinal Chemistry Letters', 'issn_l': '1948-5875', 'issn': ['1948-5875'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088073', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://lirias.kuleuven.be/bitstream/20.500.12942/695569/2/manuscript%20revised%20Tabarrini%20Def.docx', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401954', 'display_name': 'Lirias (KU Leuven)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I99464096', 'host_organization_name': 'KU Leuven', 'host_organization_lineage': ['https://openalex.org/I99464096'], 'host_organization_lineage_names': ['KU Leuven'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11584/334353', 'pdf_url': 'https://iris.unica.it/bitstream/11584/334353/1/2022%20PQQacsmedchemlett.2c00123.pdf', 'source': {'id': 'https://openalex.org/S4377196293', 'display_name': 'UNICA IRIS Institutional Research Information System (University of Cagliari)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I172446870', 'host_organization_name': 'University of Cagliari', 'host_organization_lineage': ['https://openalex.org/I172446870'], 'host_organization_lineage_names': ['University of Cagliari'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35571875', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acsmedchemlett.2c00123', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00123', 'source': {'id': 'https://openalex.org/S191852912', 'display_name': 'ACS Medicinal Chemistry Letters', 'issn_l': '1948-5875', 'issn': ['1948-5875'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.73, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320321873', 'funder_display_name': 'Ministero dell’Istruzione, dell’Università e della Ricerca', 'award_id': 'F75F21000880001'}], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W2006468788', 'https://openalex.org/W2049879791', 'https://openalex.org/W2068179023', 'https://openalex.org/W2095807050', 'https://openalex.org/W2112898697', 'https://openalex.org/W2116161740', 'https://openalex.org/W2327990997', 'https://openalex.org/W2328100822', 'https://openalex.org/W2331005861', 'https://openalex.org/W2334412610', 'https://openalex.org/W2810037075', 'https://openalex.org/W2887767551', 'https://openalex.org/W2896002881', 'https://openalex.org/W3003383509', 'https://openalex.org/W3023221016', 'https://openalex.org/W3082490235', 'https://openalex.org/W3088015719', 'https://openalex.org/W3088771767', 'https://openalex.org/W3092218013', 'https://openalex.org/W3096967708', 'https://openalex.org/W3113458973', 'https://openalex.org/W3122083218', 'https://openalex.org/W3123893662', 'https://openalex.org/W3165644756', 'https://openalex.org/W3178949169', 'https://openalex.org/W3190949342', 'https://openalex.org/W3208312080'], 'related_works': ['https://openalex.org/W3152230514', 'https://openalex.org/W3092521730', 'https://openalex.org/W3047950519', 'https://openalex.org/W3002812395', 'https://openalex.org/W2796949944', 'https://openalex.org/W2768110043', 'https://openalex.org/W2484203845', 'https://openalex.org/W2395219877', 'https://openalex.org/W2366562690', 'https://openalex.org/W2045299745'], 'abstract_inverted_index': {'A': [0, 35], 'selection': [1, 61], 'of': [2, 21, 53, 62, 69, 83, 121, 129], 'compounds': [3, 75], 'from': [4, 114], 'a': [5, 31, 39, 122, 144, 149], 'proprietary': [6], 'library,': [7], 'based': [8, 37], 'on': [9, 38], 'chemical': [10], 'diversity': [11], 'and': [12, 50, 55, 86, 108], 'various': [13], 'biological': [14], 'activities,': [15], 'was': [16], 'evaluated': [17], 'as': [18, 43, 81], 'potential': [19], 'inhibitors': [20, 82], 'the': [22, 44, 67, 94, 104, 126, 130], 'Severe': [23], 'Acute': [24], 'Respiratory': [25], 'Syndrome': [26], 'Coronavirus': [27], '2': [28], '(SARS-CoV-2)': [29], 'in': [30], 'phenotypic-based': [32], 'screening': [33], 'assay.': [34], 'compound': [36, 134], '2-phenylquinoline': [40, 131], 'scaffold': [41], 'emerged': [42], 'most': [45, 95], 'promising': [46, 96], 'hit,': [47], 'with': [48, 66, 110], 'EC50': [49, 111], 'CC50': [51], 'values': [52, 112], '6': [54], '18': [56], 'μM,': [57], 'respectively.': [58], 'The': [59, 119], 'subsequent': [60], 'additional': [63], 'analogues,': [64], 'along': [65], 'synthesis': [68], 'ad': [70], 'hoc': [71], 'derivatives,': [72], 'led': [73], 'to': [74, 116], 'that': [76, 136], 'maintained': [77], 'low': [78], 'μM': [79], 'activity': [80, 102, 139], 'SARS-CoV-2': [84, 141], 'replication': [85], 'lacked': [87], 'cytotoxicity': [88], 'at': [89, 125], '100': [90], 'μM.': [91, 118], 'In': [92], 'addition,': [93], 'congeners': [97], 'also': [98], 'show': [99], 'pronounced': [100], 'antiviral': [101], 'against': [103, 140, 151], 'human': [105], 'coronaviruses': [106], 'HCoV-229E': [107], 'HCoV-OC43,': [109], 'ranging': [113], '0.2': [115], '9.4': [117], 'presence': [120], '6,7-dimethoxytetrahydroisoquinoline': [123], 'group': [124], 'C-4': [127], 'position': [128], 'core': [132], 'gave': [133], '6g': [135], 'showed': [137], 'potent': [138], 'helicase': [142], '(nsp13),': [143], 'highly': [145], 'conserved': [146], 'enzyme,': [147], 'highlighting': [148], 'potentiality': [150], 'emerging': [152], 'HCoVs': [153], 'outbreaks.': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4225375626', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}], 'updated_date': '2025-01-06T09:51:41.801543', 'created_date': '2022-05-05'}