Publication Information

{'id': 'https://openalex.org/W4225258988', 'doi': 'https://doi.org/10.1097/ju.0000000000002516.07', 'title': 'PD01-07 THE TUMOR SUPPRESSOR FLCN REGULATES THE WARBURG EFFECT IN RENAL CELL CARCINOMA THROUGH INHIBITION OF LACTATE DEHYDROGENASE-A', 'display_name': 'PD01-07 THE TUMOR SUPPRESSOR FLCN REGULATES THE WARBURG EFFECT IN RENAL CELL CARCINOMA THROUGH INHIBITION OF LACTATE DEHYDROGENASE-A', 'publication_year': 2022, 'publication_date': '2022-04-07', 'ids': {'openalex': 'https://openalex.org/W4225258988', 'doi': 'https://doi.org/10.1097/ju.0000000000002516.07'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/ju.0000000000002516.07', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087877770', 'display_name': 'Mark R. Woodford', 'orcid': 'https://orcid.org/0000-0002-6737-2832'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mark R. Woodford', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053303684', 'display_name': 'Rebecca Sager', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Rebecca A Sager', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014299665', 'display_name': 'Sarah J. Backe', 'orcid': 'https://orcid.org/0000-0001-9275-267X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sarah J Backe', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014760455', 'display_name': 'Fiza Hashmi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fiza Hashmi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073007217', 'display_name': 'Priyanka Kancherla', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Priyanka Kancherla', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091601262', 'display_name': 'Alexandr Pinkhasov', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Alexandr Pinkhasov', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107963543', 'display_name': 'W. Marston Linehan', 'orcid': 'https://orcid.org/0000-0001-7983-3109'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'W Marston Linehan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063624667', 'display_name': 'Dimitra Bourboulia', 'orcid': 'https://orcid.org/0000-0002-8567-2775'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dimitra Bourboulia', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007706410', 'display_name': 'Gennady Bratslavsky', 'orcid': 'https://orcid.org/0000-0002-2712-4375'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gennady Bratslavsky', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058621466', 'display_name': 'Mehdi Mollapour', 'orcid': 'https://orcid.org/0000-0002-2144-1361'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mehdi Mollapour', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': '207', 'issue': 'Supplement 5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9716, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11297', 'display_name': 'Ferroptosis and cancer prognosis', 'score': 0.9426, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/folliculin', 'display_name': 'Folliculin', 'score': 0.9948747}, {'id': 'https://openalex.org/keywords/warburg-effect', 'display_name': 'Warburg Effect', 'score': 0.8150083}, {'id': 'https://openalex.org/keywords/lactate-dehydrogenase-a', 'display_name': 'Lactate dehydrogenase A', 'score': 0.43203717}], 'concepts': [{'id': 'https://openalex.org/C97329493', 'wikidata': 'https://www.wikidata.org/wiki/Q18053203', 'display_name': 'Folliculin', 'level': 3, 'score': 0.9948747}, {'id': 'https://openalex.org/C109156525', 'wikidata': 'https://www.wikidata.org/wiki/Q56770304', 'display_name': 'Warburg effect', 'level': 4, 'score': 0.8150083}, {'id': 'https://openalex.org/C179185449', 'wikidata': 'https://www.wikidata.org/wiki/Q219699', 'display_name': 'Suppressor', 'level': 3, 'score': 0.5610168}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.5382741}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5177878}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.51743084}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5026791}, {'id': 'https://openalex.org/C2910680157', 'wikidata': 'https://www.wikidata.org/wiki/Q18028499', 'display_name': 'Lactate dehydrogenase A', 'level': 4, 'score': 0.43203717}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.42767963}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.30253536}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28327984}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22555423}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.21661925}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14613688}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13696006}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.10118055}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.059312463}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/ju.0000000000002516.07', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3192325604', 'https://openalex.org/W3145560974', 'https://openalex.org/W3008581549', 'https://openalex.org/W2889229834', 'https://openalex.org/W2517394834', 'https://openalex.org/W2405190761', 'https://openalex.org/W2383032683', 'https://openalex.org/W2077076179', 'https://openalex.org/W2038440288', 'https://openalex.org/W1762294967'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 173, 181, 198, 221, 245, 259, 273, 281, 304, 314, 320, 372, 379, 438, 453, 456, 483, 492, 495], 'UrologyCME1': [4], 'May': [5], '2022PD01-07': [6], 'THE': [7, 12], 'TUMOR': [8], 'SUPPRESSOR': [9], 'FLCN': [10, 187, 232, 252, 292, 315, 321, 344, 364, 380, 390, 428, 433, 447, 468], 'REGULATES': [11], 'WARBURG': [13], 'EFFECT': [14], 'IN': [15], 'RENAL': [16], 'CELL': [17], 'CARCINOMA': [18], 'THROUGH': [19], 'INHIBITION': [20], 'OF': [21], 'LACTATE': [22], 'DEHYDROGENASE-A': [23], 'Mark': [24, 49, 547], 'R.': [25, 50, 52, 548], 'Woodford,': [26], 'Rebecca': [27, 60, 555], 'A': [28, 61, 63, 374, 556], 'Sager,': [29], 'Sarah': [30, 71, 563], 'J': [31, 72, 74, 564], 'Backe,': [32], 'Fiza': [33, 82, 571], 'Hashmi,': [34], 'Priyanka': [35, 91, 578], 'Kancherla,': [36], 'Alexandr': [37, 100, 585], 'Pinkhasov,': [38], 'W': [39, 109, 592], 'Marston': [40, 110, 112, 593], 'Linehan,': [41], 'Dimitra': [42, 120, 600], 'Bourboulia,': [43], 'Gennady': [44, 129, 607], 'Bratslavsky,': [45], 'and': [46, 138, 262, 270, 284, 287, 302, 328, 359, 367, 386, 403, 463, 474, 512, 524, 543], 'Mehdi': [47, 139, 614], 'Mollapour': [48, 141, 615], 'WoodfordMark': [51], 'Woodford': [53, 549], 'More': [54, 65, 76, 85, 94, 103, 114, 123, 132, 142, 550, 558, 566, 573, 580, 587, 595, 602, 609, 616], 'articles': [55, 66, 77, 86, 95, 104, 115, 124, 133, 143, 551, 559, 567, 574, 581, 588, 596, 603, 610, 617], 'by': [56, 67, 78, 87, 96, 105, 116, 125, 134, 144, 208, 501, 519, 538, 552, 560, 568, 575, 582, 589, 597, 604, 611, 618], 'this': [57, 68, 79, 88, 97, 106, 117, 126, 135, 145, 229, 246, 457, 553, 561, 569, 576, 583, 590, 598, 605, 612, 619], 'author': [58, 69, 80, 89, 98, 107, 118, 127, 136, 146, 554, 562, 570, 577, 584, 591, 599, 606, 613, 620], ',': [59, 70, 81, 90, 99, 108, 119, 128, 137], 'SagerRebecca': [62], 'Sager': [64, 557], 'BackeSarah': [73], 'Backe': [75, 565], 'HashmiFiza': [83], 'Hashmi': [84, 572], 'KancherlaPriyanka': [92], 'Kancherla': [93, 579], 'PinkhasovAlexandr': [101], 'Pinkhasov': [102, 586], 'LinehanW': [111], 'Linehan': [113, 594], 'BourbouliaDimitra': [121], 'Bourboulia': [122, 601], 'BratslavskyGennady': [130], 'Bratslavsky': [131, 608], 'MollapourMehdi': [140], 'View': [147], 'All': [148, 622], 'Author': [149], 'Informationhttps://doi.org/10.1097/JU.0000000000002516.07AboutPDF': [150], 'ToolsAdd': [151], 'to': [152, 171, 179, 191, 237, 239, 249, 296, 310, 323, 366, 393, 436, 460, 476], 'favoritesDownload': [153], 'CitationsTrack': [154], 'CitationsPermissionsReprints': [155], 'ShareFacebookLinked': [156], 'InTwitterEmail': [157], 'Abstract': [158], 'INTRODUCTION': [159], 'AND': [160], 'OBJECTIVE:': [161], 'Germline': [162], 'mutations': [163], 'in': [164, 282, 325, 333, 352, 398, 412, 440, 466, 478], 'the': [165, 195, 217, 222, 264, 298, 312, 370, 490, 502, 513], 'tumor': [166, 200, 326, 337, 414, 445], 'suppressor': [167, 446], 'folliculin': [168], '(FLCN)': [169], 'lead': [170, 238, 475], 'development': [172, 180], 'Birt-Hogg-Dubé': [174], 'syndrome,': [175], 'which': [176], 'predisposes': [177], 'patients': [178], 'renal': [182, 399, 413], 'cell': [183, 354, 400], 'carcinoma': [184, 401], '(RCC).': [185], 'Although': [186], 'has': [188], 'been': [189, 235], 'linked': [190], 'many': [192], 'signaling': [193], 'pathways,': [194], 'exact': [196], 'mechanism': [197, 303], 'its': [199], 'suppressive': [201], 'function': [202], 'remains': [203], 'elusive.': [204], 'RCC': [205, 353, 441, 479], 'is': [206], 'characterized': [207], 'reliance': [209], 'on': [210, 316], 'aerobic': [211], 'glycolysis,': [212], 'a': [213, 279, 340, 416, 486], 'phenomenon': [214], 'known': [215], 'as': [216, 254, 449], 'Warburg': [218, 265], 'effect.': [219, 266], 'Hyperactivity': [220], 'glycolytic': [223], 'enzyme': [224], 'lactate': [225], 'dehydrogenase-A': [226], '(LDHA)': [227], 'drives': [228], 'process.': [230], 'Previously,': [231], 'loss': [233], 'had': [234], 'shown': [236], 'increased': [240], 'LDHA': [241, 260, 274, 330, 385, 397, 410, 461, 473, 484], 'activity.': [242], 'The': [243, 318, 444], 'objective': [244], 'study': [247], 'was': [248, 308, 331, 349, 381, 391, 420, 499], 'investigate': [250], 'whether': [251], 'served': [253], 'an': [255, 450], 'endogenous': [256, 451], 'protein': [257], 'inhibitor': [258, 452], 'activity': [261, 275, 289, 371], 'therefore': [263], 'METHODS:': [267], 'FLCN-LDHA': [268], 'interaction': [269], 'FLCN-mediated': [271, 481], 'inhibition': [272, 458, 482], 'were': [276, 294], 'examined': [277, 332], 'using': [278, 356], 'variety': [280], 'vitro': [283], 'cell-based': [285], 'binding': [286], 'enzymatic': [288], 'assays.': [290], 'Synthetic': [291], 'peptides': [293], 'generated': [295], 'identify': [297], 'required': [299], 'interacting': [300], 'region': [301, 378], 'inhibition.': [305], 'Extracellular': [306], 'acidification': [307], 'measured': [309], 'determine': [311], 'effect': [313], 'glycolysis.': [317, 389, 493], 'ability': [319], 'peptide': [322, 345, 434, 469], 'accumulate': [324], 'tissue': [327, 425], 'inhibit': [329, 472], 'ex': [334, 423], 'vivo': [335, 424], 'treated': [336], 'samples': [338], 'from': [339, 396, 415, 504], 'patient': [341, 417], 'with': [342, 418, 427, 432], 'BHD.': [343], 'treatment': [346, 426, 431], 'induced': [347], 'apoptosis': [348, 439, 477], 'also': [350], 'analyzed': [351], 'lines': [355], 'flow': [357], 'cytometry': [358], 'Western': [360], 'blot': [361], 'analysis.': [362], 'RESULTS:': [363], 'binds': [365], 'specifically': [368], 'inhibits': [369, 384], 'LDHA.': [373, 408, 454], 'ten': [375], 'amino': [376], 'acid': [377], 'identified': [382], 'that': [383], 'thereby': [387], 'regulates': [388], 'found': [392], 'be': [394], 'dissociated': [395], 'cells': [402, 405], 'these': [404], 'demonstrated': [406], 'hyperactive': [407], 'Hyperactive': [409], 'present': [411], 'BHD': [419], 'inhibited': [421], 'following': [422], 'peptide.': [429], 'Additionally,': [430], 'led': [435], 'induction': [437], 'cells.': [442, 480], 'CONCLUSIONS:': [443], 'functions': [448], 'Loss': [455], 'leads': [459], 'hyperactivation': [462], 'metabolic': [464], 'shift': [465], 'RCC.': [467], 'can': [470], 'effectively': [471], 'provides': [485], 'new': [487], 'paradigm': [488], 'for': [489], 'regulation': [491], 'Source': [494], 'Funding:': [496], 'This': [497], 'work': [498], 'supported': [500], 'funds': [503], 'SUNY': [505], 'Upstate': [506, 509, 514], 'Medical': [507], 'University,': [508], 'Cancer': [510], 'Center': [511], 'Foundation': [515], '(M.M.)': [516], '©': [517], '2022': [518, 537], 'American': [520, 539], 'Urological': [521, 540], 'Association': [522, 541], 'Education': [523, 542], 'Research,': [525, 544], 'Inc.FiguresReferencesRelatedDetails': [526], 'Volume': [527], '207Issue': [528], 'Supplement': [529], '5May': [530], '2022Page:': [531], 'e32': [532], 'Advertisement': [533, 623], 'Copyright': [534], '&': [535], 'Permissions©': [536], 'Inc.MetricsAuthor': [545], 'Information': [546], 'Expand': [621], 'PDF': [624], 'downloadLoading': [625], '...': [626]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4225258988', 'counts_by_year': [], 'updated_date': '2024-12-11T23:12:17.118510', 'created_date': '2022-05-04'}