Publication Information

{'id': 'https://openalex.org/W4224254846', 'doi': 'https://doi.org/10.1016/j.tranon.2022.101431', 'title': 'Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis', 'display_name': 'Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis', 'publication_year': 2022, 'publication_date': '2022-04-19', 'ids': {'openalex': 'https://openalex.org/W4224254846', 'doi': 'https://doi.org/10.1016/j.tranon.2022.101431', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35452996'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.tranon.2022.101431', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106638657', 'display_name': 'Translational Oncology', 'issn_l': '1936-5233', 'issn': ['1936-5233', '1944-7124'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1016/j.tranon.2022.101431', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101503838', 'display_name': 'Masaki Fujimoto', 'orcid': 'https://orcid.org/0000-0001-9171-5092'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaki Fujimoto', 'raw_affiliation_strings': ['Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004966829', 'display_name': 'Ritsuko Higashiyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ritsuko Higashiyama', 'raw_affiliation_strings': ['Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076314944', 'display_name': 'Hironobu Yasui', 'orcid': 'https://orcid.org/0000-0002-6757-1110'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hironobu Yasui', 'raw_affiliation_strings': ['Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053080539', 'display_name': 'Koya Yamashita', 'orcid': 'https://orcid.org/0000-0002-9471-7533'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koya Yamashita', 'raw_affiliation_strings': ['Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007968139', 'display_name': 'Osamu Inanami', 'orcid': 'https://orcid.org/0000-0001-7895-3918'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Osamu Inanami', 'raw_affiliation_strings': ['Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5007968139'], 'corresponding_institution_ids': ['https://openalex.org/I205349734'], 'apc_list': {'value': 2300, 'currency': 'USD', 'value_usd': 2300, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'USD', 'value_usd': 2300, 'provenance': 'doaj'}, 'fwci': 0.833, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.999883, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 83, 'max': 85}, 'biblio': {'volume': '21', 'issue': None, 'first_page': '101431', 'last_page': '101431'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutaminolysis', 'display_name': 'Glutaminolysis', 'score': 0.99799705}, {'id': 'https://openalex.org/keywords/glutaminase', 'display_name': 'Glutaminase', 'score': 0.843361}, {'id': 'https://openalex.org/keywords/radiosensitivity', 'display_name': 'Radiosensitivity', 'score': 0.6542549}], 'concepts': [{'id': 'https://openalex.org/C2778160063', 'wikidata': 'https://www.wikidata.org/wiki/Q1532402', 'display_name': 'Glutaminolysis', 'level': 4, 'score': 0.99799705}, {'id': 'https://openalex.org/C109549099', 'wikidata': 'https://www.wikidata.org/wiki/Q24773687', 'display_name': 'Glutaminase', 'level': 4, 'score': 0.843361}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6721653}, {'id': 'https://openalex.org/C2779349466', 'wikidata': 'https://www.wikidata.org/wiki/Q181619', 'display_name': 'Glutamine', 'level': 3, 'score': 0.6554493}, {'id': 'https://openalex.org/C206684579', 'wikidata': 'https://www.wikidata.org/wiki/Q4387689', 'display_name': 'Radiosensitivity', 'level': 3, 'score': 0.6542549}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.53939265}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.5182452}, {'id': 'https://openalex.org/C81729549', 'wikidata': 'https://www.wikidata.org/wiki/Q4649475', 'display_name': 'A549 cell', 'level': 3, 'score': 0.47845078}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.42248183}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.419484}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38471055}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37554365}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.37495786}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36769658}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23458639}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.18339229}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16839328}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.16091499}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.09604424}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.0492208}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.tranon.2022.101431', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106638657', 'display_name': 'Translational Oncology', 'issn_l': '1936-5233', 'issn': ['1936-5233', '1944-7124'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043980', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35452996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.tranon.2022.101431', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106638657', 'display_name': 'Translational Oncology', 'issn_l': '1936-5233', 'issn': ['1936-5233', '1944-7124'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.72, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': '20H00443'}, {'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': '19H04263'}, {'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': '19K22586'}, {'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': 'KKO250'}], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1033197108', 'https://openalex.org/W1511793991', 'https://openalex.org/W1976973627', 'https://openalex.org/W1977168187', 'https://openalex.org/W2004196283', 'https://openalex.org/W2004314923', 'https://openalex.org/W2014988241', 'https://openalex.org/W2026490935', 'https://openalex.org/W2039378889', 'https://openalex.org/W2050852029', 'https://openalex.org/W2058327964', 'https://openalex.org/W2066800748', 'https://openalex.org/W2074873270', 'https://openalex.org/W2077814905', 'https://openalex.org/W2080815560', 'https://openalex.org/W2083429893', 'https://openalex.org/W2091822368', 'https://openalex.org/W2103441049', 'https://openalex.org/W2121691257', 'https://openalex.org/W2129381867', 'https://openalex.org/W2132117833', 'https://openalex.org/W2141352443', 'https://openalex.org/W2145578278', 'https://openalex.org/W2156241187', 'https://openalex.org/W2164524616', 'https://openalex.org/W2168632005', 'https://openalex.org/W2176297535', 'https://openalex.org/W2184605567', 'https://openalex.org/W2300605759', 'https://openalex.org/W2516995641', 'https://openalex.org/W2534904302', 'https://openalex.org/W2564251627', 'https://openalex.org/W2565889784', 'https://openalex.org/W2576973080', 'https://openalex.org/W2592923754', 'https://openalex.org/W2611479744', 'https://openalex.org/W2789646648', 'https://openalex.org/W2795673879', 'https://openalex.org/W2796371952', 'https://openalex.org/W2797244302', 'https://openalex.org/W2799714144', 'https://openalex.org/W2908922892', 'https://openalex.org/W2915058673', 'https://openalex.org/W2943618951', 'https://openalex.org/W2946616105', 'https://openalex.org/W2954363248', 'https://openalex.org/W2995236678', 'https://openalex.org/W3029435888', 'https://openalex.org/W3041106862', 'https://openalex.org/W3193657376'], 'related_works': ['https://openalex.org/W4389571508', 'https://openalex.org/W4231382750', 'https://openalex.org/W4205157372', 'https://openalex.org/W3120626955', 'https://openalex.org/W3095609398', 'https://openalex.org/W2996767769', 'https://openalex.org/W2980249524', 'https://openalex.org/W2809968211', 'https://openalex.org/W2563696845', 'https://openalex.org/W2074873270'], 'abstract_inverted_index': {'Glutamine': [0], 'metabolism,': [1], 'known': [2], 'as': [3], 'glutaminolysis,': [4], 'is': [5, 104, 178], 'abnormally': [6], 'activated': [7], 'in': [8, 25, 48, 145], 'many': [9], 'cancer': [10, 29, 52], 'cells': [11, 30, 136, 160], 'with': [12, 31, 58, 68, 121, 152, 170], 'KRAS': [13, 59], 'or': [14, 17, 123], 'BRAF': [15], 'mutations': [16], 'active': [18], 'c-MYC.': [19], 'Glutaminolysis': [20], 'plays': [21], 'an': [22, 143], 'important': [23, 105], 'role': [24], 'the': [26, 95, 112, 129, 146], 'proliferation': [27, 130], 'of': [28, 97, 111, 131], 'oncogenic': [32], 'mutations.': [33], 'In': [34], 'this': [35], 'study,': [36], 'we': [37], 'characterized': [38], 'radiation-induced': [39], 'cell': [40, 50, 56, 113, 148], 'death,': [41], 'which': [42], 'was': [43], 'enhanced': [44, 73], 'by': [45], 'glutaminolysis': [46, 118, 172], 'inhibition': [47], 'non-small': [49], 'lung': [51], 'A549': [53], 'and': [54, 82, 133, 174], 'H460': [55], 'lines': [57], 'mutation.': [60], 'A': [61], 'clonogenic': [62], 'survival': [63, 107], 'assay': [64], 'revealed': [65, 116], 'that': [66, 94, 117, 167], 'treatment': [67, 87, 120, 151, 169], 'a': [69, 124, 154, 171, 175], 'glutaminase': [70], 'inhibitor,': [71, 157], 'CB839,': [72], 'radiosensitivity.': [74], 'X-irradiation': [75], 'increased': [76], 'glutamate': [77], 'production,': [78, 84], 'mitochondrial': [79], 'oxygen': [80], 'consumption,': [81], 'ATP': [83, 102], 'whereas': [85], 'CB839': [86, 122], 'suppressed': [88], 'these': [89], 'effects.': [90], 'The': [91, 164], 'data': [92], 'suggest': [93, 166], 'enhancement': [96], 'glutaminolysis-dependent': [98], 'energy': [99], 'metabolism': [100], 'for': [101, 106, 180], 'production': [103], 'after': [108], 'X-irradiation.': [109], 'Evaluation': [110], 'death': [114], 'phenotype': [115], 'inhibitory': [119], 'low-glutamine': [125], 'medium': [126], 'significantly': [127], 'promoted': [128], 'β-galactosidase-positive': [132], 'IL-6/IL-8': [134], 'secretory': [135], 'among': [137], 'X-irradiated': [138], 'tumor': [139], 'cells,': [140], 'corresponding': [141], 'to': [142], 'increase': [144], 'senescent': [147, 159], 'population.': [149], 'Furthermore,': [150], 'ABT263,': [153], 'Bcl-2': [155], 'family': [156], 'transformed': [158], 'into': [161], 'apoptotic': [162], 'cells.': [163], 'findings': [165], 'combination': [168], 'inhibitor': [173], 'senolytic': [176], 'drug': [177], 'useful': [179], 'efficient': [181], 'radiotherapy.': [182]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4224254846', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-26T04:14:00.469028', 'created_date': '2022-04-26'}