Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes

Name: Work Video:
Duration: 3 min 30 s
Victoriane Peugnet; Maggy Chwastyniak; Paul Mulder; Steve Lancel; Laurent Bultot; Natacha Fourny; Edith Renguet; Heiko Bugger; Olivia Beseme; Anne Loyens; Wilfried Heyse; Vincent Richard; Philippe Amouyel; Luc Bertrand; F Pinet; Emilie Dubois‐Deruy
{'id': 'https://openalex.org/W4224232775', 'doi': 'https://doi.org/10.3390/antiox11040723', 'title': 'Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes', 'display_name': 'Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes', 'publication_year': 2022, 'publication_date': '2022-04-06', 'ids': {'openalex': 'https://openalex.org/W4224232775', 'doi': 'https://doi.org/10.3390/antiox11040723', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35453408'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/antiox11040723', 'pdf_url': 'https://www.mdpi.com/2076-3921/11/4/723/pdf?version=1649241261', 'source': {'id': 'https://openalex.org/S2737566431', 'display_name': 'Antioxidants', 'issn_l': '2076-3921', 'issn': ['2076-3921'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2076-3921/11/4/723/pdf?version=1649241261', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003195877', 'display_name': 'Victoriane Peugnet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Victoriane Peugnet', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I3018718406']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074134635', 'display_name': 'Maggy Chwastyniak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Maggy Chwastyniak', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035223402', 'display_name': 'Paul Mulder', 'orcid': 'https://orcid.org/0000-0002-5936-5704'}, 'institutions': [{'id': 'https://openalex.org/I4210105918', 'display_name': 'Normandie Université', 'ror': 'https://ror.org/01k40cz91', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I62396329', 'display_name': 'Université de Rouen Normandie', 'ror': 'https://ror.org/03nhjew95', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918', 'https://openalex.org/I62396329']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Paul Mulder', 'raw_affiliation_strings': ['Normandie Univ, UNIROUEN, Inserm U1096, FHU-REMOD-HF, 76000 Rouen, France'], 'affiliations': [{'raw_affiliation_string': 'Normandie Univ, UNIROUEN, Inserm U1096, FHU-REMOD-HF, 76000 Rouen, France', 'institution_ids': ['https://openalex.org/I4210105918', 'https://openalex.org/I154526488', 'https://openalex.org/I62396329']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090721806', 'display_name': 'Steve Lancel', 'orcid': 'https://orcid.org/0000-0002-3292-5433'}, 'institutions': [{'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Steve Lancel', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I3018718406']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042343888', 'display_name': 'Laurent Bultot', 'orcid': 'https://orcid.org/0000-0002-5088-0101'}, 'institutions': [{'id': 'https://openalex.org/I4210161702', 'display_name': 'Directorate-General Joint Research Centre', 'ror': 'https://ror.org/04j5wtv36', 'country_code': 'BE', 'type': 'government', 'lineage': ['https://openalex.org/I1320481043', 'https://openalex.org/I2800387288', 'https://openalex.org/I4210161702']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Laurent Bultot', 'raw_affiliation_strings': ['Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium', 'institution_ids': ['https://openalex.org/I4210161702']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073472319', 'display_name': 'Natacha Fourny', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210161702', 'display_name': 'Directorate-General Joint Research Centre', 'ror': 'https://ror.org/04j5wtv36', 'country_code': 'BE', 'type': 'government', 'lineage': ['https://openalex.org/I1320481043', 'https://openalex.org/I2800387288', 'https://openalex.org/I4210161702']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Natacha Fourny', 'raw_affiliation_strings': ['Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium', 'institution_ids': ['https://openalex.org/I4210161702']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030363809', 'display_name': 'Edith Renguet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210161702', 'display_name': 'Directorate-General Joint Research Centre', 'ror': 'https://ror.org/04j5wtv36', 'country_code': 'BE', 'type': 'government', 'lineage': ['https://openalex.org/I1320481043', 'https://openalex.org/I2800387288', 'https://openalex.org/I4210161702']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Edith Renguet', 'raw_affiliation_strings': ['Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium', 'institution_ids': ['https://openalex.org/I4210161702']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090858003', 'display_name': 'Heiko Bugger', 'orcid': 'https://orcid.org/0000-0002-3524-0405'}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heiko Bugger', 'raw_affiliation_strings': ['Department of Cardiology and Angiology I, Heart Center Freiburg, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology and Angiology I, Heart Center Freiburg, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006341775', 'display_name': 'Olivia Beseme', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Olivia Beseme', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I2279609970', 'https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I3018718406']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107966398', 'display_name': 'Anne Loyens', 'orcid': 'https://orcid.org/0000-0002-5906-3204'}, 'institutions': [{'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4387152542', 'display_name': 'CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers', 'ror': 'https://ror.org/05x9zmx47', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4210131356', 'https://openalex.org/I4210141925', 'https://openalex.org/I4387152542']}, {'id': 'https://openalex.org/I4210105941', 'display_name': 'Institut pour la Recherche sur le Cancer de Lille', 'ror': 'https://ror.org/01c8cwz57', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210105941']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Anne Loyens', 'raw_affiliation_strings': ['Univ. Lille, CNRS, Inserm, CHU Lille, Institut de Recherche Contre le Cancer de Lille, UMR9020-UMR-S 1277-Canther-Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, CNRS, Inserm, CHU Lille, Institut de Recherche Contre le Cancer de Lille, UMR9020-UMR-S 1277-Canther-Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I3018718406', 'https://openalex.org/I1294671590', 'https://openalex.org/I4387152542', 'https://openalex.org/I4210105941', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072527392', 'display_name': 'Wilfried Heyse', 'orcid': 'https://orcid.org/0000-0002-6773-8910'}, 'institutions': [{'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}, {'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Wilfried Heyse', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I2279609970', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016370550', 'display_name': 'Vincent Richard', 'orcid': 'https://orcid.org/0000-0003-0590-0158'}, 'institutions': [{'id': 'https://openalex.org/I4210105918', 'display_name': 'Normandie Université', 'ror': 'https://ror.org/01k40cz91', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I62396329', 'display_name': 'Université de Rouen Normandie', 'ror': 'https://ror.org/03nhjew95', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918', 'https://openalex.org/I62396329']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Richard', 'raw_affiliation_strings': ['Normandie Univ, UNIROUEN, Inserm U1096, FHU-REMOD-HF, 76000 Rouen, France'], 'affiliations': [{'raw_affiliation_string': 'Normandie Univ, UNIROUEN, Inserm U1096, FHU-REMOD-HF, 76000 Rouen, France', 'institution_ids': ['https://openalex.org/I4210105918', 'https://openalex.org/I154526488', 'https://openalex.org/I62396329']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033321689', 'display_name': 'Philippe Amouyel', 'orcid': 'https://orcid.org/0000-0001-9088-234X'}, 'institutions': [{'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}, {'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Philippe Amouyel', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I3018718406', 'https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079037154', 'display_name': 'Luc Bertrand', 'orcid': 'https://orcid.org/0000-0003-0655-7099'}, 'institutions': [{'id': 'https://openalex.org/I4210161702', 'display_name': 'Directorate-General Joint Research Centre', 'ror': 'https://ror.org/04j5wtv36', 'country_code': 'BE', 'type': 'government', 'lineage': ['https://openalex.org/I1320481043', 'https://openalex.org/I2800387288', 'https://openalex.org/I4210161702']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Luc Bertrand', 'raw_affiliation_strings': ['Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, UCLouvain, 1200 Bruxelles, Belgium', 'institution_ids': ['https://openalex.org/I4210161702']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033873633', 'display_name': 'F Pinet', 'orcid': 'https://orcid.org/0000-0002-5471-1487'}, 'institutions': [{'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Florence Pinet', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I3018718406']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040508308', 'display_name': 'Emilie Dubois‐Deruy', 'orcid': 'https://orcid.org/0000-0002-9811-617X'}, 'institutions': [{'id': 'https://openalex.org/I4387154478', 'display_name': 'Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement', 'ror': 'https://ror.org/03rvrjk28', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I2279609970', 'https://openalex.org/I2800921988', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478']}, {'id': 'https://openalex.org/I2800921988', 'display_name': 'Institut Pasteur de Lille', 'ror': 'https://ror.org/05k9skc85', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2800921988']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Emilie Dubois-Deruy', 'raw_affiliation_strings': ['Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, 59000 Lille, France', 'institution_ids': ['https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I3018718406']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 12, 'corresponding_author_ids': ['https://openalex.org/A5033873633', 'https://openalex.org/A5040508308'], 'corresponding_institution_ids': ['https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I3018718406', 'https://openalex.org/I4387154478', 'https://openalex.org/I2800921988', 'https://openalex.org/I154526488', 'https://openalex.org/I2279609970', 'https://openalex.org/I3018718406'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 1.589, 'has_fulltext': False, 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.7251, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '11', 'issue': '4', 'first_page': '723', 'last_page': '723'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12381', 'display_name': 'Electron Spin Resonance Studies', 'score': 0.9852, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sod2', 'display_name': 'SOD2', 'score': 0.9329561}, {'id': 'https://openalex.org/keywords/mitochondrial-ros', 'display_name': 'Mitochondrial ROS', 'score': 0.69210994}], 'concepts': [{'id': 'https://openalex.org/C2776108821', 'wikidata': 'https://www.wikidata.org/wiki/Q15335612', 'display_name': 'SOD2', 'level': 4, 'score': 0.9329561}, {'id': 'https://openalex.org/C2779324830', 'wikidata': 'https://www.wikidata.org/wiki/Q1806192', 'display_name': 'Mitophagy', 'level': 4, 'score': 0.90505147}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.77755034}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.7642941}, {'id': 'https://openalex.org/C2778175917', 'wikidata': 'https://www.wikidata.org/wiki/Q17125553', 'display_name': 'Mitochondrial ROS', 'level': 3, 'score': 0.69210994}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5637237}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.55257976}, {'id': 'https://openalex.org/C2780561631', 'wikidata': 'https://www.wikidata.org/wiki/Q421331', 'display_name': 'Sirtuin', 'level': 4, 'score': 0.5332064}, {'id': 'https://openalex.org/C2777229759', 'wikidata': 'https://www.wikidata.org/wiki/Q6881848', 'display_name': 'Mitochondrial biogenesis', 'level': 3, 'score': 0.439371}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.410513}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3709873}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3496169}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.33577165}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.26712132}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2354545}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.18698287}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.18682271}, {'id': 'https://openalex.org/C119157956', 'wikidata': 'https://www.wikidata.org/wiki/Q796604', 'display_name': 'Acetylation', 'level': 3, 'score': 0.09352213}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 8, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/antiox11040723', 'pdf_url': 'https://www.mdpi.com/2076-3921/11/4/723/pdf?version=1649241261', 'source': {'id': 'https://openalex.org/S2737566431', 'display_name': 'Antioxidants', 'issn_l': '2076-3921', 'issn': ['2076-3921'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/a8a72573b66a447da7800912f3ef1ff8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.hal.inserm.fr/inserm-03833020', 'pdf_url': 'https://inserm.hal.science/inserm-03833020/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://inserm.hal.science/inserm-03833020/file/antioxidants-11-00723.pdf', 'pdf_url': 'https://inserm.hal.science/inserm-03833020/file/antioxidants-11-00723.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.hal.inserm.fr/inserm-03833020/file/antioxidants-11-00723.pdf', 'pdf_url': 'https://www.hal.inserm.fr/inserm-03833020/file/antioxidants-11-00723.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/20.500.12210/77785', 'pdf_url': 'https://lilloa.univ-lille.fr/bitstream/20.500.12210/77785/1/https%3a//www.hal.inserm.fr/inserm-03833020/document', 'source': {'id': 'https://openalex.org/S4306402203', 'display_name': 'LillOA (Université de Lille (University Of Lille))', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210123514', 'host_organization_name': "Centre d'Etudes en Civilisations, Langues et Littératures Etrangères", 'host_organization_lineage': ['https://openalex.org/I4210123514'], 'host_organization_lineage_names': ["Centre d'Etudes en Civilisations, Langues et Littératures Etrangères"], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029275', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35453408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/antiox11040723', 'pdf_url': 'https://www.mdpi.com/2076-3921/11/4/723/pdf?version=1649241261', 'source': {'id': 'https://openalex.org/S2737566431', 'display_name': 'Antioxidants', 'issn_l': '2076-3921', 'issn': ['2076-3921'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.75, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320320883', 'funder_display_name': 'Agence Nationale de la Recherche', 'award_id': 'ANR-16-RHUS-0003'}], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1969512514', 'https://openalex.org/W1977307022', 'https://openalex.org/W1996885665', 'https://openalex.org/W2003563752', 'https://openalex.org/W2011348831', 'https://openalex.org/W2021318281', 'https://openalex.org/W2028514900', 'https://openalex.org/W2042891460', 'https://openalex.org/W2043276141', 'https://openalex.org/W2046746746', 'https://openalex.org/W2071228656', 'https://openalex.org/W2072593346', 'https://openalex.org/W2111542355', 'https://openalex.org/W2117205119', 'https://openalex.org/W2142408236', 'https://openalex.org/W2147909043', 'https://openalex.org/W2150874450', 'https://openalex.org/W2297449224', 'https://openalex.org/W2535378661', 'https://openalex.org/W2553902009', 'https://openalex.org/W2563510813', 'https://openalex.org/W2577171598', 'https://openalex.org/W2616187808', 'https://openalex.org/W2733051448', 'https://openalex.org/W2765709068', 'https://openalex.org/W2767030556', 'https://openalex.org/W2792351106', 'https://openalex.org/W2795696541', 'https://openalex.org/W2797357414', 'https://openalex.org/W2807364420', 'https://openalex.org/W2808487639', 'https://openalex.org/W2889362289', 'https://openalex.org/W2893271558', 'https://openalex.org/W2895013649', 'https://openalex.org/W2898053501', 'https://openalex.org/W2950796429', 'https://openalex.org/W2971456522', 'https://openalex.org/W2978334394', 'https://openalex.org/W3003559660', 'https://openalex.org/W3006152749', 'https://openalex.org/W3046479111', 'https://openalex.org/W3084965219', 'https://openalex.org/W3090866876', 'https://openalex.org/W3122226502', 'https://openalex.org/W3176601548', 'https://openalex.org/W4205161270'], 'related_works': ['https://openalex.org/W4229378408', 'https://openalex.org/W2947372090', 'https://openalex.org/W2594907337', 'https://openalex.org/W2517576200', 'https://openalex.org/W2121393320', 'https://openalex.org/W2067975635', 'https://openalex.org/W2043587027', 'https://openalex.org/W2032983681', 'https://openalex.org/W2009734791', 'https://openalex.org/W1974682175'], 'abstract_inverted_index': {'Heart': [0], 'failure,': [1], 'mostly': [2], 'associated': [3], 'with': [4], 'cardiac': [5, 51], 'hypertrophy,': [6], 'is': [7], 'a': [8, 160], 'major': [9], 'cause': [10], 'of': [11, 19, 40, 105, 116, 164, 171, 178, 199], 'illness': [12], 'and': [13, 61, 80, 91, 98, 100, 126, 131, 137, 143], 'death.': [14], 'Oxidative': [15], 'stress': [16, 97, 174], 'causes': [17], 'accumulation': [18, 198], 'reactive': [20], 'oxygen': [21], 'species': [22], '(ROS),': [23], 'leading': [24, 93, 196], 'to': [25, 44, 70, 94, 197], 'mitochondrial': [26, 55, 72, 95, 124, 135, 141, 172], 'dysfunction,': [27], 'suggesting': [28, 159], 'that': [29, 183], 'mitochondria-targeted': [30, 47, 118], 'therapies': [31, 48], 'could': [32, 49], 'be': [33], 'effective': [34], 'in': [35, 128, 148, 152, 157, 175, 188], 'this': [36, 41], 'context.': [37], 'The': [38, 145], 'purpose': [39], 'work': [42], 'was': [43, 150], 'determine': [45], 'whether': [46], 'improve': [50], 'hypertrophy': [52, 101, 127], 'induced': [53, 85], 'by': [54, 67, 139, 186], 'ROS.': [56, 73], 'We': [57, 181], 'used': [58], 'neonatal': [59], '(NCMs)': [60], 'adult': [62], '(ACMs)': [63], 'rat': [64], 'cardiomyocytes': [65, 154, 189], 'hypertrophied': [66], 'isoproterenol': [68], '(Iso)': [69], 'induce': [71], 'A': [74], 'decreased': [75, 123], 'interaction': [76], 'between': [77], 'sirtuin': [78], '3': [79], 'superoxide': [81], 'dismutase': [82], '2': [83], '(SOD2)': [84], 'SOD2': [86], 'acetylation': [87], 'on': [88], 'lysine': [89], '68': [90], 'inactivation,': [92], 'oxidative': [96, 173], 'dysfunction': [99], 'after': [102], '24': [103], 'h': [104], 'Iso': [106], 'treatment.': [107], 'To': [108], 'counteract': [109], 'these': [110], 'mechanisms,': [111], 'we': [112], 'evaluated': [113], 'the': [114, 117, 169, 176, 191], 'impact': [115], 'antioxidant': [119], 'mitoquinone': [120], '(MitoQ).': [121], 'MitoQ': [122, 187], 'ROS': [125], 'Iso-treated': [129], 'NCMs': [130], 'ACMs': [132], 'but': [133, 155], 'altered': [134], 'structure': [136], 'function': [138], 'decreasing': [140], 'respiration': [142], 'mitophagy.': [144], 'same': [146], 'decrease': [147], 'mitophagy': [149], 'found': [151], 'human': [153], 'not': [156], 'fibroblasts,': [158], 'cardiomyocyte-specific': [161], 'deleterious': [162], 'effect': [163], 'MitoQ.': [165], 'Our': [166], 'data': [167], 'showed': [168], 'importance': [170], 'development': [177], 'cardiomyocyte': [179], 'hypertrophy.': [180], 'observed': [182], 'targeting': [184], 'mitochondria': [185], 'impaired': [190], 'metabolism': [192], 'through': [193], 'defective': [194], 'mitophagy,': [195], 'deficient': [200], 'mitochondria.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4224232775', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2025-01-20T20:06:00.809095', 'created_date': '2022-04-26'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
