Health Supervision for Children and Adolescents With Down Syndrome

Name: Work Video:
Duration: 3 min 30 s
Marilyn J. Bull; Tracy L. Trotter; Stephanie L. Santoro; Celanie K. Christensen; Randall W. Grout
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886, 906, 960, 969, 1023, 1045, 1049, 1097, 1140, 1158, 1203, 1240, 1276, 1326, 1350, 1372, 1381, 1414, 1422, 1435, 1447, 1459, 1530, 1541, 1546, 1561, 1592, 1598, 1602, 1606, 1613, 1685, 1696, 1734, 1740, 1785, 1791, 1795, 1799, 1833, 1840, 1862, 1883, 1916, 2006, 2048, 2105, 2134, 2153, 2189, 2237, 2271, 2286, 2317, 2323, 2334, 2346, 2351, 2365, 2382, 2394, 2410, 2430, 2536, 2571, 2577, 2590, 2604, 2620, 2754, 2808, 2837, 2854, 2862, 2867, 2918, 2923, 2957, 2968, 2976, 3016, 3020, 3050, 3068, 3075, 3086, 3097, 3132, 3236, 3253, 3277, 3301, 3313, 3326, 3371, 3373, 3401, 3407, 3428, 3443, 3450, 3486, 3508, 3556, 3560, 3579, 3590, 3611, 3617, 3630, 3641, 3663, 3674, 3704, 3721, 3833, 3840, 3849, 3857, 3881, 3933, 3974, 3982, 4013, 4022, 4043, 4073, 4113, 4127, 4178, 4219, 4272, 4290, 4314, 4351, 4371, 4378, 4406, 4417, 4425, 4459, 4468, 4617, 4628, 4637, 4641, 4654], 'family': [16, 704, 1213, 1317, 1347, 1642, 1847, 1914, 1953, 2192, 3466, 3952], 'whom': [18], 'a': [19, 36, 55, 124, 148, 253, 445, 501, 507, 514, 539, 642, 681, 835, 839, 845, 855, 883, 907, 1066, 1163, 1168, 1212, 1232, 1255, 1259, 1279, 1288, 1293, 1312, 1420, 1468, 1473, 1476, 1512, 1516, 1633, 1659, 1720, 1730, 1770, 1782, 1810, 1819, 1826, 1902, 1909, 1952, 1956, 1976, 2031, 2051, 2090, 2097, 2162, 2165, 2173, 2216, 2255, 2288, 2331, 2358, 2472, 2494, 2498, 2529, 2569, 2573, 2688, 2693, 2785, 2830, 3060, 3071, 3081, 3108, 3158, 3165, 3302, 3498, 3512, 3538, 3582, 3609, 3613, 3678, 3766, 3831, 3836, 3844, 3882, 3915, 4292, 4320, 4329, 4352, 4365], 'diagnosis': [20, 57, 1380, 1401, 1973, 2010, 2047, 2133, 2217, 2247, 2423], 'of': [21, 58, 66, 99, 117, 129, 135, 169, 172, 230, 259, 269, 275, 282, 396, 402, 421, 431, 444, 454, 468, 486, 532, 541, 591, 605, 637, 714, 729, 739, 748, 758, 778, 842, 848, 864, 940, 962, 1013, 1029, 1093, 1132, 1170, 1183, 1225, 1235, 1323, 1331, 1430, 1454, 1493, 1632, 1664, 1671, 1690, 1714, 1769, 1781, 1830, 1842, 1855, 1865, 1887, 1893, 1912, 1922, 1930, 1979, 2019, 2033, 2066, 2148, 2161, 2218, 2234, 2283, 2294, 2313, 2326, 2368, 2407, 2424, 2664, 2668, 2768, 2826, 2882, 2893, 2896, 2905, 2908, 2914, 2921, 2959, 3013, 3030, 3037, 3043, 3073, 3083, 3095, 3124, 3152, 3171, 3200, 3315, 3381, 3395, 3462, 3468, 3511, 3518, 3532, 3552, 3562, 3567, 3681, 3692, 3795, 3826, 3828, 3838, 3846, 3855, 3955, 3960, 3997, 3999, 4078, 4124, 4237, 4285, 4340, 4368, 4408, 4436, 4442, 4457, 4461, 4480, 4600, 4614, 4626], 'Down': [22, 59, 104, 109, 157, 289, 374, 424, 458, 536, 638, 685, 754, 817, 822, 948, 1030, 1076, 1118, 1122, 1227, 1247, 1290, 1295, 1433, 1462, 1649, 1691, 1859, 2082, 2300, 2392, 2415, 2425, 2548, 2595, 3023, 3101, 3155, 3181, 3267, 3338, 3389, 3635, 3653, 3687, 4194, 4243, 4411, 4445, 4483], 'syndrome': [23, 60, 105, 110, 158, 290, 375, 459, 537, 823, 949, 1031, 1077, 1123, 1291, 1296, 1434, 1650, 1692, 1860, 2083, 2301, 2393, 2416, 2426, 3024, 3102, 3339, 3390, 3688, 4195, 4412, 4446], 'has': [24, 52, 122, 506, 805, 1129, 1216, 1348, 1570, 1584, 4228, 4259], 'been': [25, 53, 123, 1217, 1388, 3104, 3819, 4229, 4430], 'confirmed': [26, 1402, 2171], 'by': [27, 32, 641, 801, 915, 929, 1032, 1039, 1046, 1103, 1196, 1706, 1756, 1762, 1774, 2172, 2209, 2258, 2263, 2497, 2532, 2736, 2751, 2790, 2888, 3184, 3215, 3755, 3765], 'chromosome': [28, 177, 448, 473, 480, 576, 1924, 1981, 2052, 2149], 'analysis': [29, 890, 2197], 'or': [30, 277, 482, 523, 574, 645, 741, 923, 989, 1126, 1152, 1187, 1220, 1266, 1300, 1389, 1515, 1674, 1717, 1822, 1937, 1940, 1986, 2025, 2035, 2159, 2241, 2376, 2522, 2563, 2649, 2833, 2946, 3079, 3176, 3208, 3211, 3227, 3244, 3354, 3545, 3595, 3603, 3764, 3769, 3842, 3968, 4063, 4151, 4169, 4274, 4328, 4338, 4343, 4396], 'suspected': [31], 'prenatal': [33, 56, 799, 1104, 1369, 1465, 1665, 1917, 1923, 2020], 'screening.': [34], 'Although': [35, 181, 399, 1106, 3261, 4226], 'pediatrician’s': [37], 'initial': [38], 'contact': [39, 1794, 3990], 'with': [40, 103, 156, 240, 252, 288, 359, 373, 412, 423, 441, 456, 534, 552, 561, 570, 609, 711, 834, 844, 918, 1011, 1198, 1219, 1305, 1315, 1365, 1432, 1461, 1505, 1610, 1719, 1737, 1805, 1858, 1934, 1965, 2003, 2337, 2391, 2414, 2436, 2451, 2462, 2628, 2671, 2705, 2835, 2839, 2841, 2937, 3022, 3066, 3100, 3140, 3154, 3180, 3206, 3250, 3266, 3274, 3287, 3298, 3331, 3337, 3348, 3361, 3367, 3375, 3388, 3424, 3465, 3493, 3500, 3528, 3651, 3664, 3686, 3702, 3771, 3775, 3798, 3878, 3951, 3977, 4057, 4101, 4138, 4157, 4159, 4193, 4242, 4322, 4336, 4348, 4410, 4444, 4482], 'child': [42, 505, 612, 702, 1244, 1646, 1678, 2801, 4335], 'usually': [44, 271, 479, 1442], 'during': [45, 1237, 3457, 3541, 3964], 'infancy,': [46], 'occasionally': [47, 278], 'pregnant': [49, 736], 'woman': [50], 'who': [51, 980, 1309, 1969, 2388, 2500, 3340, 4164], 'given': [54], 'will': [61, 1245, 1390, 1409, 1625, 1647, 2203, 2501, 2514, 2773], 'be': [62, 266, 385, 410, 512, 564, 598, 661, 706, 744, 892, 935, 1101, 1208, 1319, 1338, 1391, 1617, 1626, 1656, 1710, 1750, 1948, 1989, 2039, 2094, 2122, 2170, 2226, 2252, 2405, 2428, 2434, 2449, 2468, 2477, 2503, 2516, 2558, 2680, 2697, 2714, 2734, 2749, 2757, 2763, 2775, 2793, 2990, 3121, 3256, 3281, 3308, 3345, 3491, 3647, 3987, 4099, 4212, 4415, 4448], 'referred': [63], 'review': [65, 1344, 1911, 2000, 3557, 3920, 4372, 4456], 'condition': [68, 427, 556, 587, 2998], 'genetic': [70, 174, 646, 1257, 1707, 1715, 1823, 2481], 'counseling;': [71], 'this': [72, 77, 579, 1667], 'offers': [74, 775], 'guidance': [75, 82, 1327, 2352], 'situation,': [78], 'as': [79, 894, 896, 1054, 1283, 1511, 1704, 2550, 2552, 2687, 2720, 2722, 2963, 3114, 3377, 3412, 3606, 4364, 4399], 'well.': [80], 'Age-specific': [81], 'clinician': [85, 195, 1336, 1995, 2077, 2100], 'provided': [87, 1705, 2492], 'Supplemental': [89], 'Fig': [90], '1.Pediatricians': [91], 'play': [92], 'an': [93, 469, 610, 1071, 1109, 1302, 1506, 1984, 2073, 2145, 2212, 2539, 2718, 2727, 3201, 3233, 3328, 3392], 'important': [94, 138, 1397, 1877, 2402, 3054], 'role': [95], 'care': [98, 984, 1614, 1683, 1736, 1888, 2266, 2489, 2506, 2513, 2519, 2584, 3044, 3048, 3624, 4015, 4020, 4217, 4441, 4476], 'children': [100, 287, 422, 1431, 1460, 1932, 1964, 1968, 2390, 2704, 2772, 3021, 3179, 3265, 3286, 3297, 3658, 3685, 3774, 3877, 3913, 4089, 4158, 4192, 4241, 4250, 4443], 'adolescents': [102], 'their': [107, 144, 586, 1412, 1415, 1436, 1645, 2314, 2321, 2327, 2344, 2373, 3991, 4254], 'families.': [108, 2354], 'most': [113, 623, 811, 2058], 'common': [114, 203, 285, 4080], 'chromosomal': [115, 463, 635, 2195], 'cause': [116, 2951], 'intellectual': [118, 718], 'disability,': [119], 'there': [121, 186, 393, 437, 1543, 2527, 3436, 4227], 'significant': [125, 1949], 'improvement': [126], 'quality': [128], 'life': [130, 1567, 2067], 'affected': [132, 140, 567, 611, 4381], 'people.': [133], 'Awareness': [134], 'issues': [137, 1639, 1654, 4401], 'children,': [141, 3434], 'adolescents,': [142], 'caregivers': [145, 4038], 'can': [146, 891, 934, 1405, 1621, 2141, 2748, 2756, 3134, 3344, 4098], 'make': [147], 'great': [149, 1233, 4437], 'difference': [150], 'outcomes': [152, 1429, 1832, 3362, 4479], 'across': [153], 'lifespan.Children': [155], 'may': [159, 265, 405, 409, 563, 588, 597, 705, 1100, 1207, 1230, 1250, 1272, 1318, 1489, 1519, 1668, 1777, 1947, 1954, 2179, 2762, 2812, 2980, 2989, 3120, 3128, 3255, 3280, 3292, 3385, 3872, 4090, 4251, 4357], 'have': [160, 1065, 1231, 1246, 1251, 1273, 1311, 1387, 1399, 1443, 1648, 1970, 2180, 2238, 2389, 2418, 3103, 3107, 3135, 3391, 3818, 4165, 4429], 'many': [161, 615, 1427, 1638, 2771], 'cooccurring': [162, 397, 3425], 'medical': [163, 594, 683, 687, 692, 983, 1333, 1508, 1588, 1635, 1757, 1853, 2014, 2534, 4095], 'conditions': [164, 284], 'cognitive': [166, 260, 389], 'impairment': [167, 261], 'because': [168, 430, 1078, 1803, 2201, 3123], 'presence': [171, 395, 443, 2158], 'extra': [173, 447, 462, 2146, 3329], 'material': [175, 464], 'from': [176, 497, 500, 600, 620, 866, 872, 878, 910, 1185, 1254, 1278, 1418, 1572, 1586, 1895, 1983, 2230, 3668, 4359], '21': [178, 474, 573, 928, 1907, 1936, 2071, 2150, 2207, 2220], '(Table': [179, 2221], '1).1,2': [180], 'phenotype': [183], 'variable,': [185], 'typically': [187, 2944, 4087], 'are': [188, 206, 438, 490, 1062, 1525, 1538, 1544, 1637, 1881, 2022, 2084, 2555, 3025, 3437, 3453, 4076, 4196], 'multiple': [189], 'features': [190], 'that': [191, 734, 1376, 1386, 1488, 1536, 1542, 1569, 1623, 1644, 1851, 1874, 1878, 1884, 1942, 1951, 1959, 2079, 2111, 2144, 2178, 2278, 2361, 2403, 2526, 2538, 2554, 2811, 2950, 3384, 3446, 3489, 3917, 4055, 4097, 4191, 4248], 'enable': [192], 'experienced': [194, 1806, 4154], 'suspect': [197], 'diagnosis.': [199, 3260], 'Among': [200], 'more': [202, 378, 565, 826, 1827, 2564, 3596, 3604, 4198, 4397], 'physical': [204, 2054, 2087, 2574, 3583, 3614, 3975], 'findings': [205, 1524, 2447, 3442], 'hypotonia,': [207], 'small': [208, 221, 223, 862], 'brachycephalic': [209], 'head,': [210], 'epicanthal': [211], 'folds,': [212], 'flat': [213], 'nasal': [214], 'bridge,': [215], 'upward-slanting': [216], 'palpebral': [217], 'fissures,': [218], 'Brushfield': [219], 'spots,': [220], 'mouth,': [222], 'ears,': [224], 'excessive': [225], 'skin': [226, 1087], 'at': [227, 663, 669, 1222, 1890, 2471, 2581, 2608, 2611, 2661, 2765, 2795, 2802, 2859, 2916, 2940, 3027, 3092, 3621, 3759, 3852, 3898, 3928, 4016, 4267, 4300], 'nape': [229], 'neck,': [232], 'single': [233], 'transverse': [234], 'palmar': [235], 'crease,': [236], 'short': [237], 'fifth': [238], 'finger': [239], 'clinodactyly,': [241], 'wide': [243, 756, 1452], 'spacing': [244], 'between': [245, 472, 1138, 3045, 4214], 'first': [247, 765, 981, 1898, 2063, 2307, 2823, 3459], 'second': [249, 767, 987, 1040], 'toes,': [250], 'often': [251, 376, 1002, 1310, 1809, 2491], 'deep': [254, 3574], 'plantar': [255], 'groove.': [256], 'The': [257, 603, 998, 1026, 1335, 1368, 1464, 1619, 2099, 2445], 'degree': [258], 'variable': [263], 'mild': [267], '(IQ': [268, 274, 281], '50–70),': [270], 'moderate': [273], '35–50),': [276], 'severe': [280, 315], '20–35).Medical': [283], 'include': [291, 589, 950, 1669, 3565], 'hearing': [292, 1419, 2642, 2702, 2806, 3749], 'loss': [293, 1182, 2807], '(75%),': [294], 'obstructive': [295, 3469], 'sleep': [296, 3275, 3288, 3299, 3470, 3477, 3504, 3514, 3879, 4316, 4331, 4349, 4369], 'apnea': [297, 4370], '(50%–79%),': [298], 'otitis': [299, 2669], 'media': [300, 2670], '(50%–70%),': [301], 'eye': [302], 'problems': [303, 595, 2810, 3300, 3488, 3880, 4054, 4096, 4168, 4350], '(60%–80%),': [304], 'including': [305, 355, 1081, 1425, 1450, 2456, 2986, 3397, 3404, 3415, 3472, 4104, 4288, 4304], 'cataracts': [306], '(<1%–3%),3': [307], 'nasolacrimal': [308, 2848], 'duct': [309, 2849, 2872], 'obstruction': [310, 2873], '(3%–36%),': [311], 'strabismus': [313], 'refractive': [316, 2851], 'errors': [317], '(36%–80%),': [318], 'congenital': [319, 1082], 'heart': [320, 1083, 1772, 2961, 2982], 'defects': [321, 2939, 2949, 3006], '(50%),': [322], 'neurologic': [323, 3137, 3369, 3382, 4286, 4293], 'dysfunction': [324, 3383], '(1%–13%),': [325], 'gastrointestinal': [326, 1501], 'atresia': [327], '(12%),': [328], 'hip': [329, 332], 'dislocation': [330], 'abnormalities': [333], '(2%–8%),4,5': [334], 'symptomatic': [335], 'atlantoaxial': [336, 4462], 'instability': [337], '(1%–2%),6,7': [338], 'thyroid': [339, 2910, 4105], 'disease': [340, 365, 368, 2678, 3744, 3927], '(24%–50%)2,8': [341], 'and,': [342, 3570], 'less': [343], 'commonly,': [344], 'transient': [345], 'abnormal': [346, 1523, 4315, 4344], 'myelopoiesis': [347], '(4%–10%)': [348], 'later': [350], 'leukemia': [351, 3316, 3343, 3352, 3358], '(1%),': [352], 'autoimmune': [353], 'diseases,2,8–10': [354], 'Hashimoto': [356], 'thyroiditis': [357], '(13%–39%),': [358], 'incidence': [360], 'dependent': [361], 'on': [362, 388, 614, 903, 1155, 1438, 1869, 2086, 2310, 2593, 3571, 3633, 3823, 3914, 4118], 'age,': [363, 956, 2769, 4121], 'celiac': [364, 3926, 4107], '(1%–5%),': [366], 'Hirschsprung': [367], '(<1%),3': [369], 'autism': [371], '(7%–19%).11,12People': [372], 'function': [377, 4058, 4174], 'effectively': [379], 'social': [381, 1298, 1594], 'situations': [382], 'than': [383, 568, 830, 2372], 'would': [384, 912], 'predicted': [386], 'based': [387], 'assessment': [390, 656, 2819], 'results,': [391], 'unless': [392, 3435], 'autism.': [398], 'level': [401], 'social–emotional': [403], 'functioning': [404], 'vary,': [406, 1861], 'these': [407, 487, 3056, 4249], 'skills': [408, 716, 4042], 'improved': [411, 1587], 'early': [413, 418, 895, 1556, 2540], 'intervention': [414, 1557, 1867], 'therapy': [416, 3353], 'through': [417, 4450], 'adulthood.In': [419], '∼96%': [420], 'syndrome,': [425, 2549, 3268, 4244], 'sporadic': [429], 'nonfamilial': [432], 'trisomy': [433, 553, 572, 601, 927, 1906, 1935, 1966, 2070, 2206], '21,': [434, 577], 'which': [436, 700, 953, 2709, 3564, 3676, 4131], '47': [439], 'chromosomes': [440], 'free': [446], '21.': [449, 483, 554, 602], 'In': [450, 526, 795, 1269, 1662], '∼3%': [451], '4%': [453], 'people': [455, 533, 569, 2413, 4409, 4481], 'phenotype,': [460, 538], 'result': [467, 496, 909, 2168, 2442], 'unbalanced': [470, 488, 2213], 'translocation': [471, 498, 520, 575, 1958], 'another': [476], 'acrocentric': [477], 'chromosome,': [478], '14': [481, 1141], 'Approximately': [484], 'three-quarters': [485], 'translocations': [489, 2177], 'de': [491, 524], 'novo,': [492], 'remainder': [495], 'inherited': [499], 'parent.': [502], 'If': [503, 2016, 2075, 2508, 2652, 2781, 2870, 3741], 'translocation,': [508], 'parents': [510, 1271, 1807, 2188, 2309, 2325, 2339, 2438, 2453, 3445, 3529], 'should': [511, 660, 1337, 1360, 1615, 1655, 1709, 1749, 1988, 2038, 2093, 2101, 2121, 2169, 2225, 2251, 2306, 2319, 2342, 2356, 2427, 2433, 2448, 2467, 2476, 2524, 2557, 2679, 2696, 2733, 2792, 3307, 3646, 3985, 4211], 'offered': [513, 745, 2478], 'karyotype': [515, 2043, 2174, 2432], 'determine': [517, 2156], 'whether': [518], 'familial': [522], 'novo.': [525], 'remaining': [528], '1%': [529, 621], '2%': [531], 'mix': [540], '2': [542, 631, 3778], 'cell': [543, 3063], 'lines': [544], 'present:': [546], '1': [547, 783, 2636, 2766, 2796, 2932, 3093, 3324, 3715, 3734, 3737, 3784, 3787, 3804, 3853, 3864, 3867, 3891, 3907, 3941, 4005, 4032, 4184, 4387], 'normal': [548], 'other': [551, 789, 1607, 1846, 2191, 2386, 3365, 3402, 3429], 'called': [558, 1003], 'mosaicism.': [559], 'People': [560], 'mosaicism': [562], 'mildly': [566], 'complete': [571, 2778, 2784, 3061, 3368], 'but': [578, 937, 1873, 2770, 3118, 3191], 'not': [581, 876, 887, 996, 1115, 1539, 2023, 2155, 2199, 2204, 2486, 2502, 2515, 2774, 2886, 2901, 3164, 3238, 3262], 'always': [582], 'case,': [584], 'any': [590, 1238, 1373, 1382, 1484, 1562, 2623, 3517, 3542, 3697, 3965, 4334], 'associated': [593, 1609, 2461, 3017, 3273, 3492, 4100], 'indistinguishable': [599], 'chance': [604, 1224], 'recurrence': [606, 1699, 1835], 'families': [608, 624, 1394, 2387], 'depends': [613, 1868], 'factors': [616], 'vary': [618], 'greatly,': [619], '100%': [626, 3219], 'some': [628, 4077], 'circumstances.': [629], 'Table': [630], 'describes': [632], 'different': [634], 'characteristics': [636], 'syndrome.Formal': [639], 'counseling': [640, 1253, 1716, 2185, 2482], 'geneticist': [644, 1821], 'counselor': [647, 1824], 'recommended': [649, 1755, 2277, 3431, 4270], 'all': [651, 735, 793, 1879, 2941, 3433], 'families.Several': [652], 'areas': [653, 673], 'require': [654, 913], 'ongoing': [655], 'throughout': [657], 'childhood': [658], 'reviewed': [662, 2435, 2469], 'every': [664, 2612, 2739, 3760, 3777, 3812, 3929, 4301], 'health': [665, 2583, 2613, 3623, 3761, 3900, 3930, 4019, 4407, 4424], 'supervision': [666, 2614, 3762, 3901], 'visit': [667, 1466, 2861, 3763, 3902, 3932, 4021], 'least': [670, 3455], 'annually.': [671], 'These': [672, 1059, 1653, 1765, 2465, 3644], 'include:': [674, 1920], 'personal': [675, 2374], 'support': [676, 693, 1277, 1324, 1480, 1801, 2242, 2350, 2395], 'available': [677, 807, 977, 1528, 2024, 2123], 'family;participation': [679], 'family-centered': [682], 'home;age-specific': [684], 'syndrome-related': [686], 'developmental': [689, 715, 1267, 1938], 'conditions;financial': [690], 'programs': [694], 'long-term': [696, 3136], 'financial': [697, 1603], 'planning': [698], 'eligible;injury': [707], 'abuse': [709], 'prevention,': [710], 'special': [712, 4160], 'consideration': [713], 'ability;': [719], 'andnutrition': [720], 'activity': [722, 4379], 'maintain': [724], 'appropriate': [725, 1507, 1563, 2200, 2865, 3748, 4046], 'weight.The': [726], 'American': [727, 4598, 4624], 'College': [728, 4599, 4625], 'Obstetricians': [730, 2316, 4627], 'Gynecologists': [732, 4629], 'recommends': [733], 'women,': [737], 'regardless': [738], 'age': [740, 1009, 2665, 2922, 3096, 3661, 3691, 3799, 3856], 'risk': [742, 1010, 2803, 2907, 3029, 3110, 3394, 3551, 3794, 4366], 'status,': [743], 'option': [747], 'screening': [749, 759, 784, 790, 815, 820, 832, 884, 945, 975, 994, 1034, 1042, 1051, 1060, 1073, 1111, 2658, 4458], 'diagnostic': [751, 916, 1116, 2694], 'testing': [752, 800, 917, 1120, 1375, 2021, 2789], 'syndrome.17,18A': [755], 'variety': [757], 'test': [760, 785, 885, 2060], 'options': [761], 'exist': [762], 'trimester': [768, 988, 1041], 'using': [769, 1658], 'maternal': [770, 856, 955, 963, 1008, 1014], 'serum': [771, 964, 1000, 1015, 3084, 3212, 3847], 'ultrasonography.': [773], 'Each': [774], 'varying': [776], 'levels': [777], 'sensitivity': [779, 3220], 'specificity.': [781], 'No': [782], 'superior': [787, 3363], 'tests': [791, 946, 1061], 'characteristics.': [794], 'recent': [796, 1192], 'years,': [797], 'noninvasive': [798], 'cell-free': [802], 'DNA': [803, 865], '(cfDNA)': [804], 'become': [806], 'sensitive': [812, 827, 2059, 4199], 'method': [813], 'syndrome.': [818, 1228, 1248, 1463, 2464, 3182], 'cfDNA': [819, 853, 870, 889, 911, 930, 2027], 'significantly': [825], 'specific': [829, 2446, 3438], 'conventional': [831], 'methods,': [833], '2017': [836], 'meta-analysis': [837], 'reporting': [838], 'detection': [840, 1027, 1768], 'rate': [841, 847, 1028, 1700], '99.7%,': [843], 'false-positive': [846, 1068], '0.04%': [849], 'singleton': [851], 'pregnancies.19': [852], 'uses': [854, 2112], 'blood': [857, 2037, 2091, 2970, 3062], 'sample': [858, 1147, 1169, 2032, 2092], 'analyze': [860], 'free-floating': [861], 'fragments': [863], 'placenta.': [868], 'Because': [869, 2904], 'placenta': [874], 'directly': [877, 4233], 'fetus,': [880], 'it': [881, 1113, 1396, 1408, 1875, 2202, 2484, 2592, 3119, 3632], 'diagnostic.': [888], 'performed': [893, 1134, 1173, 1195, 1487, 1751, 2698, 2735, 2758, 2794], '9': [897, 2889], '10': [899, 1139, 3662], 'weeks’': [900, 1143, 1176], 'gestation': [901], 'depending': [902, 1154], 'laboratory,': [905], 'high-risk': [908], 'confirmation': [914, 2293], 'chorionic': [919, 967, 1018], 'villus': [920], 'sampling': [921], '(CVS)': [922], 'amniocentesis.': [924, 1127], 'Screening': [925, 3183], 'twin': [932], 'pregnancies': [933, 1941], 'performed,': [936, 2030], 'total': [938, 3087], 'number': [939, 1234], 'reported': [941, 1063], 'cases': [942, 1663], 'small.20Other': [944], 'first-trimester': [951, 993, 1033], 'screening,': [952, 1001], 'incorporates': [954, 1007], 'nuchal': [957, 1086], 'translucency': [958], 'ultrasonography,': [959], 'measurement': [961, 1012, 2913], 'β': [965, 1016], 'human': [966, 1017], 'gonadotropin': [968], 'pregnancy-associated': [970], 'plasma': [971], 'protein': [972, 3077], 'A.': [973, 4520, 4525, 4563, 4604, 4631], 'Second-trimester': [974], 'patients': [979, 3153, 4163, 4382], 'seek': [982], 'locations': [991], 'where': [992], 'available.': [997, 2399, 2444], 'second-trimester': [999, 1050], 'quad': [1005], 'screen,': [1006], 'gonadotropin,': [1019], 'unconjugated': [1020], 'estriol,': [1021], 'α-fetoprotein,': [1022], 'inhibin': [1024], 'concentrations.': [1025], '82%': [1036], '87%,': [1038], '80%,': [1044], 'combined': [1047], 'first-': [1048], '(referred': [1052], 'integrated': [1055], 'screening)': [1056], '∼95%.': [1058], '5%': [1067], 'rate.21–24Ultrasonography': [1069], 'additional': [1072, 1110, 1485, 1747, 2788], 'tool': [1074], 'structural': [1079, 3039], 'changes,': [1080, 4103], 'defects,': [1084], 'increased': [1085, 1223, 1571, 2906, 3028, 3141, 3393, 3573], 'fold,': [1088], '“double': [1089], 'bubble”': [1090], 'sign': [1091], 'suggestive': [1092], 'duodenal': [1094], 'atresia,': [1095], 'ventriculomegaly,': [1096], 'short–long': [1098], 'bones,': [1099], 'identified': [1102, 1218], 'imaging.': [1105], 'ultrasonography': [1107, 1499], 'tool,': [1112], 'syndrome.Diagnostic': [1119], 'includes': [1124], 'CVS': [1125, 1128, 1186, 1987], 'benefit': [1131, 1417, 4358], 'being': [1133], 'earlier': [1135], 'pregnancy,': [1137], 'completed': [1142], 'gestation.': [1144], 'A': [1145, 2109, 2137, 2194, 3290, 4453], 'placental': [1146, 1159], 'obtained': [1149, 2040], 'either': [1150, 3069, 3834], 'transabdominally': [1151], 'transcervically,': [1153], 'provider': [1156, 2267], 'preference': [1157], 'location.': [1160], 'Amniocentesis': [1161], 'transabdominal': [1164], 'procedure': [1165, 3547], 'remove': [1167], 'amniotic': [1171], 'fluid': [1172], 'after': [1174, 1550, 3751], '15': [1175], 'gestational': [1177], 'age.': [1178], 'Risk': [1179], 'procedure-related': [1181], 'pregnancy': [1184, 1239, 1672, 1724, 1745], 'amniocentesis': [1188, 1202, 1985], 'comparable': [1190], 'studies': [1193, 1371, 1385, 1486, 1748, 1766], 'when': [1194, 1242, 2335, 2439, 2683], 'providers': [1197], 'expertise,': [1199], '0.22%': [1200], '0.11%': [1204], 'CVS.25,26Pediatricians': [1206], 'asked': [1209], 'counsel': [1211], 'whose': [1214], 'fetus': [1215, 1695], 'having': [1226, 1963], 'Families': [1229, 1441, 1532, 2475], 'questions': [1236, 1444], 'especially': [1241], 'They': [1249], 'received': [1252, 1274], 'certified': [1256], 'counselor,': [1258], 'geneticist,': [1261], 'maternal–fetal': [1262], 'medicine': [1263, 4332], 'specialist,': [1264], 'obstetrician,': [1265], 'specialist.': [1268], 'addition,': [1270, 2120], 'information': [1275, 1345, 1796, 2250, 2285, 2298], 'family-led': [1280], 'organization': [1281, 1478], 'such': [1282, 1510, 3411], 'Parent': [1284, 1286], 'USA,': [1287], 'local': [1289, 1798], 'group,': [1292], 'national': [1294, 1800], 'organization,': [1297], 'media,': [1299], 'possibly': [1301, 2190], 'Internet': [1303], 'site': [1304], 'inaccurate': [1306], 'information.': [1307], 'Pediatricians': [1308], 'previous': [1313, 1931, 2641], 'relationship': [1314], 'natural': [1321], 'source': [1322], 'context': [1330, 1631], 'home.': [1334, 4050], 'prepared': [1339], 'respond': [1341], 'questions,': [1343], 'received,': [1349], 'decision-making': [1354], 'process.27': [1355], 'When': [1356, 4135], 'asked,': [1357], 'discuss': [1361, 3464, 3527, 3950], 'following': [1363], 'topics': [1364, 2466, 4428, 4435], 'family:': [1367], 'laboratory': [1370, 2104, 2422], 'confirmatory': [1374], 'led': [1377, 4260], 'fetal': [1383, 1497, 1775], 'imaging': [1384], 'performed.': [1392], 'Many': [1393], 'find': [1395], 'before': [1403, 2245], 'they': [1404, 1537, 1624], 'consider': [1406], 'what': [1407], 'mean': [1410, 3143, 3160], 'infant': [1413, 1552, 1904, 2236, 2270, 2654, 2994], 'family.Families': [1416], 'fair': [1421], 'balanced': [1423, 1957, 2359], 'perspective,': [1424], 'positive': [1428, 2166], 'effects': [1437], 'family.': [1440, 1742, 1764], 'about': [1445, 1797, 2299, 2622, 3696], 'prognosis': [1446, 1495], 'phenotypic': [1448], 'manifestations,': [1449], 'range': [1453, 2367], 'variability': [1455, 2364], 'seen': [1456], 'infants': [1458, 1857, 2840, 2936, 3423], 'good': [1469], 'time': [1470, 1892], 'offer': [1472, 2287, 2383], 'connection': [1474], 'peer-to-peer': [1477], '(see': [1481, 2630, 2926, 3709, 3730, 3780, 3860, 3887, 3903, 3937, 4001, 4028, 4180, 4383], 'Family': [1482], 'Resources).Discuss': [1483], 'refine': [1490], 'estimation': [1492], '(eg,': [1496, 1767], 'echocardiography,': [1498], 'tract': [1502], 'malformations).': [1503], 'Consultation': [1504], 'subspecialist,': [1509], 'pediatric': [1513, 1517, 2831, 3503, 3767, 4325, 4330], 'cardiologist': [1514], 'surgeon,': [1518], 'occur': [1520], 'prenatally': [1521], 'if': [1522, 1752, 1754, 1760, 1926, 2026, 2129, 2397, 2483, 2566, 2885, 2900, 3240, 3333, 3516, 3598, 3757, 3815, 3935, 4026], 'detected.Discuss': [1526], 'currently': [1527], 'treatments': [1529], 'interventions.': [1531], 'need': [1533, 4373], 'hear': [1535], 'alone': [1540, 2028], 'supports': [1545, 1604], 'services': [1547, 4147], 'them': [1549, 1961], 'born.': [1554], 'Discuss': [1555, 1712, 4362], 'resources,': [1558], 'parent-support': [1559], 'programs,': [1560, 4145], 'future': [1564, 1837], 'treatments.Discuss': [1565], 'extended': [1566, 1828], 'expectancy': [1568], '30': [1573], 'years': [1574, 1579], '1973': [1576], '60': [1578], '2002.': [1581], 'increase': [1583, 4273], 'resulted': [1585], 'care,': [1589, 4150], 'educational': [1590], 'options,': [1591, 1839], 'enhanced': [1593, 4449], 'adaptation.': [1595], 'Potential': [1596], 'complications': [1597], 'adverse': [1599], 'effects,': [1600], 'costs': [1601], 'available,': [1605, 1753, 3758], 'challenges': [1608], 'comprehensive': [1611], 'management': [1612, 1783], 'also': [1616, 2799, 3026, 3133, 3272, 3986, 4091], 'discussed.': [1618], 'explain': [1622], 'supported': [1627], 'best': [1628], 'patient-centered': [1634], 'home.There': [1636], 'learning': [1643], 'consider.': [1652], 'discussed': [1657, 2450, 3317, 4213], 'nondirective': [1660], 'approach.': [1661], 'diagnosis,': [1666, 1999], 'discussion': [1670, 1829], 'continuation': [1673], 'termination,': [1675], 'raising': [1676], 'family,': [1681, 1703, 2005], 'foster': [1682], 'placement,': [1684], 'adoption.28The': [1686], 'mechanism': [1687], 'occurrence': [1689], 'potential': [1698, 2458, 3010], 'counseling,': [1708], 'shared.': [1711], 'availability': [1713], 'meeting': [1718], 'genetics': [1721], 'professional.As': [1722], 'continues,': [1725], 'may:': [1728], 'Develop': [1729], 'plan': [1731, 1784], 'delivery': [1733, 2233, 2282], 'neonatal': [1735], 'obstetrician': [1739], 'As': [1743, 2685], 'progresses,': [1746], 'subspecialists': [1758], 'and/or': [1759], 'desired': [1761], 'complex': [1771], 'defect': [1773], 'echocardiography)': [1776], 'help': [1778], 'direct': [1779], 'development': [1780, 3012, 4405], 'improve': [1786], 'outcome': [1787], 'mother': [1790, 2224], 'infant.29Offer': [1792], 'parent-to-parent': [1793], 'organizations': [1802, 2396], 'communication': [1804], 'very': [1811], 'helpful': [1812], 'resource': [1813], 'caregiver': [1815], 'decision-making.Offer': [1816], 'referral': [1817, 2479], 'variability,': [1834], 'rates,': [1836], 'reproductive': [1838, 2184], 'evaluation': [1841, 2643, 2878, 3249, 3510, 3729, 3750, 3754, 4177], 'risks': [1844], 'members.It': [1848], 'recognized': [1850], 'needs': [1854], 'newborn': [1856, 1903, 2512, 2541, 2657, 2897], 'timing': [1864], 'each': [1866, 2582, 2860, 3524, 3622, 3899, 3947, 4017], 'infant’s': [1871, 2588, 2857], 'needs,': [1872], 'interventions': [1880], 'addressed': [1882], 'careful': [1885, 1910, 3972], 'transfer': [1886], 'occurs': [1889], 'discharge': [1894], 'hospital.The': [1897], 'step': [1899], 'evaluating': [1901], 'history': [1915, 1929, 2570, 3370, 3578, 3610, 3827, 3973], 'information,': [1918], 'results': [1921, 2002, 2018, 2895], 'studies,': [1925], 'performed;': [1927], 'andfamily': [1928], 'born': [1933], 'differences': [1939], 'ended': [1943], 'miscarriage.': [1945], '(These': [1946], 'clues': [1950], 'carry': [1955], 'predisposes': [1960], '21.)For': [1967], 'had': [1971], 'made': [1974], 'prenatally,': [1975], 'formal': [1977, 2009], 'copy': [1978, 2147], 'obtained.': [1990], 'allows': [1993], 'confirm': [1997, 2045, 3259], 'add': [2007], 'child’s': [2013, 3628, 4120, 4224, 4281], 'record.': [2015], 'was': [2029, 2485], 'cord': [2034, 3554], 'peripheral': [2036], 'postnatal': [2042], 'rule': [2049], 'out': [2050], 'translocation.A': [2053], 'examination': [2055, 2725, 3372, 3507], '24': [2064, 2125], 'hours': [2065], 'diagnose': [2069], 'infant.': [2074, 2315], 'believes': [2078], 'criteria': [2080], 'present': [2085, 2152, 2244, 3147, 3243], 'examination,': [2088, 3572, 3584, 3976], 'then': [2089, 2924], 'sent': [2095], 'karyotype.': [2098], 'alert': [2102, 3309], 'request': [2106], 'rapid': [2107], 'results.': [2108, 4346], 'study': [2110], 'fluorescent': [2113], 'situ': [2115], 'hybridization': [2116], '(FISH)': [2117], 'technology,': [2118], 'within': [2124], '48': [2127], 'hours,': [2128], 'necessary,': [2130], 'facilitate': [2132], 'parent': [2135], 'counseling.': [2136], 'FISH': [2138, 2167], 'study,': [2139, 2659], 'however,': [2140], 'only': [2142], 'indicate': [2143, 2981, 4247], 'does': [2154], 'absence': [2160, 3036], 'translocation.': [2163], 'Therefore,': [2164], 'identify': [2176], 'implications': [2181], 'further': [2183, 3509], 'members.': [2193], 'microarray': [2196], 'differentiate': [2205], 'caused': [2208], 'nondisjunction': [2210], 'versus': [2211], 'translocation.When': [2214], 'delivering': [2215, 2273], 'Trisomy': [2219], '3):': [2222], 'allowed': [2227], 'recover': [2229], 'immediate': [2232], 'her': [2239], 'partner': [2240], 'person': [2243], 'given;the': [2249], 'relayed': [2253], 'private': [2256, 2289, 2332], 'setting': [2257, 2496, 4129], 'physicians': [2260], 'involved,': [2261], 'optimally': [2262], 'primary': [2265, 2505, 2518, 3047, 4216], 'physician30;': [2274], 'andit': [2275], 'hospitals': [2279], 'coordinate': [2280, 2320], 'hospital': [2290, 2495], 'room': [2291], 'pending': [2292], 'diagnosis.When': [2296], 'providing': [2297, 2349, 2511], 'families,': [2303], 'physician': [2305, 2499, 2510, 3049, 3291, 3499, 3871, 3992, 4218, 4321], 'congratulate': [2308], 'birth': [2312], 'pediatricians': [2318], 'messaging': [2322], 'inform': [2324], 'suspicion': [2328], 'immediately,': [2329], 'setting,': [2333], 'appropriate,': [2336], 'both': [2338, 2452, 4422], 'together.': [2340], 'Physicians': [2341], 'use': [2343, 2863, 4236], 'experience': [2345, 2838], 'expertise': [2347, 2836, 3501, 3772, 4323], 'Clinicians': [2355], 'ensure': [2357, 2525, 2616, 3705], 'approach': [2360], 'reflects': [2362], 'broad': [2366], 'current': [2369, 2379], 'outcomes,': [2370], 'rather': [2371], 'opinions': [2375], 'experience,': [2377], 'give': [2378], 'printed': [2380], 'materials,': [2381], 'access': [2384], 'locally': [2398], 'It': [2400], 'clinicians': [2404], 'cognizant': [2406], 'realities': [2409], 'possibilities': [2411], 'healthy,': [2419], 'productive': [2420], 'lives.30The': [2421], 'confirmed,': [2429], 'final': [2441], 'whenever': [2454], 'possible,': [2455], 'manifestations': [2460], 'again': [2470], 'subsequent': [2473, 3248], 'meeting.': [2474], 'conducted': [2487], 'prenatally.Newborn': [2488], 'pediatrician.': [2507], 'pediatrician,': [2520], 'he': [2521], 'she': [2523], 'smooth': [2530], 'transition': [2531], 'transferring': [2533], 'records': [2535], 'ensuring': [2537], 'follow-up': [2542, 3822], 'appointment': [2543], 'scheduled.Characteristics': [2545], 'attributable': [2546], 'well': [2551], 'those': [2553], 'familial,': [2556], 'discussed.Follow': [2559], 'Bright': [2560, 3592, 3600, 4393], 'Futures': [2561, 3593, 3601, 4394], 'schedule': [2562, 3594, 3602, 4395], 'frequently': [2565, 3597, 3605, 4197, 4398], 'indicated.': [2567, 3607], 'Obtain': [2568, 3059, 3577, 3608], 'perform': [2572, 3581, 3612, 4291], 'examination.Monitor': [2575, 3615], 'weight': [2576, 2601, 2978, 3616], 'follow': [2578, 3618], 'weight-for-length': [2579], 'trends': [2580, 3620], 'visit.': [2585, 3625], 'Review': [2586, 3626], 'growth': [2589, 3629], 'plot': [2591, 3631], 'syndrome-specific': [2596, 3636, 3654], 'charts': [2597, 3637, 3645], 'weight,': [2599, 3639], 'length,': [2600, 2603], 'head': [2605, 3642], 'circumference': [2606], '(available': [2607], 'www.cdc.gov).57,58Review': [2609], 'feeding': [2610, 2629, 2974, 3703], 'visit,': [2615, 3526, 3949, 4303], 'adequate': [2617, 3706], 'iron': [2618, 3085, 3172, 3188, 3193, 3213, 3223, 3225, 3251, 3278, 3294, 3707, 3848, 3874, 4360], 'intake,': [2619], 'inquire': [2621], 'changes': [2624, 3698], 'respiratory': [2626, 3418, 3700], 'symptoms': [2627, 2956, 3314, 3334, 3467, 3522, 3561, 3701, 3922, 3998, 4136, 4284, 4295, 4339], '“Health': [2631, 3801], 'Supervision': [2632, 2928, 3320, 3711, 3732, 3782, 3802, 3862, 3889, 3905, 3939, 4003, 4030, 4182, 4385], 'From': [2633, 2929, 3321, 3712, 3733, 3783, 3803, 3863, 3890, 3906, 3940, 4004, 4031, 4183, 4386], 'Birth': [2634, 2930, 3322, 3713], 'Month”': [2637], 'discussion).Review': [2639], '(brainstem': [2644], 'auditory': [2645], 'evoked': [2646], 'response': [2647, 4255], '[BAER]': [2648], 'otoacoustic': [2650], 'emission).': [2651], 'passed': [2655], 'rescreen': [2660], '6': [2662, 2742, 2824, 2917, 3460, 3813], 'months': [2663, 2743, 2825, 2892, 2920, 3461, 3814], 'confirmation.Risk': [2667], 'effusion': [2672], '50%': [2674], '75%.43': [2676], 'Middle-ear': [2677], 'treated': [2681, 3346], 'immediately': [2682, 3993], 'diagnosed.': [2684], 'soon': [2686, 2721], 'clear': [2689], 'ear': [2690, 2731, 3743], 'established,': [2692], 'BAER': [2695, 2791], 'accurately': [2700], 'establish': [2701], 'status.In': [2703], 'stenotic': [2706], 'canals': [2707], 'tympanic': [2711, 2746], 'membranes': [2712], 'cannot': [2713], 'seen,': [2715], 'refer': [2716, 2828, 2876, 4023, 4141], 'otolaryngologist': [2719, 2738], 'possible': [2723, 3513], 'under': [2726], 'office': [2728], 'microscope.': [2729], 'Interval': [2730], 'examinations': [2732], '3': [2740], 'until': [2744, 2992], 'membrane': [2747], 'visualized': [2750], 'tympanometry': [2755], 'reliably.43A': [2759], 'behavioral': [2760, 2786, 4152, 4167], 'audiogram': [2761], 'attempted': [2764], 'year': [2767, 3094, 3854], 'able': [2776], 'study.': [2780], 'unable': [2782], 'audiogram,': [2787], 'year.Ear': [2797], 'anomalies': [2798], 'place': [2800], 'sensorineural': [2805], 'vestibular': [2809], 'affect': [2813], 'balance,': [2814], 'making': [2815], 'thorough': [2817], 'audiologic': [2818, 3728], 'additionally': [2820], 'important.59–61Within': [2821], 'life,': [2827, 3463], 'ophthalmologist': [2832, 2834, 3768, 3770], 'disabilities': [2842, 3776], 'evaluate': [2844, 3934], 'strabismus,': [2846], 'cataracts,': [2847], 'obstruction,': [2850], 'errors,': [2852], 'glaucoma,': [2853], 'nystagmus.16,62–64Check': [2855], 'vision': [2858], 'developmentally': [2864, 3747, 4045], 'subjective': [2866], 'objective': [2868], 'criteria.': [2869], 'lacrimal': [2871], 'present,': [2875], 'surgical': [2880], 'repair': [2881, 3004], 'drainage': [2883], 'system': [2884], 'resolved': [2887], '12': [2891, 2919], 'age.65Verify': [2894], 'thyroid-function': [2898], 'screen': [2899, 3167], 'previously': [2902, 3520], 'reviewed.': [2903], 'acquired': [2909], 'disease,': [2911, 4108], 'repeat': [2912], 'TSH': [2915, 3791, 3811], 'annually': [2925, 3098, 3858], 'Health': [2927, 3319, 3710, 3731, 3781, 3861, 3888, 3904, 3938, 4002, 4029, 4181, 4384, 4616, 4635, 4643], 'Month': [2933, 3325, 3716, 3735, 3785, 3865], 'discussion).Monitor': [2935], 'cardiac': [2938, 3001, 3829], 'well-child': [2942, 3525, 3948, 4302], 'visits,': [2943], 'ventricular': [2945], 'atrioventricular': [2947], 'septal': [2948], 'intracardiac': [2952, 3038], 'left-to-right': [2953], 'shunts,': [2954], 'signs': [2958, 3312, 3380, 3559, 3589, 3981, 4337], 'congestive': [2960], 'failure': [2962], 'pulmonary': [2964, 2969, 3014, 3031], 'vascular': [2965], 'resistance': [2966], 'decreases': [2967], 'flow': [2971], 'increases.': [2972], 'Tachypnea,': [2973], 'difficulties,': [2975], 'poor': [2977, 3494], 'gain': [2979], 'failure.': [2983], 'Medical': [2984, 4601], 'management,': [2985, 4208], 'nutritional': [2987], 'support,': [2988], 'required': [2991], 'optimal': [2997, 4478], 'undergo': [3000], 'surgery': [3002], 'limit': [3008], 'hypertension': [3015, 3032], 'complications.66': [3018], 'Infants': [3019], 'even': [3033], 'defects.': [3040], 'Close': [3041], 'coordination': [3042], 'subspecialist': [3052], 'infants.Anemia/iron': [3057], 'deficiency:': [3058], 'count': [3064], '(CBC)': [3065], 'differential': [3067, 3332], '(1)': [3070, 3835], 'combination': [3072, 3082, 3837, 3845], 'ferritin': [3074, 3207, 3230, 3270, 3303, 3839, 3883, 4353], 'C-reactive': [3076], '(CRP),': [3078], '(2)': [3080, 3843], 'iron-binding': [3088], 'capacity': [3089], '(TIBC),': [3090], 'beginning': [3091, 3851], 'thereafter.Children': [3099], 'shown': [3105], 'similar': [3109, 3349], 'iron-deficiency': [3112, 3130], 'anemia': [3113, 3131, 3190], 'typical': [3116], 'population,': [3117], 'missed': [3122], 'macrocytosis.67': [3125], 'Iron': [3126], 'insufficiency': [3127], 'precede': [3129], 'effects.67,68': [3138], 'Macrocytosis,': [3139], 'erythrocyte': [3142], 'corpuscular': [3144, 3161], 'volume,': [3145], 'up': [3149, 3659], 'one-third': [3151], 'syndrome.69': [3156], 'Thus,': [3157], 'low': [3159, 3269], 'volume': [3162], 'useful': [3166, 3239], 'diagnoses': [3170], 'deficiency/insufficiency,': [3173], 'lead': [3174], 'toxicity,': [3175], 'thalassemia': [3177], 'hemoglobin': [3185], 'concentration': [3186, 3231, 3252, 3304, 3884, 4354], 'identifies': [3187], 'deficiency': [3189, 3279], 'misses': [3192], 'deficiency/iron': [3194], 'insufficiency.': [3195], 'Using': [3196], 'CBC': [3198, 3330, 3832], 'parameter': [3199], 'elevated': [3202], 'relative': [3203], 'distribution': [3204], 'width': [3205], 'transferrin': [3209], 'saturation': [3210], 'divided': [3214], 'TIBC': [3216, 3254], 'leads': [3217], 'identifying': [3222], 'insufficiency,': [3224], 'deficiency,': [3226], 'anemia.': [3228], 'Serum': [3229], 'acute-phase': [3234], 'reactant': [3235], 'inflammation': [3241], 'CRP': [3245], 'elevated:': [3247], 'needed': [3257, 3378, 4027], 'unique': [3263], 'problems,': [3276, 4066, 4313], 'considered': [3282], 'differentials': [3284], 'difficulty.70': [3289], 'prescribe': [3293, 3873], 'supplementation': [3295, 3875], '<50': [3305, 3885, 4355], 'μg/L.70,71Pediatricians': [3306], 'obtain': [3327, 3746], 'occur.': [3335, 3386, 4092], 'Children': [3336, 3387, 4347], 'develop': [3341], 'acute': [3342, 3350, 3356, 4171], 'successfully': [3347], 'lymphocytic': [3351], 'de-intensified': [3355], 'myeloid': [3357], 'chemotherapy': [3359], 'regimens': [3360], 'children.72,73Assess': [3366], 'consult': [3374], 'neurology': [3376], 'seizures,': [3396, 4289], 'infantile': [3398], 'spasms': [3399], '(1%–13%)74,75': [3400], 'conditions,': [3403, 3427], 'moyamoya': [3405], 'disease76,77': [3406], 'benign': [3408], 'movement': [3409], 'disorders': [3410, 3505, 4085], 'shuddering.Administer': [3413], 'immunizations,': [3414], 'influenza': [3416], 'vaccine,': [3417], 'syncytial': [3419], 'virus': [3420], 'vaccine': [3421], 'qualifying': [3426], 'vaccines': [3430], 'contraindications.78Assess': [3439], 'dermatologic': [3441], 'advise': [3444], 'xerosis': [3447], '(dry': [3448], 'skin)': [3449], 'cutis': [3451], 'marmorata': [3452], 'common.At': [3454], 'once': [3456], 'apnea,': [3471], 'heavy': [3473], 'breathing,': [3474, 4110], 'snoring,': [3475, 4305], 'uncommon': [3476], 'positions,': [3478], 'frequent': [3479], 'night': [3480], 'awakening,': [3481, 4311], 'daytime': [3482, 4308], 'sleepiness,': [3483, 4309], 'apneic': [3484], 'pauses,': [3485], 'behavior': [3487, 4053, 4081, 4102, 4207, 4312], 'could': [3490, 4447], 'sleep.': [3495], 'Refer': [3496, 4162, 4318], 'disorder': [3515], 'mentioned': [3521], 'occur.79,80At': [3523], 'importance': [3531, 3954, 4438], 'maintaining': [3533], 'cervical': [3535, 3962], 'spine': [3536, 3963], 'neutral': [3539], 'position': [3540], 'anesthetic,': [3543, 3966], 'surgical,': [3544, 3967], 'radiographic': [3546, 3969], 'minimize': [3549], 'spinal': [3553], 'injury': [3555], 'myelopathy,': [3563], 'asymmetry': [3566], 'movement,': [3568], 'weakness,': [3569], 'tendon': [3575], 'reflexes.': [3576], 'carefully': [3580], 'paying': [3585], 'attention': [3586, 3978], 'myelopathic': [3588, 3980], 'symptoms.Follow': [3591], 'indicated.Follow': [3599], 'BMI': [3619, 3655, 3666], 'height,': [3640], 'circumference.120': [3643], 'used': [3648], 'conjunction': [3650], 'chart': [3656, 3667], 'Centers': [3670, 4650], 'Disease': [3672, 4652], 'Control': [3673, 4653], 'Prevention,': [3675], 'better': [3679], 'indicator': [3680], 'excess': [3682], 'adiposity': [3683], 'over': [3689], '10.58Review': [3693], 'feeding.': [3694], 'Ask': [3695], 'intake': [3708], 'discussion).Emphasize': [3718], 'healthy': [3719, 4376], 'diet': [3720, 3916, 4377], 'lifestyle': [3722], 'preventing': [3724], 'obesity.Obtain': [3725], 'annual': [3726], 'ear-specific': [3727], 'Year': [3738, 3788, 3868], 'discussion).': [3740, 3809], 'middle': [3742], 'occurs,': [3745], 'treatment.Obtain': [3752], 'ophthalmologic': [3753], 'photoscreening,': [3756], 'years63,85': [3779], 'discussion).Measure': [3790], 'annually;': [3792], 'hypothyroidism': [3796], 'increases': [3797], '(See': [3800], '5': [3806, 3893, 3909, 3943, 4007, 4034, 4186, 4389], 'Years”': [3807], 'Measure': [3810], 'antithyroid': [3816], 'antibodies': [3817], 'detected.Individualize': [3820], 'cardiology': [3821], 'basis': [3825], 'defects.Obtain': [3830], 'CRP,': [3841], 'TIBC,': [3850], 'thereafter': [3859], 'discussion).A': [3870], 'μg/L': [3886, 4356], 'Years': [3894, 3910, 3944, 4008, 4035, 4187, 4390], 'discussion).Palpate': [3896], 'testes': [3897], 'discussion).For': [3912], 'contains': [3918], 'gluten,': [3919], 'potentially': [3923], 'related': [3924, 4296, 4402], 'maintenance': [3931], 'indicated': [3936], 'discussion).At': [3946], 'universal': [3956], 'precautions': [3957], 'protection': [3959], 'procedure.': [3970], 'Perform': [3971], 'symptoms.': [3983], 'Caregivers': [3984], 'instructed': [3988], 'new': [3995], 'onset': [3996], 'myelopathy': [4000], 'discussion).Discuss': [4010], 'skin,': [4011], 'hair,': [4012], 'scalp': [4014], 'preventive': [4018], 'dermatologist': [4025], 'discussion).Encourage': [4037], 'promote': [4040], 'self-help': [4041], 'assume': [4044], 'responsibilities': [4047], 'Monitor': [4051], 'interfere': [4056, 4137], 'home,': [4061], 'community,': [4062], 'school.': [4064], 'Attention': [4065], 'attention-deficit/hyperactivity': [4067], 'disorder,': [4068], 'obsessive-compulsive': [4069], 'behaviors,': [4070], 'noncompliant': [4071], 'behavior,': [4072], 'wandering': [4074], 'off': [4075], 'concerns': [4082], 'reported.': [4083], 'Psychiatric': [4084], 'affecting': [4086], 'developing': [4088], 'Evaluate': [4093], 'abnormalities,': [4106], 'sleep-disordered': [4109, 4298, 4341], 'gastroesophageal': [4111], 'reflux,': [4112], 'constipation.': [4114], 'Intervention': [4115], 'strategies': [4116], 'depend': [4117], 'severity': [4123], 'problem,': [4126], 'problem': [4133], 'occurs.': [4134], 'daily': [4139], 'activities,': [4140], 'community': [4143], 'treatment': [4144, 4460], 'psychosocial': [4146], 'consultative': [4149], 'specialists': [4153, 4220], 'working': [4156], 'needs.': [4161], 'chronic': [4166], 'manifest': [4170], 'deterioration': [4172], 'specialized': [4176], 'intervention112,113,121': [4179], 'discussion).Be': [4189], 'aware': [4190], 'certain': [4201], 'medications.': [4202, 4257], 'Before': [4203], 'initiating': [4204], 'medication': [4205], 'process': [4210], 'involved': [4221], 'care.': [4225], 'little': [4230], 'research': [4231, 4418, 4470], 'address': [4234], 'psychotropic': [4238], 'medications': [4239, 4266], 'among': [4240], 'anecdotal': [4245], 'reports': [4246], 'differ': [4252], 'Experience': [4258], 'recommendation': [4263], 'start': [4265], 'lowest': [4269], 'dose': [4271, 4277], 'decrease': [4275], 'according': [4278], 'response.122Inquire': [4282], 'regarding': [4283], 'dysfunction,': [4287], 'examination.Discuss': [4294], 'breathing': [4299, 4342], 'restless': [4306], 'sleep,': [4307, 4326], 'nighttime': [4310], 'position.': [4317], 'otolaryngologist,': [4327], 'specialist': [4333], 'sleep-study': [4345], 'supplementation.70,71': [4361], 'obesity': [4363], 'factor': [4367], 'implement': [4375], 'discussion).Follow': [4392], 'indicated.Many': [4400], 'remain': [4413], 'evaluated,': [4416], 'agendas': [4419], 'addressing': [4421], 'public': [4423], 'basic': [4426], 'science': [4427], 'developed.': [4431], 'Knowledge': [4432], 'several': [4434], 'population-based': [4451], 'research.': [4452], 'rigorous,': [4454], 'evidence-based': [4455], 'instability,': [4463], 'example,': [4465], 'needed,': [4467], 'continuing': [4469], 'critical': [4472], 'directing': [4474], 'syndrome.1,139–141Marilyn': [4484], 'J.': [4485, 4534, 4539, 4544, 4621], 'Bull,': [4486], 'MD,': [4487, 4491, 4496, 4500, 4506, 4511, 4516, 4522, 4527, 4531, 4536, 4541, 4546, 4551, 4555, 4560, 4565, 4568, 4574, 4580, 4585, 4591, 4595, 4606, 4648], 'FAAP': [4488, 4492, 4497, 4502, 4523, 4528, 4532, 4537, 4542, 4547, 4552, 4556, 4561, 4576, 4587], 'Tracy': [4489, 4577], 'Trotter,': [4490, 4515, 4579], 'Stephanie': [4493], 'L.': [4494, 4514, 4578], 'Santoro,': [4495], 'Celanie': [4498], 'Christensen,': [4499], 'MS,': [4501, 4507, 4586, 4592, 4633], 'Randall': [4503, 4588], 'W.': [4504, 4509, 4589], 'Grout,': [4505, 4590], 'FAAPLeah': [4508], 'Burke,': [4510], 'FAAP;': [4512, 4597, 4608], 'ChairpersonTracy': [4513], 'FAAP,': [4517, 4570, 4581], 'Co-Chairperson': [4518, 4571], 'Susan': [4519], 'Berry,': [4521], 'Timothy': [4524], 'Geleske,': [4526], 'Ingrid': [4529], 'Holm,': [4530], 'Robert': [4533], 'Hopkin,': [4535], 'Wendy': [4538], 'Introne,': [4540], 'Michael': [4543], 'Lyons,': [4545], 'Danielle': [4548], 'C.': [4549], 'Monteil,': [4550], 'Angela': [4553], 'Scheuerle,': [4554], 'Joan': [4557, 4630], 'M.': [4558, 4583], 'Stoler,': [4559], 'Samantha': [4562], 'Vergano,': [4564], 'FAAPEmily': [4566], 'Chen,': [4567], 'PhD,': [4569, 4575, 4596, 4607], 'Rizwan': [4572], 'Hamid,': [4573], 'Co-ChairpersonStephen': [4582], 'Downs,': [4584], 'FAAPChristopher': [4593], 'Cunniff,': [4594], 'Genetics': [4602], 'Melissa': [4603], 'Parisi,': [4605], 'Eunice': [4609], 'Kennedy': [4610], 'Shriver': [4611], 'National': [4612], 'Institute': [4613], 'Child': [4615, 4642], 'Human': [4618], 'Development': [4619], 'Steven': [4620], 'Ralston,': [4622], 'MD;': [4623], 'Scott,': [4632], 'CGC;': [4634], 'Resources': [4636], 'Services': [4638], 'Administration,': [4639], 'Maternal': [4640], 'Bureau': [4644], 'Stuart': [4645], 'K.': [4646], 'Shapira,': [4647], 'PhD;': [4649], 'PreventionPaul': [4655], 'Spire': [4656]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4223962902', 'counts_by_year': [{'year': 2024, 'cited_by_count': 79}, {'year': 2023, 'cited_by_count': 53}, {'year': 2022, 'cited_by_count': 12}], 'updated_date': '2024-12-24T18:17:21.860878', 'created_date': '2022-04-19'}
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