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'targeting': [25, 60, 264], 'CSCs': [26], 'should': [27], 'be': [28, 48, 252], 'effective': [29], 'in': [30, 78, 101, 149, 157, 229], 'eliminating': [31], 'impeding': [36], 'recurrence.': [38], 'Objective:': [39], 'This': [40], 'study': [41], 'aimed': [42], 'test': [44], 'if': [45], 'PPVII': [46, 207, 222, 235, 250], 'can': [47], 'a': [49, 114, 253], 'potent': [50, 254], 'drug': [51], 'candidate': [52, 255], 'the': [54, 130, 139, 167, 178, 183, 196, 210, 225, 258], 'of': [56, 142, 170, 177, 185, 198, 213, 227, 260], 'CD44': [61, 74, 97, 109, 143, 171, 228, 243, 265], 'positive': [62, 168, 244, 266], 'cells.': [65, 201, 216, 232, 247, 269], 'Methods:': [66], 'In': [67, 90, 233], 'this': [68, 91], 'study,': [69, 92], 'we': [70, 93], 'first': [71, 94], 'demonstrated': [72, 95, 205], 'that': [73, 96, 138, 180, 206, 221], 'is': [75, 98], 'highly': [76, 99], 'expressed': [77, 100], 'tissues': [81, 104, 160], 'TCGA/GTEX': [83, 106], 'database': [84, 107], 'analysis': [85, 135], 'immunohistochemical': [87, 165], 'staining.': [88], 'Results:': [89], 'analysis.': [108, 128], 'had': [110], 'high': [111, 140], 'accuracy': [112], 'as': [113], 'diagnostic': [115], 'predictive': [117], 'index': [118], 'colorectal': [120], 'through': [122], 'receiver': [123], 'operating': [124], 'characteristic': [125], 'curve': [126, 134], '(ROC)': [127], 'At': [129], 'same': [131], 'time,': [132], 'survival': [133], 'also': [136, 204], 'showed': [137, 220], 'expression': [141, 156, 172, 226], 'was': [144, 161, 173, 236], 'associated': [145], 'with': [146, 151], 'poor': [147], 'prognosis': [148], 'patients': [150], 'cancer.': [153], 'CD44’s': [154], 'higher': [155], 'further': [162], 'confirmed': [163, 193], 'staining;': [166], 'rate': [169], '87.95%.': [174], 'Then,': [175], 'one': [176], 'constituents': [179], 'derives': [181], 'from': [182], 'root': [184], 'Paris': [186], 'polyphylla,': [187], 'Polyphyllin': [188], 'VII': [189], '(PPVII),': [190], 'has': [191], 'been': [192], 'inhibit': [195, 209], 'migration': [197], 'Our': [202], 'results': [203, 219], 'could': [208, 223], 'sphere-forming': [211], 'ability': [212], 'Further': [217], 'experiment': [218], 'downregulate': [224], 'addition,': [234], 'proved': [237], 'have': [239], 'inhibitory': [240], 'effects': [241], 'against': [242], 'Conclusion:': [248], 'Therefore,': [249], 'might': [251], 'reagent': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4221133694', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-18T05:59:38.824882', 'created_date': '2022-04-03'}