Publication Information

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'the': [38, 44, 87, 91, 115, 134, 137, 154, 171, 178, 216, 239, 265, 292, 300], 'selective': [39, 172, 240, 266, 301], 'pressure': [40, 173, 241, 267, 302], 'tamoxifen': [42], 'activates': [43], 'NFκB': [45, 72, 95, 116, 155, 180, 256], 'pathway': [46, 141], 'in': [47, 142, 160, 200, 208, 229], 'ER': [48, 202, 315], '+': [49, 73, 96, 117, 156, 181, 203, 316], 'patient': [50, 283], 'tumors,': [51, 60], 'cancer': [53, 58, 144, 297], 'cell': [54, 78, 97, 118, 145, 182, 210, 252], 'lines,': [55], 'and': [56, 61, 80, 110, 120, 132, 147, 189, 205, 233, 257, 262, 270, 309], 'xenograft': [59], 'this': [63, 273], 'activation': [64], 'allows': [65], 'for': [66, 312], 'survival': [67], 'a': [69, 165, 186, 251, 277], 'subpopulation': [70], 'cells': [74, 287, 298], 'contribute': [76], 'regrowth': [79], 'tumor': [81, 196], 'relapse': [82, 197, 307], 'withdrawal.': [85], 'However,': [86], 'mechanisms': [88, 293], 'contributing': [89], 'expansion': [92], 'an': [94], 'population': [98, 119, 157, 167, 253, 274], 'are': [101], 'unknown.': [102], 'Methods': [103], 'Here,': [104], 'we': [105, 184, 213], 'utilized': [106], 'single-cell': [107], 'RNA': [108], 'sequencing': [109], 'bioinformatics': [111], 'approaches': [112], 'characterize': [114], 'its': [121], 'clinical': [122], 'relevance.': [123], 'Follow-up': [124], 'studies': [125], 'were': [126], 'conducted': [127], 'validate': [129], 'our': [130, 247], 'findings': [131, 248], 'assess': [133], 'function': [135], 'integrated': [138, 217], 'stress': [139, 218], 'response': [140, 161, 219, 230], 'lines': [146], 'patient-derived': [148], 'models.': [149], 'Results': [150], 'found': [152, 190], 'arises': [159], 'preexisting': [166, 179], 'enriched': [169], 'under': [170, 238, 264], 'ET.': [175, 243, 290], 'Based': [176], 'population,': [183], 'developed': [185], 'gene': [187], 'signature': [188], 'it': [192], 'predictive': [194], 'when': [198], 'expressed': [199], 'primary': [201], 'retained': [207], 'metastatic': [209], 'populations.': [211], 'Moreover,': [212], 'identified': [214], '(ISR),': [220], 'as': [221], 'indicated': [222], 'by': [223, 285, 294], 'increased': [224], 'phosphorylation': [225], 'eIF2α,': [227], 'occurs': [228], 'contributes': [234], 'clonogenic': [236], 'growth': [237], 'Conclusions': [244], 'Taken': [245], 'together,': [246], 'suggest': [249], 'with': [254, 314], 'active': [255], 'ISR': [258], 'signaling': [259], 'can': [260], 'survive': [261, 289, 299], 'expand': [263], 'targeting': [272], 'may': [275, 305], 'be': [276], 'viable': [278], 'therapeutic': [279], 'strategy': [280], 'improve': [282, 306], 'outcome': [284, 311], 'eliminating': [286], 'Understanding': [291], 'which': [295], 'rates': [308], 'overall': [310], 'tumors.': [318]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220912046', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}], 'updated_date': '2024-12-08T08:52:49.234472', 'created_date': '2022-04-03'}