Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4220845808', 'doi': 'https://doi.org/10.1016/j.phymed.2022.154062', 'title': 'Urokinase plasminogen activator induces epithelial-mesenchymal and metastasis of pancreatic cancer through plasmin/MMP14/TGF-β axis, which is inhibited by 4-acetyl-antroquinonol B treatment', 'display_name': 'Urokinase plasminogen activator induces epithelial-mesenchymal and metastasis of pancreatic cancer through plasmin/MMP14/TGF-β axis, which is inhibited by 4-acetyl-antroquinonol B treatment', 'publication_year': 2022, 'publication_date': '2022-06-01', 'ids': {'openalex': 'https://openalex.org/W4220845808', 'doi': 'https://doi.org/10.1016/j.phymed.2022.154062', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35366491'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2022.154062', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029957851', 'display_name': 'Chung‐Ze Wu', 'orcid': 'https://orcid.org/0000-0001-6118-6070'}, 'institutions': [{'id': 'https://openalex.org/I47519274', 'display_name': 'Taipei Medical University', 'ror': 'https://ror.org/05031qk94', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I47519274']}, {'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chung-Ze Wu', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan, ROC', 'Division of Endocrinology and Metabolism, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I47519274']}, {'raw_affiliation_string': 'Division of Endocrinology and Metabolism, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I4210158385']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102497367', 'display_name': 'Yi Cheng Chu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133879957', 'display_name': "St. George's University", 'ror': 'https://ror.org/01m1s6313', 'country_code': 'GD', 'type': 'education', 'lineage': ['https://openalex.org/I133879957']}], 'countries': ['GD'], 'is_corresponding': False, 'raw_author_name': 'Yi Cheng Chu', 'raw_affiliation_strings': ["Department of Medicine, School of Medicine, St. George's University, St. George SW17 0RE, Grenada"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine, School of Medicine, St. George's University, St. George SW17 0RE, Grenada", 'institution_ids': ['https://openalex.org/I133879957']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085961801', 'display_name': 'Shiue‐Wei Lai', 'orcid': 'https://orcid.org/0000-0003-2928-5401'}, 'institutions': [{'id': 'https://openalex.org/I68171755', 'display_name': 'National Defense Medical Center', 'ror': 'https://ror.org/02bn97g32', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I68171755']}, {'id': 'https://openalex.org/I1293718874', 'display_name': 'Tri-Service General Hospital', 'ror': 'https://ror.org/007h4qe29', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1293718874']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Shiue-Wei Lai', 'raw_affiliation_strings': ['Department of Internal Medicine, Tri-Service General Hospital Penghu Branch, Penghu, Taiwan, ROC', 'Division of Hematology-Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology-Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I68171755', 'https://openalex.org/I1293718874']}, {'raw_affiliation_string': 'Department of Internal Medicine, Tri-Service General Hospital Penghu Branch, Penghu, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I1293718874']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019857041', 'display_name': 'Ming‐Shou Hsieh', 'orcid': 'https://orcid.org/0000-0002-9228-683X'}, 'institutions': [{'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ming-Shou Hsieh', 'raw_affiliation_strings': ['Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I4210158385']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076657463', 'display_name': 'Vijesh Kumar Yadav', 'orcid': 'https://orcid.org/0000-0002-2679-1205'}, 'institutions': [{'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Vijesh Kumar Yadav', 'raw_affiliation_strings': ['Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I4210158385']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013680967', 'display_name': 'Iat-Hang Fong', 'orcid': 'https://orcid.org/0000-0002-8235-0877'}, 'institutions': [{'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Iat-Hang Fong', 'raw_affiliation_strings': ['Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I4210158385']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055054595', 'display_name': 'Li Deng', 'orcid': 'https://orcid.org/0000-0001-8792-529X'}, 'institutions': [{'id': 'https://openalex.org/I75390827', 'display_name': 'Beijing University of Chemical Technology', 'ror': 'https://ror.org/00df5yc52', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I75390827']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Deng', 'raw_affiliation_strings': ['Amoy-BUCT Industrial Bio-Technovation Institute, Amoy 361022, China', 'Beijing Bioprocess Key Laboratory, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Bioprocess Key Laboratory, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I75390827']}, {'raw_affiliation_string': 'Amoy-BUCT Industrial Bio-Technovation Institute, Amoy 361022, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065884752', 'display_name': 'Chun-Chih Huang', 'orcid': 'https://orcid.org/0000-0002-7461-4369'}, 'institutions': [{'id': 'https://openalex.org/I178613991', 'display_name': 'National Taitung University', 'ror': 'https://ror.org/05j9d8v51', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I178613991']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chun-Chih Huang', 'raw_affiliation_strings': ['Center for General Education, National Taitung University, Taitung, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Center for General Education, National Taitung University, Taitung, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I178613991']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089202859', 'display_name': 'Yew‐Min Tzeng', 'orcid': 'https://orcid.org/0000-0002-9360-2072'}, 'institutions': [{'id': 'https://openalex.org/I178613991', 'display_name': 'National Taitung University', 'ror': 'https://ror.org/05j9d8v51', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I178613991']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Yew-Min Tzeng', 'raw_affiliation_strings': ['Center for General Education, National Taitung University, Taitung, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Center for General Education, National Taitung University, Taitung, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I178613991']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006041425', 'display_name': 'Chi‐Tai Yeh', 'orcid': 'https://orcid.org/0000-0001-5189-9755'}, 'institutions': [{'id': 'https://openalex.org/I25251306', 'display_name': 'Yuanpei University', 'ror': 'https://ror.org/02jb3jv25', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I25251306']}, {'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Chi-Tai Yeh', 'raw_affiliation_strings': ['Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan, ROC', 'Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I25251306']}, {'raw_affiliation_string': 'Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City, 235, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I4210158385']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034223519', 'display_name': 'Jin‐Shuen Chen', 'orcid': 'https://orcid.org/0000-0002-8697-7968'}, 'institutions': [{'id': 'https://openalex.org/I4210152230', 'display_name': 'Kaohsiung Veterans General Hospital', 'ror': 'https://ror.org/04jedda80', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152230']}, {'id': 'https://openalex.org/I68171755', 'display_name': 'National Defense Medical Center', 'ror': 'https://ror.org/02bn97g32', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I68171755']}, {'id': 'https://openalex.org/I1293718874', 'display_name': 'Tri-Service General Hospital', 'ror': 'https://ror.org/007h4qe29', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1293718874']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Jin-Shuen Chen', 'raw_affiliation_strings': ['Administration Department and Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC', 'Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC'], 'affiliations': [{'raw_affiliation_string': 'Administration Department and Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I4210152230']}, {'raw_affiliation_string': 'Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC', 'institution_ids': ['https://openalex.org/I68171755', 'https://openalex.org/I1293718874']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 9, 'corresponding_author_ids': ['https://openalex.org/A5089202859', 'https://openalex.org/A5006041425', 'https://openalex.org/A5034223519'], 'corresponding_institution_ids': ['https://openalex.org/I178613991', 'https://openalex.org/I25251306', 'https://openalex.org/I4210158385', 'https://openalex.org/I4210152230', 'https://openalex.org/I68171755', 'https://openalex.org/I1293718874'], 'apc_list': {'value': 3390, 'currency': 'USD', 'value_usd': 3390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.746, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.999962, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '100', 'issue': None, 'first_page': '154062', 'last_page': '154062'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic Cancer Research and Treatment', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic Cancer Research and Treatment', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12110', 'display_name': 'Role of Osteopontin in Biomineralization and Inflammation', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/metastatic-pancreatic-cancer', 'display_name': 'Metastatic Pancreatic Cancer', 'score': 0.55953}, {'id': 'https://openalex.org/keywords/cancer-progression', 'display_name': 'Cancer Progression', 'score': 0.515001}, {'id': 'https://openalex.org/keywords/pancreatic-cancer', 'display_name': 'Pancreatic Cancer', 'score': 0.513783}], 'concepts': [{'id': 'https://openalex.org/C2780210213', 'wikidata': 'https://www.wikidata.org/wiki/Q212961', 'display_name': 'Pancreatic cancer', 'level': 3, 'score': 0.8278326}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7410592}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.6954425}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.6782887}, {'id': 'https://openalex.org/C56219504', 'wikidata': 'https://www.wikidata.org/wiki/Q7900869', 'display_name': 'Urokinase receptor', 'level': 3, 'score': 0.5980179}, {'id': 'https://openalex.org/C2781071845', 'wikidata': 'https://www.wikidata.org/wiki/Q21173374', 'display_name': 'Plasmin', 'level': 3, 'score': 0.59114456}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.5490851}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.48317328}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44177485}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4200705}, {'id': 'https://openalex.org/C2779679481', 'wikidata': 'https://www.wikidata.org/wiki/Q13581432', 'display_name': 'Plasminogen activator', 'level': 2, 'score': 0.39388672}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36012197}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3441668}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32032925}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.27544117}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005341', 'descriptor_name': 'Fibrinolysin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005341', 'descriptor_name': 'Fibrinolysin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053511', 'descriptor_name': 'Matrix Metalloproteinase 14', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D053511', 'descriptor_name': 'Matrix Metalloproteinase 14', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014451', 'descriptor_name': 'Ubiquinone', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D014451', 'descriptor_name': 'Ubiquinone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2022.154062', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35366491', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.51, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1078787812', 'https://openalex.org/W1969071401', 'https://openalex.org/W2000241906', 'https://openalex.org/W2011816149', 'https://openalex.org/W2021808705', 'https://openalex.org/W2091811255', 'https://openalex.org/W2106505027', 'https://openalex.org/W2126117802', 'https://openalex.org/W2133968430', 'https://openalex.org/W2149411663', 'https://openalex.org/W2158089750', 'https://openalex.org/W2298494136', 'https://openalex.org/W2325967130', 'https://openalex.org/W2508123382', 'https://openalex.org/W2554987853', 'https://openalex.org/W2586630468', 'https://openalex.org/W2607413117', 'https://openalex.org/W2774807260', 'https://openalex.org/W2791482536', 'https://openalex.org/W2805163386', 'https://openalex.org/W2884985642', 'https://openalex.org/W2906315792', 'https://openalex.org/W2917161013', 'https://openalex.org/W2940057770', 'https://openalex.org/W2979189134', 'https://openalex.org/W2985049724', 'https://openalex.org/W3136346673', 'https://openalex.org/W3180345462'], 'related_works': ['https://openalex.org/W2409713745', 'https://openalex.org/W2365805995', 'https://openalex.org/W2355221664', 'https://openalex.org/W2348383661', 'https://openalex.org/W2158665528', 'https://openalex.org/W2014249782', 'https://openalex.org/W1995841674', 'https://openalex.org/W1984395407', 'https://openalex.org/W1866400601', 'https://openalex.org/W1008965720'], 'abstract_inverted_index': {'The': [0, 18], 'current': [1], 'standard': [2], 'therapy': [3], 'for': [4, 15, 255], 'metastatic': [5], 'pancreatic': [6, 38, 48, 64, 82, 94, 113, 200, 243, 259], 'cancer': [7, 31, 39, 49, 83, 244], 'is': [8, 22, 235], 'ineffective,': [9], 'necessitating': [10], 'a': [11, 23, 86, 127, 251], 'new': [12, 252], 'treatment': [13, 174, 203], 'approach': [14, 53, 88, 254], 'prognosis': [16], 'improvement.': [17], 'urokinase-plasmin': [19], 'activator': [20], '(uPA)': [21], 'critical': [24], 'factor': [25, 139], 'in': [26, 37, 46, 63, 81, 93, 112, 119], 'epithelial-mesenchymal': [27], 'transition': [28], '(EMT)': [29], 'and': [30, 69, 79, 84, 109, 134, 136, 152, 167, 177, 181, 208, 214, 228, 240, 246, 248], 'metastasis,': [32], 'but': [33], 'its': [34], 'underlying': [35], 'mechanisms': [36], 'remains': [40], 'elusive.': [41], 'We': [42, 66, 96], 'investigated': [43], 'uPA': [44, 62, 76, 92, 100, 115, 131, 146, 213], 'expression': [45, 102, 133], 'our': [47, 226], 'cohort.': [50], 'A': [51], 'bioinformatics': [52], 'was': [54, 103, 116], 'used': [55], 'to': [56, 73, 156, 223], 'further': [57], 'determine': [58], 'the': [59, 157, 186, 194, 216, 219], 'role': [60], 'of': [61, 159, 191, 198, 218, 225], 'cancer.': [65, 95, 114, 260], 'employed': [67], 'MiaPaCa-2': [68, 176], 'PANC-1': [70, 160, 178], 'cell': [71, 168, 179], 'lines': [72], 'investigate': [74], 'how': [75], 'regulates': [77], 'EMT': [78, 135, 162, 245], 'metastasis': [80, 209, 247], 'present': [85], 'novel': [87], 'aimed': [89], 'at': [90], 'inhibiting': [91, 185], 'observed': [97], 'that': [98, 233], 'higher': [99], 'mRNA': [101, 132], 'significantly': [104], 'associated': [105], 'with': [106, 257], 'overall-poor': [107], 'survival': [108, 111, 217], 'progression-free': [110], 'highly': [117], 'expressed': [118], 'tumor': [120, 206], 'tissue.': [121], 'Gene': [122], 'set': [123], 'enrichment': [124], 'analysis': [125], 'revealed': [126], 'positive': [128], 'association': [129], 'between': [130], 'transforming': [137], 'growth': [138, 207], 'β': [140], '(TGF-β)': [141], 'signaling': [142], 'pathways.': [143], 'Moreover,': [144], 'shRNA-mediated': [145], 'gene': [147], 'knockdown': [148], 'reduced': [149, 205], 'plasmin,': [150], 'MMP14,': [151], 'TGF-β': [153], 'activation,': [154], 'leading': [155], 'inhibition': [158], "cells'": [161], 'marker': [163], 'expression,': [164], 'migration,': [165], 'invasion,': [166], 'viability.': [169], 'Notably,': [170], '4-acetyl-antroquinonol': [171], 'B': [172], '(4-AAQB)': [173], 'suppressed': [175], 'migratory': [180], 'invasive': [182], 'abilities': [183], 'by': [184, 211], 'uPA/MMP14/TGF-β': [187], 'axis': [188], 'through': [189], 'upregulation': [190], 'miR-181d-5p.': [192], 'In': [193], 'xenograft': [195], 'mouse': [196], 'model': [197], 'orthotropic': [199], 'cancer,': [201], '4-AAQB': [202, 234], 'has': [204], 'rate': [210], 'deactivating': [212], 'improving': [215], 'mice': [220], 'model.': [221], 'Accordingly,': [222], 'extent': [224], 'knowledge': [227], 'previous': [229], 'studies,': [230], 'we': [231], 'demonstrated': [232], 'an': [236], 'anti': [237], 'Pan-Cancer': [238], 'drug,': [239], 'may': [241], 'inhibit': [242], 'serve': [249], 'as': [250], 'therapeutic': [253], 'patients': [256], 'late-stage': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220845808', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-08-22T00:53:01.047608', 'created_date': '2022-04-03'}