Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4220820431', 'doi': 'https://doi.org/10.3389/fphys.2022.830925', 'title': 'A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling', 'display_name': 'A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling', 'publication_year': 2022, 'publication_date': '2022-02-28', 'ids': {'openalex': 'https://openalex.org/W4220820431', 'doi': 'https://doi.org/10.3389/fphys.2022.830925', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35295571'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphys.2022.830925', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphys.2022.830925/pdf', 'source': {'id': 'https://openalex.org/S52732750', 'display_name': 'Frontiers in Physiology', 'issn_l': '1664-042X', 'issn': ['1664-042X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fphys.2022.830925/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043585154', 'display_name': 'Anneloes G. Munneke', 'orcid': 'https://orcid.org/0000-0001-8934-2370'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Anneloes G. Munneke', 'raw_affiliation_strings': ['Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034213745', 'display_name': 'Joost Lumens', 'orcid': 'https://orcid.org/0000-0001-8129-7384'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Joost Lumens', 'raw_affiliation_strings': ['Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019378102', 'display_name': 'Theo Arts', 'orcid': 'https://orcid.org/0000-0003-0223-8496'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Theo Arts', 'raw_affiliation_strings': ['Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080175953', 'display_name': 'Tammo Delhaas', 'orcid': 'https://orcid.org/0000-0001-6897-9700'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tammo Delhaas', 'raw_affiliation_strings': ['Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands', 'institution_ids': ['https://openalex.org/I34352273']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5043585154'], 'corresponding_institution_ids': ['https://openalex.org/I34352273'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 1.347, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.999944, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 85, 'max': 87}, 'biblio': {'volume': '13', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10372', 'display_name': 'Cardiac Imaging and Diagnostics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10372', 'display_name': 'Cardiac Imaging and Diagnostics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10821', 'display_name': 'Cardiovascular Function and Risk Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10193', 'display_name': 'Coronary Interventions and Diagnostics', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/coronary-arteries', 'display_name': 'Coronary arteries', 'score': 0.5619575}, {'id': 'https://openalex.org/keywords/coronary-circulation', 'display_name': 'Coronary circulation', 'score': 0.5476552}, {'id': 'https://openalex.org/keywords/aortic-pressure', 'display_name': 'Aortic pressure', 'score': 0.418207}], 'concepts': [{'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.64989877}, {'id': 'https://openalex.org/C178853913', 'wikidata': 'https://www.wikidata.org/wiki/Q1642137', 'display_name': 'Hemodynamics', 'level': 2, 'score': 0.56423706}, {'id': 'https://openalex.org/C2778742706', 'wikidata': 'https://www.wikidata.org/wiki/Q18361829', 'display_name': 'Coronary arteries', 'level': 3, 'score': 0.5619575}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5610866}, {'id': 'https://openalex.org/C2776157398', 'wikidata': 'https://www.wikidata.org/wiki/Q497232', 'display_name': 'Coronary circulation', 'level': 3, 'score': 0.5476552}, {'id': 'https://openalex.org/C158846371', 'wikidata': 'https://www.wikidata.org/wiki/Q1642137', 'display_name': 'Blood flow', 'level': 2, 'score': 0.5325716}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.50362533}, {'id': 'https://openalex.org/C21141959', 'wikidata': 'https://www.wikidata.org/wiki/Q657936', 'display_name': 'Shear stress', 'level': 2, 'score': 0.4711118}, {'id': 'https://openalex.org/C57879066', 'wikidata': 'https://www.wikidata.org/wiki/Q41217', 'display_name': 'Mechanics', 'level': 1, 'score': 0.46650925}, {'id': 'https://openalex.org/C2780714102', 'wikidata': 'https://www.wikidata.org/wiki/Q616071', 'display_name': 'Aortic valve', 'level': 2, 'score': 0.4481095}, {'id': 'https://openalex.org/C2780007028', 'wikidata': 'https://www.wikidata.org/wiki/Q2343082', 'display_name': 'Stenosis', 'level': 2, 'score': 0.43608117}, {'id': 'https://openalex.org/C39124391', 'wikidata': 'https://www.wikidata.org/wiki/Q4778759', 'display_name': 'Aortic pressure', 'level': 3, 'score': 0.418207}, {'id': 'https://openalex.org/C2776820930', 'wikidata': 'https://www.wikidata.org/wiki/Q9655', 'display_name': 'Artery', 'level': 2, 'score': 0.24105698}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.20870829}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphys.2022.830925', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphys.2022.830925/pdf', 'source': {'id': 'https://openalex.org/S52732750', 'display_name': 'Frontiers in Physiology', 'issn_l': '1664-042X', 'issn': ['1664-042X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/1df112dc6a004d8490ad3580a6a0649b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919076', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35295571', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphys.2022.830925', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphys.2022.830925/pdf', 'source': {'id': 'https://openalex.org/S52732750', 'display_name': 'Frontiers in Physiology', 'issn_l': '1664-042X', 'issn': ['1664-042X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.63}], 'grants': [{'funder': 'https://openalex.org/F4320321642', 'funder_display_name': 'Hartstichting', 'award_id': '2015T082'}, {'funder': 'https://openalex.org/F4320321800', 'funder_display_name': 'Nederlandse Organisatie voor Wetenschappelijk Onderzoek', 'award_id': '016.176.340'}], 'datasets': [], 'versions': [], 'referenced_works_count': 93, 'referenced_works': ['https://openalex.org/W1581381064', 'https://openalex.org/W1781725885', 'https://openalex.org/W1791990521', 'https://openalex.org/W196068948', 'https://openalex.org/W1966484956', 'https://openalex.org/W1970840945', 'https://openalex.org/W1972929158', 'https://openalex.org/W1976999901', 'https://openalex.org/W1979141199', 'https://openalex.org/W1979613575', 'https://openalex.org/W1990069033', 'https://openalex.org/W2002207030', 'https://openalex.org/W2004407918', 'https://openalex.org/W2011469267', 'https://openalex.org/W2012988381', 'https://openalex.org/W2015060736', 'https://openalex.org/W2017138224', 'https://openalex.org/W2020221647', 'https://openalex.org/W2021735829', 'https://openalex.org/W2027048415', 'https://openalex.org/W2027184282', 'https://openalex.org/W2028339130', 'https://openalex.org/W2029397647', 'https://openalex.org/W2032117584', 'https://openalex.org/W2032767423', 'https://openalex.org/W2033261826', 'https://openalex.org/W2033600563', 'https://openalex.org/W2034476147', 'https://openalex.org/W2039073962', 'https://openalex.org/W2039281749', 'https://openalex.org/W2039285874', 'https://openalex.org/W2043729055', 'https://openalex.org/W2053162899', 'https://openalex.org/W2053863063', 'https://openalex.org/W2055656223', 'https://openalex.org/W2056210683', 'https://openalex.org/W2060720384', 'https://openalex.org/W2074687333', 'https://openalex.org/W2074865775', 'https://openalex.org/W2078333035', 'https://openalex.org/W2096667993', 'https://openalex.org/W2096864230', 'https://openalex.org/W2096886420', 'https://openalex.org/W2096917705', 'https://openalex.org/W2104005850', 'https://openalex.org/W2106490434', 'https://openalex.org/W2110923087', 'https://openalex.org/W2125233552', 'https://openalex.org/W2128070479', 'https://openalex.org/W2130598429', 'https://openalex.org/W2130883549', 'https://openalex.org/W2131805750', 'https://openalex.org/W2132401137', 'https://openalex.org/W2133130833', 'https://openalex.org/W2134429729', 'https://openalex.org/W2134688511', 'https://openalex.org/W2136827139', 'https://openalex.org/W2138634698', 'https://openalex.org/W2143456954', 'https://openalex.org/W2143803845', 'https://openalex.org/W2145950740', 'https://openalex.org/W2146495334', 'https://openalex.org/W2147311248', 'https://openalex.org/W2147953800', 'https://openalex.org/W2148232499', 'https://openalex.org/W2148749723', 'https://openalex.org/W2153739290', 'https://openalex.org/W2154417113', 'https://openalex.org/W2155579919', 'https://openalex.org/W2165479769', 'https://openalex.org/W2168208849', 'https://openalex.org/W2169753629', 'https://openalex.org/W2171795111', 'https://openalex.org/W2208686036', 'https://openalex.org/W2226955764', 'https://openalex.org/W2321796526', 'https://openalex.org/W2337288809', 'https://openalex.org/W2346274213', 'https://openalex.org/W2409850213', 'https://openalex.org/W2411358621', 'https://openalex.org/W2444574684', 'https://openalex.org/W2519867706', 'https://openalex.org/W2810837128', 'https://openalex.org/W2937881404', 'https://openalex.org/W2949202674', 'https://openalex.org/W2957010928', 'https://openalex.org/W2958604052', 'https://openalex.org/W2971384420', 'https://openalex.org/W3008695490', 'https://openalex.org/W3049654482', 'https://openalex.org/W3109703284', 'https://openalex.org/W3114529349', 'https://openalex.org/W4402744808'], 'related_works': ['https://openalex.org/W3210069968', 'https://openalex.org/W3186365864', 'https://openalex.org/W3018059578', 'https://openalex.org/W2992584400', 'https://openalex.org/W2756057606', 'https://openalex.org/W234727149', 'https://openalex.org/W2253906518', 'https://openalex.org/W2227573863', 'https://openalex.org/W2076797183', 'https://openalex.org/W1967179032'], 'abstract_inverted_index': {'The': [0, 75, 173], 'mechanisms': [1], 'by': [2], 'which': [3], 'cardiac': [4], 'mechanics': [5, 58, 131, 229], 'effect': [6, 252], 'coronary': [7, 15, 25, 57, 76, 182, 192, 228, 259], 'perfusion': [8], '(cardiac-to-coronary': [9], 'coupling)': [10], 'remain': [11], 'incompletely': [12], 'understood.': [13], 'Several': [14], 'models': [16], 'have': [17], 'been': [18], 'proposed': [19], 'to': [20, 110], 'deepen': [21], 'our': [22], 'understanding': [23], 'of': [24, 56, 70, 79, 85, 114, 138, 146, 160, 169, 181, 227, 245, 250, 253], 'hemodynamics,': [26], 'but': [27], 'possibilities': [28], 'for': [29, 103, 242], 'in-depth': [30, 243], 'studies': [31, 244], 'on': [32, 128, 258], 'cardiac-to-coronary': [33, 246], 'coupling': [34], 'are': [35, 45], 'limited': [36], 'as': [37, 92, 94, 122, 124, 143, 145, 238], 'mechanical': [38], 'properties': [39, 257], 'like': [40], 'myocardial': [41, 120, 125, 255], 'stress': [42], 'and': [43, 59, 90, 132, 149, 153, 188, 194, 230], 'strain': [44], 'most': [46], 'often': [47], 'neglected.': [48], 'To': [49], 'overcome': [50], 'this': [51], 'limitation,': [52], 'a': [53, 80, 95, 166, 218, 239], 'mathematical': [54], 'model': [55, 69, 77, 98, 162], 'hemodynamics': [60], 'was': [61, 108, 163, 206], 'implemented': [62], 'in': [63, 165, 191, 202, 207, 212], 'the': [64, 71, 86, 104, 119, 161, 178, 251], 'previously': [65], 'published': [66], 'multi-scale': [67, 220], 'CircAdapt': [68], 'closed-loop': [72], 'cardiovascular': [73], 'system.': [74], 'consisted': [78], 'relatively': [81], 'simple': [82], 'one-dimensional': [83], 'network': [84], 'major': [87], 'conduit': [88], 'arteries': [89], 'veins': [91], 'well': [93, 123, 144], 'lumped': [96], 'parameter': [97], 'with': [99, 156, 209], 'three': [100], 'transmural': [101], 'layers': [102], 'microcirculation.': [105], 'Intramyocardial': [106], 'pressure': [107, 117], 'assumed': [109], 'arise': [111], 'from': [112], 'transmission': [113], 'ventricular': [115], 'cavity': [116], 'into': [118], 'wall': [121], 'stiffness,': [126], 'based': [127], 'global': [129, 139], 'pump': [130], 'local': [133], 'myofiber': [134], 'mechanics.': [135], 'Model-predicted': [136], 'waveforms': [137], 'epicardial': [140], 'flow': [141, 148, 183, 186, 193, 198], 'velocity,': [142, 184], 'intramyocardial': [147, 189], 'diameter': [150], 'were': [151], 'qualitatively': [152], 'quantitatively': [154], 'compared': [155], 'reported': [157], 'data.': [158], 'Versatility': [159], 'demonstrated': [164], 'case': [167], 'study': [168, 249], 'aortic': [170, 203], 'valve': [171, 204], 'stenosis.': [172], 'reference': [174], 'simulation': [175, 226], 'correctly': [176], 'described': [177], 'phasic': [179], 'pattern': [180], 'arterial': [185], 'impediment,': [187], 'differences': [190], 'diameter.': [195], 'Predicted': [196], 'retrograde': [197], 'during': [199], 'early': [200], 'systole': [201], 'stenosis': [205], 'agreement': [208], 'measurements': [210], 'obtained': [211], 'patients.': [213], 'In': [214], 'conclusion,': [215], 'we': [216], 'presented': [217], 'powerful': [219], 'modeling': [221, 233], 'framework': [222, 234], 'that': [223], 'enables': [224], 'realistic': [225], 'hemodynamics.': [231, 260], 'This': [232], 'can': [235], 'be': [236], 'used': [237], 'research': [240], 'platform': [241], 'coupling,': [247], 'enabling': [248], 'abnormal': [254], 'tissue': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220820431', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-17T16:42:05.022987', 'created_date': '2022-04-03'}