Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance

Name: Work Video:
Duration: 3 min 30 s
Anton Safonov; Chai Bandlamudi; Paulino Tallón de Lara; Emanuela Ferraro; Fatemeh Derakhshan; Marie Will; Mark T.A. Donoghue; Pier Selenica; Joshua Z. Drago; Ezra Rosen; Carlos dos Anjos; Elaine M. Walsh; Elizabeth Comen; Mehnaj Ahmed; Barbara Acevedo; Ahmet Zehir; Michael F. Berger; David B. Solit; Larry Norton; Ronglai Shen; Zsofia K. Stadler; Simon N. Powell; Jorge S. Reis‐Filho; Sarat Chandarlapaty; Mark E. Robson; Pedram Razavi
{'id': 'https://openalex.org/W4220775266', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs21-gs4-08', 'title': 'Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance', 'display_name': 'Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance', 'publication_year': 2022, 'publication_date': '2022-02-15', 'ids': {'openalex': 'https://openalex.org/W4220775266', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs21-gs4-08'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs21-gs4-08', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032548225', 'display_name': 'Anton Safonov', 'orcid': 'https://orcid.org/0000-0002-4100-8071'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anton Safonov', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031608201', 'display_name': 'Chai Bandlamudi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chai Bandlamudi', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051314981', 'display_name': 'Paulino Tallón de Lara', 'orcid': 'https://orcid.org/0000-0001-7368-4798'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paulino Tallón de Lara', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057465756', 'display_name': 'Emanuela Ferraro', 'orcid': 'https://orcid.org/0000-0001-5863-2391'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Emanuela Ferraro', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039203448', 'display_name': 'Fatemeh Derakhshan', 'orcid': 'https://orcid.org/0000-0002-1346-589X'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fatemeh Derakhshan', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068141849', 'display_name': 'Marie Will', 'orcid': 'https://orcid.org/0000-0002-8819-537X'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marie Will', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037377971', 'display_name': 'Mark T.A. Donoghue', 'orcid': 'https://orcid.org/0000-0003-4538-6069'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Donoghue', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014140313', 'display_name': 'Pier Selenica', 'orcid': 'https://orcid.org/0000-0003-0086-0513'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pier Selenica', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012686198', 'display_name': 'Joshua Z. Drago', 'orcid': 'https://orcid.org/0000-0002-7245-1172'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joshua Drago', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079802645', 'display_name': 'Ezra Rosen', 'orcid': 'https://orcid.org/0000-0002-5289-1541'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ezra Rosen', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073342939', 'display_name': 'Carlos dos Anjos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carlos dos Anjos', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083737662', 'display_name': 'Elaine M. Walsh', 'orcid': 'https://orcid.org/0000-0002-9950-5978'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elaine Walsh', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009038938', 'display_name': 'Elizabeth Comen', 'orcid': 'https://orcid.org/0000-0002-9179-0399'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth A Comen', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109010964', 'display_name': 'Mehnaj Ahmed', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mehnaj Ahmed', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086821458', 'display_name': 'Barbara Acevedo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara Acevedo', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013778834', 'display_name': 'Ahmet Zehir', 'orcid': 'https://orcid.org/0000-0001-5406-4104'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ahmet Zehir', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037092952', 'display_name': 'Michael F. Berger', 'orcid': 'https://orcid.org/0000-0003-3882-5000'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael F Berger', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102710156', 'display_name': 'David B. Solit', 'orcid': 'https://orcid.org/0000-0002-6614-802X'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Solit', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039225060', 'display_name': 'Larry Norton', 'orcid': 'https://orcid.org/0000-0003-3701-9250'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Larry Norton', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055884560', 'display_name': 'Ronglai Shen', 'orcid': 'https://orcid.org/0000-0001-9694-584X'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronglai Shen', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074087271', 'display_name': 'Zsofia K. Stadler', 'orcid': 'https://orcid.org/0000-0002-6985-2864'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zsofia Stadler', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056895130', 'display_name': 'Simon N. Powell', 'orcid': 'https://orcid.org/0000-0002-8183-4765'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Simon Powell', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077235697', 'display_name': 'Jorge S. Reis‐Filho', 'orcid': 'https://orcid.org/0000-0003-2969-3173'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jorge S Reis-Filho', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041961484', 'display_name': 'Sarat Chandarlapaty', 'orcid': 'https://orcid.org/0000-0003-4532-8053'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarat Chandarlapaty', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045514288', 'display_name': 'Mark E. Robson', 'orcid': 'https://orcid.org/0000-0002-3109-1692'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Robson', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029733167', 'display_name': 'Pedram Razavi', 'orcid': 'https://orcid.org/0000-0003-4236-0576'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pedram Razavi', 'raw_affiliation_strings': ['Memorial Sloan Kettering Cancer Center, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Memorial Sloan Kettering Cancer Center, New York, NY', 'institution_ids': ['https://openalex.org/I1334819555']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.34, 'has_fulltext': False, 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.999942, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '82', 'issue': '4_Supplement', 'first_page': 'GS4', 'last_page': '08'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10769', 'display_name': 'BRCA gene mutations in cancer', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10769', 'display_name': 'BRCA gene mutations in cancer', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9664, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 0.9485, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.8803812}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.6300078}, {'id': 'https://openalex.org/C13514818', 'wikidata': 'https://www.wikidata.org/wiki/Q5552256', 'display_name': 'Germline mutation', 'level': 4, 'score': 0.6111796}, {'id': 'https://openalex.org/C143589142', 'wikidata': 'https://www.wikidata.org/wiki/Q2617554', 'display_name': 'Loss of heterozygosity', 'level': 4, 'score': 0.60911506}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.54410625}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48966935}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45829874}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4273638}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.42729008}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4213258}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.36098212}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.326127}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.32553774}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.20591462}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15995452}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs21-gs4-08', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4380367488', 'https://openalex.org/W3110326965', 'https://openalex.org/W2801856468', 'https://openalex.org/W2792795442', 'https://openalex.org/W2044081309', 'https://openalex.org/W2012364379', 'https://openalex.org/W1999800876', 'https://openalex.org/W1995692004', 'https://openalex.org/W1970798969', 'https://openalex.org/W1906082248'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Germline': [2], 'genetic': [3], 'alterations': [4, 81, 85, 328, 393], 'are': [5, 24, 69], 'established': [6, 136, 259], 'mediators': [7], 'of': [8, 17, 26, 32, 39, 77, 79, 158, 171, 200, 265, 281, 288, 312, 317, 417, 426, 432, 461, 469, 476, 487, 501, 515, 520, 558, 629, 643], 'breast': [9, 528, 632], 'carcinogenesis,': [10], 'often': [11], 'giving': [12], 'rise': [13], 'to': [14, 45, 109, 135, 140, 153, 168, 196, 345, 471, 478, 495, 527, 540, 544], 'specific': [15, 37, 83], 'forms': [16], 'genomic': [18, 40, 151, 627], 'instability.': [19], 'BRCA1/2': [20], 'pathogenic': [21, 392], 'variants': [22, 183, 269, 406], '(PVs)': [23], 'emblematic': [25], 'this': [27, 292, 563], 'phenomenon': [28], 'through': [29], 'their': [30, 55], 'induction': [31], 'homologous': [33], 'recombination': [34], 'deficiency.': [35], 'While': [36], 'patterns': [38, 76], 'instability': [41], 'may': [42], 'sensitize': [43], 'cancers': [44], 'therapies': [46, 59], 'such': [47, 60, 261], 'as': [48, 61, 262, 465], 'PARP': [49], 'inhibitors': [50, 67], '(PARPi)': [51], 'or': [52, 65], 'platinum': [53], 'chemotherapy,': [54], 'implications': [56, 550], 'for': [57, 142, 299, 509, 551], 'lineage-directed': [58], 'endocrine': [62], 'therapy': [63, 555, 638], '(ET)': [64], 'CDK4/6': [66], '(CDK4/6i)': [68], 'unknown.': [70], 'Herein,': [71], 'we': [72, 422, 483, 536], 'systematically': [73], 'investigated': [74, 423], 'the': [75, 88, 146, 155, 198, 313, 414, 424, 459, 474, 492, 644], 'association': [78, 199, 386], 'germline': [80, 98, 115, 143, 161, 185, 207, 223, 231], 'with': [82, 205, 222, 327, 404, 440, 455, 548, 631], 'somatic': [84, 159, 182, 225, 390, 462], 'and': [86, 99, 112, 160, 164, 177, 184, 188, 209, 224, 267, 368, 389, 489, 531, 556], 'explored': [87], 'resulting': [89], 'effect': [90, 425], 'on': [91, 145, 429, 451, 480], 'clinical': [92, 430], 'outcomes.': [93], 'Methods:': [94], 'Patients': [95], 'who': [96], 'underwent': [97], 'matched': [100], 'tumor': [101], 'tissue': [102], 'sequencing': [103, 226, 557], 'utilizing': [104], 'MSK-IMPACT': [105], 'from': [106, 130, 219], 'April': [107], '2014': [108], 'May': [110], '2021': [111, 645, 651], 'had': [113, 513], 'available': [114], 'analysis': [116, 122, 144, 215, 382], 'results': [117], 'were': [118, 194, 283, 351, 437], 'included.': [119], 'The': [120, 213, 228, 254, 310], 'final': [121], 'presented': [123], 'at': [124], 'SABCS': [125], 'will': [126], 'include': [127], '6000': [128], 'tumors': [129, 218, 507], '5,150': [131], 'patients,': [132], 'anonymized': [133], 'according': [134], 'institutional': [137], 'IRB': [138], 'guidelines': [139], 'allow': [141], 'full': [147, 156], 'cohort.': [148], 'We': [149, 174, 457], 'analyzed': [150], 'data': [152], 'inform': [154], 'spectrum': [157], 'mutations,': [162], 'ploidy,': [163], 'allele-specific': [165, 510], 'copy': [166, 511], 'number': [167, 512], 'determine': [169], 'loss': [170, 324, 464, 497], 'heterozygosity': [172], '(LOH).': [173], 'performed': [175], 'gene-': [176], 'pathway-level': [178], 'enrichment': [179, 460], 'analyses': [180], 'between': [181, 387], 'PVs.': [186], 'Univariable': [187], 'multivariable': [189], 'Cox': [190], 'proportional': [191], 'hazards': [192], 'models': [193], 'constructed': [195], 'assess': [197], 'therapy-specific': [201], 'progression-free': [202], 'survival': [203], '(PFS)': [204], 'select': [206], 'PVs': [208, 232, 370, 436], 'germline-somatic': [210, 521, 635], 'interactions.': [211], 'Results:': [212], 'preliminary': [214], 'includes': [216], '2,798': [217], '2,242': [220], 'patients': [221, 630], 'results.': [227], 'most': [229, 405], 'frequent': [230], 'were:': [233], 'BRCA2': [234, 427, 479, 488, 538], '(n': [235, 239, 243, 247, 251], '=': [236, 240, 244, 248, 252, 278, 308, 341, 366, 379, 402], '81),': [237], 'BRCA1': [238], '67),': [241], 'CHEK2': [242], '57),': [245], 'ATM': [246], '32),': [249], 'PALB2': [250], '19).': [253], 'cohort': [255, 314], 'robustly': [256], 'confirmed': [257], 'previously': [258], 'relationships': [260], 'mutual': [263], 'exclusivity': [264], 'gATM': [266], 'TP53': [268, 282], '(OR': [270, 302, 333, 358, 371, 394], '0.10,': [271], '95%': [272, 304, 335, 360, 373, 396, 445], 'CI': [273, 305, 336, 361, 374, 397, 446], '0.032': [274], '-': [275, 338, 363, 376, 399], '0.33,': [276], 'q': [277, 307, 340, 365, 378, 401], '0.005).': [279], 'Alterations': [280], 'seen': [284], 'in': [285, 329, 355, 409, 419, 562], '83%': [286], '(56/67)': [287], 'gBRCA1': [289, 369], 'patients;': [290], 'however,': [291], 'did': [293], 'not': [294], 'achieve': [295], 'significance': [296], 'when': [297], 'adjusted': [298], 'receptor': [300], 'subtype': [301], '3.90,': [303], '1.34-11.38,': [306], '0.15).': [309], 'size': [311], 'allowed': [315], 'discovery': [316], 'several': [318], 'novel': [319, 524], 'relationships.': [320], 'For': [321], 'instance,': [322], 'gBRCA2': [323, 357, 388, 411, 435, 505], 'was': [325], 'associated': [326, 439], 'TGF-B': [330], 'pathway': [331], 'components': [332], '3.58,': [334, 395], '1.70': [337, 398], '7.56,': [339, 400], '0.002),': [342], 'potentially': [343], 'relevant': [344, 526], 'metastatic': [346, 410], 'disease': [347], 'progression.': [348], 'PIK3CA': [349], 'mutations': [350], 'significantly': [352, 438], 'less': [353], 'prevalent': [354], 'both': [356], '0.52,': [359], '0.31': [362], '0.87,': [364], '0.063)': [367], '0.21,': [372], '0.085': [375], '0.51,': [377], '0.014).': [380], 'Our': [381], 'uncovered': [383], 'a': [384, 466], 'strong': [385], 'RB1': [391, 418, 463, 477, 490, 516], '0.011),': [403], '(80%)': [407], 'encountered': [408], 'tumors.': [412], 'Given': [413, 473], 'essential': [415], 'role': [416], 'CDK4/6i': [420, 559], 'response,': [421], 'status': [428], 'efficacy': [431], 'CDK4/6i-ET.': [433, 456], 'Strikingly,': [434], 'inferior': [441, 542], 'PFS': [442], '(HR': [443], '2.17,': [444], '1.46-3.22,': [447], 'p': [448], '&amp;lt;': [449], '0.001)': [450], 'first': [452, 545, 553], 'line': [453, 546, 554], 'treatment': [454, 532], 'posited': [458], 'potential': [467, 549], 'mechanism': [468], 'resistance': [470, 639], 'CDK4/6i.': [472, 502], 'proximity': [475], 'chromosome': [481], '13,': [482], 'hypothesized': [484], 'that': [485], 'co-LOH': [486], 'predisposes': [491], 'cancer': [493, 529, 633], 'cells': [494], 'bi-allelic': [496], 'under': [498], 'therapeutic': [499], 'pressure': [500], 'Indeed,': [503], '18/26': [504], '(69.2%)': [506], 'evaluable': [508], 'evidence': [514], 'LOH.': [517], 'Discussion:': [518], 'Analysis': [519], 'interactions': [522, 636], 'yielded': [523], 'associations': [525], 'progression': [530], 'resistance.': [533], 'Among': [534], 'these,': [535], 'demonstrated': [537], 'carriers': [539], 'have': [541], 'outcomes': [543], 'CDK4/6i-ET': [547], 'optimal': [552], 'vs': [560], 'PARPi': [561], 'patient': [564], 'population.': [565], 'Citation': [566], 'Format:': [567], 'Anton': [568], 'Safonov,': [569], 'Chai': [570], 'Bandlamudi,': [571], 'Paulino': [572], 'Tallón': [573], 'de': [574], 'Lara,': [575], 'Emanuela': [576], 'Ferraro,': [577], 'Fatemeh': [578], 'Derakhshan,': [579], 'Marie': [580], 'Will,': [581], 'Mark': [582, 622], 'Donoghue,': [583], 'Pier': [584], 'Selenica,': [585], 'Joshua': [586], 'Drago,': [587], 'Ezra': [588], 'Rosen,': [589], 'Carlos': [590], 'dos': [591], 'Anjos,': [592], 'Elaine': [593], 'Walsh,': [594], 'Elizabeth': [595], 'A': [596], 'Comen,': [597], 'Mehnaj': [598], 'Ahmed,': [599], 'Barbara': [600], 'Acevedo,': [601], 'Ahmet': [602], 'Zehir,': [603], 'Michael': [604], 'F': [605], 'Berger,': [606], 'David': [607], 'Solit,': [608], 'Larry': [609], 'Norton,': [610], 'Ronglai': [611], 'Shen,': [612], 'Zsofia': [613], 'Stadler,': [614], 'Simon': [615], 'Powell,': [616], 'Jorge': [617], 'S': [618], 'Reis-Filho,': [619], 'Sarat': [620], 'Chandarlapaty,': [621], 'Robson,': [623], 'Pedram': [624], 'Razavi.': [625], 'Comprehensive': [626], 'profiling': [628], 'identifies': [634], 'mediating': [637], '[abstract].': [640], 'In:': [641], 'Proceedings': [642], 'San': [646, 654], 'Antonio': [647], 'Breast': [648], 'Cancer': [649, 660], 'Symposium;': [650], 'Dec': [652], '7-10;': [653], 'Antonio,': [655], 'TX.': [656], 'Philadelphia': [657], '(PA):': [658], 'AACR;': [659], 'Res': [661], '2022;82(4': [662], 'Suppl):Abstract': [663], 'nr': [664], 'GS4-08.': [665]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220775266', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 4}], 'updated_date': '2025-01-05T03:14:21.348890', 'created_date': '2022-04-03'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
