Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase–mediated inhibitory phosphorylation of the transcriptional coactivator YAP

Name: Work Video:
Duration: 3 min 30 s
Louise Thines; Laëtitia Gorisse; Zhigang Li; Samar Sayedyahossein; David B. Sacks
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3626, 3857], 'regulates': [4, 71, 252, 319, 753, 1226, 1351, 1587, 1697, 1818, 1886, 2222], 'tissue': [5, 178, 253, 426, 510, 825, 984, 3307, 3436, 3634, 3660], 'growth': [6, 179, 254, 427, 584, 826, 985, 1127, 1166, 2990, 3308, 3340, 3437, 3469, 3635, 3661, 3930], 'and': [7, 10, 70, 100, 115, 121, 147, 182, 192, 195, 224, 234, 244, 255, 258, 318, 348, 363, 369, 395, 430, 440, 443, 472, 482, 492, 509, 519, 530, 554, 585, 588, 612, 630, 639, 710, 722, 756, 824, 894, 897, 917, 921, 983, 1018, 1021, 1046, 1079, 1095, 1126, 1167, 1196, 1200, 1206, 1224, 1252, 1273, 1293, 1311, 1317, 1334, 1388, 1429, 1450, 1480, 1533, 1572, 1704, 1712, 1762, 1765, 1837, 1986, 1994, 2019, 2104, 2116, 2143, 2150, 2154, 2184, 2192, 2216, 2258, 2286, 2352, 2390, 2455, 2477, 2492, 2553, 2582, 2606, 2614, 2622, 2642, 2656, 2662, 2692, 2711, 2713, 2729, 2742, 2761, 2811, 2830, 2848, 2988, 3064, 3069, 3121, 3306, 3435, 3633, 3664, 3672, 3688, 3750, 3754, 3785, 3799, 3830, 3896, 3929, 3993, 4167, 4179, 4212, 4233, 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3473, 3514, 3554, 3562, 3623, 3709, 3752, 3772, 3820, 3860, 3948, 3975, 4057, 4069, 4092, 4136, 4177, 4218, 4247, 4266], 'cell–cell': [21, 269, 1744, 3254, 3563, 3821, 3862], 'contact,': [22, 270], 'extracellular': [23, 271, 1249], 'signals,': [24, 272, 1241], 'or': [25, 53, 273, 301, 1746, 2244, 2281, 2371, 2420, 2778, 3048, 3381, 3737, 3864, 4303], 'polarity': [27, 275], 'among': [28, 276], 'others,': [29, 277], 'the': [30, 41, 51, 65, 80, 133, 198, 220, 242, 278, 289, 299, 313, 328, 381, 446, 468, 490, 567, 618, 660, 690, 716, 761, 815, 901, 936, 974, 1025, 1051, 1072, 1160, 1258, 1302, 1328, 1514, 1528, 1650, 1663, 1678, 1693, 1731, 1754, 1760, 1793, 1813, 1832, 1955, 2014, 2043, 2053, 2080, 2087, 2093, 2096, 2145, 2162, 2167, 2173, 2176, 2194, 2197, 2210, 2246, 2277, 2298, 2311, 2317, 2327, 2335, 2358, 2384, 2415, 2434, 2449, 2473, 2483, 2585, 2590, 2628, 2668, 2687, 2716, 2776, 2779, 2786, 2794, 2804, 2842, 2911, 2943, 2984, 2994, 3000, 3099, 3146, 3180, 3201, 3218, 3297, 3371, 3426, 3516, 3548, 3579, 3624, 3649, 3683, 3778, 3856, 3878, 3894, 3945, 3959, 3967, 3973, 4002, 4013, 4061, 4097, 4133, 4201, 4226, 4253, 4279, 4287, 4301, 4304, 4319, 4335, 4348], 'large': [31, 279, 635, 692], 'tumor': [32, 193, 280, 441, 636, 693], 'suppressor': [33, 281, 637, 652, 694, 848, 2881], '1': [34, 282, 629, 638, 728, 2239], '(LATS1)': [35, 283], 'kinase': [36, 97, 222, 284, 345, 470, 610, 620, 687, 695, 1517, 1574, 1727, 2054, 3550, 4155, 4203, 4312, 4332, 4355], 'catalyzes': [37, 285], 'inhibitory': [38, 286], 'phosphorylation': [39, 287, 633, 714, 1193, 1221, 2859, 2992, 3078, 3157, 3187, 3202, 3500, 3544, 3570, 4164, 4176, 4209, 4261], 'of': [40, 67, 135, 172, 200, 210, 288, 315, 383, 420, 448, 458, 607, 634, 715, 764, 811, 854, 915, 970, 1085, 1162, 1194, 1257, 1286, 1301, 1314, 1319, 1327, 1355, 1360, 1396, 1400, 1464, 1527, 1585, 1589, 1681, 1774, 1831, 1884, 1888, 2013, 2042, 2084, 2095, 2113, 2164, 2175, 2212, 2241, 2245, 2251, 2267, 2279, 2297, 2300, 2314, 2319, 2329, 2337, 2360, 2386, 2388, 2417, 2436, 2442, 2485, 2527, 2546, 2580, 2592, 2604, 2611, 2670, 2781, 2788, 2844, 2860, 2887, 2942, 2993, 2997, 3034, 3053, 3124, 3151, 3169, 3198, 3203, 3220, 3250, 3293, 3373, 3422, 3509, 3518, 3571, 3584, 3620, 3651, 3653, 3686, 3748, 3780, 3797, 3827, 3847, 3882, 3953, 3961, 3969, 4063, 4099, 4160, 4215, 4239, 4262, 4292, 4306, 4321, 4337, 4341, 4345, 4360, 4362], 'transcriptional': [42, 290, 615, 717, 732, 1064, 1957, 2985], 'coactivator': [43, 291, 733, 1958], 'Yes-associated': [44, 292, 719], 'protein': [45, 62, 293, 310, 720, 727, 1390, 1516, 1815, 2252, 3002, 3054, 3186, 3190], '(YAP)': [46, 294, 721], 'to': [47, 119, 295, 367, 932, 1050, 1060, 1076, 1083, 1187, 1402, 1447, 1503, 1810, 1967, 1976, 2033, 2039, 2214, 2270, 2294, 2309, 2325, 2332, 2392, 2400, 2430, 2463, 2512, 2521, 2529, 2563, 2571, 2595, 2608, 2665, 2846, 2909, 3215, 3224, 3239, 3558, 3578, 3716, 3873, 3893, 3991, 4104, 4347, 4369], 'maintain': [48, 296], 'YAP': [49, 114, 146, 167, 201, 226, 297, 362, 394, 415, 449, 474, 812, 916, 971, 1045, 1078, 1195, 1227, 1703, 1996, 2028, 2075, 2103, 2117, 2149, 2153, 2183, 2215, 2268, 2292, 2370, 2389, 2397, 2409, 2427, 2460, 2476, 2581, 2605, 2613, 2621, 2655, 2661, 2730, 2760, 2810, 2847, 2861, 2987, 3029, 3077, 3156, 3171, 3204, 3294, 3423, 3499, 3543, 3572, 3621, 3871, 3890, 3962, 3992], 'in': [50, 79, 93, 127, 298, 327, 341, 375, 512, 528, 566, 711, 820, 935, 979, 1090, 1164, 1290, 1331, 1411, 1423, 1426, 1460, 1505, 1683, 1710, 1713, 2079, 2109, 2129, 2190, 2204, 2236, 2302, 2334, 2375, 2414, 2433, 2465, 2482, 2487, 2494, 2566, 2575, 2635, 2649, 2667, 2699, 2803, 2836, 3041, 3302, 3365, 3375, 3431, 3520, 3545, 3629, 3670, 3693, 3697, 3728, 3832, 3877, 3972, 4006, 4032, 4102, 4106, 4118, 4245, 4300, 4314, 4318, 4334], 'cytoplasm': [52, 300, 937], 'promote': [54, 302], 'degradation.': [56, 304, 3191], 'Separately,': [57, 305], 'calmodulin': [58, 106, 120, 162, 218, 306, 354, 368, 410, 466, 1391, 1454, 1682, 1696, 1708, 1735, 1768, 1952, 2025, 2036, 2069, 2108, 2115, 2138, 2158, 2189, 2213, 2271, 2333, 2361, 2432, 2464, 2478, 2530, 2565, 2615, 2643, 2666, 2693, 2798, 2831, 2845, 2857, 3090, 3103, 3125, 3199, 3221, 3510, 3537, 3719, 3764, 3813, 3844, 3950, 4073, 4083, 4138, 4145, 4294, 4327, 4346], 'a': [60, 123, 229, 308, 371, 477, 500, 608, 613, 851, 1346, 1352, 1408, 1461, 1506, 1757, 1770, 2009, 2126, 2202, 2466, 2495, 2567, 2632, 2646, 2695, 2833, 2884, 3118, 3236, 3559, 3793, 4115, 4263, 4271, 4315], 'Ca2+-dependent': [61, 124, 309, 372, 1507, 2467, 2696, 2834], 'that': [63, 105, 112, 144, 161, 188, 217, 311, 353, 360, 392, 409, 436, 465, 505, 1299, 1350, 1646, 1695, 1702, 1767, 1778, 1980, 2023, 2055, 2068, 2102, 2121, 2181, 2196, 2291, 2357, 2425, 2459, 2472, 2479, 2517, 2558, 2627, 2689, 2751, 2800, 2826, 3155, 3179, 3196, 3491, 3536, 3682, 3744, 3762, 3843, 4015, 4060, 4082, 4200, 4225, 4274, 4285], 'modulates': [64, 312, 1455, 1781, 2858, 3721, 3951, 4096, 4139], 'activity': [66, 134, 227, 314, 382, 475, 1057, 4098, 4238, 4297, 4313, 4333], 'target': [68, 175, 211, 316, 423, 459, 1087, 1427, 3586, 3657, 3853, 3883, 3955], 'proteins': [69, 317, 1367, 1417, 2123, 2199, 2630, 2717], 'several': [72, 320, 1365, 1509, 1819], 'cascades;': [74, 322], 'however,': [75, 323], 'potential': [77, 325, 3233], 'role': [78, 326, 1289, 1326, 3234, 4117], 'has': [83, 331, 1500, 4365], 'not': [84, 332, 1297, 1687, 2273, 2542, 2773, 3173, 4066, 4329, 4352], 'been': [85, 333, 1501, 1688], 'identified.': [86, 334], 'Here,': [87, 335, 3646], 'using': [88, 336, 3235, 4252, 4268], 'diverse': [89, 337, 1452], 'experimental': [90, 338], 'approaches,': [91, 339], 'including': [92, 340, 1242, 1309, 1467, 1513], 'vitro': [94, 342, 4246], 'binding': [95, 343, 1059, 1446, 1555, 1859, 2211, 2387, 2501, 2526, 2594, 2603, 2675, 2843, 3872], 'analyses,': [96, 344], 'assays,': [98, 346], 'RT–PCR,': [99, 347], 'confocal': [101, 349], 'microscopy,': [102, 350], 'we': [103, 142, 159, 351, 390, 407, 1691, 1948, 2046, 2135, 2218, 2402, 2651, 2706, 2748, 2854, 3026, 3097, 3230, 3489, 3647, 3957, 4142, 4206], 'reveal': [104, 352, 1766, 3842], 'promotes': [107, 355, 589, 891, 1015, 3765], 'signaling.': [109, 357, 1699, 1776, 2852], 'We': [110, 358, 1700, 2058, 2838, 3360, 3712, 3775, 3810, 3965, 4055, 4150], 'show': [111, 160, 359, 408, 2516], 'purified': [113, 361, 2507, 2654, 4152, 4202, 4216, 4240, 4293], 'LATS1': [116, 136, 148, 233, 364, 384, 396, 481, 653, 849, 1705, 1726, 2061, 2072, 2105, 2119, 2155, 2185, 2320, 2330, 2364, 2372, 2391, 2518, 2528, 2560, 2583, 2607, 2623, 2657, 2663, 2728, 2762, 2849, 2882, 4148, 4154, 4161, 4217, 4227, 4242, 4267, 4296, 4311, 4331, 4354], 'bind': [117, 365, 2664], 'directly': [118, 131, 366, 379, 1724, 2399, 2429, 2462, 2520, 2562, 4146], 'form': [122, 370, 2125, 2201, 2631, 2645, 2694, 2832], 'ternary': [125, 373, 2127, 2633, 2647, 2697], 'complex': [126, 374, 2128, 2203, 2496, 2634, 2648, 2698, 2808, 2835], 'vitro.': [128, 376, 1714, 2700, 2837], 'Importantly,': [129, 377, 1715, 2440, 2792, 4037, 4339], 'Ca2+/calmodulin': [130, 243, 378, 491, 1723, 1761, 2522], 'stimulated': [132, 380], 'kinase.': [137, 385, 4149], 'In': [138, 153, 386, 401, 617, 1038, 1185, 1721, 1729, 1965, 2031, 2323, 2746, 3213, 3980, 4325], 'cultured': [139, 387, 3699, 3727, 4031], 'mammalian': [140, 388, 626], 'cells,': [141, 389, 1730], 'demonstrated': [143, 391, 2067], 'endogenous': [145, 151, 393, 399, 1995, 2024, 2060, 2182, 2188, 2363, 3655, 3851], 'coimmunoprecipitate': [149, 397, 2156], 'with': [150, 155, 202, 232, 398, 403, 450, 480, 734, 927, 1415, 1707, 1954, 1982, 1999, 2027, 2051, 2071, 2090, 2107, 2118, 2157, 2170, 2187, 2256, 2321, 2347, 2362, 2378, 2412, 2497, 2506, 2548, 2587, 2616, 2624, 2658, 2682, 2718, 2809, 3138, 3387, 3511, 3700, 3733, 3898, 3963, 3988, 4012, 4041, 4221], 'calmodulin.': [152, 400, 2322, 2393, 2596], 'cells': [154, 402, 1711, 1973, 2191, 2233, 3038, 3058, 3073, 3081, 3135, 3377, 3492, 3521, 3546, 3695, 3698, 3726, 3802, 3833, 3985, 4023, 4030, 4039, 4051], 'signaling,': [158, 406, 4141], 'antagonism': [163, 411, 3720, 3814, 4074], 'significantly': [164, 412, 1738, 2274, 2532, 3159, 3174, 3691, 3794, 3824, 4067, 4309], '(i)': [165, 413], 'decreases': [166, 414], 'phosphorylation,': [168, 416], '(ii)': [169, 417], 'increases': [170, 418, 3746, 3825], 'expression': [171, 419, 1084, 3583, 3652, 3684, 3747, 3796, 3818, 3826, 3846, 3881, 3952], 'two': [173, 421, 3654, 3850, 4003], 'genes': [176, 424, 1088, 3587, 3854], '(connective': [177, 425], 'factor': [180, 428, 3662], '[CTGF]': [181, 429], 'cysteine-rich': [183, 431, 3665], 'angiogenic': [184, 432, 3666], 'inducer': [185, 433, 3667], '61': [186, 434, 3668], '[CYR61])': [187, 435], 'regulate': [189, 437, 1504], 'proliferation': [191, 439, 518, 587, 755, 893, 1017], 'progression,': [194, 442, 1470], '(iii)': [196, 444], 'enhances': [197, 445], 'interaction': [199, 231, 447, 479, 2359, 2451, 2474, 3960], 'major': [204, 452, 1073, 1510], 'transcription': [205, 209, 453, 457, 725, 1061, 1074, 1157, 3767, 3875], 'factor,': [206, 454], 'thereby': [207, 236, 455, 484, 1458], 'facilitating': [208, 456, 1413], 'genes.': [212, 460, 3884], 'Collectively,': [213, 461, 3192, 3839], 'our': [214, 462, 1750, 2099, 2514, 2599, 3023, 3366, 3533], 'data': [215, 463, 1751, 2100, 2179, 2355, 2515, 2556, 2600, 2685, 2784, 2824, 3194, 3389, 3534, 3841, 4080], 'demonstrate': [216, 464, 2557, 2601, 2825, 3535, 4081], 'activates': [219, 467, 689, 1625, 1924, 3259, 4018], 'cascade': [223, 471, 611, 3551], 'inhibits': [225, 473, 2056, 2983, 4181], 'via': [228, 476, 1364, 2991], 'direct': [230, 478, 2602], 'YAP,': [235, 483, 2326, 2513, 2640, 2690, 2709, 2828], 'uncovering': [237, 485], 'previously': [238, 486, 1771], 'unidentified': [239, 487], 'crosstalk': [240, 488], 'between': [241, 489, 1759, 2475, 4270], 'pathways.': [247, 495], 'highly': [501, 1386, 1732, 3100], 'conserved': [502, 1387], 'network': [504, 1304, 1652, 2914], 'governs': [506], 'organ': [507], 'size': [508, 2736], 'homeostasis': [511], 'higher-order': [513], 'vertebrates': [514], 'restricting': [516], 'promoting': [520], 'apoptosis': [521, 757, 1320], '(1Pan': [522], 'D.': [523, 646, 747], 'hippo': [525, 902, 1026, 1270], 'development': [529], 'cancer.Dev.': [531], 'Cell.': [532], '2010;': [533, 1232], '19:': [534], '491-505Abstract': [535], 'Full': [536, 538, 594, 596, 769, 771, 862, 864, 1175, 1177, 1375, 1377, 1435, 1437, 1562, 1564, 1600, 1602, 1633, 1635, 1866, 1868, 1899, 1901, 1932, 1934, 2895, 2897, 2953, 2955, 3350, 3352, 3479, 3481, 4188, 4190], 'Text': [537, 539, 595, 597, 770, 772, 863, 865, 1176, 1178, 1376, 1378, 1436, 1438, 1563, 1565, 1601, 1603, 1634, 1636, 1867, 1869, 1900, 1902, 1933, 1935, 2896, 2898, 2954, 2956, 3351, 3353, 3480, 3482, 4189, 4191], 'PDF': [540, 598, 773, 866, 1179, 1379, 1439, 1566, 1604, 1637, 1870, 1903, 1936, 2899, 2957, 3354, 3483, 4192], 'PubMed': [541, 559, 599, 668, 700, 774, 832, 867, 909, 991, 1033, 1133, 1180, 1235, 1280, 1341, 1380, 1440, 1494, 1539, 1567, 1605, 1638, 1673, 1803, 1843, 1871, 1904, 1937, 2900, 2958, 3013, 3314, 3355, 3443, 3484, 3641, 3936, 4124, 4193], 'Scopus': [542, 560, 600, 669, 701, 775, 833, 868, 910, 992, 1034, 1134, 1181, 1236, 1281, 1381, 1441, 1495, 1540, 1568, 1606, 1639, 1674, 1804, 1844, 1872, 1905, 1938, 2901, 2959, 3014, 3315, 3356, 3444, 3485, 3642, 3937, 4125, 4194], '(1614)': [543], 'Google': [544, 562, 602, 671, 703, 777, 835, 870, 912, 994, 1036, 1136, 1183, 1238, 1283, 1342, 1383, 1443, 1497, 1542, 1570, 1608, 1641, 1676, 1806, 1846, 1874, 1907, 1940, 2903, 2961, 3016, 3131, 3317, 3358, 3446, 3487, 3644, 3939, 4127, 4196], 'Scholar,': [545, 672, 778, 836, 871, 995, 1137, 1543, 1609, 1847, 1875, 1908, 2962, 3318, 3447], '2Halder': [546], 'G.': [547, 806, 965, 3288, 3417, 3615], 'Johnson': [548, 2965], 'R.L.': [549], 'signaling:': [551], 'Growth': [552], 'control': [553], 'beyond.Development.': [555], '2011;': [556], '138:': [557], '9-22Crossref': [558], '(756)': [561], 'Scholar).': [563, 704, 913, 1037, 1184, 1239, 1284, 1343, 1384, 1444, 1498, 1642, 2904, 3017, 3132, 3359, 3645, 3940, 4128, 4197], 'First': [564], 'identified': [565], 'fruit': [568], 'fly': [569], 'Drosophila': [570, 579], 'melanogaster': [571], '(3Harvey': [572], 'K.F.': [573], 'Pfleger': [574], 'C.M.': [575, 1580, 1879], 'Hariharan': [576], 'I.K.': [577], 'Mst': [580], 'ortholog,': [581], 'hippo,': [582], 'restricts': [583], 'apoptosis.Cell.': [590], '2003;': [591], '114:': [592], '457-467Abstract': [593], '(708)': [601], 'Scholar),': [603, 1677, 1941, 3488], 'this': [604, 2704, 3020, 3714, 3981], 'consists': [606], 'serine/threonine': [609], 'downstream': [614], 'module.': [616], 'core': [619], 'cascade,': [621], 'when': [622, 1040, 2343, 2678, 2814, 2866, 3206, 3547, 3768, 3855, 4001, 4088], 'activated,': [625], 'Ste20-like': [627, 686], 'kinases': [628, 642, 4101], '2': [631, 640], 'catalyze': [632, 713], '(LATS1/2)': [641], '(4Hergovich': [643], 'A.': [644, 680, 804, 840, 963, 2873, 2978, 3009, 3286, 3324, 3415, 3453, 3613], 'Schmitz': [645], 'Hemmings': [647], 'B.A.': [648], 'human': [650, 657, 691, 1332, 2228, 2407, 2508], 'tumour': [651], 'MOB1': [658], 'at': [659, 2733, 2753, 3244, 3256, 3379, 3493, 3503, 3522, 3789, 3803, 3834, 3848, 4165, 4210, 4230], 'membrane.Biochem.': [661], 'Biophys.': [662], 'Res.': [663], 'Commun.': [664], '2006;': [665], '345:': [666], '50-58Crossref': [667], '(132)': [670], '5Chan': [673], 'E.H.': [674], 'Nousiainen': [675], 'M.': [676, 1421, 3320, 3449, 4170], 'Chalamalasetty': [677], 'R.B.': [678, 1582, 1881], 'Schäfer': [679], 'Nigg': [681], 'E.A.': [682], 'Silljé': [683], 'H.H.': [684], 'Mst2': [688], 'Lats1.Oncogene.': [696], '2005;': [697, 766], '24:': [698, 1233], '2076-2086Crossref': [699], '(411)': [702], 'Once': [705], 'phosphorylated,': [706], 'LATS1/2': [707, 3001], 'become': [708], 'active': [709, 4153, 4241], 'turn': [712], 'coactivators': [718], 'WW': [723], 'domain–containing': [724], 'regulator': [726, 853, 1773, 2886], '(also': [729], 'known': [730, 2908], 'as': [731, 2008, 2618, 2620, 3031, 3680, 3808], 'PDZ-binding': [735], 'motif': [736], '[TAZ])': [737], '(6Huang': [738], 'J.': [739, 743, 790, 792, 796, 949, 951, 955, 1102, 1110, 1147, 2928, 3109, 3272, 3274, 3278, 3401, 3403, 3407, 3599, 3601, 3605, 3905, 3913, 4174], 'Wu': [740], 'S.': [741, 885, 1009, 1108, 1149, 1262, 1545, 1615, 1849, 1914, 3008, 3326, 3332, 3334, 3455, 3461, 3463, 3911], 'Barrera': [742], 'Matthews': [744], 'K.': [745, 802, 842, 961, 1214, 2875, 2932, 3284, 3413, 3611], 'Pan': [746], 'coordinately': [752], 'inactivating': [759], 'Yorkie,': [760], 'drosophila': [762], 'homolog': [763], 'YAP.Cell.': [765], '122:': [767], '421-434Abstract': [768], '(1265)': [776], '7Zhao': [779], 'B.': [780, 844, 877, 939, 1001, 1098, 1145, 1210, 2877, 2918, 3262, 3391, 3589, 3901], 'Wei': [781, 940, 3263, 3392, 3590], 'X.': [782, 846, 941, 1100, 2879, 3264, 3393, 3591, 3903], 'Li': [783, 797, 942, 956, 1103, 1105, 1107, 1211, 1546, 1655, 1785, 1850, 2933, 3265, 3279, 3394, 3408, 3592, 3606, 3906, 3908, 3910], 'W.': [784, 943, 1106, 1656, 1786, 3266, 3395, 3593, 3909], 'Udan': [785, 944, 3267, 3396, 3594], 'R.S.': [786, 945, 3268, 3397, 3595], 'Yang': [787, 845, 946, 2878, 3269, 3398, 3596], 'Q.': [788, 947, 3270, 3399, 3597], 'Kim': [789, 948, 3271, 3400, 3598], 'Xie': [791, 950, 3273, 3402, 3600], 'Ikenoue': [793, 952, 3275, 3404, 3602], 'T.': [794, 953, 3276, 3322, 3405, 3451, 3603], 'Yu': [795, 954, 1101, 1109, 3277, 3406, 3604, 3904, 3912], 'L.': [798, 957, 1104, 1212, 3280, 3409, 3607, 3907], 'Zheng': [799, 958, 3281, 3410, 3608], 'P.': [800, 959, 1525, 1829, 3282, 3411, 3609], 'Ye': [801, 960, 1099, 3283, 3412, 3610, 3902], 'Chinnaiyan': [803, 962, 1115, 3285, 3414, 3612, 3918], 'Halder': [805, 964, 3287, 3416, 3614], 'Lai': [807, 966, 1117, 3289, 3418, 3616, 3920], 'Z.C.': [808, 967, 1118, 3290, 3419, 3617, 3921], 'et': [809, 968, 3291, 3420, 3618], 'al.Inactivation': [810, 969, 3292, 3421, 3619], 'oncoprotein': [813, 972, 3295, 3424, 3622], 'involved': [819, 978, 1089, 3301, 3430, 3628], 'contact': [822, 981, 1745, 3255, 3304, 3433, 3631, 3863], 'inhibition': [823, 982, 1318, 3197, 3305, 3434, 3632], 'control.Genes': [827, 986, 1128, 3309, 3438, 3636, 3931], 'Dev.': [828, 987, 1129, 1231, 1668, 1798, 3310, 3439, 3637, 3932], '2007;': [829, 988, 1372, 3311, 3440, 3638], '21:': [830, 989, 3312, 3441, 3639], '2747-2761Crossref': [831, 990, 3313, 3442, 3640], '(1946)': [834, 993, 3316, 3445, 3643], '8Hao': [837], 'Y.': [838, 887, 1011, 1151, 1654, 1784, 2871, 2976], 'Chun': [839, 2872], 'Cheung': [841, 2874], 'Rashidi': [843, 2876], 'Tumor': [847, 2880], 'negative': [852, 2010, 2885], 'oncogene': [855, 2888], 'YAP.J.': [856, 2889], 'Biol.': [857, 905, 1029, 1170, 1557, 1595, 1628, 1669, 1799, 1861, 1894, 1927, 2890, 4184], 'Chem.': [858, 1171, 1490, 1558, 1596, 1629, 1862, 1895, 1928, 2891], '2008;': [859, 906, 1030, 1130, 2892, 3933, 4185], '283:': [860, 2893], '5496-5509Abstract': [861, 2894], '(576)': [869, 2902], '9Lei': [872, 996], 'Q.Y.': [873, 997, 1153], 'Zhang': [874, 998], 'H.': [875, 999, 1139, 2930, 2934], 'Zhao': [876, 884, 1000, 1008, 1144, 1148, 2917, 2927], 'Zha': [878, 1002, 1142], 'Z.Y.': [879, 1003, 1143], 'Bai': [880, 1004], 'F.': [881, 1005, 3328, 3457, 4172], 'Pei': [882, 1006], 'X.H.': [883, 1007], 'Xiong': [886, 1010, 1150], 'Guan': [888, 1012, 1119, 1154, 1217, 1267, 2939, 3922], 'K.L.': [889, 1013, 1120, 1155, 1218, 1268, 2940, 3923], 'TAZ': [890, 918, 1014, 1047, 1080, 1163], 'epithelial-mesenchymal': [895, 1019, 1168], 'transition': [896, 1020], 'inhibited': [899, 1023], 'pathway.Mol.': [903, 1027], 'Cell': [904, 1028, 1667, 1797], '28:': [907, 1031], '2426-2436Crossref': [908, 1032], '(673)': [911, 1035], 'Phosphorylation': [914], 'on': [919, 1198, 2316, 2862, 3573, 3783, 4278, 4295], 'Ser127': [920, 3574], 'Ser89,': [922], 'respectively,': [923, 1202], 'triggers': [924, 1203, 3880], 'their': [925, 933, 1189, 1204, 1456, 2223, 2593, 2734], 'association': [926, 1414, 2318], '14-3-3': [928], 'proteins,': [929], 'which': [930, 1077, 1817, 2864, 3949, 4137, 4364], 'leads': [931], 'retention': [934], '(7Zhao': [938, 3261, 3390, 3588], 'contrast,': [1039, 3886, 4326], 'inactive,': [1043, 3870], 'unphosphorylated': [1044], 'are': [1048, 1071, 1362, 3986, 4005], 'translocated': [1049], 'nucleus': [1052, 3879, 3895, 3974], 'where': [1053], 'they': [1054], 'exert': [1055], 'cotranscriptional': [1056], 'factors.': [1062], 'enhanced': [1065], 'associate': [1066], 'domain': [1067], '(TEAD)': [1068], 'family': [1069], 'members': [1070], 'factors': [1075, 1158, 3876], 'bind,': [1081], 'leading': [1082], 'growth,': [1092], 'proliferation,': [1093, 1472], 'migration,': [1094], 'survival': [1096, 1588, 1887], '(10Zhao': [1097, 3900], 'Lin': [1111, 3914], 'J.D.': [1112, 1324, 3915], 'Wang': [1113, 1215, 2925, 3916], 'C.Y.': [1114, 1141, 1216, 3917], 'A.M.': [1116, 3919], 'TEAD': [1121, 1156, 3874, 3899, 3924, 4064], 'mediates': [1122, 3925], 'YAP-dependent': [1123, 3926], 'gene': [1124, 3723, 3817, 3927], 'induction': [1125, 3928], '22:': [1131, 3934], '1962-1971Crossref': [1132, 3935], '(1529)': [1135, 3938], '11Zhang': [1138], 'Liu': [1140], 'Yao': [1146], 'Lei': [1152], 'mediate': [1159], 'function': [1161, 3538], 'transition.J.': [1169], '2009;': [1172], '284:': [1173], '13355-13362Abstract': [1174], '(381)': [1182], 'addition': [1186, 4340], 'regulating': [1188], 'subcellular': [1190], 'localization,': [1191], 'LATS1/2-mediated': [1192, 3569], 'TAZ,': [1197], 'Ser381': [1199], 'Ser306,': [1201], 'ubiquitination': [1205], 'subsequent': [1207], 'degradation': [1208], '(12Zhao': [1209], 'Tumaneng': [1213, 2931], 'A': [1219, 2285, 2351, 3335, 3464, 3995], 'coordinated': [1220], 'Lats': [1223], 'CK1': [1225], 'stability': [1228], 'through': [1229, 3341, 3470], 'SCF(beta-TRCP).Genes': [1230], '72-85Crossref': [1234], '(853)': [1237], 'Diverse': [1240], 'mechanical': [1243, 3336, 3465], 'cues,': [1244], 'polarity,': [1246], 'adhesion,': [1248], 'soluble': [1250], 'factors,': [1251], 'cellular': [1253, 1356, 1465, 4119], 'stresses,': [1254], 'modulate': [1255], 'activation': [1256, 1430, 1584, 1741, 1883, 3093, 3226, 3249, 3708, 3888, 4159], '(13Ma': [1261], 'Meng': [1263], 'Z.': [1264, 1547, 1851], 'Chen': [1265], 'R.': [1266], 'pathway:': [1271], 'Biology': [1272], 'pathophysiology.Annu.': [1274], 'Rev.': [1275], 'Biochem.': [1276], '2019;': [1277], '88:': [1278], '577-604Crossref': [1279], '(266)': [1282], 'Because': [1285], 'key': [1288], 'metazoan': [1291], 'physiology': [1292], 'development,': [1294], 'it': [1295, 2049, 2801], 'surprising': [1298], 'may': [1305], 'have': [1306, 1718, 3247, 3792, 4024, 4043], 'severe': [1307], 'consequences,': [1308], 'organomegaly': [1310], 'tumorigenesis,': [1312], 'because': [1313], 'hyperproliferation': [1316], '(14Barron': [1321], 'D.A.': [1322], 'Kagey': [1323], 'disease': [1333], 'tumorigenesis.Clin.': [1335], 'Trans.': [1336], 'Med.': [1337], '2014;': [1338], '3:': [1339], '25Crossref': [1340], 'Ca2+': [1344, 1361, 1401, 1647, 1779, 2221, 2280, 2315, 2338, 2344, 2437, 2443, 2486, 2547, 2671, 2679, 2815, 4109, 4322], 'fundamental': [1347], 'intracellular': [1348, 1660, 1790, 4107], 'messenger': [1349, 1661, 1791], 'broad': [1353, 1462], 'range': [1354, 1463], 'functions.': [1357], 'effects': [1359], 'conveyed': [1363], 'Ca2+-binding': [1366, 1397, 1405, 1814], '(15Clapham': [1368], 'D.E.': [1369, 2966], 'Calcium': [1370], 'signaling.Cell.': [1371, 2949], '131:': [1373], '1047-1058Abstract': [1374], '(2736)': [1382], 'ubiquitous': [1389], 'an': [1393, 1658, 1788, 3032, 4282], 'archetypal': [1394], 'example': [1395], 'protein.': [1398], 'Binding': [1399], 'four': [1404], 'sites': [1406, 4277], 'induces': [1407], 'conformational': [1409], 'change': [1410], 'calmodulin,': [1412, 1816, 2295, 2401, 2625, 2712, 4370], 'numerous': [1416, 4100], '(16Hoeflich': [1418], 'K.P.': [1419], 'Ikura': [1420], 'Calmodulin': [1422, 1499, 1550, 1624, 1854, 1923, 4095, 4113, 4308], 'action:': [1424], 'Diversity': [1425], 'recognition': [1428], 'mechanisms.Cell.': [1431], '2002;': [1432, 1536, 1840], '108:': [1433], '739-742Abstract': [1434], '(566)': [1442], 'Through': [1445], 'structurally': [1449], 'functionally': [1451], 'targets,': [1453], 'activity,': [1457], 'participating': [1459], 'processes,': [1466], 'cycle': [1469], 'cyclic': [1473], 'nucleotide': [1474], 'metabolism,': [1475, 1477], 'glycogen': [1476], 'cytoskeletal': [1478], 'arrangement,': [1479], 'smooth': [1481], 'muscle': [1482], 'contraction': [1483], '(17Klee': [1484], 'C.B.': [1485], 'Vanaman': [1486], 'T.C.': [1487], 'Calmodulin.Adv.': [1488], 'Protein': [1489], '1982;': [1491], '35:': [1492], '213-321Crossref': [1493], '(731)': [1496], 'documented': [1502], 'manner': [1508, 4317], 'pathways,': [1512], 'mitogen-activated': [1515], '(18Agell': [1518, 1822], 'N.': [1519, 1523, 1823, 1827, 2920, 3330, 3459], 'Bachs': [1520, 1824], 'O.': [1521, 1825], 'Rocamora': [1522, 1826], 'Villalonga': [1524, 1828], 'Modulation': [1526, 1830], 'Ras/Raf/MEK/ERK': [1529, 1833], 'Ca2+,': [1532, 1836, 2301], 'calmodulin.Cell': [1534, 1838], 'Signal.': [1535, 1839], '14:': [1537, 1841], '649-654Crossref': [1538, 1842], '(344)': [1541, 1845], '19Parvathaneni': [1544, 1848], 'Sacks': [1548, 1622, 1852, 1921], 'D.B.': [1549, 1623, 1853, 1922], 'influences': [1551, 1649, 1855, 1942, 3091, 3815, 4147], 'MAPK': [1552, 1856], 'KSR1.J.': [1556, 1860], '2021;': [1559, 1670, 1800, 1863], '296:': [1560, 1864], '100577Abstract': [1561, 1865], '(1)': [1569, 1675, 1805, 1873], 'Scholar)': [1571, 1807], 'PI3K/protein': [1573], 'B': [1575], 'networks': [1576, 1821], '(20Deb': [1577], 'T.B.': [1578, 1877], 'Coticchia': [1579, 1878], 'Dickson': [1581, 1880], 'Calmodulin-mediated': [1583, 1882], 'Akt': [1586, 1885], 'c-Myc-overexpressing': [1590, 1889], 'mouse': [1591, 1890], 'mammary': [1592, 1891], 'carcinoma': [1593, 1892], 'cells.J.': [1594, 1893], '2004;': [1597, 1896], '279:': [1598, 1897], '38903-38911Abstract': [1599, 1898], '(81)': [1607, 1906], '21Joyal': [1610, 1909], 'J.L.': [1611, 1910, 2922], 'Burks': [1612, 1911], 'D.J.': [1613, 1912], 'Pons': [1614, 1913], 'Matter': [1616, 1915], 'W.F.': [1617, 1916], 'Vlahos': [1618, 1917], 'C.J.': [1619, 1918], 'White': [1620, 1919], 'M.F.': [1621, 1920], 'phosphatidylinositol': [1626, 1925], '3-kinase.J.': [1627, 1926], '1997;': [1630, 1929], '272:': [1631, 1930], '28183-28186Abstract': [1632, 1931], '(144)': [1640, 1939], 'Nevertheless,': [1643], 'despite': [1644], 'reports': [1645], '(22Wei': [1653, 1783], 'Calcium,': [1657, 1787], 'emerging': [1659, 1789], 'for': [1662, 1753, 1792, 2148, 2797, 3066, 3541], 'regulation.Front.': [1666, 1796], '9:': [1671, 1801], '694828Crossref': [1672, 1802], 'possible': [1679, 2312], 'involvement': [1680], 'modulating': [1684], 'had': [1686, 3496], 'investigated.': [1689], 'Therefore,': [1690], 'tested': [1692], 'hypothesis': [1694], 'observed': [1701, 2481, 2574, 2749, 3490], 'interact': [1706, 2106, 2186], 'both': [1709, 2114, 2612, 2759, 3828, 4231], 'these': [1716, 2122, 2133, 2757, 2823, 3057, 3193, 3363, 3840, 4079], 'interactions': [1717, 4087], 'functional': [1719], 'consequences.': [1720], 'vitro,': [1722, 2650], 'stimulates': [1725, 4310], 'activity.': [1728], 'selective': [1733, 3101, 3122], 'cell-permeable': [1734, 3102], 'antagonist': [1736, 3104], 'CGS9343B': [1737, 3105, 3164, 3512, 3736, 3745, 3823, 4042], 'reduces': [1739], 'mediated': [1742], 'serum': [1747, 3046, 3095, 3211, 3228, 3710, 3773, 4016, 4070, 4093], 'starvation.': [1748, 3212, 3711, 3774, 3866, 4094], 'Altogether,': [1749], 'identify': [1752], 'first': [1755, 1949], 'time': [1756], 'communication': [1758], 'pathways': [1764], 'unrecognized': [1772], 'Reports': [1777], 'prompted': [1808], 'us': [1809], 'investigate': [1811], 'whether': [1812, 1951, 2048, 2220, 2396, 2639, 2841, 2856, 3089, 3217, 3718, 3812, 4144], '20Deb': [1876], 'activation.': [1944, 3036, 3086], 'To': [1945, 2131, 2207, 2225, 2394, 2637, 2701, 3018, 3087, 3941, 4129, 4198], 'do': [1946, 2226], 'so,': [1947, 2227], 'assessed': [1950, 3648, 3966], 'associates': [1953], 'YAP.': [1959, 2057, 3071], 'Analysis': [1960, 2012, 4214], 'was': [1961, 1997, 2006, 2076, 2272, 2307, 2373, 2410, 2480, 2573, 2676, 2680, 3145, 3172, 4204, 4243, 4298], 'performed': [1962, 2308], 'immunoprecipitation.': [1964], 'order': [1966, 2032, 3214], 'stabilize': [1968], 'transient': [1969], 'protein–protein': [1970], 'interactions,': [1971], 'HeLa': [1972, 2063, 2140, 2205, 3037, 3134, 3725], 'were': [1974, 1991, 2234, 2254, 2260, 2503, 2723, 2731, 2772, 3039, 3059, 3136, 3731], 'exposed': [1975], 'dithiobis(succinimidyl': [1977], 'propionate)': [1978, 2720], '(DSP)': [1979], 'reacts': [1981], 'primary': [1983], 'amine': [1984], 'groups': [1985], 'crosslinks': [1987], 'bound': [1988, 2269, 2331], 'proteins.': [1989, 2405], 'Cells': [1990, 3242, 3788], 'then': [1992, 2714], 'lysed,': [1993], 'immunoprecipitated': [1998, 2015, 2059, 2137], 'anti-YAP': [2000], 'monoclonal': [2001], 'antibody.': [2002], 'Immunoglobulin': [2003], 'G': [2004], '(IgG)': [2005], 'used': [2007, 2403, 3098, 3713, 4151], 'control.': [2011, 3148], 'samples': [2016, 2088, 2168, 2259, 2376], 'SDS-PAGE': [2018], 'Western': [2020, 2065, 2146, 2263, 2422, 2726, 3062, 3149, 4058, 4219], 'blotting': [2021, 2066, 2423, 3063, 3150, 4059, 4220], 'revealed': [2022, 4224], 'coimmunoprecipitates': [2026], '(Fig.': [2029, 2073, 2159, 2283, 2349, 2381, 2438, 2452, 2523, 2550, 2672, 2737, 2763, 2818, 3082, 3165, 3176, 3384, 3506, 3525, 3702, 3757, 3806, 3837, 4020, 4034, 4052, 4075, 4235, 4323, 4356], '1A).': [2030], 'ascertain': [2034], 'if': [2035], 'also': [2037, 2077, 3776], 'binds': [2038, 2293, 2398, 2428, 2461, 2519, 2561], 'other': [2040], 'components': [2041], 'pathway,': [2045], 'investigated': [2047, 2855, 3811], 'interacts': [2050], 'LATS1,': [2052, 2217, 2617, 2641, 2691, 2710, 2812, 2829], 'from': [2062, 2086, 2139, 2166, 2584, 3056, 3891], 'cells.': [2064, 2110, 2130, 2206, 2636, 3674], 'coimmunoprecipitated': [2070], '1B).': [2074], 'present': [2078, 2817], 'immunoprecipitates.': [2081], 'absence': [2083, 2163, 2484, 2579, 2780, 4305, 4336], 'signal': [2085, 2165, 3183, 3238, 3997], 'precipitated': [2089, 2169], 'IgG': [2091, 2171], 'validates': [2092, 2172, 2589], 'specificity': [2094, 2174, 2385, 2591], 'interactions.': [2097, 2177], 'Together,': [2098, 2822], 'imply': [2101, 2356], 'Furthermore,': [2111], 'coimmunoprecipitation': [2112], 'suggests': [2120, 2471, 2626, 3761], 'could': [2124, 2200], 'validate': [2132, 3019, 4199], 'observations,': [2134], 'reciprocally': [2136], 'lysates': [2142, 2253, 2489, 3055, 3153], 'probed': [2144, 3065], 'blot': [2147], 'LATS1.': [2151, 2510], 'Both': [2152, 2660], '1C).': [2160], 'Again,': [2161], 'These': [2178, 2354, 2555, 2684, 2770, 2783], 'confirm': [2180], 'support': [2193, 2686], 'premise': [2195], 'three': [2198, 2629], 'further': [2208, 2470, 2702], 'characterize': [2209], 'evaluated': [2219, 4143, 4207], 'interaction.': [2224], 'embryonic': [2229], 'kidney': [2230], '293': [2231], '(HEK293)': [2232], 'lysed': [2235], 'buffer': [2237], 'containing': [2238], 'mM': [2240], 'either': [2242, 2418, 3861], 'CaCl2': [2243, 2419], 'Ca2+-chelator': [2247], 'EGTA.': [2248, 2421, 2683], 'Equal': [2249, 3051], 'amounts': [2250, 3052], 'incubated': [2255, 2377, 2411, 2653, 2707, 3137, 3732, 3987, 4040], 'calmodulin-Sepharose,': [2257], 'resolved': [2261], 'blotting.': [2264, 2727], 'amount': [2266, 2328, 3168, 3517, 4062], 'altered': [2275, 3175, 4068], 'presence': [2278, 2336, 2416, 2435, 2669, 2777, 4302, 4320], 'EGTA': [2282, 2348, 2445, 2549], '2,': [2284, 2350, 2453, 2551], 'B).': [2287, 2353], 'This': [2288, 2457, 2469, 3704, 3759], 'result': [2289, 3705, 3760], 'confirms': [2290, 3706], 'regardless': [2296], 'presence/absence': [2299], 'lysates.': [2304, 2577], 'Similar': [2305, 2511], 'analysis': [2306, 3678, 3742], 'examine': [2310], 'effect': [2313, 3219, 3779, 4291, 4361], 'contrast': [2324], '11-fold': [2340], 'greater': [2341], 'than': [2342, 3079, 3189, 3501, 3696, 3801, 4029, 4049], 'chelated': [2346, 2681], 'regulated': [2366], 'Ca2+.': [2368, 2782, 4307, 4338], 'No': [2369, 2674], 'detected': [2374, 2677, 2732], 'glutathione-S-transferase': [2379], '(GST)–Sepharose': [2380], '2A),': [2382], 'demonstrating': [2383], 'determine': [2395, 3088, 3216, 3717], 'pure': [2404, 2426, 2431, 2559, 2564, 2708, 2827, 4342], 'Purified': [2406], 'recombinant': [2408, 2509], 'calmodulin-Sepharose': [2413], 'reveals': [2424, 2799, 3154], '2C).': [2439], 'chelation': [2441], 'almost': [2446], 'completely': [2447], 'abolishes': [2448], 'calmodulin–YAP': [2450], 'C': [2454], 'D).': [2456], 'shows': [2458, 3743], 'manner.': [2468], 'indirect': [2491], 'occurs': [2493, 2865], '(an)other': [2498], 'protein(s).': [2499], 'Analogous': [2500], 'assays': [2502], 'carried': [2504], 'out': [2505], '2E).': [2524], 'reduced': [2533, 3160, 3513], '(by': [2534], '70.9': [2535], '±': [2536, 2539], '12.9%,': [2537], 'mean': [2538], 'SD),': [2540], 'but': [2541], 'eliminated,': [2543], 'removal': [2545], 'E': [2552], 'F).': [2554], 'Ca2+-regulated': [2568], 'manner,': [2569], 'similar': [2570, 4366], 'what': [2572], 'pull-downs': [2586], 'GST-Sepharose': [2588], 'Taken': [2597, 3531, 4077], 'together,': [2598, 3532, 4078], 'Ca2+/calmodulin.': [2609], 'Coimmunoprecipitation': [2610], 'well': [2619], 'assess': [2638], 'simultaneously': [2652], 'calmodulin-Sepharose.': [2659], '3A).': [2673], 'concept': [2688], 'test': [2703], 'hypothesis,': [2705], 'crosslinked': [2715], "3,3'-dithiobis(sulfosuccinimidyl": [2719], '(DTSSP).': [2721], 'Samples': [2722], 'analyzed': [2724, 3060], 'expected': [2735], '3B,': [2738, 2819], 'upper': [2739, 2766], 'panel,': [2740, 2767], 'red': [2741], 'green': [2743], 'bands,': [2744], 'respectively).': [2745], 'addition,': [2747], 'bands': [2750, 2771], 'migrated': [2752], 'higher': [2754, 3257], 'molecular': [2755, 2806, 3946, 4134, 4367], 'mass;': [2756], 'comprise': [2758], '3,': [2764], 'B,': [2765], 'yellow': [2768], 'bands).': [2769], 'influenced': [2774], 'indicate': [2785, 3195], 'formation': [2787, 3968], 'Ca2+-independent': [2789], 'YAP–LATS1': [2790], 'complexes.': [2791], 'probing': [2793], 'same': [2795], 'membrane': [2796], 'high': [2805, 3382, 3494, 3523, 3790, 3835], 'mass': [2807], 'only': [2813, 4000], 'lower': [2820, 3692, 3795], 'panel).': [2821], 'next': [2839], 'studied': [2840], 'affects': [2850], 'Initially,': [2853], 'Ser127,': [2863], '(8Hao': [2870], 'Serum': [2905, 2981], 'starvation': [2906, 3556, 4017, 4071], 'activate': [2910, 3240], '(23Yu': [2915], 'F.X.': [2916], 'Panupinthu': [2919], 'Jewell': [2921], 'Lian': [2923], 'I.': [2924], 'L.H.': [2926], 'Yuan': [2929], 'Fu': [2935], 'X.D.': [2936], 'Mills': [2937], 'G.B.': [2938], 'Regulation': [2941], 'Hippo-YAP': [2944], 'G-protein-coupled': [2947], 'receptor': [2948], '2012;': [2950], '150:': [2951], '780-791Abstract': [2952], '(1014)': [2960], '24Adler': [2963], 'J.J.': [2964], 'Heller': [2967], 'B.L.': [2968], 'Bringman': [2969], 'L.R.': [2970], 'Ranahan': [2971], 'W.P.': [2972], 'Conwell': [2973], 'M.D.': [2974], 'Sun': [2975], 'Hudmon': [2977], 'Wells': [2979], 'C.D.': [2980], 'deprivation': [2982], 'co-activator': [2986], '130-kDa': [2995], 'isoform': [2996], 'Angiomotin': [2998], 'kinases.Proc.': [3003], 'Natl.': [3004], 'Acad.': [3005], 'Sci.': [3006], 'U.': [3007], '2013;': [3010, 3347, 3476], '110:': [3011], '17368-17373Crossref': [3012], '(99)': [3015], 'observation': [3021, 4014], 'under': [3022], 'assay': [3024, 3367, 3715, 3978, 4259], 'conditions,': [3025], 'quantified': [3027], 'phosphorylated': [3028, 4229, 4276], '(pYAP)': [3030], 'indicator': [3033], 'grown': [3040, 3243, 3378], 'complete': [3042], '(10%': [3043], 'fetal': [3044], 'bovine': [3045], '[FBS])': [3047], 'serum-free': [3049, 3729], 'medium.': [3050], 'pYAP': [3067, 3182, 3374, 3519], '(Ser127)': [3068], 'total': [3070, 3170], 'Starved': [3072, 3133], 'display': [3074], '2.1-fold': [3075], 'more': [3076, 3498, 4045], 'fed': [3080, 3671], '4A),': [3083, 3177, 4021], 'confirming': [3084], 'starvation,': [3096, 3229], '(25Norman': [3106], 'J.A.': [3107], 'Ansell': [3108], 'Stone': [3110], 'G.A.': [3111], 'Wennogle': [3112], 'L.P.': [3113], 'Wasley': [3114], 'J.W.': [3115], 'CGS': [3116], '9343B,': [3117], 'novel,': [3119], 'potent,': [3120], 'inhibitor': [3123], 'activity.Mol.': [3126], 'Pharmacol.': [3127], '1987;': [3128], '31:': [3129], '535-540PubMed': [3130], '40': [3139, 3734], 'μM': [3140, 3735], 'CGS9343B.': [3141], 'Dimethyl': [3142], 'sulfoxide': [3143], '(DMSO)': [3144], 'vehicle': [3147], '74%': [3162], '4A).': [3166], 'validating': [3178], 'decreased': [3181], 'reflects': [3184], 'diminished': [3185], 'rather': [3188], 'impairs': [3200, 3845, 4084], 'induced': [3205, 3819], 'restricted': [3223], 'examined': [3231, 3777, 4299], 'different': [3237], 'Hippo.': [3241], 'low': [3245, 3380, 3504, 3804], 'confluency': [3246, 3383, 3495, 3505, 3524, 3782, 3791], 'minimal': [3248], 'Hippo,': [3251], 'whereas': [3252], 'increased': [3253], 'density': [3258, 3805, 3836], '26Aragona': [3319, 3448], 'Panciera': [3321, 3450], 'Manfrin': [3323, 3452], 'Giulitti': [3325, 3454], 'Michielin': [3327, 3456], 'Elvassore': [3329, 3458], 'Dupont': [3331, 3460], 'Piccolo': [3333, 3462], 'checkpoint': [3337, 3466], 'controls': [3338, 3467], 'multicellular': [3339, 3468], 'YAP/TAZ': [3342, 3471], 'regulation': [3343, 3472], 'actin-processing': [3345, 3474], 'factors.Cell.': [3346, 3475], '154:': [3348, 3477], '1047-1059Abstract': [3349, 3478], '(918)': [3357, 3486], 'initially': [3361], 'validated': [3362], 'observations': [3364], 'system': [3368], 'comparing': [3370], 'abundance': [3372], 'HEK293': [3376], '4B).': [3385], 'Consistent': [3386, 4011], 'published': [3388], '1.5-fold': [3497], 'those': [3502], '4C).': [3507], 'Inhibition': [3508], '12%': [3515], '4D),': [3526], 'albeit': [3527], 'without': [3528], 'statistical': [3529], 'significance.': [3530], 'required': [3540], 'maximal': [3542], 'and,': [3557], 'lesser': [3560], 'extent,': [3561], 'contact.': [3564, 3822], 'active,': [3568, 4205], 'hinders': [3575], 'translocation': [3577], 'nucleus,': [3580], 'hence': [3581], 'inhibiting': [3582, 3763], 'level': [3650, 3685], 'genes,': [3658, 3956], 'connective': [3659], '(CTGF)': [3663], '(CYR61),': [3669], 'serum-starved': [3673], 'Quantitative': [3675, 3739], 'real-time': [3676, 3740], 'PCR': [3677, 3741], 'revealed,': [3679], 'anticipated,': [3681], 'CTGF': [3687, 3749, 3784, 3798, 3829], 'CYR61': [3689, 3751, 3786, 3800, 3831], 'starved': [3694, 4022, 4038], 'FBS': [3701, 4033], '5A).': [3703], 'expression.': [3724, 3787], 'medium': [3730], 'DMSO.': [3738], '2.6-fold': [3753], '4.0-fold,': [3755], 'respectively': [3756], '5B).': [3758], 'YAP-mediated': [3766, 3816], '5C),': [3807], 'expected.': [3809], '5D).': [3838], 'least': [3849], 'By': [3885], 'prevents': [3889], 'translocating': [3892], 'interacting': [3897], 'gain': [3942, 4130], 'insight': [3943, 4131], 'into': [3944, 4132], 'mechanism': [3947, 4135], 'measured': [3958, 4244], 'TEAD.': [3964], 'YAP–TEAD': [3970, 4027, 4047, 4085], 'complexes': [3971, 4028, 4048], 'proximity': [3976, 4008], 'ligation': [3977], '(PLA).': [3979], 'assay,': [3982], 'fixed': [3983], 'permeabilized': [3984], 'antibodies': [3989, 4004, 4223], 'specific': [3990, 4222], 'TEAD1.': [3994], 'fluorescence': [3996, 4250], 'generated': [3999], 'close': [4007], '(nanometer': [4009], 'range).': [4010], '60%': [4025], 'fewer': [4026], '6,': [4035, 4053], 'A–C).': [4036, 4054], '2.2-fold': [4044], 'nuclear': [4046, 4086], 'DMSO-treated': [4050], 'verified': [4056], 'and/or': [4072], '6D).': [4076], 'response': [4103], 'changes': [4105], 'free': [4108], 'concentration': [4110], '(27Cheung': [4111], 'W.Y.': [4112], 'plays': [4114], 'pivotal': [4116], 'regulation.Science.': [4120], '1980;': [4121], '207:': [4122], '19-27Crossref': [4123], '(1839)': [4126], '(Active': [4156], 'Motif).': [4157], 'Cellular': [4158], 'requires': [4162], 'Ser909': [4166, 4211, 4232], 'Thr1079': [4168, 4234], '(28Praskova': [4169], 'Xia': [4171], 'Avruch': [4173], 'MOBKL1A/MOBKL1B': [4175], 'MST1': [4178], 'MST2': [4180], 'proliferation.Curr.': [4183], '18:': [4186], '311-321Abstract': [4187], '(287)': [4195], 'Thr1079.': [4213], '7A).': [4236], 'homogeneous': [4248], 'time-resolved': [4249], '(HTRF)': [4251], 'KinEASE': [4254], 'STK': [4255], 'S1': [4256], 'kit.': [4257], 'quantifies': [4260], 'peptide': [4264, 4280, 4288], 'substrate': [4265], 'FRET': [4269], 'donor': [4272], 'antibody': [4273], 'recognizes': [4275], 'acceptor': [4283], 'molecule': [4284], 'targets': [4286], 'substrate.': [4289], 'dose-dependent': [4316], '7B).': [4324, 4357], 'does': [4328, 4351], 'increase': [4330], 'myoglobin': [4343], 'instead': [4344], 'reaction': [4349], 'mixture': [4350], 'stimulate': [4353], 'lack': [4359], 'myoglobin,': [4363], 'weight': [4368], 'valid': [4371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220698810', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-08T18:07:55.743176', 'created_date': '2022-04-03'}
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