Publication Information

{'id': 'https://openalex.org/W4214951756', 'doi': 'https://doi.org/10.1002/adhm.202200192', 'title': 'Extracellular Vesicles — A Versatile Biomaterial', 'display_name': 'Extracellular Vesicles — A Versatile Biomaterial', 'publication_year': 2022, 'publication_date': '2022-03-01', 'ids': {'openalex': 'https://openalex.org/W4214951756', 'doi': 'https://doi.org/10.1002/adhm.202200192', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35233995'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/adhm.202200192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2500736452', 'display_name': 'Advanced Healthcare Materials', 'issn_l': '2192-2640', 'issn': ['2192-2640', '2192-2659'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'editorial', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003278106', 'display_name': 'Juliane Nguyen', 'orcid': 'https://orcid.org/0000-0002-8578-7396'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Juliane Nguyen', 'raw_affiliation_strings': ['Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA'], 'affiliations': [{'raw_affiliation_string': 'Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084255852', 'display_name': 'Gregor Fuhrmann', 'orcid': 'https://orcid.org/0000-0002-6688-5126'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Gregor Fuhrmann', 'raw_affiliation_strings': ['Chair of Pharmaceutical Biology Department of Biology Friedrich‐Alexander‐University Erlangen‐Nürnberg  Staudtstr. 5 Erlangen 91058 Germany'], 'affiliations': [{'raw_affiliation_string': 'Chair of Pharmaceutical Biology Department of Biology Friedrich‐Alexander‐University Erlangen‐Nürnberg  Staudtstr. 5 Erlangen 91058 Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5003278106', 'https://openalex.org/A5084255852'], 'corresponding_institution_ids': ['https://openalex.org/I114027177', 'https://openalex.org/I181369854'], 'apc_list': {'value': 4430, 'currency': 'USD', 'value_usd': 4430, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.775785, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '11', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10873', 'display_name': 'Bacterial Infections and Vaccines', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11899', 'display_name': 'Brucella: diagnosis, epidemiology, treatment', 'score': 0.9177, 'subfield': {'id': 'https://openalex.org/subfields/3404', 'display_name': 'Small Animals'}, 'field': {'id': 'https://openalex.org/fields/34', 'display_name': 'Veterinary'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/extracellular-vesicles', 'display_name': 'Extracellular Vesicles', 'score': 0.51465476}, {'id': 'https://openalex.org/keywords/crosstalk', 'display_name': 'Crosstalk', 'score': 0.51442915}, {'id': 'https://openalex.org/keywords/extracellular-vesicle', 'display_name': 'Extracellular vesicles', 'score': 0.45016488}, {'id': 'https://openalex.org/keywords/microvesicle', 'display_name': 'Microvesicle', 'score': 0.4237116}, {'id': 'https://openalex.org/keywords/nanoparticle-tracking-analysis', 'display_name': 'Nanoparticle tracking analysis', 'score': 0.42232385}], 'concepts': [{'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.7768477}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.59803873}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.554686}, {'id': 'https://openalex.org/C2992929900', 'wikidata': 'https://www.wikidata.org/wiki/Q21097485', 'display_name': 'Extracellular vesicles', 'level': 2, 'score': 0.51465476}, {'id': 'https://openalex.org/C169822122', 'wikidata': 'https://www.wikidata.org/wiki/Q230187', 'display_name': 'Crosstalk', 'level': 2, 'score': 0.51442915}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.48970512}, {'id': 'https://openalex.org/C39944091', 'wikidata': 'https://www.wikidata.org/wiki/Q423279', 'display_name': 'Lipid bilayer', 'level': 3, 'score': 0.4835741}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45025316}, {'id': 'https://openalex.org/C2908689518', 'wikidata': 'https://www.wikidata.org/wiki/Q21097485', 'display_name': 'Extracellular vesicle', 'level': 5, 'score': 0.45016488}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.44949716}, {'id': 'https://openalex.org/C58123911', 'wikidata': 'https://www.wikidata.org/wiki/Q467410', 'display_name': 'Biofilm', 'level': 3, 'score': 0.42775524}, {'id': 'https://openalex.org/C2909763251', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicle', 'level': 5, 'score': 0.4237116}, {'id': 'https://openalex.org/C2778120352', 'wikidata': 'https://www.wikidata.org/wiki/Q3870163', 'display_name': 'Nanoparticle tracking analysis', 'level': 5, 'score': 0.42232385}, {'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.41331828}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38626212}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.35516638}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.35341403}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.3269477}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.23751274}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.1903497}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16998366}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000067128', 'descriptor_name': 'Extracellular Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/adhm.202200192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2500736452', 'display_name': 'Advanced Healthcare Materials', 'issn_l': '2192-2640', 'issn': ['2192-2640', '2192-2659'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35233995', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W2111951615', 'https://openalex.org/W2127735999', 'https://openalex.org/W2135130533', 'https://openalex.org/W2150904674', 'https://openalex.org/W2170852633', 'https://openalex.org/W2218656852', 'https://openalex.org/W2290891464', 'https://openalex.org/W2478602097', 'https://openalex.org/W3175628958', 'https://openalex.org/W3185205121'], 'related_works': ['https://openalex.org/W4391232704', 'https://openalex.org/W4287251520', 'https://openalex.org/W4248868287', 'https://openalex.org/W4238096637', 'https://openalex.org/W3189276748', 'https://openalex.org/W2956025391', 'https://openalex.org/W2591927717', 'https://openalex.org/W2504108804', 'https://openalex.org/W2228398540', 'https://openalex.org/W2088276922'], 'abstract_inverted_index': {'In': [0, 216, 423, 750, 843, 1139], 'recent': [1, 243, 421], 'years,': [2], 'extracellular': [3, 1449], 'vesicles': [4, 171, 697, 949, 974, 981, 1084, 1450], '(EVs)': [5], 'have': [6, 75, 258, 416], 'attracted': [7, 417], 'a': [8, 57, 160, 198, 218, 480, 524, 668, 725, 751, 799, 1014, 1040, 1104, 1226, 1347, 1361, 1393, 1424], 'lot': [9], 'of': [10, 28, 42, 61, 92, 111, 133, 178, 212, 221, 255, 263, 270, 285, 310, 345, 394, 470, 517, 528, 557, 574, 600, 629, 671, 841, 905, 927, 940, 961, 965, 971, 1007, 1017, 1021, 1059, 1089, 1116, 1186, 1211, 1223, 1229, 1254, 1267, 1273, 1278, 1339, 1363, 1382], 'interdisciplinary': [11], 'interest': [12], 'from': [13, 156, 339, 736, 1166, 1316, 1336, 1377, 1399, 1440], 'biomedical,': [14], 'bioengineering,': [15], 'and': [16, 33, 71, 84, 104, 140, 186, 209, 249, 282, 303, 319, 323, 334, 363, 372, 385, 400, 428, 433, 447, 462, 472, 476, 488, 497, 501, 521, 539, 565, 578, 623, 657, 665, 691, 706, 739, 758, 770, 783, 787, 812, 850, 881, 899, 908, 921, 955, 1011, 1048, 1066, 1145, 1152, 1157, 1180, 1203, 1237, 1261, 1269, 1290, 1298, 1322, 1345, 1391, 1427, 1433, 1453], 'biomaterials': [17], 'researchers.': [18], 'EVs': [19, 74, 127, 153, 276, 286, 315, 329, 337, 406, 583, 601, 613, 631, 653, 676, 716, 732, 766, 797, 807, 829, 864, 883, 941, 1023, 1037, 1052, 1060, 1124, 1158, 1187], 'are': [20, 89, 98, 107, 287, 297, 507, 614, 1239], 'nanoscale,': [21], 'membrane-bound': [22], 'particles': [23, 54], 'produced': [24, 99, 108, 328, 651], 'by': [25, 56, 100, 109, 154, 317, 478, 588, 632, 721], 'all': [26, 164, 568], 'kingdoms': [27], 'life': [29], 'including': [30, 175], 'eukaryotes,': [31], 'bacteria,': [32], 'fungi.[1-4]': [34], 'According': [35], 'to': [36, 67, 123, 168, 195, 202, 227, 241, 336, 494, 510, 717, 764, 862, 865, 876, 878, 884, 924, 1026, 1044, 1061, 1085, 1131, 1159, 1175, 1244], 'the': [37, 49, 62, 112, 120, 157, 176, 271, 291, 308, 343, 376, 392, 403, 468, 514, 546, 554, 571, 597, 626, 686, 731, 737, 747, 778, 821, 866, 903, 937, 959, 962, 968, 1005, 1018, 1027, 1051, 1057, 1062, 1087, 1093, 1114, 1150, 1170, 1183, 1208, 1234, 1242, 1265, 1276, 1307, 1312, 1317, 1323, 1337, 1367, 1378, 1414, 1435, 1441], 'Minimal': [38], 'Information': [39], 'for': [40, 52, 233, 350, 405, 532, 616, 677, 714, 825, 936, 950, 1024, 1241, 1294, 1417], 'Studies': [41], 'Extracellular': [43], 'Vesicles': [44], '(MISEV)': [45], 'guidelines,': [46], 'EV': [47, 134, 214, 351, 382, 398, 431, 445, 474, 499, 781, 911, 1212, 1231], 'is': [48, 225, 410, 808, 933, 1129, 1258, 1423], 'generic': [50], 'term': [51], 'cell-derived': [53, 94], 'enclosed': [55], 'lipid': [58, 1155], 'bilayer,': [59], 'regardless': [60], 'organism': [63], 'producing': [64], 'them.': [65], 'Due': [66], 'their': [68, 145, 355, 413, 424, 448, 543, 606, 617, 844, 851, 972, 1100, 1140], 'important': [69, 173, 509], 'physiological': [70], 'pathophysiological': [72], 'roles,': [73], 'been': [76, 1304, 1360], 'studied': [77, 167, 902, 958], 'as': [78, 85, 277, 370, 407, 450, 584, 798, 830, 832, 1125], 'therapeutics,': [79], 'in': [80, 136, 163, 230, 245, 274, 293, 332, 354, 375, 660, 675, 724, 743, 1074, 1077, 1119, 1169, 1188, 1214, 1233, 1264, 1333, 1389, 1451], 'drug': [81, 586, 1126], 'delivery': [82, 177, 408, 680, 800, 1025, 1042, 1292], 'applications,': [83, 197], 'novel': [86, 1287], 'diagnostics.[5-7]': [87], 'There': [88], 'two': [90, 131], 'subclasses': [91], 'mammalian': [93], 'EVs:': [95], 'microvesicles,': [96], 'which': [97, 106, 116, 294, 506], 'plasma': [101, 121], 'membrane': [102, 122, 1083, 1117], 'blebbing,': [103], 'exosomes,': [105], 'budding': [110], 'late': [113], 'endosomal': [114], 'membrane,': [115, 159], 'then': [117], 'fuses': [118], 'with': [119, 252, 437, 591, 635, 698, 746, 768, 893, 1053, 1207, 1306, 1342, 1354, 1386, 1401], 'release': [124, 882], 'multiple': [125], 'small': [126], 'at': [128, 983, 991, 1000, 1275, 1281, 1352, 1366, 1395, 1413], 'once.': [129], 'These': [130], 'types': [132], 'overlap': [135], 'size,': [137], 'buoyant': [138], 'density,': [139], 'surface': [141, 434], 'marker': [142], 'expression,': [143], 'so': [144], 'individual': [146], 'isolation': [147], 'has': [148, 1303, 1359], 'proven': [149], 'difficult.': [150], 'Bacteria': [151], 'form': [152], 'blebbing': [155], '(outer)': [158], 'mechanism': [161], 'found': [162, 324, 552, 646, 729, 1034], 'bacterial': [165, 973, 985, 1082, 1095], 'species': [166], 'date.[8]': [169], 'Bacterial': [170], 'serve': [172], 'functions': [174, 415], 'virulence': [179], 'factors,[9]': [180], 'nutrient': [181], 'acquisition,[2]': [182], 'host': [183], 'cell': [184, 377, 611], 'modulation,': [185], 'biofilm': [187], 'architecture.[10]': [188], 'To': [189, 695, 945], 'apply': [190], 'these': [191, 442], 'natural': [192], 'carrier': [193], 'systems': [194], 'biomedical': [196, 1235], 'few': [199], 'challenges': [200, 273, 1205], 'need': [201], 'be': [203, 860, 1039], 'addressed,': [204], 'not': [205, 567], 'least': [206], 'reproducible': [207, 471], 'loading': [208, 530, 555, 563, 598, 633, 803, 827, 837], 'large-scale': [210], 'characterization': [211, 458], 'heterogeneous': [213], 'preparations.': [215], 'addition,': [217], 'deeper': [219], 'understanding': [220], 'EV-mediated': [222], 'cellular': [223, 823], 'crosstalk': [224], 'needed': [226], 'inform': [228], 'robust': [229], 'vitro': [231, 1078], 'models': [232], 'mechanistic': [234], 'studies.': [235, 352], 'The': [236, 280, 1249], 'present': [237, 523, 1013], 'themed': [238], 'issue': [239], 'aims': [240], 'link': [242], 'developments': [244], 'biomaterials,': [246, 699], 'tissue': [247, 880], 'culture,': [248], 'model': [250, 1079, 1102], 'development': [251], 'biological': [253, 283, 515, 547, 572, 607], 'evaluations': [254], 'EVs.': [256, 518, 842], 'We': [257, 1218], 'compiled': [259], 'an': [260, 438, 711, 761, 1076], 'exciting': [261], 'collection': [262, 1222], 'articles': [264, 1224], 'that': [265, 325, 483, 553, 566, 647, 654, 685, 730, 777, 819, 834, 980, 1035, 1049, 1099, 1161, 1220], 'shine': [266], 'light': [267], 'on': [268, 290, 314, 397, 440, 467, 545, 892, 910, 967, 1004, 1081, 1192, 1448], 'some': [269], 'ongoing': [272], 'using': [275, 796], 'smart': [278], 'biomaterials.': [279], 'composition': [281, 335, 386, 399, 432], 'function': [284, 333, 742, 790], 'highly': [288, 525], 'dependent': [289], 'conditions': [292, 964], 'parent': [295], 'cells': [296, 322, 327, 857, 996], 'cultured.': [298], 'Christopher': [299], 'Millan,': [300], 'Daniel': [301, 848], 'Eberli,': [302], 'co-workers': [304, 463, 522, 579, 759, 900, 1012, 1146, 1181], '(manuscript': [305, 387, 453, 464, 549, 580, 643, 681, 708, 773, 814, 869, 913, 975, 1031, 1070, 1147, 1196], '2002067)': [306], 'assessed': [307, 542], 'impact': [309], '3D': [311, 347], 'engineered': [312, 346, 582], 'microtissues': [313], 'secreted': [316], 'benign': [318], 'malignant': [320], 'prostate': [321], '3D-cultured': [326], 'significantly': [330, 784], 'different': [331, 562], 'isolated': [338, 982, 999], '2D': [340], 'cultures,': [341], 'highlighting': [342], 'value': [344], 'microtissue': [348], 'cultures': [349], 'Similarly,': [353], 'systematic': [356], 'analysis,': [357], 'Jeremy': [358], 'P.': [359], 'Bost,': [360], 'Osama': [361], 'Saher,': [362], 'colleagues': [364, 429, 624, 666, 707, 813], 'showed': [365, 684, 776, 979, 1098], 'how': [366, 441, 854], 'exogenous': [367], 'factors': [368, 374, 396, 505, 772], 'such': [369], 'serum': [371], 'signaling': [373], 'culture': [378], 'medium': [379], 'can': [380, 859], 'affect': [381, 444], 'production,': [383], 'secretion,': [384], '2101658).': [388], 'Both': [389], 'studies': [390, 1202], 'highlight': [391], 'importance': [393, 1115], 'external': [395, 839], 'function.': [401], 'While': [402], 'potential': [404, 449, 1184], 'vehicles': [409], 'widely': [411], 'recognized,': [412], 'immunomodulatory': [414, 969], 'particular': [418], 'attention': [419], 'over': [420], 'years.': [422], 'article,': [425], 'Mei': [426], 'He': [427, 1372, 1422], 'discuss': [430, 816, 1149], 'receptor': [435], 'expression': [436], 'emphasis': [439], 'parameters': [443], 'immunogenicity': [446], 'cancer': [451], 'immunotherapeutics': [452], '2100650).': [454], 'Looking': [455], 'into': [456, 806, 828, 942], 'enhanced': [457], 'methods,': [459], 'Paolo': [460], 'Arosio': [461], '2100021)': [465], 'focused': [466], 'problem': [469], 'efficient': [473], 'sizing': [475], 'classification': [477], 'introducing': [479], 'microfluidic': [481], 'device': [482, 491], 'accurately': [484], 'determines': [485], 'vesicle': [486], 'concentration': [487], 'composition.': [489], 'Their': [490], 'was': [492, 602, 1346, 1392], 'shown': [493], 'simultaneously': [495], 'detect': [496], 'distinguish': [498], 'subtypes': [500], 'any': [502], 'non-vesicular': [503], 'impurities,': [504], 'extremely': [508], 'quantify': [511], 'when': [512], 'studying': [513], 'effects': [516], 'Jean-Christophe': [519, 1387], 'Leroux': [520, 1388], 'relevant': [526, 1230], 'comparison': [527], 'various': [529], 'methods': [531, 564], 'EVs—including': [533], 'saponin': [534], 'treatment,': [535], 'sonication,': [536], 'fusion,': [537], 'freeze-thawing,': [538], 'osmotic': [540], 'shock—and': [541], 'influence': [544, 904, 960], 'activity': [548], '2100047).': [550], 'They': [551, 645, 683, 728, 775, 1033, 1097, 1198], 'efficacy': [556, 628], 'hydrophilic': [558], 'drugs': [559], 'varied': [560], 'between': [561, 1154], 'techniques': [569], 'preserved': [570], 'functionality': [573], 'vesicles.': [575], 'Pieter': [576], 'Vader': [577], '2101202)': [581], 'RNA': [585, 638, 642], 'carriers': [587], 'hybridizing': [589], 'them': [590, 634, 723, 1133], 'liposomes.': [592], 'Using': [593], 'this': [594, 1215, 1221, 1246], 'simple': [595], 'approach,': [596, 753], 'capacity': [599, 970], 'increased': [603, 625, 780], 'without': [604], 'compromising': [605], 'functionality.': [608], 'Mesenchymal': [609], 'stem': [610], '(MSC)': [612], 'known': [615], 'angiogenic': [618], 'effects.': [619], 'Steven': [620], 'M.': [621, 1403], 'Jay': [622], 'therapeutic': [627, 804], 'MSC': [630], 'long': [636], 'non-coding': [637], 'HOX': [639], 'transcript': [640], 'antisense': [641], '2002070).': [644], 'MSCs': [648], 'overexpressing': [649], 'HOTAIR': [650], 'HOTAIR-enriched': [652], 'promoted': [655], 'angiogenesis': [656], 'wound': [658], 'healing': [659], 'diabetic': [661], 'mice.': [662], 'Ramasamy': [663], 'Paulmurugan': [664], 'created': [667], 'nanococktail': [669, 687], 'composed': [670], 'polymeric': [672], 'nanocarriers': [673, 1156], 'coated': [674], 'systemic': [678], 'miRNA': [679], '2101387).': [682], 'displayed': [688], 'tumor': [689, 693, 867], 'tropism': [690], 'inhibited': [692], 'growth.': [694], 'combine': [696], 'Junnan': [700], 'Tang,': [701], 'Xiaolin': [702], 'Cui,': [703], 'Jinying': [704], 'Zhang,': [705], '2100312)': [709], 'developed': [710], 'injection-free': [712], 'approach': [713], 'delivering': [715], 'treat': [718], 'myocardial': [719, 1296], 'infarction': [720, 1297], 'entrapping': [722], 'hydrogel': [726, 763, 779], 'network.': [727], 'were': [733, 988, 1072], 'slowly': [734], 'released': [735], 'network': [738], 'improved': [740, 785], 'cardiac': [741], 'mice': [744], 'treated': [745], 'EV-laden': [748], 'hydrogel.': [749], 'similar': [752], 'Haifeng': [754], 'Liu,': [755], 'Yubo': [756], 'Fan,': [757], 'used': [760, 861], 'injectable': [762], 'deliver': [765, 863], 'loaded': [767], 'growth': [769, 963, 986], 'transcription': [771], '2100334).': [774], 'stability': [782, 912], 'neovascularization': [786], 'recovered': [788], 'limb': [789, 793], 'after': [791], 'critical': [792], 'ischemia.': [794], 'When': [795, 1122], 'vehicle,': [801], 'effectively': [802], 'cargo': [805, 826, 836], 'key.': [809], 'Gordana': [810], 'Vunjak-Novakovic': [811], '2101557)': [815], 'engineering': [817], 'approaches': [818, 833], 'utilize': [820], 'endogenous': [822], 'machinery': [824], 'well': [831], 'allow': [835], 'through': [838, 1092], 'manipulation': [840], 'paper,': [845], 'Natalia': [846, 1009], 'Higuita-Castro,': [847], 'Gallego-Perez,': [849], 'team': [852, 1069], 'show': [853], 'myeloid-derived': [855], 'suppressor': [856], '(MDSCs)': [858], 'niche': [868], '2101619).': [870], 'After': [871], 'non-viral': [872], 'transfection,': [873], 'MDSCs': [874], 'continue': [875], 'home': [877], 'cancerous': [879], 'mediate': [885], 'antitumoral': [886], 'responses': [887, 1047], 'via': [888], 'paracrine': [889], 'signaling.': [890], 'Following': [891, 1173], 'further': [894], 'physicochemical': [895], 'characterizations,': [896], 'Wolfgang': [897], 'Friess': [898], 'comprehensively': [901], 'lyophilization': [906], '(freeze-drying)': [907], 'cryoprotectants': [909], '2100538).': [914], 'This': [915], 'evaluation': [916], 'included': [917], 'several': [918, 1200], 'common': [919, 1090], 'excipients': [920], 'examined': [922], 'up': [923, 1174], 'six': [925], 'months': [926], 'storage': [928, 932], 'stability,': [929], 'since': [930, 1370], 'long-term': [931], 'ultimately': [934], 'required': [935], 'technological': [938], 'translation': [939, 1210], 'real-world': [943], 'practice.': [944], 'better': [946, 990], 'characterize': [947], 'pathogen-derived': [948], 'vaccination': [951], 'approaches,': [952], 'Gregor': [953, 1357, 1407], 'Fuhrmann': [954, 1358], 'his': [956, 1067, 1374, 1409], 'group': [957, 1412], 'streptococci': [966], '2101151).': [976], 'Proteomic': [977], 'analyses': [978], 'later': [984], 'stages': [987], 'no': [989, 1252], 'modulating': [992], 'primary': [993], 'human': [994], 'immune': [995], 'than': [997, 1108], 'those': [998], 'earlier': [1001], 'timepoints.': [1002], 'Expanding': [1003], 'role': [1006, 1185], 'EVs,': [1008], 'Higuita-Castro': [1010], 'detailed': [1015], 'study': [1016], 'manufacturing': [1019], 'process': [1020], 'neurogenic': [1022], 'central': [1028], 'nervous': [1029], 'system': [1030], '2100805).': [1032], 'designer': [1036], 'could': [1038], 'promising': [1041], 'platform': [1043], 'modulate': [1045], 'pro-neuronal': [1046], 'modifying': [1050], 'glutamate': [1054], 'receptors': [1055], 'facilitated': [1056], 'deployment': [1058], 'brain.': [1063], 'Claus-Michael': [1064], 'Lehr': [1065], 'research': [1068, 1163, 1216, 1232, 1411, 1446], '2101180)': [1071], 'interested': [1073], 'developing': [1075, 1123], 'based': [1080], 'predict': [1086], 'diffusion': [1088], 'antibiotics': [1091], 'Gram-negative': [1094], 'membrane.': [1096], 'vesicle-based': [1101], 'had': [1103], 'greater': [1105], 'predictive': [1106], 'accuracy': [1107], 'commonly': [1109], 'applied': [1110], 'liposomal': [1111], 'models,': [1112], 'emphasizing': [1113], 'proteins': [1118], 'vesicular': [1120], 'transport.': [1121], 'carriers,': [1127], 'it': [1128], 'pivotal': [1130], 'assess': [1132], 'against': [1134], 'appropriate': [1135], 'lipid-based': [1136], 'comparator': [1137], 'systems.': [1138], 'review': [1141], 'manuscript,': [1142], 'Alika': [1143], 'Nagelkerke': [1144], '2100639)': [1148], 'similarities': [1151], 'differences': [1153], 'ensure': [1160], 'both': [1162], 'areas': [1164], 'benefit': [1165], 'each': [1167], 'other': [1168], 'near': [1171], 'future.': [1172], 'this,': [1176], 'James': [1177], 'C.': [1178], 'Iatridis': [1179], 'reviewed': [1182], 'regenerative': [1189], 'medicine,': [1190], 'focusing': [1191], 'intervertebral': [1193], 'disc': [1194], 'degeneration': [1195], '2100596).': [1197], 'evaluated': [1199], 'preclinical': [1201], 'identified': [1204], 'associated': [1206], 'clinical': [1209], 'therapeutics': [1213], 'area.': [1217], 'believe': [1219], 'covers': [1225], 'wide': [1227], 'range': [1228], 'arena,': [1236], 'we': [1238], 'grateful': [1240], 'opportunity': [1243], 'co-edit': [1245], 'special': [1247], 'issue.': [1248], 'authors': [1250], 'declare': [1251], 'conflict': [1253], 'interest.': [1255], 'Juliane': [1256], 'Nguyen': [1257], 'associate': [1259], 'professor': [1260, 1362], 'Vice': [1262], 'Chair': [1263], 'Division': [1266], 'Pharmacoengineering': [1268], 'Molecular': [1270], 'Pharmaceutics,': [1271], 'School': [1272], 'Pharmacy,': [1274], 'University': [1277], 'North': [1279], 'Carolina': [1280], 'Chapel': [1282], 'Hill.': [1283], 'Her': [1284], 'lab': [1285], 'develops': [1286], 'protein-,': [1288], 'RNA-,': [1289], 'exosome-based': [1291], 'platforms': [1293], 'treating': [1295], 'cancer.': [1299], 'Dr.': [1300], 'Nguyen’s': [1301], 'work': [1302], 'recognized': [1305], 'NSF': [1308], 'CAREER': [1309], 'Award': [1310, 1315, 1327, 1439], '(2018),': [1311], 'Young': [1313, 1437], 'Innovator': [1314], 'Biomedical': [1318], 'Engineering': [1319], 'Society': [1320], '(2019),': [1321], 'AAPS': [1324], 'Emerging': [1325], 'Leader': [1326], '(2019).': [1328], 'She': [1329], 'received': [1330, 1434], 'her': [1331], 'Ph.D.': [1332], 'pharmaceutical': [1334, 1364], 'sciences': [1335], 'Philipps-University': [1338], 'Marburg': [1340], '(Germany)': [1341], 'Thomas': [1343], 'Kissel': [1344], 'Deutsche': [1348], 'Forschungsgemeinschaft': [1349], 'Postdoctoral': [1350], 'Fellow': [1351], 'UCSF': [1353], 'Frank': [1355], 'Szoka.': [1356], 'biology': [1365], 'Friedrich-Alexander-University': [1368], 'Erlangen-Nürnberg': [1369], '2021.': [1371], 'obtained': [1373], 'doctoral': [1375], 'degree': [1376], 'Swiss': [1379], 'Federal': [1380], 'Institute': [1381, 1416], 'Technology': [1383], 'ETH': [1384], 'Zurich': [1385], '2013,': [1390], 'postdoc': [1394], 'Imperial': [1396], 'College': [1397], 'London': [1398], '2013–2016': [1400], 'Molly': [1402], 'Stevens.': [1404], 'From': [1405], '2016–2021,': [1406], 'led': [1408], 'junior': [1410], 'Helmholtz': [1415], 'Pharmaceutical': [1418, 1443], 'Research': [1419], 'Saarland,': [1420], 'Germany.': [1421], 'former': [1425], 'Marie-Curie': [1426], 'current': [1428], 'ERC': [1429], 'Starting': [1430], 'Grant': [1431], 'awardee,': [1432], '2019s': [1436], 'Invetigator': [1438], 'German': [1442], 'Society.': [1444], 'His': [1445], 'focusses': [1447], 'infection': [1452], 'inflammatory': [1454], 'dispositions.': [1455]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4214951756', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}], 'updated_date': '2024-12-17T12:18:46.096449', 'created_date': '2022-03-05'}