Title: Faculty Opinions recommendation of CD8- dendritic cell activation status plays an integral role in influencing Th2 response development.
Abstract: Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8- DC pulsed with Th2-polarizing Ag (soluble egg Ag (SEA)) from Schistosoma mansoni potently stimulate Th2 responses in vivo and in vitro while failing to undergo a conventional maturation process. Thus, in contrast to DC pulsed with the Th1 response inducing Ag Propionebacterium acnes, SEA-exposed DC exhibit a phenotype that is most similar to that of immature DC, failing to up-regulate expression of CD40, CD54, CD80, CD86, or OX40L; producing no detectable IL-4, IL-10, or IL-12; and displaying only a minor increase in MHC class II expression. Importantly, in vitro derived DC exposed to SEA were phenotypically similar to CD8- DC isolated from active S. mansoni infection. By discriminating between different types of pathogen and responding appropriately, CD8- DC play a major role in the decision process to mount either a Th1 or Th2 response. PMID: 11489979 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: N01-AI-55270 PHS HHS, United States Grant ID: A132573
Publication Year: 2001
Publication Date: 2001-09-27
Language: en
Type: dataset
Indexed In: ['crossref']
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