Title: High serum and epidermal extracellular levels of galectin-7 in atopic dermatitis
Abstract:Background • Atopic dermatitis (AD) patients show an impaired barrier function with Th2 dominant skin inflammation • Galectin-7 is specifically developed in epidermal keratinocytes • Galectin-7 was hi...Background • Atopic dermatitis (AD) patients show an impaired barrier function with Th2 dominant skin inflammation • Galectin-7 is specifically developed in epidermal keratinocytes • Galectin-7 was highly expressed in the cornified layer of AD patients Galectin-7/Glyceraldehyde-3phosphate dehydrogenase Healthy Controls AD patients Summary P143 Objective To investigate the relationship between serum Galectin-7 levels and AD-associated markers Results25 Japanese AD patients and 7 healthy controls were enrolled in this study.A serum galetin-7 level was significantly increased in AD patients compared to healthy controls.Among total AD patients, a serum galectin-7 positively correlated with SCORAD, (CCL17/)TARC, LDH, % eosinophils, TEWL, and pruritus.※AD patients were also divided into extrinsic types(high IgE levels) and intrinsic (normal IgE levels) ones.Read More