Abstract: Voor mijn ouders en Joost Gwite/tft List of abbreviations.8 Chapter I. Tumor angiogenesis: an introduction.9 Chapter 2. Development of an in vitro proliferation assay.27 toy />rinri/?/«,SciVncr.7>C/WK>/O&V, M«//C/>W./?. /f.Ltf/ig<rr, £#s.B/nUtóur*r Krrfas BOJW, 26/-26J, Chapter 3. Mitogenic properties of tumor spheroids for endothelial cells 37 are related to their age.fE/u/or/iW/um /99J, /n Chapter 4. Tumor spheroid induced vesicle formation on endothelial cells is 47 associated with procoagulant properties.fJ.CW/ Sriinc?/ 9 9 i , occ.Y Chapter 5. Lipid peroxidation of the endothelial cell membrane: a possible 59 mechanism in tumor angiogenesis?Chapter 6. Mast cells modify tumor-induced procoagulant properties of 73 endothelial cells.(77jromZ>.fley.7PPJ, Chapter 7. Cisplatin and 5-Fluorouracil inhibit endothelial cell proliferation 85 and interfere with endothelial cell procoagulant activity.Chapter 8.