2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Name: Work Video:
Duration: 3 min 30 s
Scott M. Grundy; Neil J. Stone; Alison L. Bailey; Craig Beam; Kim K. Birtcher; Roger S. Blumenthal; Lynne T. Braun; Sarah D. de Ferranti; Joseph Faiella-Tommasino; Daniel E. Forman; Ronald Goldberg; Paul A. Heidenreich; Mark A. Hlatky; Daniel W. Jones; Donald M. Lloyd‐Jones; Nuria Lopez-Pajares; Chiadi E Ndumele; Carl E. Orringer; Carmen Peralta; Joseph J. Saseen; Sidney C. Smith; Laurence S. Sperling; Salim S. Virani; Joseph Yeboah
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'and': [211, 345, 426, 438, 449, 459, 465, 502, 554, 562, 573, 602, 618, 637, 697, 727, 824, 871, 888, 943, 970, 989, 1083, 1102, 1110, 1119, 1122, 1137, 1199, 1220, 1312, 1354, 1406, 1462, 1468, 1497, 1545, 1574, 1589, 1594, 1603, 1611, 1669, 1691, 1700, 1708, 1711, 1722, 1735, 1750, 1753, 1774, 1800, 1805, 1809, 1815, 1825, 1830, 1850, 1867, 1876, 1883, 1927, 1935, 1945, 1974, 1998, 2029, 2044, 2046, 2135, 2154, 2168, 2176, 2249, 2257, 2259, 2282, 2325, 2339, 2366, 2460, 2477, 2484, 2498, 2504, 2592, 2602, 2607, 2660, 2684, 2728, 2764, 2787, 2805, 2835, 2858, 2870, 2884, 2927, 2934, 2937, 2979, 3037, 3064, 3092, 3105, 3124, 3152, 3159, 3169, 3192, 3257, 3272, 3277, 3305, 3313, 3360, 3378, 3469, 3569, 3576, 3583, 3617, 3698, 3726, 3728, 3813, 3839, 3935, 3955], 'Yeboah,': [213], 'GrundyScott': [220], 'Grundy': [222], ',': [223, 229, 235, 239, 245, 251, 257, 263, 267, 273, 277, 283, 289, 295, 299, 303, 309, 315, 321, 327, 335, 339], 'StoneNeil': [226], 'Stone': [228], 'BaileyAlison': [232], 'Bailey': [234], 'BeamCraig': [237], 'Beam': [238], 'BirtcherKim': [242], 'Birtcher': [244], 'BlumenthalRoger': [248], 'Blumenthal': [250], 'BraunLynne': [254], 'Braun': [256], 'FerrantiSarah': [260], 'Ferranti': [262], 'Faiella-TommasinoJoseph': [265], 'Faiella-Tommasino': [266], 'FormanDaniel': [270], 'Forman': [272], 'GoldbergRonald': [275], 'Goldberg': [276], 'HeidenreichPaul': [280], 'Heidenreich': [282], 'HlatkyMark': [286], 'Hlatky': [288], 'JonesDaniel': [292], 'Jones': [294], 'Lloyd-JonesDonald': [297], 'Lloyd-Jones': [298], 'Lopez-PajaresNuria': [301], 'Lopez-Pajares': [302], 'NdumeleChiadi': [306], 'Ndumele': [308], 'OrringerCarl': [312], 'Orringer': [314], 'PeraltaCarmen': [318], 'Peralta': [320], 'SaseenJoseph': [324], 'Saseen': [326], 'JrSidney': [331], 'Jr': [334], 'SperlingLaurence': [337], 'Sperling': [338], 'ViraniSalim': [342], 'Virani': [344], 'YeboahJoseph': [347], 'Yeboah': [348], 'Originally': [349], 'published10': [350], 'Nov': [351], '2018https://doi.org/10.1161/CIR.0000000000000624Circulation.': [352], '2019;139:e1046–e1081is': [353], 'corrected': [354], 'byCorrection': [355], 'to:': [356], '2018': [357, 2122, 2269, 2511], 'GuidelinesOther': [383], 'version(s)': [384], 'this': [386, 395, 2227, 2532, 2537, 2574, 2809, 2901], 'articleYou': [387], 'are': [388, 1192, 1521, 1567, 1643, 1675, 1714, 1836, 1881, 1916, 2147, 2174, 2314, 2479, 2893, 2963, 2972, 3096, 3286, 3311, 3338, 3413, 3430, 3443, 3601], 'viewing': [389], 'most': [391, 3077], 'recent': [392, 3864], 'version': [393, 1959, 2183], 'article.': [396], 'Previous': [397], 'versions:': [398], 'November': [399], '10,': [400, 2510], '2018:': [401], 'Ahead': [402], 'Print': [404], 'Table': [405, 2873, 3341, 3446, 3755], 'ContentsTop': [407], '10': [408, 651, 3485, 3491, 3495], 'Take-Home': [409, 652], 'Messages': [410, 653], 'Reduce': [412, 655], 'Risk': [413, 503, 544, 581, 592, 598, 656, 1062], 'Atherosclerotic': [415, 658], 'Cardiovascular': [416, 659, 2683, 2730], 'Disease': [417, 660], 'Through': [418, 661], 'Cholesterol': [419, 458, 629, 648, 662, 2270, 3271, 3585], 'e1047Preamble': [421], 'e10481.': [422], 'Introduction': [423], 'e10491.1.': [424], 'Methodology': [425, 1997], 'Evidence': [427, 452, 1999, 2440, 3172, 3195], 'Review': [428, 437, 2441, 2763], 'e10491.2.': [429], 'Organization': [430, 2634], 'Writing': [433, 2637], 'Committee': [434], 'e10501.3.': [435], 'Document': [436, 2762], 'Approval': [439], 'e10511.4.': [440], 'Scope': [441, 2837], 'e10511.5.': [445], 'Class': [446, 3089, 3166, 3189, 3751], 'Recommendation': [448, 3091, 3168, 3191, 3753], 'Level': [450, 3093, 3170, 3193], 'e10511.6.': [453], 'Abbreviations': [454], 'e10512.': [455], 'High': [456, 3269], 'ASCVD': [460, 482, 702, 817, 822, 831, 911, 954, 1002, 1051, 1148, 1368, 1510, 2102, 2962, 2995, 3084, 3736, 3758, 3806, 3811, 3848, 3850, 3910, 3948, 3953], 'e10522.1.': [461], 'Measurements': [462, 3274], 'LDL-C': [464, 516, 765, 785, 794, 846, 860, 919, 932, 990, 1037, 1139, 1195, 1206, 1249, 1356, 1504, 1525, 2358, 3276, 3367, 3391, 3464, 3519, 3540, 3547, 3924], 'Non–HDL-C': [466], 'e10523.': [467], 'Therapeutic': [468, 3279], 'Modalities': [469], 'e10523.1.': [470], 'Lipid-Lowering': [471, 3281], 'Drugs': [472], 'e10523.1.1.': [473], 'Statin': [474, 552, 3347, 3421, 3471], 'Therapy': [475, 532], 'e10524.': [476], 'Patient': [477, 3182, 3205, 3732], 'Groups': [479, 539], 'e10534.1.': [480], 'Secondary': [481, 3735, 3741], 'Prevention': [483, 499, 507, 535], 'e10534.2.': [484], 'Severe': [485], 'Hypercholesterolemia': [486], '(LDL-C': [487, 902, 3925], '≥190': [488, 904], 'mg/dL': [489, 521, 798, 850, 864, 905, 923, 940, 992, 1142, 1252, 1290, 1316, 1359, 1362, 1528, 2483, 2493, 3927], '[≥4.9': [490, 906], 'mmol/L])': [491, 3929], 'e10554.3.': [492], 'Diabetes': [493, 2707, 3912], 'Mellitus': [494], 'in': [495, 528, 536, 590, 1124, 1296, 1333, 1399, 1427, 1503, 1636, 1685, 1740, 1858, 1885, 1891, 2003, 2027, 2031, 2149, 2170, 2180, 2276, 2322, 2346, 2360, 2481, 2492, 2519, 2622, 2808, 2875, 2900, 2946, 2980, 3055, 3128, 3181, 3204, 3291, 3340, 3343, 3395, 3417, 3432, 3445, 3448, 3527, 3539, 3546, 3563, 3581, 3596, 3614, 3623, 3650, 3665, 3718, 3743, 3754], 'Adults': [496, 508, 548], 'e10554.4.': [497], 'Primary': [498, 506, 534], 'e10554.4.1.': [500], 'Evaluation': [501], 'Assessment': [504, 582], 'e10574.4.2.': [505], '40': [509, 980, 1042, 1128, 1211, 1345, 2982, 3497, 3501, 3508], '75': [511, 982, 1022, 1044, 1130, 1213, 1347, 2984], 'Years': [512], 'Age': [514, 538, 3889], 'With': [515, 549, 616, 635], 'Levels': [517], '70': [518, 797], '189': [520, 1361], '(1.7': [522], '4.8': [524], 'mmol/L)': [525, 800, 866, 942, 1530], 'e10574.4.3.': [526], 'Monitoring': [527, 601], 'Response': [529], 'LDL-C–Lowering': [531], 'e10594.4.4.': [533], 'Other': [537, 541, 619, 638, 3297], 'e10594.5.': [540], 'Populations': [542], 'at': [543, 683, 855, 893, 975, 1009, 1145, 1321, 1335, 1365, 1512, 1623, 2309, 2948, 2993], 'e10604.5.1.': [545], 'Ethnicity': [546], 'e10604.5.4': [547], 'CKD': [550, 3915], 'e10625.': [551], 'Safety': [553], 'Statin-Associated': [555], 'Side': [556], 'Effects': [557, 3722], 'e10626.': [558], 'Implementation': [559], 'e10647.': [560], 'Cost': [561], 'Value': [563, 567], 'Considerations': [564], 'e10647.1.': [565], 'Economic': [566], 'Considerations:': [568], 'PCSK9': [569, 876, 957, 2082, 2935, 3306, 3841], 'Inhibitors': [570], 'e10648.': [571], 'Limitations': [572], 'Knowledge': [574], 'Gaps': [575], 'e10658.1.': [576], 'Randomized': [577], 'Controlled': [578], 'Trials': [579], 'e10658.2.': [580], 'e10668.2.1.': [583], 'Continuing': [584], 'Refinement': [585, 595], 'PCE': [587], 'e10668.2.2.': [588], 'Improvement': [589], 'Lifetime': [591], 'Estimate': [593], 'e10668.2.3.': [594], 'Clinician–Patient': [597], 'Discussion': [599], 'e10668.2.4.': [600], 'Adjustment': [603], 'Treatment': [605, 3230, 3586], 'e10668.2.5.': [606], 'Prognostic': [607], 'Significance': [608], 'CAC': [610, 1386, 1417, 1438], 'e1066References': [611], 'e1067Appendix': [612], '1:': [613], 'Author': [614], 'Relationships': [615, 634], 'Industry': [617, 636], 'Entities': [620, 639], '(Relevant)—2018': [621], '(August': [630, 649], '2018)e1077Appendix': [631], '2:': [632], 'Reviewer': [633], '(Comprehensive)—2018': [640], '2018)e1079Top': [650], 'ManagementIn': [663], 'all': [664, 684, 733, 2424, 2610, 3794], 'individuals,': [665, 688, 1298], 'emphasize': [666], 'a': [667, 779, 793, 812, 875, 956, 1031, 1054, 1066, 1146, 1153, 1157, 1366, 1375, 1409, 1578, 1786, 1886, 1896, 1900, 1936, 2196, 2377, 2512, 2549, 2559, 2649, 2653, 2656, 2658, 2661, 2880, 3010, 3043, 3074, 3100, 3106, 3317, 3403, 3594, 3801, 3943], 'heart-healthy': [668], 'lifestyle': [669, 676, 690, 730, 736, 1101, 1469, 1496, 3087, 3295], 'across': [670, 3605], 'life': [672], 'course.': [673], 'healthy': [675, 689, 3294], 'reduces': [677], 'atherosclerotic': [678, 2299, 2385, 2426, 2429, 2953, 3796, 3825, 3967], 'cardiovascular': [679, 1562, 1585, 1627, 2095, 2331, 2386, 2430, 2437, 2954, 3219, 3598, 3826, 3968], 'disease': [680, 1628, 2300, 2387, 2419, 2955, 3789, 3876], '(ASCVD)': [681, 2388, 2956], 'risk': [682, 695, 703, 718, 722, 776, 858, 952, 1016, 1056, 1070, 1086, 1149, 1174, 1202, 1222, 1337, 1369, 1459, 1624, 3012, 3020, 3030, 3039, 3085, 3217, 3253, 3687, 3720], 'ages.': [685], 'In': [686, 705, 732, 828, 853, 1004, 1509, 2968, 3061], 'younger': [687], 'can': [691, 1727, 1854, 3032, 3458], 'reduce': [692, 749, 1035, 1194, 1205], 'development': [693, 1593], 'factors': [696, 948, 1017, 1071, 1093, 1166, 1230, 1240, 1328, 3021], 'is': [698, 738, 766, 834, 878, 886, 891, 928, 968, 973, 1027, 1176, 1203, 1380, 1387, 1440, 1449, 1632, 1663, 1775, 1952, 1964, 2274, 2759, 2806, 2846, 2940, 3007, 3041, 3049, 3073, 3079, 3353, 3677], 'foundation': [700, 1579], 'reduction.': [704, 777], 'young': [706, 3065], 'adults': [707, 1041, 1127, 1210, 1344, 2292, 2981, 3056, 3564], '20': [708, 3481, 3515], '39': [710], 'years': [711, 983, 1023, 1045, 1131, 1214, 1348, 1430, 2294, 2985, 3058], 'age,': [713, 1025], 'an': [714, 1953, 2187, 2520, 3050, 3710], 'assessment': [715], 'lifetime': [717, 3083], 'facilitates': [719], 'clinician–patient': [721, 1055, 1458, 3011, 3029], 'discussion': [723, 1057, 1063, 1158, 3013, 3031], '(see': [724, 1094, 1170, 1187, 1236, 1535], '6)': [726], 'emphasizes': [728], 'intensive': [729], 'efforts.': [731], 'age': [734, 985, 1047, 1133, 1216, 1350, 2296, 2987], 'groups,': [735], 'therapy': [737, 757, 843, 998, 1169, 1235, 1332, 1379, 1392, 1448, 1499, 1520, 1534, 2375, 3352, 3364, 3373, 3381, 3612, 3934], 'primary': [740, 900, 1050, 2091, 2889, 2969, 3523, 3567], 'intervention': [741, 3144, 3905], 'for': [742, 1049, 1107, 1516, 1580, 1697, 1918, 1940, 1971, 2041, 2219, 2267, 2466, 2494, 2505, 2720, 2816, 2974, 3014, 3548], 'metabolic': [743, 1255], 'syndrome.In': [744], 'patients': [745, 854, 897, 979, 1005, 1334, 1511, 1620, 1646, 1684, 2853, 2947, 2960, 2975, 3744], 'with': [746, 754, 898, 986, 1006, 1014, 1138, 1355, 1390, 1403, 1408, 1471, 1507, 1558, 1621, 1671, 1737, 1812, 1848, 1956, 2226, 2278, 2297, 2373, 2382, 2395, 2552, 2572, 2854, 2906, 2961, 2965, 2976, 2989, 3069, 3098, 3255, 3441, 3521, 3565, 3630, 3745, 3766, 3880], 'clinical': [747, 1555, 1597, 1695, 1704, 1803, 2202, 2298, 3157, 3396, 3528, 3624, 3746], 'ASCVD,': [748, 791, 2312, 3824, 3966], 'low-density': [750, 2444, 2471, 3264, 3266, 3702, 3829], 'lipoprotein': [751, 1313, 1325, 2445, 2472, 2475, 3241, 3267, 3703, 3830, 3834], 'cholesterol': [752, 2206, 2469, 2857, 2917], '(LDL-C)': [753], 'high-intensity': [755, 914, 1032], 'statin': [756, 761, 769, 782, 807, 842, 870, 915, 935, 997, 1033, 1060, 1103, 1117, 1155, 1163, 1168, 1234, 1331, 1378, 1391, 1424, 1447, 1480, 1498, 1533, 2105, 2374, 2383, 3332, 3351, 3363, 3372, 3380, 3455, 3524, 3550, 3611, 3716, 3933], 'or': [758, 819, 1018, 1263, 1276, 1317, 1396, 1444, 1482, 1622, 1658, 1821, 1840, 1911, 2306, 2308, 2402, 2405, 2407, 2416, 2627, 2632, 2992, 3178, 3201, 3672, 3773, 3776, 3786, 3808, 3883, 3886, 3902, 3950], 'maximally': [759, 780, 840, 868, 3931], 'tolerated': [760, 781, 841, 869, 3932], 'therapy.': [762, 808, 916, 1061, 1164], 'The': [763, 1587, 1630, 1823, 1843, 1962, 2143, 2242, 2264, 2581, 2615, 2664, 2861, 2888, 3111, 3132], 'more': [764], 'reduced': [767], 'therapy,': [770, 873, 1425, 1701, 2106, 3290], 'greater': [772, 3404], 'will': [773, 3393], 'be': [774, 960, 1394, 1653, 1728, 1855, 1870, 2566, 3459, 3619], 'subsequent': [775, 951], 'Use': [778], 'lower': [784], 'levels': [786, 1140, 1196, 1207, 1250, 1357, 1505, 1526, 3368], 'by': [787, 1039, 1197, 1208, 1454, 1500, 1523, 1719, 1730, 1782, 1806, 2131, 2159, 2215, 2502, 2507, 2585, 2594, 2598, 2609, 2769, 2775, 2818, 3369, 3374, 3382, 3680], '≥50%.In': [788, 1040, 1209], 'very': [789, 829, 856, 1513, 2949], 'high-risk': [790, 810, 826, 830, 1279, 2310, 2950, 3799, 3815, 3941, 3957], 'use': [792, 1030, 2939, 3327], 'threshold': [795, 1524], '(1.8': [799], 'consider': [802, 1178, 1382], 'addition': [803, 3292], 'nonstatins': [805], 'Very': [809, 3798, 3844], 'includes': [811, 1895, 2283, 2389, 3800, 3942], 'history': [813, 1243, 1260, 1412, 2396, 3767, 3802, 3944], 'multiple': [815, 825, 947, 1015, 3804, 3814, 3946, 3956], 'major': [816, 821, 1069, 3019, 3597, 3805, 3810, 3909, 3947, 3952], 'events': [818, 2328, 2350, 3807, 3949], '1': [820, 1420, 2735, 3638, 3809], 'event': [823, 3812, 3866, 3954], 'conditions.': [827], 'patients,': [832, 1736], 'it': [833, 1026, 2544], 'reasonable': [835, 1028], 'add': [837], 'ezetimibe': [838, 872, 927, 937, 2933, 3936], 'when': [844, 1717, 1907, 2141, 2536, 3038], 'level': [847, 861, 903, 920, 933, 1038, 3107, 3133], 'remains': [848, 862, 921, 938], '≥70': [849, 863, 991, 1141, 1358, 1527], '(≥1.8': [851, 865, 993, 1143, 1529], 'mmol/L).': [852], 'high': [857, 2855], 'whose': [859], 'adding': [874, 926, 1517], 'inhibitor': [877, 958], 'reasonable,': [879], 'although': [880, 962], 'long-term': [882, 964], 'safety': [883, 965, 3422], '(>3': [884, 966], 'years)': [885, 967], 'uncertain': [887, 969], 'cost': [889], 'effectiveness': [890], 'low': [892, 974], 'mid-2018': [894, 976], 'list': [895, 977, 2881], 'prices.In': [896, 978], 'severe': [899, 2977], 'hypercholesterolemia': [901, 2978, 3071, 3894], 'mmol/L]),': [907], 'without': [908, 999, 1134, 1217, 1351, 1600, 1838], 'calculating': [909, 1000], '10-year': [910, 1001, 1085, 1147, 1201, 1221, 1336, 1367], 'risk,': [912, 1011], 'begin': [913], 'If': [917, 930, 1173, 1190, 1385], '≥100': [922, 939, 1441, 3926], '(≥2.6': [924, 941], 'mmol/L),': [925, 994, 1144, 1364], 'reasonable.': [929], 'plus': [936, 2376], 'patient': [945, 1120, 1738, 3712], 'has': [946, 3423], 'that': [949, 1765, 1834, 2558, 3437, 3578, 3627], 'increase': [950], 'events,': [955], 'may': [959, 1329, 1393, 1652, 3401, 3438], 'considered,': [961], 'economic': [971], 'value': [972], 'diabetes': [987, 1007, 1135, 1218, 1352, 1404, 2107, 2354, 2990], 'mellitus': [988, 1008, 1136, 1219, 1353, 2991, 3913], 'start': [995, 1152], 'moderate-intensity': [996, 1154, 3371], 'risk.': [1003, 2996, 3131], 'higher': [1010, 1322, 2994], 'especially': [1012, 1320, 1426], 'those': [1013, 1019, 1402, 1407, 1428, 2394, 3068, 3765], '50': [1020], 'evaluated': [1048, 2232, 3580, 3664], 'prevention,': [1052, 2092, 2094, 2970], 'have': [1053, 1550, 1827, 1865, 2903, 2924, 3316, 3402], 'before': [1058], 'starting': [1059], 'should': [1064, 1692, 3618, 3628], 'include': [1065, 1241, 2932, 3033, 3300], 'review': [1067, 1612, 2190, 2199, 2247, 2266, 2628], '(eg,': [1072, 1272, 1282, 2301, 2329], 'cigarette': [1073, 1400], 'smoking,': [1074], 'elevated': [1075, 1248, 3923], 'blood': [1076, 2856], 'pressure,': [1077], 'LDL-C,': [1078, 2076, 2443, 2496, 3701, 3828], 'hemoglobin': [1079], 'A1C': [1080], '[if': [1081], 'indicated],': [1082], 'calculated': [1084], 'ASCVD);': [1088], 'presence': [1090], 'risk-enhancing': [1092, 1229, 2103, 3035], '8);': [1096], 'potential': [1098, 1106], 'benefits': [1099], 'therapies;': [1104], 'adverse': [1108, 2349], 'effects': [1109, 3429], 'drug–drug': [1111, 3456], 'interactions;': [1112], 'consideration': [1113], 'costs': [1115], 'therapy;': [1118], 'preferences': [1121], 'values': [1123, 1323, 2465, 2491], 'shared': [1125, 1731, 3016], 'decision-making.In': [1126], '≥7.5%,': [1151], 'if': [1156, 1200, 1294, 1374, 1436, 3643], 'treatment': [1160, 1389], 'options': [1161], 'favors': [1162, 1423], 'Risk-enhancing': [1165, 1239, 1327], 'favor': [1167, 1231, 1330], '8).': [1172], 'status': [1175, 3040], 'uncertain,': [1177, 1381, 3042], 'using': [1179, 2540, 3535], 'coronary': [1180, 2097, 2391, 2406, 2433, 3044, 3212, 3762, 3777, 3822, 3898, 3904, 3964], 'artery': [1181, 2098, 2304, 2418, 3045, 3221, 3788, 3899], 'calcium': [1182, 3046], '(CAC)': [1183, 3047], 'improve': [1185, 1561, 1665], 'specificity': [1186], '9).': [1189], 'statins': [1191, 2907, 2966, 2971, 3285, 3412, 3442, 3575], 'indicated,': [1193], '≥30%,': [1198], '≥20%,': [1204], '7.5%': [1224, 1341], '19.9%': [1226], '(intermediate': [1227], 'risk),': [1228], 'initiation': [1232, 1481, 3667], '7).': [1238], 'family': [1242, 1411], 'premature': [1245, 1264, 1414], 'ASCVD;': [1246], 'persistently': [1247], '≥160': [1251], '(≥4.1': [1253], 'mmol/L);': [1254, 1292], 'syndrome;': [1256, 3823, 3965], 'chronic': [1257, 1269, 1277, 3971], 'kidney': [1258, 3226, 3972], 'disease;': [1259, 2431, 2435, 2438, 3827, 3969, 3973], 'preeclampsia': [1262], 'menopause': [1265], '(age': [1266], '<40': [1267], 'years);': [1268], 'inflammatory': [1270], 'disorders': [1271], 'rheumatoid': [1273], 'arthritis,': [1274], 'psoriasis,': [1275], 'HIV);': [1278], 'ethnic': [1280], 'groups': [1281], 'South': [1283, 2112], 'Asian);': [1284], 'persistent': [1285], 'elevations': [1286], 'triglycerides': [1288], '≥175': [1289], '(≥1.97': [1291], 'and,': [1293, 1906], 'measured': [1295], 'selected': [1297, 2048, 2167], 'apolipoprotein': [1299], 'B': [1300], '≥130': [1301], 'mg/dL,': [1302], 'high-sensitivity': [1303], 'C-reactive': [1304], 'protein': [1305], '≥2.0': [1306], 'mg/L,': [1307], 'ankle-brachial': [1308, 3960], 'index': [1309], '(ABI)': [1310], '<0.9': [1311], '(a)': [1314], '≥50': [1315], '125': [1318], 'nmol/L,': [1319], '(a).': [1326], '5%': [1339], '(borderline': [1342], 'risk).In': [1343], '(≥1.8–4.9': [1363], '≥7.5%': [1371], '19.9%,': [1373], 'decision': [1376], 'about': [1377], 'measuring': [1383], 'CAC.': [1384], 'zero,': [1388], 'withheld': [1395], 'delayed,': [1397], 'except': [1398], 'smokers,': [1401], 'mellitus,': [1405, 2108], 'strong': [1410], 'ASCVD.': [1415, 3747], 'score': [1418, 1439, 3048], '99': [1422], '≥55': [1429], 'age.': [1432, 3060], 'For': [1433, 2746], 'any': [1434, 2569, 2623], 'patient,': [1435], 'Agatston': [1442], 'units': [1443], '≥75th': [1445], 'percentile,': [1446], 'indicated': [1450], 'unless': [1451], 'otherwise': [1452], 'deferred': [1453], 'outcome': [1456], 'discussion.Assess': [1460], 'adherence': [1461], 'percentage': [1463, 1501], 'response': [1464, 3405], 'LDL-C–lowering': [1466], 'medications': [1467, 3436, 3525, 3551], 'changes': [1470], 'repeat': [1472], 'lipid': [1473], 'measurement': [1474], '4': [1475], '12': [1477, 1489, 3857], 'weeks': [1478], 'after': [1479], 'dose': [1483], 'adjustment,': [1484], 'repeated': [1485], 'every': [1486], '3': [1487, 3356], 'months': [1490], 'as': [1491, 1819, 2789, 2791, 2908, 3328], 'needed.': [1492], 'Define': [1493], 'responses': [1494, 3609], 'reductions': [1502, 3520, 3600], 'compared': [1506, 2381], 'baseline.': [1508], 'high-risk,': [1514], 'triggers': [1515], 'nonstatin': [1518], 'drug': [1519], 'defined': [1522], 'maximal': [1532], '3).PreambleSince': [1537], '1980,': [1538], 'Cardiology': [1543, 2674, 2722], '(ACC)': [1544], '(AHA)': [1549], 'translated': [1551], 'scientific': [1552, 3140], 'evidence': [1553, 2010, 2015, 2139, 2145, 2157, 2189, 2246, 2868, 2892, 3109, 3135, 3141], 'into': [1554, 2221, 3355], 'practice': [1556, 1598, 1614, 1635, 3529], 'guidelines': [1557, 1599, 1615, 1642, 1651, 1864, 1874, 2999], 'recommendations': [1559, 1617, 1726, 2001, 2261], 'health.': [1563], 'These': [1564], 'guidelines,': [1565, 2867, 3004], 'which': [1566, 1702, 1892, 2017, 2212, 2524], 'based': [1568], 'systematic': [1570, 2198, 2265], 'methods': [1571, 1831], 'evaluate': [1573], 'classify': [1575], 'evidence,': [1576], 'provide': [1577, 1616], 'delivery': [1582], 'quality': [1584, 1666, 3138], 'care.': [1586], 'ACC': [1588, 1824, 3463], 'AHA': [1590, 1826], 'sponsor': [1591], 'publication': [1595, 2817], 'commercial': [1601], 'support,': [1602], 'members': [1604, 2231, 2253], 'volunteer': [1605], 'their': [1606, 2517, 2938, 3326], 'time': [1607], 'writing': [1610, 1768, 2126, 2133, 2161, 2217, 2229, 2251, 2513, 2562, 2587, 2612, 2616, 2639, 2665, 2741, 2753, 2803, 2862], 'efforts.Clinical': [1613], 'applicable': [1618], 'developing': [1626], '(CVD).': [1629], 'focus': [1631], 'medical': [1634, 1780, 2643], 'United': [1638], 'States,': [1639], 'but': [1640, 1687, 1942, 2067, 3321], 'these': [1641, 2998, 3591], 'relevant': [1644, 2050, 2117, 2235, 2530, 2550, 2570, 2744], 'throughout': [1647], 'world.': [1649], 'Although': [1650], 'used': [1654, 2158, 3526], 'inform': [1656], 'regulatory': [1657], 'payer': [1659], 'decisions,': [1660], 'intent': [1662], 'care': [1668], 'align': [1670], "patients'": [1672], 'interests.': [1673], 'intended': [1676], 'define': [1678], 'practices': [1679], 'meeting': [1680], 'needs': [1682], 'most,': [1686], 'not': [1688, 1693, 2069, 2177, 2529, 2620, 3324, 3678], 'all,': [1689], 'circumstances,': [1690], 'replace': [1694], 'judgment.Recommendations': [1696], 'guideline-directed': [1698], 'management': [1699, 2851], 'encompasses': [1703], 'evaluation,': [1705], 'diagnostic': [1706], 'testing,': [1707], 'both': [1709, 1720, 1770, 2482, 3099], 'pharmacological': [1710], 'procedural': [1712], 'treatments,': [1713], 'effective': [1715], 'only': [1716, 2910], 'followed': [1718], 'practitioners': [1721], 'patients.': [1723], 'Adherence': [1724], 'enhanced': [1729], 'decision-making': [1732, 3054], 'between': [1733], 'clinicians': [1734], 'engagement': [1739], 'selecting': [1741, 1783], 'interventions': [1742], 'basis': [1745, 3147], 'individual': [1747, 2323, 2793], 'values,': [1748], 'preferences,': [1749], 'associated': [1751], 'conditions': [1752, 3816], 'comorbidities.The': [1754], 'ACC/AHA': [1755, 1989, 2542, 2916], 'strives': [1762], 'ensure': [1764, 1833], 'guideline': [1767, 1938, 2006, 2125, 2561, 2600, 2625, 2845], 'committee': [1769, 2134, 2162, 2191, 2218, 2230, 2248, 2252, 2514, 2563, 2588, 2613, 2617, 2640, 2666, 2742, 2754, 2804, 2863], 'contains': [1771, 1980, 2879], 'requisite': [1772], 'expertise': [1773, 1816], 'representative': [1776, 2175], 'broader': [1779], 'community': [1781], 'experts': [1784, 2644], 'from': [1785, 2021, 2057, 2357, 2578, 2669, 3156, 3461, 3541, 3603, 3637], 'broad': [1787], 'array': [1788], 'backgrounds,': [1790], 'representing': [1791], 'different': [1792], 'geographic': [1793], 'regions,': [1794], 'sexes,': [1795], 'races,': [1796], 'ethnicities,': [1797], 'intellectual': [1798], 'perspectives/biases,': [1799], 'scopes': [1801], 'practice,': [1804], 'inviting': [1807], 'organizations': [1808], 'professional': [1810], 'societies': [1811], 'related': [1813, 2204, 2859, 2871], 'interests': [1814], 'participate': [1818, 2621], 'partners': [1820], 'collaborators.': [1822], 'rigorous': [1828], 'policies': [1829], 'documents': [1835], 'developed': [1837], 'bias': [1839], 'improper': [1841], 'influence.': [1842], 'complete': [1844], 'policy': [1845, 2557], 'relationships': [1847, 2571], 'industry': [1849, 3256], 'other': [1851, 2047, 2408, 2959, 3034, 3160, 3258, 3549, 3778], 'entities': [1852], '(RWI)': [1853], 'found': [1856], 'online.Beginning': [1857], '2017,': [1859], 'numerous': [1860], 'modifications': [1861], 'been': [1866, 2904, 2925, 3424], 'continue': [1868], 'implemented': [1871], 'make': [1873], 'shorter': [1875], 'enhance': [1877], '"user': [1878], 'friendliness."': [1879], 'written': [1882, 2597], 'presented': [1884, 2256], 'modular': [1887, 1920], 'knowledge': [1888, 1921], 'chunk': [1889, 1894, 1922], 'format,': [1890], 'each': [1893, 1919, 2773, 3635], 'table': [1897], 'recommendations,': [1899], 'brief': [1901], 'synopsis,': [1902], 'recommendation-specific': [1903], 'supportive': [1904], 'text': [1905], 'appropriate,': [1908], 'flow': [1909], 'diagrams': [1910], 'additional': [1912, 1972], 'tables.': [1913], 'Hyperlinked': [1914], 'references': [1915], 'provided': [1917], 'facilitate': [1924, 3053], 'quick': [1925], 'access': [1926], 'review.': [1928], 'More': [1929, 3452], 'structured': [1930], 'guidelines—including': [1931], 'word': [1932], 'limits': [1933], '("targets")': [1934], 'web': [1937], 'supplement': [1939], 'useful': [1941], 'noncritical': [1943], 'tables': [1944, 2140, 2146], 'figures—are': [1946], '2': [1947, 2582], 'such': [1948], 'changes.': [1949], 'This': [1950], 'Preamble': [1951], 'abbreviated': [1954], 'version,': [1955], 'detailed': [1958, 2182], 'available': [1960, 2760], 'online.': [1961], 'reader': [1963], 'encouraged': [1965], 'consult': [1967], 'full-text': [1969, 2280], 'guidelineP-1': [1970], 'guidance': [1973], 'details,': [1975], 'since': [1976], 'executive': [1978], 'summary': [1979], 'mainly': [1981, 2942], 'recommendations.Glenn': [1983], 'N.': [1984], 'Levine,': [1985], 'FAHAChair,': [1988], 'Guidelines1.': [1995], 'Introduction1.1.': [1996], 'ReviewThe': [2000], 'listed': [2002, 3444, 3633, 3867], 'present': [2005, 2053, 2172, 2223, 2738, 2844], 'are,': [2007], 'whenever': [2008], 'possible,': [2009], 'based.': [2011], 'An': [2012], 'initial': [2013], 'extensive': [2014], 'review,': [2016], 'included': [2018, 2066, 2148, 2667], 'literature': [2019], 'derived': [2020, 2356], 'research': [2022], 'involving': [2023], 'human': [2024], 'subjects,': [2025], 'published': [2026, 2119, 2169, 2275, 2807, 2866], 'English,': [2028], 'indexed': [2030], 'MEDLINE': [2032], '(through': [2033], 'PubMed),': [2034], 'EMBASE,': [2035], 'Cochrane': [2037], 'Library,': [2038], 'Agency': [2040], 'Healthcare': [2042], 'Research': [2043], 'Quality,': [2045], 'databases': [2049], 'guideline,': [2054], 'was': [2055, 2192, 2528, 2538, 2545, 2576, 2767, 2799, 2814, 3663], 'conducted': [2056], 'May': [2058, 2509], '1980': [2059], 'July': [2061], '2017.': [2062], 'Key': [2063], 'search': [2064], 'words': [2065], 'were': [2068, 2128, 2213, 2254, 2262, 2500, 2590, 3533, 3556, 3579], 'limited': [2070, 2941], 'following:': [2073], 'hyperlipidemia,': [2074, 3566], 'cholesterol,': [2075], 'HDL-C,': [2077, 2497, 3832], 'ezetimibe,': [2078, 3301], 'bile': [2079, 3302], 'acid': [2080, 3303], 'sequestrants,': [2081, 3304], 'inhibitors,': [2083, 2936], 'lifestyle,': [2084], 'diet,': [2085], 'exercise,': [2086], 'medications,': [2087], 'child,': [2088], 'adolescent,': [2089], 'screening,': [2090], 'secondary': [2093, 2944], 'disease,': [2096, 2305], 'calcium,': [2099], 'familial': [2100, 3070, 3893], 'hypercholesterolemia.': [2101], 'factors,': [2104, 3036], 'women,': [2109], 'adherence,': [2110], 'Hispanic/Latino,': [2111], 'Asian,': [2113], 'African': [2114], 'American.': [2115], 'Additional': [2116], 'studies': [2118], 'through': [2120, 3086, 3655], 'August': [2121, 3185, 3208], 'during': [2123], 'process,': [2127, 2228], 'also': [2129], 'considered': [2130, 2214, 2546], 'added': [2136], 'appropriate.': [2142], 'final': [2144], 'Online': [2151], 'Data': [2152], 'Supplement': [2153, 2878], 'summarize': [2155], 'formulate': [2164], 'recommendations.': [2165], 'References': [2166], 'document': [2173, 2739, 2766, 2810, 2813], 'all-inclusive.As': [2178], 'noted': [2179], 'Preamble,': [2186], 'independent': [2188], 'commissioned': [2193], 'perform': [2195], 'formal': [2197], 'critical': [2201], 'questions': [2203], '(Table': [2207, 3162, 3384, 3415, 3817], '1),': [2208], 'results': [2210], 'incorporation': [2220], 'guideline.': [2224, 2241, 2534], 'Concurrent': [2225], 'study': [2233], 'data': [2234, 2286, 3155, 3604, 3713], 'rest': [2238], 'findings': [2243], 'formally': [2255], 'discussed,': [2258], 'then': [2260], 'developed.': [2263], 'GuidelinesS1.1-1': [2273], 'conjunction': [2277], 'guideline,S1.1-2': [2281], 'its': [2284], 'respective': [2285], 'supplements.Table': [2287], '1.': [2288, 3740], 'ERC': [2289], 'QuestionsQuestionSection': [2290], 'NumberIn': [2291], '≥20': [2293], 'CHD,': [2302, 2432], 'peripheral': [2303, 2417, 3787, 3874], 'CVD)': [2307], 'what': [2313], 'magnitude': [2316, 2340, 3123, 3389], 'benefit': [2318, 3127], '(absolute': [2319, 2343], 'reduction;': [2320], 'NNT)': [2321], 'endpoints': [2324], 'composite': [2326], 'ischemic': [2327, 2413, 3783, 3871], 'fatal': [2330], 'event,': [2332], 'nonfatal': [2333, 2335], 'MI,': [2334, 2447, 3836], 'stroke,': [2336, 2411, 3781], 'unstable': [2337, 2403, 3774], 'angina/revascularization)': [2338], 'harm': [2342], 'increase;': [2344], 'NNH)': [2345], 'terms': [2347], '(e.g,': [2351], 'cancer,': [2352], 'rhabdomyolysis,': [2353], 'mellitus)': [2355], 'lowering': [2359, 3309, 3392, 3626], 'large': [2361, 3606], 'RCTs': [2362, 2899, 3322, 3592, 3616], '(>1': [2363], '000': [2364], 'participants': [2365], 'originally': [2367], 'designed': [2368], 'last': [2370], '>12': [2371], 'months)': [2372], 'second': [2378], 'lipid-modifying': [2379], 'agent': [2380], 'alone?4.1Clinical': [2384], 'acute': [2390, 3761, 3821, 3963], 'syndrome': [2392, 3763], '(ACS),': [2393, 3764], 'myocardial': [2398, 2448, 3769, 3837], 'infarction': [2399, 3770], '(MI),': [2400, 3771], 'stable': [2401, 3772], 'angina': [2404, 3775], 'arterial': [2409, 3779, 3875], 'revascularization,': [2410, 3780], 'transient': [2412, 3782], 'attack': [2414, 3784], '(TIA),': [2415, 3785], '(PAD)': [2420, 3790], 'including': [2421, 2645, 3690, 3791], 'aortic': [2422, 3792], 'aneurysm,': [2423, 3793], 'origin.ASCVD': [2427], 'indicates': [2428, 3115, 3573, 3692, 3820, 3959], 'heart': [2434, 3223], 'CVD,': [2436], 'ERC,': [2439], 'Committee;': [2442], 'cholesterol;': [2446, 3704, 3831, 3835], 'infarction;': [2449, 3838], 'NNH,': [2450], 'number': [2451, 2456], 'needed': [2452, 2457], 'harm;': [2454], 'NNT': [2455], 'treat;': [2459], 'RCT,': [2461, 3705], 'randomized': [2462, 2894, 3706], 'controlled': [2463, 2895, 3251, 3707], 'trial.Numerical': [2464], 'triglycerides,': [2467, 2506], 'total': [2468], '(TC),': [2470], '(LDL-C),': [2473], 'high-density': [2474, 3833], '(HDL-C),': [2476], 'non–HDL-C': [2478, 2499], 'given': [2480, 3008, 3080], 'mmol/L.': [2485], 'To': [2486], 'convert': [2487], 'mmol/L,': [2489], 'TC,': [2495], 'divided': [2501, 3354], '38.6': [2503], '88.6.On': [2508], 'member': [2515, 2564, 2575, 2589, 2618], 'discussed': [2516, 3431], 'participation': [2518], 'industry-supported,': [2521], 'multicenter': [2522], 'study,': [2523], 'they': [2525, 3315], 'had': [2526], 'thought': [2527], 'prevention': [2533, 2560, 2945, 3742], 'However,': [2535, 3076], 'reviewed': [2539, 2606, 2768, 2864], 'specific': [2541, 3574], 'criteria,': [2543], 'represent': [2548], 'relationship': [2551], 'industry.': [2553], 'Given': [2554], 'current': [2556], 'must': [2565], 'free': [2567], 'industry,': [2573], 'removed': [2577, 2591], 'committee.': [2580], 'sections': [2583, 2605], 'authored': [2584], 'replaced': [2593], 'new': [2595, 2952], 'material': [2596], 'chairs,': [2601], 'revised': [2604], 'approved': [2608, 2815], 'remaining': [2611], 'members.': [2614], 'did': [2619], 'further': [2624], 'discussions': [2626], 'manuscript': [2631], 'recommendations.1.2.': [2633], 'CommitteeThe': [2638], 'consisted': [2641], 'cardiologists,': [2646], 'internists,': [2647], 'interventionalists,': [2648], 'nurse': [2650], 'practitioner,': [2651], 'pharmacists,': [2652], 'physician': [2654], 'assistant,': [2655], 'pediatrician,': [2657], 'nephrologist,': [2659], 'lay/patient': [2662], 'representative.': [2663], 'representatives': [2668], '(ACC),': [2675], '(AHA),': [2679], 'Pulmonary': [2685], 'Rehabilitation': [2686], '(AACVPR),': [2687], 'Academy': [2690], 'Physician': [2692], 'Assistants': [2693], '(AAPA),': [2694], 'Black': [2697], 'Cardiologists': [2698], '(ABC),': [2699], 'Preventive': [2703, 2721, 2729], 'Medicine': [2704], '(ACPM),': [2705], '(ADA),': [2709], 'Geriatrics': [2711], 'Society': [2712, 2719], '(AGS),': [2713], 'Pharmacists': [2715], '(APhA),': [2717], '(ASPC),': [2723], 'National': [2724], 'Lipid': [2725, 3657], '(NLA),': [2727], 'Nurses': [2731], '(PCNA).': [2733], 'Appendix': [2734], 'lists': [2740], "members'": [2743, 2755], 'RWI.': [2745], 'purposes': [2748], 'full': [2750], 'transparency,': [2751], 'comprehensive': [2756], 'disclosure': [2757], 'information': [2758, 2798, 3453], 'online.1.3.': [2761], 'ApprovalThis': [2765], '21': [2770], 'official': [2771], 'reviewers': [2772], 'nominated': [2774], 'ACC,': [2777, 2824], 'AHA,': [2778, 2826], 'AAPA,': [2779, 2827], 'ABC,': [2780, 2828], 'ACPM,': [2781, 2829], 'ADA,': [2782, 2830], 'AGS,': [2783, 2831], 'APhA,': [2784, 2832], 'ASPC,': [2785, 2833], 'NLA,': [2786, 2834], 'PCNA,': [2788], 'well': [2790], '27': [2792], 'content': [2794], 'reviewers.': [2795], "Reviewers'": [2796], 'RWI': [2797], 'distributed': [2800], '(Appendix': [2811], '2).This': [2812], 'governing': [2820], 'bodies': [2821], 'PCNA.1.4.': [2836], 'GuidelineThe': [2840], 'purpose': [2841], 'address': [2848], 'practical': [2850], 'disorders.': [2860], 'previously': [2865], 'reviews,': [2869], 'statements.': [2872], 'S1': [2874], 'Web': [2877, 3345, 3419, 3450], 'publications': [2883], 'statements': [2885], 'deemed': [2886], 'pertinent.': [2887], 'sources': [2890, 3161], 'trials': [2896, 3158], '(RCTs).': [2897], 'Most': [2898, 2958], 'area': [2902], 'performed': [2905], 'cholesterol-lowering': [2911, 2920], 'drug.S1.4-1–S1.4-3': [2912], 'Since': [2913], '2013': [2915, 3003], 'guideline,S1.4-4': [2918], 'newer': [2919], 'agents': [2921], '(nonstatin': [2922], 'drugs)': [2923], 'introduced': [2926], 'subjected': [2928], 'RCTs.': [2930], 'They': [2931], 'events.': [2957], 'treated': [2964], 'alone.': [2967], 'recommended': [2973, 3679], 'either': [2988], 'Throughout': [2997], 'similar': [3000], 'consistent': [3005], 'attention': [3006, 3078], 'making': [3015], 'decisions.': [3017], 'Besides': [3018], 'pooled': [3024], 'cohort': [3025, 3247], 'equations': [3026], '(PCE),': [3027], 'option': [3051], '≥40': [3057], 'children,': [3062], 'adolescents,': [3063], 'adults,': [3066], 'identifying': [3067], '(FH)': [3072], 'priority.': [3075], 'reducing': [3082], 'therapies.1.5.': [3088], 'EvidenceRecommendations': [3095], 'designated': [3097], 'class': [3101, 3112], 'recommendation': [3103, 3114], '(COR)': [3104], '(LOE).': [3110], 'strength': [3117], 'recommendation,': [3119], 'encompassing': [3120], 'estimated': [3122, 3534, 3975], 'certainty': [3125], 'proportion': [3129], 'rates': [3136], 'supporting': [3142], 'type,': [3150], 'quantity,': [3151], 'consistency': [3153], '2).S1.5-1Table': [3163], '2.': [3164, 3187, 3756], 'Applying': [3165, 3188], 'Strategies,': [3175, 3198], 'Interventions,': [3176, 3199], 'Treatments,': [3177, 3200], 'Diagnostic': [3179, 3202], 'Testing': [3180, 3203], 'Care*': [3183, 3206], '(Updated': [3184, 3207], '2015)Table': [3186], '2015)1.6.': [3209], 'AbbreviationsAbbreviationMeaning/PhraseABIankle-brachial': [3210], 'indexACSacute': [3211], 'syndromeAIDSacquired': [3213], 'immunodeficiency': [3214, 3239], 'syndromeapoBapolipoprotein': [3215], 'BARRabsolute': [3216], 'reductionASCVDatherosclerotic': [3218], 'diseaseCACcoronary': [3220], 'calciumCHDcoronary': [3222], 'diseaseCKcreatine': [3224], 'kinaseCKDchronic': [3225], 'diseaseCORClass': [3227], 'RecommendationCTTCholesterol': [3229], 'TrialistsCVDcardiovascular': [3231], 'diseaseeGFRestimated': [3232], 'glomerular': [3233], 'filtration': [3234], 'rateFHfamilial': [3235], 'hypercholesterolemiaHDLhigh-density': [3236], 'lipoproteinHFheart': [3237], 'failureHIVhuman': [3238], 'virusLDL-Clow-density': [3240], 'cholesterolLOELevel': [3242], 'EvidenceLp(a)lipoprotein': [3244], '(a)MImyocardial': [3245], 'infarctionPCEpooled': [3246], 'equationsQALYquality-adjusted': [3248], 'life-yearRArheumatoid': [3249], 'arthritisRCTrandomized': [3250], 'trialsRRRrelative': [3252], 'reductionRWIrelationships': [3254], 'entitiesSAMSstatin-associated': [3259], 'muscle': [3260], 'symptomsSRsystematic': [3261], 'reviewTCtotal': [3262], 'cholesterolVLDLvery': [3263], 'lipoproteinVLDL-Cvery': [3265], 'cholesterol2.': [3268], 'ASCVD2.1.': [3273], 'Non–HDL-C3.': [3278], 'Modalities3.1.': [3280], 'DrugsAmong': [3282], 'lipid-lowering': [3283], 'drugs,': [3284], 'cornerstone': [3288], 'interventions.': [3296], 'LDL-lowering': [3298, 3319, 3336], 'drugs': [3299, 3310, 3330, 3337], 'inhibitors.': [3307], 'Triglyceride-': [3308], 'fibrates': [3312], 'niacin;': [3314], 'mild': [3318], 'action,': [3320], 'do': [3323], 'support': [3325], 'add-on': [3329], 'therapy.S3.1-1': [3333], 'Characteristics': [3334], 'summarized': [3339], 'S3': [3342], 'Supplement.3.1.1.': [3346], 'TherapyThe': [3348], 'intensity': [3349], 'categories:': [3357], 'high-intensity,': [3358], 'moderate-intensity,': [3359], 'low-intensity.S3.1.1-1': [3361], 'High-intensity': [3362], 'typically': [3365], 'lowers': [3366], '≥50%,': [3370], '30%': [3375], '49%,': [3377], 'low-intensity': [3379], '<30%': [3383], '3).': [3385], 'Of': [3386, 3715], 'course,': [3387], 'vary': [3394, 3622], 'practice.S3.1.1-2': [3397], 'Certain': [3398], 'Asian': [3399], 'populations': [3400], 'certain': [3407], 'statins.S3.1.1-3': [3408], 'Pharmacokinetic': [3409], 'profiles': [3410], 'among': [3411], 'heterogeneous': [3414], 'S4': [3416], 'Supplement).': [3420], 'extensively': [3425], 'evaluated.S3.1.1-4': [3426], 'Statin-associated': [3427], 'side': [3428], 'Section': [3433], '5.': [3434], 'Common': [3435], 'potentially': [3439], 'interact': [3440], 'S5': [3447], 'Supplement.': [3451], 'interactions': [3457], 'obtained': [3460], 'Manager.S3.1.1-5Table': [3465], '3.': [3466], 'High-,': [3467], 'Moderate-,': [3468], 'Low-Intensity': [3470], 'Therapy*High': [3472], 'IntensityModerate': [3473], 'IntensityLow': [3474], 'IntensityLDL-C': [3475], 'lowering†≥50%30%–49%<30%StatinsAtorvastatin': [3476], '(40': [3477, 3483], 'mg‡)': [3478], '80': [3479, 3506, 3648, 3661, 3670, 3675], 'mgRosuvastatin': [3480], 'mg': [3482, 3486, 3498, 3502, 3509, 3649, 3662, 3671, 3676], 'mg)Atorvastatin': [3484], '(20': [3487], 'mg)Rosuvastatin': [3488], '(5': [3489], 'mg)': [3490], 'mgSimvastatin': [3492], '20–40': [3493, 3517], 'mg§Simvastatin': [3494], 'mg…Pravastatin': [3496], '(80': [3499, 3503], 'mg)Lovastatin': [3500], 'mg)Fluvastatin': [3504], 'XL': [3505], 'mgFluvastatin': [3507, 3516], 'BIDPitavastatin': [3510], '1–4': [3511], 'mgPravastatin': [3512], '10–20': [3513], 'mgLovastatin': [3514], 'mgPercent': [3518], '(atorvastatin,': [3530], 'rosuvastatin,': [3531], 'simvastatin)': [3532], 'median': [3537], 'reduction': [3538, 3595], 'VOYAGER': [3543], 'database.S3.1.1-2': [3544], 'Reductions': [3545], '(fluvastatin,': [3552], 'lovastatin,': [3553], 'pitavastatin,': [3554], 'pravastatin)': [3555], 'identified': [3557], 'according': [3558], 'FDA-approved': [3560], 'product': [3561], 'labeling': [3562], 'hypercholesterolemia,': [3568], 'mixed': [3570], 'dyslipidemia.S3.1.1-6Boldface': [3571], 'type': [3572], 'doses': [3577], 'RCTs,S3.1.1-7–S3.1.1-19': [3582], "Trialists'": [3587], '2010': [3588], 'meta-analysis.S3.1.1-20': [3589], 'All': [3590], 'demonstrated': [3593], 'events.*Percent': [3599], 'estimates': [3602], 'populations.': [3607], 'Individual': [3608], 'varied': [3613], 'expected': [3620], 'practice.S3.1.1-2†LDL-C': [3625], 'occur': [3629], 'dosage': [3632], 'below': [3634], 'intensity.‡Evidence': [3636], 'RCT': [3639], 'only:': [3640], 'down': [3641], 'titration': [3642, 3673], 'unable': [3644], 'tolerate': [3646], 'atorvastatin': [3647, 3725], 'IDEAL': [3652], '(Incremental': [3653], 'Decrease': [3654], 'Aggressive': [3656], 'Lowering)': [3658], 'study.S3.1.1-18§Although': [3659], 'simvastatin': [3660, 3669], 'RCTs,': [3666], 'FDA': [3682], 'because': [3683], 'increased': [3686], 'myopathy,': [3689], 'rhabdomyolysis.BID': [3691], 'twice': [3693], 'daily;': [3694], 'FDA,': [3695], 'US': [3696], 'Food': [3697], 'Drug': [3699], 'Administration;': [3700], 'trial;': [3708], 'VOYAGER,': [3709], 'indiVidual': [3711], 'meta-analysis': [3714], 'therapY': [3717], 'At': [3719], 'Groups:': [3721], 'Rosuvastatin,': [3724], 'simvastatin;': [3727], 'XL,': [3729], 'extended': [3730], 'release.4.': [3731], 'Groups4.1.': [3734], 'PreventionDownload': [3737], 'figureDownload': [3738], 'PowerPointFigure': [3739], 'Colors': [3748], 'correspond': [3749], 'consists': [3759], 'origin.': [3797], '4).': [3818], 'ACS': [3819, 3853, 3865], 'PCSK9i,': [3840], 'inhibitor.Table': [3842], '4.': [3843], 'High-Risk*': [3845], 'Future': [3847], 'EventsMajor': [3849], 'Events': [3851], 'Recent': [3852], '(within': [3854], 'past': [3856], 'mo)': [3858], 'History': [3859, 3869, 3895, 3937], 'MI': [3861], '(other': [3862], 'than': [3863], 'above)': [3868], 'stroke': [3872], 'Symptomatic': [3873], '(history': [3877], 'claudication': [3879], 'ABI': [3881], '<0.85,': [3882], 'previous': [3884], 'revascularization': [3885], 'amputationS4.1-39)High-Risk': [3887], 'Conditions': [3888], '≥65': [3890], 'y': [3891], 'Heterozygous': [3892], 'prior': [3897], 'bypass': [3900], 'surgery': [3901], 'percutaneous': [3903], 'outside': [3906], 'event(s)': [3911], 'Hypertension': [3914], '(eGFR': [3916], '15-59': [3917], 'mL/min/1.73': [3918], 'm2)S4.1-15,S4.1-17': [3919], 'Current': [3920], 'smoking': [3921], 'Persistently': [3922], '[≥2.6': [3928], 'despite': [3930], 'congestive': [3939], 'HF*Very': [3940], 'one': [3951], 'conditions.ABI': [3958], 'index;': [3961], 'ACS,': [3962], 'CKD,': [3970], 'eGFR,': [3974], 'gl': [3976]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4211152466', 'counts_by_year': [{'year': 2024, 'cited_by_count': 121}, {'year': 2023, 'cited_by_count': 144}, {'year': 2022, 'cited_by_count': 141}, {'year': 2021, 'cited_by_count': 93}, {'year': 2020, 'cited_by_count': 70}, {'year': 2019, 'cited_by_count': 64}], 'updated_date': '2024-12-24T05:10:45.986075', 'created_date': '2022-02-13'}
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