Abstract: This Chapter Contains Sections titled: 2 + 2-Cycloaddition 2 + 3-Cycloaddition 2 + 4-Cycloaddition Miscellaneous Cycloadditions References A review of advances in Nickel-catalysed cycloaddition reactions directed towards the synthesis of carbocycles and heterocycles has been presented. The discussion includes the development and mechanistic studies of the Ni/NHC catalysts that couple diynes and nitriles to form pyridines. The use of vinyl cyclopropanes, aldehydes, ketones, tropones, 3-azetidinones, and 3-oxetenones as substrates in new Ni-catalysed cycloaddition reactions is also discussed. A second extensive review concerning Ni-catalysed cycloaddition reactions that have been studied since 2004 has been published. 1,3-Dipolar cycloadditions, Diels-Alder cycloadditions, 2+2+2- cycloadditions, and 3+3-cycloadditions are discussed. NHC-stabilized silylene monohydride reacted with diphenylacetylene to yield a 2,3,4,5-tetraphenyl-1-(tri-t-butylsilyl)-1H-silole via a 2+2+1-cycloaddition. DFT calculations indicate that the reaction mechanism did not include a silirene, the typical 2+1-cycloaddition product. The Rhodium-catalysed enantioselective 2+2+2-cycloaddition of silicon-containing prochiral triynes and internal alkynes yielded silicon-stereogenic dibenzosiloles with high enantoselectivities and high yields.
Publication Year: 2019
Publication Date: 2019-03-07
Language: en
Type: other
Indexed In: ['crossref']
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