Publication Information

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'cortex.Neural': [871, 2614], 'Regen.': [872, 2615], 'Res.': [873, 2616], '16:': [875, 1790, 2618], '750-756https://doi.org/10.4103/1673-5374.295925Google': [876, 2619], 'generating': [879], 'controversy': [880], 'around': [881], 'conversion.': [883, 2080, 2538, 2835, 2849, 2871], 'Here': [884], 'we': [885, 1098, 1228, 1357, 1424, 1559, 1572, 1666, 1795, 1848, 1863, 1889, 1930, 1981, 2104, 2550, 2837], 'report': [886, 2622], 'limited,': [887], 'brain-area-specific': [888], 'mice': [892, 1204, 1389, 1420, 1580, 1737, 1830, 1951, 1969], 'compare': [894, 2824], 'our': [895, 2115, 2158, 2568, 3205], 'recent': [898, 2486, 3212], 'reports.': [899], 'We': [900, 991, 1135, 1246, 1308, 1386, 1399, 1817, 1941, 2063, 2147, 2633, 3031], 'initially': [901], 'set': [902], 'out': [903, 2636], 'test': [905, 1225, 1669], 'across': [908, 2130, 2230], 'using': [912, 2250, 2989], 'systemic': [913, 1132], 'delivery': [914, 946, 2086, 2946], 'blood-brain-barrier-penetrating': [917], 'AAV-PHP.eB': [918, 2978], 'capsid23Chan': [919], 'K.Y.': [920], 'Jang': [921], 'M.J.': [922], 'Yoo': [923], 'B.B.': [924], 'Greenbaum': [925], 'Ravi': [927], 'W.L.': [930], 'Sánchez-Guardado': [931], 'Lois': [933], 'Mazmanian': [935], 'S.K.': [936], 'Deverman': [937], 'B.E.': [938], 'al.Engineered': [940], 'AAVs': [941, 2948, 2965], 'efficient': [943, 2640, 2834, 2847], 'noninvasive': [944], 'peripheral': [951], 'systems.Nat.': [953], '2017;': [955, 1071, 1661, 2480], '20:': [956], '1172-1179https://doi.org/10.1038/nn.4593Google': [957], 'shortened': [961], 'human': [962, 2924], 'GFAP': [963, 973, 2523], 'promoter': [964, 974, 1547, 2056, 2524], '(hGFAP)24Lee': [965], 'Messing': [967], 'Brenner': [971], 'elements': [975], 'required': [976], 'region-specific': [978], 'astrocyte-specific': [980], 'expression.Glia.': [981], '2008;': [982, 1293, 1789], '56:': [983], '481-493https://doi.org/10.1002/glia.20622Google': [984], 'restrict': [987, 1082], 'expression': [988, 995, 1063, 1083, 1092, 1104, 1115, 1208, 1218, 1230, 1448, 1563, 1935, 2889, 2970], 'astrocytes.': [990, 2146], 'achieved': [992], 'improved': [993], 'broad': [994], 'self-complementary': [999, 1020], 'AAV': [1000, 1133, 2161, 3041], 'genomes25McCarty': [1001], 'D.M.': [1002], 'Fu': [1003], 'Monahan': [1005], 'P.E.': [1006], 'Toulson': [1007], 'C.E.': [1008, 2780], 'Naik': [1009], 'Samulski': [1011], 'R.J.': [1012], 'Adeno-associated': [1013], 'virus': [1014, 1586, 1590, 1597], 'terminal': [1015], 'repeat': [1016], '(TR)': [1017], 'mutant': [1018], 'generates': [1019], 'vectors': [1021, 1191, 1360], 'overcome': [1023], 'rate-limiting': [1025], 'step': [1026], 'transduction': [1028], 'vivo.Gene': [1030], '2003;': [1032], '10:': [1033], '2112-2118https://doi.org/10.1038/sj.gt.3302134Google': [1034], '(Figures': [1036, 1086, 1107, 1440, 1564, 1939], '1A–1C': [1037], ';': [1038], 'Figure': [1039, 1593], 'S1B)': [1040, 1110], 'confirmed': [1042, 1301], 'that': [1043, 1413, 1624, 1810, 2150, 2192, 2517, 2529, 2869, 3005], 'miR-124': [1044], 'targeting': [1045, 1128, 1170, 1297, 2091, 3105], 'sites': [1046], '(miR-124-TSs)26Taschenberger': [1047], 'Tereshchenko': [1049], 'Kügler': [1051], 'A': [1053], 'MicroRNA124': [1054], 'target': [1055], 'sequence': [1056, 2521], 'restores': [1057], 'specificity': [1059], 'gfaABC1D-driven': [1061], 'transgene': [1062], 'AAV-mediated': [1065], 'transfer.Mol.': [1067], 'Nucleic': [1069], 'Acids.': [1070], '13-25https://doi.org/10.1016/j.omtn.2017.03.009Google': [1073], '3′': [1077], 'untranslated': [1078], 'region': [1079, 1614], '(UTR)': [1080], 'helped': [1081], 'S1A': [1087], 'S1B).': [1089], 'level': [1093], 'generally': [1095], 'low,': [1096], 'noted': [1099, 1560, 1931, 2975], 'trace': [1100], 'levels': [1101, 1798], 'off-target': [1103], '1C': [1108], 'as': [1111, 1113, 1840, 2549, 2974], 'well': [1112], 'scattered': [1114], 'liver': [1118], '(data': [1119, 1221, 1540, 1598, 1961], 'shown).': [1121, 1223, 1542, 1600, 1963], 'These': [1122, 1736], 'results': [1123, 1604, 1712, 1883, 2116, 2127, 2246, 2569, 2858], 'underscore': [1124], 'difficulty': [1126], 'specifically': [1130], 'injection.': [1134, 2661], 'instead': [1136, 2541], 'decided': [1137, 1667], 'permanently': [1139], 'label': [1140], 'tdTomato': [1143], '(tdTom)': [1144], 'Aldh1l1CreERT2;': [1146, 1880, 2546], 'Rosa26LSL-tdTom': [1147, 1881, 2547], 'mice27Srinivasan': [1148], 'Lu': [1150], 'T.Y.': [1151], 'Chai': [1152], 'Huang': [1156], 'B.S.': [1157, 1163], 'Golshani': [1158], 'Coppola': [1160], 'Khakh': [1162], 'New': [1164], 'transgenic': [1165], 'lines': [1167], 'selectively': [1169], 'studying': [1173], 'calcium': [1174], 'signals': [1175], 'processes': [1178], 'vivo.Neuron.': [1183], '92:': [1185], '1181-1195https://doi.org/10.1016/j.neuron.2016.11.030Google': [1186], 'deliver': [1189], 'AAV1': [1190, 1359], 'expressing': [1192], 'factors': [1194], 'directly': [1195], 'parenchyma.': [1199], 'Tamoxifen': [1200], 'administration': [1201, 2930], 'these': [1203, 1364, 1473, 1937, 2061, 2576, 2631, 2826, 3016], 'led': [1205], 'tdTom': [1207], 'vast': [1211], 'majority': [1212], 'astrocytes,': [1214, 2198], 'only': [1216, 2891], 'rare': [1217], 'To': [1224, 1844], 'conversion,': [1227, 2665, 2955], 'designed': [1229, 1248, 3090, 3101, 3110, 3116], 'cassettes': [1231, 1241], 'hGFAP': [1233, 1546, 2055], 'promoters': [1234], 'driving': [1235], 'NeuroD1.P2A.EGFP': [1236], 'EGFP': [1238, 1562, 1584, 1857, 1954], 'alone.': [1239], 'Both': [1240], 'included': [1242], '3′UTR': [1244, 1347], 'miR-124-TS.': [1245], 'also': [1247, 2148], 'artificial': [1250, 2089, 3103], 'microRNA28McBride': [1251], 'J.L.': [1252], 'Boudreau': [1253], 'R.L.': [1254, 1316, 1689], 'Harper': [1255], 'S.Q.': [1256], 'Staber': [1257], 'P.D.': [1258], 'Monteys': [1259], 'A.M.': [1260], 'Martins': [1261], 'I.': [1262], 'Gilmore': [1263], 'B.L.': [1264, 1320, 1771], 'Burstein': [1265], 'Peluso': [1267], 'R.W.': [1268], 'Polisky': [1269], 'al.Artificial': [1272], 'miRNAs': [1273], 'mitigate': [1274], 'shRNA-mediated': [1275], 'toxicity': [1276], 'brain:': [1279], 'development': [1284], 'RNAi.Proc.': [1286], '105:': [1294], '5868-5873https://doi.org/10.1073/pnas.0801775105Google': [1295], 'Ptbp1': [1298, 2092, 2108, 2673, 2820], '(miPtbp1)': [1299], 'its': [1302, 2883], 'activity': [1303, 1719, 2525], '(Figure': [1306, 1384, 1475, 1493, 1587, 1591, 1815, 1842, 1872, 1912, 1956], 'S1C).': [1307], 'then': [1309], 'cloned': [1310], 'miPtbp1': [1311, 1589, 1959], 'control': [1314, 1585, 1955], 'microRNA29Boudreau': [1315], 'Spengler': [1317], 'R.M.': [1318], 'Davidson': [1319, 1770], 'Rational': [1321], 'design': [1322], 'siRNAs:': [1325], 'minimizing': [1326, 2943], 'off-targeting': [1327], 'potential': [1328], 'improve': [1330], 'safety': [1332], 'RNAi': [1334], 'disease.Mol.': [1338], '2011;': [1340], '19:': [1341], '2169-2177https://doi.org/10.1038/mt.2011.185Google': [1342], '(miControl)': [1344], 'hGFAP-EGFP': [1350], 'transgene.': [1351], 'Four': [1352], 'weeks': [1353, 1392, 1744, 1807, 1814, 2050], 'tamoxifen': [1355], 'administration,': [1356], 'infused': [1358, 1819], 'each': [1362], 'four': [1365], 'transgenes': [1366], 'unilaterally': [1367], 'striatum,': [1370, 1823], 'hippocampus,': [1371, 1446, 1824], 'cerebellum': [1373, 1826], 'at': [1374, 1754], '1': [1375, 1464, 1832], '×': [1376, 1833], '109': [1377, 1834], 'vector': [1378, 3042], 'genomes': [1379], '(vg)': [1380], 'per': [1381], 'injection': [1382, 1618, 2019, 2052, 2899], 'site': [1383], '1D).': [1385], 'perfused': [1387], '4': [1391, 2049], 'collected': [1394], 'brains': [1396], 'histology.': [1398], 'next': [1400, 1818], 'performed': [1401, 1849, 3093], 'immunofluorescence': [1402, 1851], 'marker': [1406, 1803], 'NeuN': [1407, 1521, 1850, 2888], 'identify': [1409, 1845], 'fate-mapped': [1410], 'tdTom-positive': [1411], 'had': [1414], 'neuron-like': [1417], 'cells.': [1418, 2062], 'treated': [1421, 1581], 'NeuroD1,': [1423, 1571], 'observed': [1425, 1573, 1796, 1890, 1982], 'extensive': [1426], 'tdTom/NeuN': [1427], 'overlap': [1428, 1867, 1893, 1899], 'hippocampus': [1431, 1497, 1906, 1991, 2584], 'cerebellar': [1433, 1481, 1499, 1910, 1916, 1993, 2586], 'but': [1435, 1897, 1995, 2579, 2956], 'striatum': [1439, 1896, 2629, 2647], '1E': [1441, 1565], '1F).': [1443, 1567], 'viral': [1447, 2650], 'confined': [1451, 1471], 'molecular': [1454, 1902], 'layers': [1455, 1903], 'dentate': [1458], 'gyrus': [1459], '(DG)': [1460], 'cornu': [1462], 'ammonis': [1463], '(CA1),': [1465], 'apparent': [1467, 1607, 1919, 2203], 'entirely': [1470], 'regions': [1474, 1486, 1917], 'S1D).': [1476, 1494], 'Concerningly,': [1477], 'localized': [1484, 2027], 'damaged': [1489, 1925], 'granule': [1490, 1926, 2180, 2185], 'cell': [1491, 1927, 2186], 'layer': [1492], 'cortex,': [1500, 1822], 'always': [1503], 'within': [1504, 2012], 'few': [1506, 2014], 'hundred': [1507, 2015], 'micrometers': [1508, 2016], 'needle': [1511, 1519, 2036], 'track.': [1512, 2037], 'despite': [1514], 'proximity': [1516], 'track,': [1520], 'staining': [1522], 'far-red': [1525], 'channel': [1526], 'due': [1532, 2024], 'autofluorescence,': [1534], 'which': [1535, 2140, 2157, 2177, 2228], 'punctate': [1537], 'faint': [1539], 'addition,': [1544, 2039], 'remained': [1548, 2057], 'active': [1549, 2059], 'NeuN-positive': [1552, 2999], 'cells,': [1553, 2195], 'unlike': [1554], 'mature': [1556, 2046, 3003], 'neurons,': [1557, 1847, 2224], 'because': [1558, 2053, 2074], 'continued': [1561], 'contrast': [1569, 2082], 'no': [1574, 1865, 1891, 1944, 2555], 'evidence': [1575, 1945, 1983], 'S1E),': [1588], '1G;': [1592], 'S1D),': [1594], 'miControl': [1596], 'Although': [1601, 2872, 3015], 'encouraging,': [1606], 'occurred': [1610], 'narrow': [1613], 'close': [1615, 2896], 'site.': [1619, 2020, 2900], 'It': [1620], 'has': [1621], 'been': [1622, 2676], 'proposed': [1623], 'may': [1627, 2022, 2829, 2875, 2949, 3021], 'be': [1628, 2023, 2830, 2876, 2936, 2950, 2993, 3022], 'more': [1629, 2982], 'than': [1634, 2197], 'nonreactive': [1635], 'astrocytes.30Brulet': [1636], 'Matsuda': [1638, 2457], 'Miranda': [1642, 2461], 'Giacca': [1644, 2463], 'Kaspar': [1646, 2465], 'B.K.': [1647, 2466], 'Nakashima': [1648, 2467], 'Hsieh': [1650, 2469], 'NEUROD1': [1652, 2471], 'Instructs': [1653, 2472], 'non-reactive': [1657, 2476], 'astrocytes.Stem': [1658, 2477], '1506-1515https://doi.org/10.1016/j.stemcr.2017.04.013Google': [1663, 2482], 'Therefore,': [1665, 1964, 2926], 'Tpp1−/−': [1673, 1829, 1861, 1887, 1950, 1968], 'mice,31Sleat': [1674], 'D.E.': [1675, 1761], 'Wiseman': [1676], 'J.A.': [1677], 'El-Banna': [1678], 'Kim': [1680], 'K.H.': [1681], 'Mao': [1682], 'Price': [1684], 'Macauley': [1686], 'S.L.': [1687], 'Sidman': [1688], 'Shen': [1690], 'M.M.': [1691], 'classical': [1699], 'late-infantile': [1700], 'ceroid': [1702, 1734, 1786], 'lipofuscinosis': [1703], 'based': [1704], 'targeted': [1706], 'disruption': [1707], 'CLN2': [1710], 'tripeptidyl-peptidase': [1717], 'I': [1718], 'progressive': [1721, 1739], 'neurodegeneration.J.': [1722], '2004;': [1724], '24:': [1725, 2810], '9117-9126https://doi.org/10.1523/JNEUROSCI.2729-04.2004Google': [1726], 'late': [1731, 1783], 'infantile': [1732, 1784], 'lipofuscinosis.': [1735], 'develop': [1738, 3001], 'astrogliosis': [1740, 1966], 'beginning': [1741], '9': [1743], 'age': [1746, 1809], 'some': [1748, 2580], 'neurodegeneration': [1749], 'end': [1752], 'stage': [1753], '21': [1755], 'weeks.32Chang': [1756], 'Cooper': [1758], 'J.D.': [1759], 'Sleat': [1760], 'S.H.': [1763], 'Dodge': [1764], 'Passini': [1766], 'Lobel': [1768], 'Intraventricular': [1772], 'enzyme': [1773], 'replacement': [1774], 'improves': [1775], 'phenotypes': [1777], 'lipofuscinosis.Mol.': [1787], '649-656https://doi.org/10.1038/mt.2008.9Google': [1791], 'As': [1793, 1914], 'expected,': [1794], 'elevated': [1797], 'Gfap': [1804, 1934], '11': [1806], 'increased': [1811], '14': [1813], 'S1F).': [1816], '10-week-old': [1828], 'vg': [1835], 'same': [1838], 'viruses': [1839, 1960], 'above': [1841, 2976], '1H).': [1843], 'identified': [1853], 'transduced': [1854], 'expression.': [1858], 'NeuroD1-treated': [1860], 'mice,': [1862, 1882, 2139, 2548], 'detected': [1864], 'EGFP/NeuN': [1866], '1I).': [1873, 1913, 1940], 'areas': [1876, 1938, 2578], 'tested': [1877], 'previously': [1878], 'comparable': [1885], 'mice;': [1888], 'NeuN/EGFP': [1892], 'significant': [1898], 'above,': [1915, 2552], 'marked': [1922], 'layer,': [1928], 'particularly': [1932], 'strong': [1933], 'again': [1942], 'saw': [1943], 'injected': [1952], 'S1G)': [1957], 'did': [1970, 2064, 2093, 2105, 2551], 'enhance': [1972], 'compared': [1975], 'wild-type': [1977], 'mice.': [1978, 2632, 2980], 'summary,': [1980], 'striatum.': [2002, 2563], 'Where': [2003], 'observed,': [2006], 'it': [2007, 2189, 2843, 3020], 'limited': [2009, 2077], 'spatially': [2010], 'This': [2021, 2209, 2564], 'dose': [2028, 2932, 2963], 'effect': [2029, 2911], 'damage': [2031], 'inflammation': [2033], 'along': [2034], 'likely': [2043, 2214, 2919, 2959], 'fully': [2045], 'highly': [2058], 'follow': [2066], 'longer': [2071, 2657], 'time': [2072, 2240, 2658], 'period': [2073, 2659], 'scope': [2078], 'overexpression,': [2085], 'microRNA': [2090, 3104], 'lead': [2095, 2532, 2967], 'any': [2100], 'area,': [2102], 'although': [2103], 'quantify': [2107], 'vivo.': [2111], 'caveat': [2113], 'regarding': [2114, 2882], 'small': [2119], 'scale': [2120, 2904], 'pilot': [2123], 'study.': [2124], 'consistent': [2129, 2566], 'animals': [2132], 'two': [2134], 'lines,': [2136], 'including': [2137], 'Aldh1l1CreERT2': [2138], 'enable': [2141], 'robust': [2142], 'fate': [2143, 2542], 'mapping': [2144], 'note': [2149], 'Aldh1l1': [2151], 'Gfap,': [2153], 'genes': [2155], 'Cre': [2159], 'reporter': [2162], 'systems': [2163], 'are': [2164, 2166, 2838, 3017], 'based,': [2165], 'expressed': [2167], 'stem': [2170, 2194], 'subgranular': [2174], 'zone': [2175], '(SGZ),': [2176], 'normally': [2178], 'DG': [2184], 'layer.': [2187], 'Thus,': [2188], 'possible': [2191], 'rather': [2196], 'gave': [2199], 'rise': [2200], 'hippocampus.': [2208], 'possibility': [2210, 2638], 'made': [2212], 'less': [2213, 2918], 'distance': [2217], 'between': [2218, 2825], 'SGZ': [2220], 'farthest': [2226], 'hippocampal': [2232], 'fissure': [2233], 'CA1,': [2235], 'relatively': [2238], 'short': [2239], 'frame': [2241], 'experiments.': [2244], 'Published': [2245], 'vary': [2253], 'widely.12Guo': [2254], 'Scholar,16Puls': [2373], 'Scholar,17Tang': [2414], 'Scholar,30Brulet': [2455], 'publication,': [2487], 'al.20Wang': [2490], 'propose': [2516], 'Neurod1': [2519], 'DNA': [2520], 'upregulates': [2522], 'can': [2531, 3006], 'spurious': [2534], 'reports': [2535], 'When': [2539], 'they': [2540, 2553], 'mapped': [2543], 'showing': [2570], 'lack': [2572], 'cortex.': [2587], 'Xian': [2589], 'al.22Xiang': [2591], 'do': [2621], 'cannot': [2634], 'rule': [2635], 'alternative': [2649], 'vectors,': [2651], 'higher': [2653], 'dose,': [2654], 'Similar': [2662], 'widely': [2666], 'varying': [2667], 'efficiencies': [2668], 'reported.18Qian': [2677], '19Zhou': [2714], '20Wang': [2750], 'Scholar,33Maimon': [2775], 'Chillon-Marinas': [2777], 'Snethlage': [2779], 'Singhal': [2781], 'S.M.': [2782], 'McAlonis-Downes': [2783], 'Ling': [2785], 'Rigo': [2787], 'Bennett': [2789], 'C.F.': [2790], 'Da': [2791], 'Cruz': [2792], 'Hnasko': [2794], 'T.S.': [2795], 'al.Therapeutically': [2797], 'viable': [2798], 'generation': [2799], 'antisense': [2803], 'oligonucleotide': [2804], 'suppression': [2805], 'PTB.Nat.': [2807], '1089-1099https://doi.org/10.1038/s41593-021-00864-yGoogle': [2811], 'degree': [2814], 'difficult': [2822, 2842], 'studies': [2827, 2988], 'critical': [2831], 'achieve': [2833], 'Overall,': [2836], 'concerned': [2839], 'how': [2841], 'reproduce': [2846], 'Additional': [2850], 'clearly': [2853], 'needed': [2854, 2994], 'verify': [2856], 'experiments': [2863], 'establish': [2865], 'precise': [2867], 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