When breaks get hot: inflammatory signaling in BRCA1/2-mutant cancers

Name: Work Video:
Duration: 3 min 30 s
Marcel A.T.M. van Vugt; Eileen E. Parkes
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1591, 1830, 2096, 2408, 2541, 3032, 3115, 3214, 3225, 3253, 3769], 'hallmarks': [6], 'of': [7, 49, 58, 79, 167, 177, 184, 197, 285, 295, 302, 313, 322, 327, 336, 362, 380, 445, 456, 482, 510, 551, 578, 614, 648, 658, 757, 776, 783, 852, 885, 905, 916, 965, 973, 1047, 1058, 1084, 1109, 1155, 1166, 1197, 1206, 1217, 1244, 1266, 1283, 1313, 1418, 1440, 1461, 1479, 1501, 1520, 1569, 1593, 1603, 1625, 1645, 1661, 1681, 1710, 1724, 1762, 1770, 1798, 1800, 1814, 1834, 1841, 1900, 1924, 1936, 1977, 1989, 2058, 2126, 2194, 2236, 2243, 2248, 2290, 2306, 2314, 2343, 2393, 2410, 2417, 2428, 2469, 2481, 2499, 2506, 2511, 2535, 2546, 2588, 2607, 2628, 2641, 2648, 2653, 2704, 2716, 2734, 2834, 2866, 2893, 2908, 2934, 2947, 2956, 2963, 3044, 3071, 3079, 3093, 3128, 3135, 3143, 3161, 3177, 3229, 3292, 3298, 3302, 3357, 3378, 3384, 3432, 3445, 3467, 3477, 3490, 3511, 3592, 3606, 3609, 3617, 3666, 3688, 3816, 3826, 3863, 3933], 'cancer.Cancer-associated': [8], 'DNA': [9, 81, 199, 347, 382, 386, 552, 585, 643, 662, 686, 784, 1036, 1462, 1504, 1509, 1646, 1791, 1801, 1985, 2016, 2201, 2705, 2970, 3019, 3027, 3037, 3051, 3714, 3767, 3805, 3811, 3832, 3921], 'repair': [10, 82, 200, 348, 379, 610, 645, 1505, 1508, 1986, 2202, 2423, 3817, 3865], 'defects,': [11], 'including': [12, 133, 251, 1139, 1394, 1962, 2061, 2484], 'defects': [13, 83, 201, 2203], 'in': [14, 61, 319, 346, 391, 449, 532, 575, 591, 593, 620, 642, 661, 705, 772, 808, 832, 913, 920, 937, 957, 977, 998, 1051, 1088, 1112, 1117, 1159, 1210, 1345, 1351, 1360, 1443, 1465, 1628, 1649, 1664, 1716, 1737, 1818, 1844, 1905, 1959, 1966, 2062, 2073, 2099, 2169, 2182, 2213, 2250, 2274, 2280, 2298, 2322, 2346, 2369, 2461, 2475, 2513, 2560, 2611, 2655, 2682, 2707, 2764, 2783, 2803, 2837, 2857, 2872, 2914, 2940, 2972, 3012, 3034, 3053, 3100, 3116, 3120, 3227, 3269, 3313, 3322, 3330, 3369, 3405, 3435, 3536, 3540, 3550, 3599, 3668, 3728, 3787, 3844, 3886, 3890, 3925], 'homologous': [15, 392, 659, 1480, 1682, 3729, 3754, 3788, 3845, 3908], 'recombination': [16, 393, 602, 660, 1481, 1683], 'repair,': [17, 1549, 1713], 'lead': [18, 1355], 'to': [19, 42, 85, 119, 121, 138, 203, 237, 239, 256, 389, 598, 683, 739, 781, 911, 1032, 1319, 1327, 1356, 1507, 1578, 1586, 1690, 1707, 1786, 1794, 1803, 1807, 1893, 1954, 2082, 2084, 2091, 2093, 2129, 2138, 2145, 2149, 2171, 2185, 2191, 2350, 2400, 2412, 2455, 2810, 2996, 3024, 3036, 3076, 3098, 3133, 3183, 3191, 3341, 3386, 3407, 3423, 3450, 3508, 3524, 3546, 3663, 3809, 3823], 'cytoplasmic': [20], 'DNA.Genomic': [21], 'fuels': [23], 'inflammatory': [24, 40, 97, 152, 215, 270, 2051, 2067, 2146, 2167, 2452, 2900, 2943, 2991], 'signaling,': [25, 2723, 2944], 'triggering': [26], 'both': [27, 100, 218, 2739], 'tumor-suppressive': [28, 101, 219], 'as': [29, 31, 102, 104, 220, 222, 434, 436, 646, 1144, 1347, 1349, 1579, 1942, 2055, 2405, 2426, 2778, 3029, 3156, 3158, 3382, 3411], 'well': [30, 103, 221, 435, 1348, 3157], 'tumor-promoting': [32, 105, 223], 'traits.Through': [33], 'largely': [34], 'unknown': [35], 'mechanisms,': [36], 'tumor': [37, 46, 314, 737, 822, 963, 996, 1040, 1081, 1960, 2075, 2206, 2434, 2997, 3337, 3593, 3613], 'cells': [38, 117, 161, 235, 279, 315, 1031, 1115, 2072, 2549, 2958, 3014, 3147, 3598, 3611, 3705, 3894, 3958], 'rewire': [39], 'prevent': [43, 108, 226], 'immune': [44, 67, 89, 112, 123, 140, 169, 179, 207, 230, 241, 258, 287, 297, 2071, 2085, 2112, 2121, 2187, 2293, 2316, 2351, 2413, 2429, 2470, 2548, 2608, 2630, 2743, 2858, 2957, 2966, 3047, 3162, 3300, 3319, 3364, 3387, 3454, 3472, 3515, 3538, 3619, 3651], 'clearance.Unique': [45], 'microenvironment': [47, 2076, 3338], 'features': [48, 78, 196, 455, 1057, 1142, 1165, 1216, 2090, 3297], 'genomically': [50, 62, 114, 130, 185, 232, 248, 303, 2100, 2116, 2132, 3669], 'unstable': [51, 131, 249, 2355, 3670], 'tumors': [52, 416, 425, 453, 980, 1055, 1135, 1163, 1188, 1214, 1321, 2184, 2347, 2766, 3185, 3449, 3463], 'may': [53, 65, 181, 299], 'promote': [54], 'immunotherapy': [55, 2095, 2128], 'resistanceTherapeutic': [56], 'targeting': [57], 'immune-suppressive': [59], 'mechanisms': [60, 146, 157, 264, 275, 1506, 2156, 2164], 'instable': [63, 115, 186, 233, 304, 2101, 2117, 2133], 'cancer': [64, 116, 160, 234, 278, 398, 405, 533, 1466, 1650, 1667, 1847, 1868, 2094, 2127, 2217, 2282, 2363, 2370, 2477, 2807, 3325, 3574, 3631, 3731, 3790, 3847, 3942], 'potentiate': [66], 'checkpoint': [68, 2086, 2113, 2294, 2352, 2414, 2430, 2631, 3163, 3320, 3342, 3365, 3388, 3620, 3937, 3961], 'inhibition.': [69], 'Genomic': [70, 188, 306], 'inflammation': [73, 191, 2733, 2763, 2777], 'intricately': [75, 193], 'connected': [76, 194], 'hallmark': [77, 195, 361], 'cancer.': [80, 198], 'due': [84, 202, 388, 3023, 3808], 'BRCA1/2': [86, 204, 1925, 2176, 2210, 2278, 2473, 2581, 2841, 3208, 3512, 3646, 3820], 'mutation': [87, 205, 967, 1108, 1459, 1643, 1926, 2211, 2279, 2311, 2435, 2474, 2528, 2674, 3209, 3441, 3513, 3647], 'instigate': [88, 206], 'through': [91, 209, 554, 3722, 3753, 3781, 3838, 3907], 'the': [92, 111, 145, 165, 168, 178, 210, 229, 263, 283, 286, 296, 320, 325, 511, 576, 595, 600, 612, 649, 833, 906, 914, 917, 961, 970, 978, 994, 1190, 1458, 1499, 1541, 1567, 1642, 1708, 1763, 1934, 2074, 2163, 2291, 2341, 2372, 2390, 2532, 2629, 2761, 2891, 3018, 3077, 3233, 3256, 3299, 3336, 3488, 3509, 3618, 3772, 3891], 'cGAS/STING': [93, 211], 'pathway.': [94, 212], 'The': [95, 213, 755, 987, 1133, 1922, 3643, 3931], 'subsequent': [96, 214, 3230, 3892], 'provides': [99, 217], 'traits.': [106, 224], 'To': [107, 225, 2123], 'clearance': [109, 227, 2188], 'by': [110, 147, 158, 228, 265, 276, 428, 529, 580, 711, 806, 857, 942, 1498, 1545, 1721, 1743, 1871, 2175, 2543, 2968, 3049, 3217, 3595, 3615], 'system,': [113, 231], 'need': [118, 236], 'adapt': [120, 238], 'escape': [122, 139, 240, 257], 'surveillance.': [124, 242], 'Currently,': [125, 243], 'it': [126, 244, 2135, 2464], 'is': [127, 245, 310, 317, 479, 826, 1415, 1517, 1600, 1719, 1760, 1864, 2136, 2387, 2465, 2529, 2583, 2767, 3413, 3522, 3653], 'unclear': [128, 246], 'how': [129, 174, 247, 292, 2140, 2153], 'cancers,': [132, 250, 2102, 2134, 2539, 3295], 'BRCA1/2-mutant': [134, 252, 1199, 1717, 2063, 2394, 3421, 3672], 'tumors,': [135, 253], 'rewired': [137, 255], 'clearance.': [141, 259], 'Here,': [142, 260], 'we': [143, 172, 261, 290], 'summarize': [144, 262], 'which': [148, 159, 266, 277, 1029, 1829, 2540, 2850], 'triggers': [151, 269], 'describe': [155, 273], 'adaptive': [156, 274, 2155], 'can': [162, 280, 1495, 2069, 2157], "'fly": [163, 281], 'under': [164, 282], "radar'": [166, 284], 'system.': [170, 288], 'Additionally,': [171, 289], 'discuss': [173, 291, 2180], 'therapeutic': [175, 293, 526], 'activation': [176, 294], 'system': [180, 298], 'improve': [182, 300, 2192], 'treatment': [183, 301, 2193], 'cancers.': [187, 305, 323, 2064, 2196, 3542, 3671], '(see': [308], 'Glossary)': [309], 'a': [311, 480, 786, 1089, 1357, 1416, 1518, 1601, 1831, 1865, 1978, 2056, 2220, 2401, 2466, 2694, 2768, 2779, 2846, 3290, 3438, 3452, 3534, 3553, 3590, 3604, 3649, 3664, 3934], 'trait': [312], 'that': [316, 514, 1194, 1387, 1590, 2165, 2344, 2389, 2932, 3021, 3241, 3518, 3959, 3965], 'observed': [318, 962, 2345, 3033, 3404, 3420], 'majority': [321], 'However,': [324], 'level': [326], 'ranges': [330], 'significantly': [331], 'between': [332, 3556, 3645], 'tumors.': [333], 'High': [334], 'levels': [335, 2545, 2703, 3142], 'genome': [337, 621, 762, 855, 1361, 1714, 1928], 'associated': [340, 862, 2530, 2584, 2712, 3139, 3254], 'with': [341, 417, 454, 863, 960, 1027, 1034, 1056, 1164, 1215, 1322, 1688, 2104, 2131, 2199, 2219, 2239, 2270, 2284, 2310, 2458, 2479, 2502, 2531, 2565, 2585, 2602, 2644, 2677, 2713, 2840, 3118, 3137, 3140, 3186, 3244, 3255, 3274, 3308, 3363, 3428, 3437, 3459, 3464, 3470, 3603, 3657], 'hereditary': [342], 'or': [343, 410, 778, 975, 1582, 2842, 2937, 3246, 3442, 3462, 3813], 'somatic': [344, 1662, 1842], 'mutations': [345, 390, 1344, 1350, 1663, 1843, 2407, 2425, 2600, 2844, 3679], 'genes': [349, 395, 414, 2718, 2855], 'oncogene-induced': [351], 'replication': [352, 689, 708, 730, 1550, 1726, 1740, 1773, 3747, 3773, 3812, 3901], 'stress': [353, 1551, 3774], '[1.Negrini': [354], 'S.': [355, 466, 1068, 1176, 1227, 1658, 1838, 1912], 'et': [356, 442, 477, 558, 608, 654, 698, 727, 799, 820, 850, 882, 903, 933, 1044, 1079, 1106, 1152, 1203, 1238, 1280, 1306, 1413, 1437, 1456, 1476, 1515, 1539, 1598, 1622, 1640, 1659, 1679, 1730, 1768, 1812, 1839, 1859, 1895, 1975, 2008, 2034, 2231, 2366, 2421, 2494, 2552, 2596, 2636, 2670, 2731, 2775, 2796, 2862, 2904, 2961, 2986, 3042, 3067, 3091, 3170, 3261, 3328, 3484, 3567, 3624, 3682, 3720, 3779, 3836, 3859], 'al.Genomic': [357, 3485], 'an': [359, 991, 2867, 2909], 'evolving': [360], 'cancer.Nat.': [363, 1095], 'Rev.': [364, 625, 1369, 3944], 'Mol.': [365], 'Cell': [366], 'Biol.': [367, 627, 866, 893, 1696], '2010;': [368, 537, 1296], '11:': [369, 1485], '220-228Crossref': [370], 'PubMed': [371, 471, 495, 540, 568, 631, 675, 721, 750, 815, 843, 875, 898, 928, 949, 1010, 1073, 1100, 1128, 1181, 1232, 1254, 1273, 1299, 1338, 1374, 1431, 1449, 1471, 1487, 1533, 1560, 1616, 1634, 1655, 1673, 1700, 1753, 1779, 1824, 1853, 1884, 1917, 2001, 2027, 2045, 2259, 2328, 2381, 2446, 2522, 2575, 2620, 2664, 2688, 2755, 2791, 2828, 2881, 2923, 2980, 3005, 3061, 3085, 3110, 3202, 3284, 3349, 3394, 3499, 3581, 3638, 3698, 3737, 3760, 3796, 3853, 3879, 3914, 3949], 'Scopus': [372, 472, 496, 541, 569, 676, 722, 751, 844, 876, 950, 1011, 1074, 1101, 1129, 1182, 1233, 1255, 1274, 1300, 1339, 1375, 1432, 1450, 1488, 1534, 1561, 1617, 1635, 1674, 1701, 1754, 1780, 1825, 1854, 1885, 1918, 2002, 2028, 2046, 2260, 2329, 2382, 2523, 2576, 2621, 2665, 2689, 2756, 2829, 2882, 2924, 2981, 3006, 3062, 3086, 3203, 3285, 3350, 3395, 3500, 3582, 3639, 3699, 3738, 3761, 3797, 3854, 3880, 3915, 3950], '(1327)': [373], 'Google': [374, 474, 498, 543, 571, 632, 678, 724, 753, 816, 846, 878, 899, 929, 952, 1013, 1076, 1103, 1131, 1184, 1235, 1257, 1276, 1302, 1341, 1377, 1434, 1452, 1472, 1490, 1536, 1563, 1619, 1637, 1656, 1676, 1703, 1756, 1782, 1827, 1856, 1887, 1920, 2004, 2030, 2048, 2262, 2331, 2384, 2447, 2525, 2578, 2623, 2667, 2691, 2758, 2792, 2831, 2884, 2926, 2983, 3008, 3064, 3088, 3111, 3205, 3287, 3352, 3397, 3502, 3584, 3641, 3701, 3740, 3763, 3799, 3856, 3882, 3917, 3952], 'Scholar].': [375, 499, 544, 572, 633, 754, 953, 1014, 1132, 1185, 1342, 1491, 1564, 1704, 1757, 1921, 2049, 2263, 2332, 2385, 2448, 2526, 2579, 2692, 2759, 2832, 2885, 2927, 3009, 3112, 3206, 3288, 3353, 3398, 3503, 3585, 3642, 3764, 3918], 'In': [376, 1565, 1705, 2197, 2264, 2693, 3289], 'particular,': [377, 1566], 'defective': [378, 1711, 1722, 3026], 'double-stranded': [381], 'breaks': [383], '(DSBs)': [384], 'crosslinks': [387], '(HR)': [394], '[e.g.,': [396], 'Breast': [397, 404], '1,': [399], 'early': [400, 407, 792, 921, 938], 'onset': [401, 408, 1041], '(BRCA1)': [402], '2,': [406], '(BRCA2)]': [409], 'Fanconi': [411, 735], 'anemia': [412, 736], '(FA)': [413], 'yields': [415, 1384], 'extensive': [418], '(Figure': [421, 604, 694, 795, 981, 1511], '1A': [422], ').': [423], 'These': [424, 954, 1492, 3113, 3504, 3765], 'characterized': [427, 941, 2542, 3216], 'focal': [429], 'deletions': [431, 1587], 'amplifications': [433], 'complex': [437, 651, 1191, 1981, 3528], 'rearrangements': [439, 1193], '[2.Liu': [440, 1042, 1150, 1201], 'X.': [441, 1043, 1105, 1151, 1202], 'al.Somatic': [443, 1045, 1153, 1204], 'loss': [444, 775, 861, 972, 1046, 1149, 1154, 1205, 3127, 3444, 3466], 'BRCA1': [446, 483, 545, 573, 638, 758, 974, 988, 999, 1048, 1156, 1207, 1419, 1521, 1604, 1943, 1965, 2527, 2566, 2700, 3248, 3275, 3331, 3379, 3558], 'p53': [448, 1050, 1087, 1158, 1209, 1314, 3178], 'mice': [450, 809, 1052, 1160, 1211], 'induces': [451, 1053, 1161, 1212], 'mammary': [452, 1054, 1113, 1162, 1213, 1320, 3184], 'human': [457, 1059, 1167, 1198, 1218, 1267, 1289, 1328, 1444, 1629, 1906, 3192], 'BRCA1-mutated': [458, 1060, 1168, 1219], 'basal-like': [459, 1061, 1137, 1169, 1220, 1329, 3193], 'breast': [460, 1062, 1094, 1170, 1221, 1246, 1268, 1293, 1330, 1666, 1846, 2281, 2323, 2785, 2806, 2873, 2915, 2973, 3054, 3103, 3194, 3294, 3324, 3433, 3480, 3492, 3690], 'cancer.Proc.': [461, 1063, 1171, 1222], 'Natl.': [462, 1064, 1172, 1223, 1908, 2875, 2917, 2975, 3056], 'Acad.': [463, 1065, 1173, 1224, 1909], 'Sci.': [464, 1066, 1174, 1225, 1910], 'U.': [465, 1067, 1175, 1226, 1911], 'A.': [467, 849, 986, 1069, 1177, 1228, 1366, 1913, 3066, 3566, 3623], '2007;': [468, 1070, 1178, 1229, 3946], '104:': [469, 1071, 1179, 1230], '12111-12116Crossref': [470, 1072, 1180, 1231], '(327)': [473, 1075, 1183, 1234], 'Scholar,3.Davies': [475], 'H.': [476, 1279, 1412, 1514, 1597], 'al.HRDetect': [478, 1414, 1516, 1599], 'predictor': [481, 1417, 1519, 1602], 'BRCA2': [485, 547, 588, 640, 704, 760, 976, 1085, 1421, 1523, 1606, 1736, 1945, 2568, 2599, 3277, 3333, 3381, 3745, 3899], 'deficiency': [486, 935, 1422, 1524, 1607, 1684, 2988], 'based': [487, 1423, 1525, 1608], 'on': [488, 1424, 1526, 1609, 1927, 2699, 3232, 3474, 3869, 3938], 'mutational': [489, 1392, 1425, 1441, 1527, 1543, 1610, 1626, 1686, 2207, 2450], 'signatures.Nat.': [490, 1426, 1528, 1611], 'Med.': [491, 1427, 1529, 1612, 2438, 3081], '2017;': [492, 1428, 1530, 1613, 1821, 2978, 3059, 3734, 3757, 3793, 3850, 3911], '23:': [493, 1429, 1531, 1614], '517-525Crossref': [494, 1430, 1532, 1615], '(391)': [497, 1433, 1535, 1618], 'Notably,': [500], 'drives': [503, 2738], 'intratumor': [504], 'heterogeneity': [505, 531, 2368, 3532, 3661], 'enables': [507], 'rapid': [508], 'acquisition': [509], 'aberrations': [513], 'drive': [515, 2166], 'therapy': [516], 'failure': [517, 527, 912], '[4.Gerlinger': [518], 'M.': [519, 1767, 2730, 3376, 3744, 3898, 3928], 'Swanton': [520], 'C.': [521, 557, 1237, 1538, 3681, 3858], 'How': [522], 'Darwinian': [523], 'models': [524, 3316], 'inform': [525], 'initiated': [528], 'clonal': [530, 3443], 'medicine.Br.': [534], 'J.': [535, 1078, 2551, 2818, 3105, 3260], 'Cancer.': [536, 1295, 1370, 1468, 1652, 2819, 3106, 3345, 3945], '103:': [538], '1139-1143Crossref': [539], '(304)': [542], 'key': [549], 'regulators': [550], 'maintenance': [553, 763, 1362, 1988], 'HR': [555, 579, 1353, 1383, 1764, 1938, 1949, 2271, 2406, 3212, 3223], '[5.Wyman': [556], 'al.Homologous': [559], 'recombination-mediated': [560], 'double-strand': [561, 1547], 'break': [562, 700, 1548, 1732], 'repair.DNA': [563], 'Repair.': [564], '2004;': [565], '3:': [566, 896], '827-833Crossref': [567], '(0)': [570, 1130, 1919, 3396], 'functions': [574, 589, 656, 1958], 'initiation': [577], 'controlling': [581], 'DNA-end': [582], 'resection': [583], 'at': [584, 687], 'breaks,': [586], 'whereas': [587], 'downstream': [590], 'HR,': [592], 'loading': [594], 'RAD51': [596], 'recombinase': [597], 'facilitate': [599], 'actual': [601], 'process': [603], '1B)': [605, 695], '[6.Chen': [606], 'C.-C.': [607], 'al.Homology-directed': [609], 'role': [613, 702, 1734, 3535], 'BRCA1,': [615, 2935], 'BRCA2,': [616, 2936], 'related': [618], 'proteins': [619], 'integrity': [622, 1715, 1929], 'cancer.Annu.': [624], 'Cancer': [626, 1332, 2570, 2876, 2918, 2976, 3057, 3196, 3279, 3494, 3957], '2018;': [628, 1876, 2685, 3578, 3635], '2:': [629], '313-336Crossref': [630], 'Besides': [634], 'these': [635, 1187, 2141, 2154, 2183, 2195, 3013, 3448, 3610, 3704], 'canonical': [636], 'roles,': [637], 'function': [641], 'crosslink': [644, 664], 'part': [647, 2462], 'FA': [650, 2843], '[7.Bunting': [652], 'S.F.': [653], 'al.BRCA1': [655, 2035, 2597], 'independently': [657], 'interstrand': [663], 'repair.Mol.': [665], 'Cell.': [666, 741, 1001, 1875, 1992, 2018], '2012;': [667, 742, 1251, 1270, 2617, 3695], '46:': [668, 2789], '125-135Abstract': [669], 'Full': [670, 672, 716, 718, 745, 747, 838, 840, 870, 872, 1005, 1007, 1748, 1750, 1879, 1881, 1996, 1998, 2022, 2024, 2441, 2443, 2750, 2752, 2823, 2825], 'Text': [671, 673, 717, 719, 746, 748, 839, 841, 871, 873, 1006, 1008, 1749, 1751, 1880, 1882, 1997, 1999, 2023, 2025, 2442, 2444, 2751, 2753, 2824, 2826], 'PDF': [674, 720, 749, 842, 874, 1009, 1752, 1883, 2000, 2026, 2445, 2754, 2827], '(201)': [677], 'Scholar]': [679, 1783, 2624, 3800, 3883], 'were': [681, 956, 2711, 3306], 'shown': [682], 'protect': [684], 'nascent': [685], 'stalled': [688, 707, 1725, 1739, 1804], 'forks': [690, 1727, 1805], 'from': [691, 769, 1286, 2111, 3017, 3612, 3655], 'nucleolytic': [692], 'degradation': [693, 710, 1742], '[8.Schlacher': [696, 1728], 'K.': [697, 726, 1729], 'al.Double-strand': [699, 1731], 'repair-independent': [701, 1733], 'for': [703, 761, 828, 993, 1093, 1390, 1735, 1964, 1983, 2374, 2854, 3771], 'blocking': [706, 1738], 'fork': [709, 731, 1741, 1774, 1787, 1940], 'MRE11.Cell.': [712, 1744], '2011;': [713, 1745, 2042, 3876], '145:': [714, 1746], '529-542Abstract': [715, 1747], '(720)': [723, 1755], 'Scholar,9.Schlacher': [725], 'al.A': [728, 1307, 3171], 'distinct': [729, 1872, 3296, 3867], 'protection': [732, 1723], 'pathway': [733], 'connects': [734], 'suppressors': [738], 'RAD51-BRCA1/2.Cancer': [740], '22:': [743, 1126], '106-116Abstract': [744], '(548)': [752], 'relevance': [756], 'cellular': [765, 830], 'viability': [766], 'became': [767], 'evident': [768], 'genetic': [770, 3658], 'studies': [771, 884, 2929, 3417], 'mice.': [773], 'Specifically,': [774], 'Brca1': [777, 825, 886, 908, 1316, 3131, 3180], 'Brca2': [779, 853, 888], 'leads': [780, 910, 1585, 1785, 1806, 3132, 3822], 'accumulation': [782], 'lesions,': [785], 'consequent': [787, 2205], 'cell': [788, 2361, 2471, 2609, 2727, 2898, 3708], 'cycle': [789, 3709], 'arrest,': [790], 'embryonal': [793], 'death': [794], '1C)': [796, 1512], '[10.Sharan': [797], 'S.K.': [798], 'al.Embryonic': [800], 'lethality': [801, 940], 'radiation': [803], 'hypersensitivity': [804], 'mediated': [805], 'Rad51': [807], 'lacking': [810], 'Brca2.Nature.': [811], '1997;': [812], '386:': [813], '804-810Crossref': [814], 'Scholar,': [817, 847, 879, 900, 930, 1258, 1277, 1303, 1453, 1473, 2005, 2031], '11.Hakem': [818], 'R.': [819, 881], 'al.The': [821, 1239, 1438, 1623, 1860, 3683, 3860], 'suppressor': [823, 989, 1082], 'gene': [824, 909, 1873, 1968, 2424, 2554, 2835, 2847, 3237, 3263, 3455], 'required': [827, 1982], 'embryonic': [829, 939], 'proliferation': [831], 'mouse.Cell.': [834], '1996;': [835, 925, 946], '85:': [836], '1009-1023Abstract': [837], '(563)': [845], '12.Tutt': [848], 'al.Absence': [851], 'causes': [854], 'chromosome': [858, 3872], 'breakage': [859], 'centrosome': [864], 'amplification.Curr.': [865], '1999;': [867, 1125], '9:': [868, 2686, 3579, 3636], '1107-1110Abstract': [869], '(254)': [877], '13.Hakem': [880], 'al.Developmental': [883], 'knock-out': [889], 'mice.J.': [890], 'Mammary': [891], 'Gland': [892], 'Neoplasia.': [894], '1998;': [895], '431-445Crossref': [897], '14.Liu': [901], 'C.Y.': [902], 'al.Inactivation': [904], 'mouse': [907, 1091, 1287, 1308, 3123, 3172, 3315], 'morphogenesis': [915, 1120], 'egg': [918], 'cylinder': [919], 'postimplantation': [922], 'development.Genes': [923], 'Dev.': [924], '10:': [926, 1297, 3003], '1835-1843Crossref': [927], '15.Gowen': [931], 'L.C.': [932], 'al.Brca1': [934], 'results': [936, 1116, 2939, 3885, 3924], 'neuroepithelial': [943], 'abnormalities.Nat.': [944], 'Genet.': [945, 1096, 1124], '12:': [947], '191-194Crossref': [948], '(380)': [951], 'findings': [955, 3114], 'apparent': [958], 'contrast': [959], 'predisposition': [964], 'BRCA': [966, 1016, 3440], 'carriers': [968], 'full': [971], 'ensuing': [979], '1A)': [982], '[16.Elledge': [983], 'S.J.': [984], 'Amon': [985], 'hypothesis:': [990], 'explanation': [992], 'tissue-specific': [995, 1311, 3126, 3175], 'development': [997, 3134], 'patients.Cancer': [1000], '2002;': [1002], '1:': [1003, 3347], '129-132Abstract': [1004], '(81)': [1012], 'This': [1015, 1758], 'paradox': [1017], 'was': [1018, 1023, 2053, 2851, 3563], 'partly': [1019], 'explained': [1020, 1497], 'when': [1021], 'Trp53': [1022, 3129], 'conditionally': [1024], 'inactivated': [1025], 'along': [1026], 'Brca1/2,': [1028], 'allows': [1030], 'survive': [1033, 3960], 'damaged': [1035], 'ultimately': [1038], 'promotes': [1039, 1772, 3724, 3783, 3840], 'Scholar,17.Jonkers': [1077], 'al.Synergistic': [1080], 'activity': [1083], 'conditional': [1090], 'model': [1092, 1309, 3173], '2001;': [1097], '29:': [1098], '418-425Crossref': [1099], '(764)': [1102], 'Scholar,18.Xu': [1104], 'al.Conditional': [1107], 'Brca': [1110], '1': [1111], 'epithelial': [1114], 'blunted': [1118], 'ductal': [1119], 'tumour': [1122, 2036], 'formation.Nat.': [1123], '37-43Crossref': [1127], 'resulting': [1134], 'showed': [1136], 'characteristics,': [1138], 'recurrent': [1140, 1832], 'such': [1143, 2105, 3410], 'MYC': [1145], 'amplification': [1146], 'RB1': [1148], 'Moreover,': [1186, 2760, 3530], 'displayed': [1189], 'resemble': [1195], 'those': [1196], 'cancers': [1200, 1595, 1718, 1836, 2106, 2118, 2142, 2300, 2395, 2564, 2710, 2737, 3136, 3243, 3252, 3273, 3361, 3422, 3434, 3481, 3673], 'Scholar,19.Curtis': [1236], 'transcriptomic': [1242, 1325, 3189, 3686], 'architecture': [1243, 3687], '2,000': [1245, 3689], 'tumours': [1247, 3691], 'reveals': [1248, 3692], 'novel': [1249, 3693], 'subgroups.Nature.': [1250, 3694], '486:': [1252, 3696], '346-352Crossref': [1253, 3697], '(3261)': [1256, 3700], '20.Cancer': [1259], 'Genome': [1260], 'Atlas': [1261], 'Network': [1262], 'Comprehensive': [1263], 'molecular': [1264, 3520], 'portraits': [1265], 'tumours.Nature.': [1269], '490:': [1271], '61-70Crossref': [1272], '(7479)': [1275], '21.Holstege': [1278], 'al.Cross-species': [1281], 'comparison': [1282], 'aCGH': [1284], 'data': [1285], 'BRCA1-': [1290, 2307, 3303, 3358], 'BRCA2-mutated': [1292], 'cancers.BMC': [1294], '455Crossref': [1298], '(29)': [1301], '22.Hollern': [1304], 'D.P.': [1305, 3169], 'featuring': [1310, 3174], 'deletion': [1312, 3176], 'gives': [1317, 3181], 'rise': [1318, 3182], 'similarities': [1326, 3190], 'cancer.Breast': [1331, 3195], 'Res.': [1333, 1556, 2571, 3197, 3280, 3495, 3875], 'Treat.': [1334, 3198], '2019;': [1335, 1697, 1776, 2326, 3002, 3199, 3496], '174:': [1336, 3200], '143-155Crossref': [1337, 3201], '(6)': [1340, 3204], 'Loss-of-function': [1343], 'BRCA1/2,': [1346], 'other': [1352, 1948, 1957, 3211, 3408], 'genes,': [1354, 2483, 2895, 3164], 'profound': [1358], 'defect': [1359, 1759, 1765], '[23.Lord': [1363], 'C.J.': [1364], 'Ashworth': [1365], 'BRCAness': [1367, 1542], 'revisited.Nat.': [1368], '2016;': [1371, 1670, 1850, 1914, 2256, 2519, 2661, 3107], '16:': [1372], '110-120Crossref': [1373], '(623)': [1376], 'Scholar],': [1378, 1828, 3702], 'generically': [1379], 'termed': [1380], 'BRCAness.': [1381], 'Defective': [1382], 'aberrant': [1385], 'genomes': [1386], 'enriched': [1389, 2853], 'several': [1391], 'signatures,': [1393], 'base': [1395], 'substitution': [1396], 'signatures': [1397, 1401, 1406, 1442, 1460, 1627, 1644, 1687, 3138, 3486], '(SBS3,': [1398], 'SBS8),': [1399], 'indel': [1400], '(ID6,': [1402], 'ID8),': [1403], 'rearrangement': [1405], '(RS1,': [1407], 'RS3,': [1408], 'RS5)': [1410], '[3.Davies': [1411, 1513, 1596], 'Scholar,24.Alexandrov': [1435, 1620], 'L.B.': [1436, 1621], 'repertoire': [1439, 1624], 'cancer.Nature.': [1445, 1630], '2020;': [1446, 1469, 1484, 1631, 1653, 2439, 2820, 3346], '578:': [1447, 1632], '94-101Crossref': [1448, 1633], '(613)': [1451, 1636], '25.Hwang': [1454], 'T.': [1455, 1639], 'al.Defining': [1457, 1641], 'polymerase': [1463, 1572, 1647], 'θ': [1464, 1648], 'genomes.NAR': [1467, 1651], '2zcaa017Crossref': [1470, 1654], '26.Nguyen': [1474], 'L.': [1475, 2795], 'al.Pan-cancer': [1477], 'landscape': [1478, 1544], 'deficiency.Nat.': [1482], 'Commun.': [1483, 3001, 3577, 3634, 3733, 3756, 3792, 3849, 3910], '5584Crossref': [1486], '(54)': [1489, 3739, 3798, 3855], 'alterations': [1494, 2181, 2559, 3268], 'be': [1496, 2158, 2398, 3403, 3424], 'usage': [1500, 1568], 'alternative,': [1502], 'nonconservative': [1503], 'DSBs': [1510], 'Scholar,27.Stok': [1537], 'al.Shaping': [1540], 'alternative': [1546, 1580], 'mitotic': [1553, 3749, 3766, 3827, 3903, 3920], 'aberrancies.Nucleic': [1554], 'Acids': [1555, 3874], '2021;': [1557, 2748, 3392], '49:': [1558], '4239-4257Crossref': [1559], '(3)': [1562], 'non-homologous': [1570], 'end-joining,': [1571], 'Theta': [1573], '(POLQ)-mediated': [1574], 'end-joining': [1575], '(also': [1576], 'referred': [1577], 'end-joining),': [1581], 'single-strand': [1583], 'annealing': [1584], 'translocations': [1589], 'characteristic': [1592], 'HR-deficient': [1594], 'Scholar,25.Hwang': [1638], 'Scholar,28.Nik-Zainal': [1657], 'al.Landscape': [1660, 1840], '560': [1665, 1845], 'whole-genome': [1668, 1848], 'sequences.Nature.': [1669, 1849], '534:': [1671, 1851], '47-54Crossref': [1672, 1852], '(1083)': [1675, 1855], 'Scholar,29.Póti': [1677], 'Á.': [1678], 'al.Correlation': [1680], 'induced': [1685], 'sensitivity': [1689, 2995], 'PARP': [1691, 3725, 3784, 3841], 'inhibitors': [1692], 'cytotoxic': [1694], 'agents.Genome': [1695], '20:': [1698, 3083], '240Crossref': [1699], '(7)': [1702, 2330], 'addition': [1706], 'effects': [1709, 1923, 1935, 3031, 3231, 3868], 'DSB': [1712], 'affected': [1720], 'independent': [1761, 2416], '[30.Daza-Martin': [1766], 'al.Isomerization': [1769], 'BRCA1–BARD1': [1771], 'protection.Nature.': [1775], '571:': [1777], '521-527Crossref': [1778], '(41)': [1781], 'collapse': [1788], 'persistent': [1790], 'breaks.': [1792], 'Specific': [1793], 'BRCA1-mutant': [1795, 1819, 1835, 2299, 2708, 2765, 3323, 3479], 'cells,': [1796, 3145, 3151, 3155], 're-replication': [1797], 'tracts': [1799], 'adjacent': [1802], 'tandem': [1808, 1815, 1861, 1902], 'duplications': [1809], '[31.Willis': [1810], 'N.A.': [1811], 'al.Mechanism': [1813], 'duplication': [1816], 'formation': [1817], 'cells.Nature.': [1820], '551:': [1822], '590-595Crossref': [1823], '(57)': [1826], 'feature': [1833, 2771], '[28.Nik-Zainal': [1837], 'Scholar,32.Menghi': [1857], 'F.': [1858, 1889], 'duplicator': [1862, 1903], 'phenotype': [1863], 'prevalent': [1866], 'genome-wide': [1867], 'configuration': [1869], 'driven': [1870], 'mutations.Cancer': [1874], '34:': [1877], '197-210Abstract': [1878], '(68)': [1886], 'Scholar,33.Menghi': [1888], 'Liu': [1890], 'E.T.': [1891], 'Reply': [1892], 'Watkins': [1894], 'al.:': [1896], 'Whole-genome': [1897], 'sequencing-based': [1898], 'identification': [1899], 'diverse': [1901, 3601], 'phenotypes': [1904], 'cancers.Proc.': [1907], '113:': [1915], 'E5259-E5260Crossref': [1916], 'will': [1930], 'likely': [1931, 2388, 2460, 3015, 3802], 'extend': [1932], 'beyond': [1933, 2433], 'impaired': [1937], 'protection,': [1941], '(and': [1946], 'multiple': [1947, 1956], 'genes)': [1950], 'have': [1951, 2143, 2930, 3418, 3451, 3706], 'been': [1952, 2080], 'described': [1953], 'perform': [1955], 'suppression,': [1961], 'roles': [1963], 'regulating': [1967], 'expression': [1969, 2247, 2289, 2313, 2480, 2510, 2555, 2627, 2652, 2681, 2836, 2892, 3160, 3238, 3264, 3321, 3456, 3559], 'chromatin': [1971, 3828], 'remodeling': [1972], '[34.Savage': [1973], 'K.I.': [1974], 'al.Identification': [1976, 2863, 2905], 'BRCA1-mRNA': [1979], 'splicing': [1980], 'efficient': [1984], 'stability.Mol.': [1991], '2014;': [1993, 2878, 2920, 3082], '54:': [1994], '445-459Abstract': [1995], '(110)': [2003], '35.Filipponi': [2006], 'D.': [2007, 2420], 'al.Wip1': [2009], 'controls': [2010], 'global': [2011], 'heterochromatin': [2012], 'silencing': [2013], 'via': [2014, 2039, 2745], 'ATM/BRCA1-dependent': [2015], 'methylation.Cancer': [2017], '2013;': [2019, 2378, 2572, 3281], '24:': [2020], '528-541Abstract': [2021], '(45)': [2029], '36.Zhu': [2032], 'Q.': [2033], 'suppression': [2037], 'occurs': [2038], 'heterochromatin-mediated': [2040], 'silencing.Nature.': [2041], '477:': [2043], '179-184Crossref': [2044], '(310)': [2047], 'Recently,': [2050], 'identified': [2054], 'consequence': [2057], 'instability,': [2060, 3220], 'Tumor-cell': [2065], 'intrinsic': [2066, 2899, 2942], 'activate': [2070], '(TME)': [2077], 'has': [2079, 3866], 'linked': [2081], 'responses': [2083], 'inhibitors.': [2087, 2114], 'Although': [2088], 'important': [2089], 'respond': [2092], 'clearly': [2097, 3525], 'present': [2098], 'patients': [2103, 2130, 2808, 3436], 'paradoxically': [2107], 'only': [2108, 2297, 2697, 2888, 3372], 'minimally': [2109], 'benefit': [2110, 2125, 3368], 'Apparently,': [2115], 'somehow': [2119], 'evade': [2120, 2186], 'eradication.': [2122], 'expand': [2124], 'crucial': [2137], 'understand': [2139, 3526], 'adapted': [2144], 'investigate': [2150], 'if': [2151], 'therapeutically': [2159], 'targeted.': [2160], 'We': [2161, 2178], 'review': [2162], 'response': [2170, 2411, 2432, 2870, 2912, 3035, 3097, 3340, 3385, 3406], 'caused': [2174], 'inactivation.': [2177], 'also': [2179], 'options': [2190], 'line': [2198, 3117], 'their': [2200, 3025], 'burden': [2208], '(TMB),': [2209], 'status': [2212, 2238, 2501, 2582, 2643, 2675, 2802], 'high-grade': [2214, 2536, 2561, 2613, 3270], 'serous': [2215, 2253, 2516, 2537, 2562, 2614, 2658, 3271], 'ovarian': [2216, 2254, 2476, 2517, 2538, 2563, 2612, 2659, 2683, 2709, 2736, 3242, 3272, 3551, 3573, 3630], 'associates': [2218, 2283, 2478, 2676], 'predicted': [2221], 'higher': [2222, 3141], 'neoantigen': [2223, 2240, 2267, 2503, 2645], 'load': [2224, 2268], 'improved': [2226], 'overall': [2227], 'survival': [2228], '[37.Strickland': [2229, 2492, 2634], 'K.C.': [2230, 2493, 2635], 'al.Association': [2232, 2495, 2637], 'prognostic': [2234, 2497, 2639, 2770, 2781], 'significance': [2235, 2498, 2640], 'BRCA1/2-mutation': [2237, 2500, 2642], 'load,': [2241, 2504, 2646], 'number': [2242, 2505, 2558, 2647, 3267], 'tumor-infiltrating': [2244, 2507, 2547, 2592, 2649], 'lymphocytes': [2245, 2508, 2593, 2650, 2798], 'PD-1/PD-L1': [2249, 2512, 2654], 'high': [2251, 2514, 2544, 2656], 'grade': [2252, 2515, 2657], 'cancer.Oncotarget.': [2255, 2518, 2660, 2684], '7:': [2257, 2520, 2662, 3947], '13587-13598Crossref': [2258, 2521, 2663], '(345)': [2261, 2524, 2666], 'this': [2265, 2335, 3527], 'study,': [2266], 'correlates': [2269], 'deficiency,': [2272], 'even': [2273], 'non-BRCA': [2275], 'mutations.': [2276], 'Similarly,': [2277], 'increased': [2285, 2288, 2336, 2391, 2586, 2626, 2702, 2721, 2725, 3309, 3318, 3561], 'TMB': [2286, 2337, 2418], 'PD1/PDL-1': [2292], 'components,': [2295], 'albeit': [2296], '[38.Wen': [2301], 'W.X.': [2302], 'Leong': [2303], 'C.-O.': [2304], 'Association': [2305], 'BRCA2-deficiency': [2309], 'burden,': [2312, 2451], 'PD-L1/PD-1,': [2315], 'infiltrates,': [2317], 'T': [2319, 2726, 3154, 3597], 'cell-inflamed': [2320], 'signature': [2321], 'cancer.PLoS': [2324], 'One.': [2325], '14e0215381Crossref': [2327], 'Even': [2333], 'so,': [2334], 'does': [2338], 'not': [2339, 3221, 3250, 3414], 'reach': [2340], 'scale': [2342], 'classically': [2348], 'responsive': [2349], 'blockade:': [2353], 'microsatellite': [2354], 'colorectal': [2356], 'cancer,': [2357, 3552], 'melanoma,': [2358], 'non-small': [2360], 'lung': [2362], '[39.Lawrence': [2364], 'M.S.': [2365], 'al.Mutational': [2367], 'search': [2373], 'new': [2375], 'cancer-associated': [2376], 'genes.Nature.': [2377], '499:': [2379], '214-218Crossref': [2380], '(3303)': [2383], 'It': [2386], 'immunogenicity': [2392, 3489, 3667], 'cannot': [2396], 'solely': [2397], 'attributed': [2399], 'moderately': [2402], 'elevated': [2403, 2714, 3159, 3824], 'TMB,': [2404], 'predictors': [2409, 2427], 'inhibitors,': [2415], '[40.Hsiehchen': [2419], 'al.DNA': [2422], 'inhibitor': [2431], 'burden.Cell': [2436], 'Reports': [2437], '1100034Abstract': [2440], 'Beyond': [2449], 'appears': [2454], 'strongly': [2456], 'associate': [2457], 'immunogenicity,': [2459], 'because': [2463], 'direct': [2467], 'read-out': [2468], 'activation.': [2472], 'immune-related': [2482, 2894], 'type': [2485, 3072, 3461], 'II': [2486], 'interferon': [2487, 2717, 3074], 'gamma': [2488], '(IFNγ)': [2489], 'TNFR': [2491], 'immunoreactive': [2533, 3257], 'subtype': [2534, 3258], '[41.George': [2550, 3259], 'al.Nonequivalent': [2553, 3262], 'copy': [2557, 3266], 'mutations.Clin.': [2569, 3278], '19:': [2573, 3282], '3474-3484Crossref': [2574, 3283], '(64)': [2577, 3286], 'Also,': [2580], 'abundance': [2587], 'CD3+': [2589, 3596], 'CD4+': [2591], '[42.McAlpine': [2594], 'J.N.': [2595], 'correlate': [2601], 'TP53': [2603, 2673, 3678], 'abnormalities': [2604, 3752, 3906], 'presence': [2606], 'infiltrates': [2610], 'carcinoma.Mod.': [2615], 'Pathol.': [2616, 2787], '25:': [2618, 3497], '740-750Crossref': [2619], '(118)': [2622], 'molecules': [2632], 'PD1/PDL1': [2633], 'Scholar,43.Wieser': [2668], 'V.': [2669], 'al.BRCA1/2': [2671], 'PD-1': [2678], 'PD-L1': [2680], '17501-17511Crossref': [2687], '(52)': [2690], 'separate': [2695], 'study': [2696, 3291, 3356], 'focusing': [2698], 'status,': [2701], 'damage': [2706, 2971, 3052, 3715, 3922], 'stimulator': [2715], '(STING)': [2719], 'levels,': [2720], 'STAT1': [2722], 'infiltrate': [2728], '[44.Bruand': [2729], 'al.Cell-autonomous': [2732], 'BRCA1-deficient': [2735], 'tumor-intrinsic': [2740], 'immunoreactivity': [2741], 'resistance': [2744], 'STING.Cell': [2746], 'Rep.': [2747], '36109412Abstract': [2749], '(5)': [2757], 'tumor-associated': [2762, 3311], 'favorable': [2769, 3650], '[45.van': [2772], 'Verschuer': [2773], 'V.M.T.': [2774], 'al.Tumor-associated': [2776], 'potential': [2780], 'tool': [2782], 'BRCA1/2-associated': [2784], 'cancer.Hum.': [2786], '2015;': [2788], '182-190Crossref': [2790], 'Scholar,46.de': [2793], 'Boo': [2794], 'al.Tumour-infiltrating': [2797], '(TILs)': [2799], 'BRCA-like': [2801], 'stage': [2804], 'III': [2805], 'randomised': [2809], 'adjuvant': [2811], 'intensified': [2812], 'platinum-based': [2813], 'chemotherapy': [2814, 2869, 2911, 3099, 3412], 'versus': [2815, 3304, 3359], 'conventional': [2816], 'chemotherapy.Eur.': [2817], '127:': [2821], '240-250Abstract': [2822], '(9)': [2830], 'Analysis': [2833, 3431], 'patient': [2838], 'samples': [2839], 'yielded': [2845], 'set': [2848], 'signature,': [2849], 'highly': [2852], 'involved': [2856], '[47.Mulligan': [2860, 2902], 'J.M.': [2861, 2903], 'validation': [2865, 2907], 'anthracycline/cyclophosphamide-based': [2868, 2910], 'assay': [2871, 2913], 'cancer.J.': [2874, 2916, 2974, 3055], 'Inst.': [2877, 2919, 2977, 3058], '106:': [2879, 2921], 'djt335Crossref': [2880, 2922], '(74)': [2883, 2925], 'Lymphocyte': [2886], 'infiltration': [2887, 3473], 'partially': [2889], 'explains': [2890], 'pointing': [2896], 'towards': [2897], 'Subsequent': [2928], 'revealed': [2931, 3240, 3589], 'inactivation': [2933, 3821], 'FANCD2': [2938, 3776], 'tumor-cell': [2941], 'involving': [2945], 'secretion': [2946], 'proinflammatory': [2948], 'cytokines': [2949], 'CXCL10,': [2950], 'CCL5,': [2951], 'TNF-α': [2953], 'attraction': [2955], '[48.Parkes': [2959, 3040], 'E.E.': [2960, 3041], 'al.Activation': [2962, 3043, 3092], 'STING-dependent': [2964, 3045], 'innate': [2965, 3046], 'S-phase-specific': [2969, 3050], '109djw199Crossref': [2979, 3060], '(197)': [2982, 3063], 'Scholar,49.Heijink': [2984], 'A.M.': [2985], 'al.BRCA2': [2987], 'instigates': [2989], 'cGAS-mediated': [2990], 'confers': [2994], 'necrosis': [2998], 'factor-alpha-mediated': [2999], 'cytotoxicity.Nat.': [3000], '100Crossref': [3004], '(42)': [3007], 'stems': [3016], 'lesions': [3020, 3768], 'arise': [3022], 'maintenance,': [3028], 'similar': [3030, 3400], 'damaging': [3038], 'agents': [3039], 'Scholar,50.Sistigu': [3065], 'al.Cancer': [3068], 'cell–autonomous': [3069], 'contribution': [3070], 'I': [3073], 'efficacy': [3078], 'chemotherapy.Nat.': [3080], '1301-1309Crossref': [3084], '(576)': [3087], 'Scholar,51.Legrier': [3089], 'M.E.': [3090], 'IFN/STAT1': [3094], 'signalling': [3095], 'predicts': [3096], 'oestrogen': [3101], 'receptor-negative': [3102], 'cancer.Br.': [3104], '114:': [3108], '177-187Crossref': [3109], 'observations': [3119, 3505], 'genetically': [3121], 'engineered': [3122], 'models.': [3124], 'Combined': [3125], 'Th2': [3144], 'T-regulatory': [3146], '(Tregs),': [3148], 'central': [3149], 'memory': [3150], 'exhausted': [3153], 'Pd1': [3165], 'Ctla4': [3167], '[22.Hollern': [3168], 'Whereas': [3207], 'deficiencies': [3213, 3224], 'all': [3215, 3222], 'severe': [3218], 'equal': [3226], 'terms': [3228], 'TME.': [3234], 'For': [3235], 'instance,': [3236], 'analysis': [3239, 3476, 3521], 'mutant': [3245], 'hypermethylated': [3247], 'but': [3249], 'BRCA2-mutant': [3251, 3305, 3360, 3370], 'BRCA-mutant': [3293, 3541], 'TME': [3301], 'identified,': [3307], 'immunosuppressive': [3310], 'macrophages': [3312], 'Brca1-null': [3314], '[52.Samstein': [3326], 'R.M.': [3327, 3956], 'al.Mutations': [3329], 'differentially': [3334], 'affect': [3335], 'blockade': [3343, 3366], 'immunotherapy.Nat.': [3344], '1188-1203Crossref': [3348], '(34)': [3351], 'A': [3354], 'pan-cancer': [3355], 'treated': [3362], 'suggests': [3367], 'disease': [3371], '[53.Zhou': [3373], 'Z.': [3374], 'Li': [3375], 'Evaluation': [3377], 'indicators': [3383], 'inhibitors.JAMA': [3389], 'Netw.': [3390], 'Open.': [3391], '4e217728Crossref': [3393], 'Whether': [3399], 'patterns': [3401], 'could': [3402], 'treatments': [3409], 'known.': [3415], 'Some': [3416], 'instead': [3419], 'poorly': [3425], 'immunogenic': [3426], 'compared': [3427, 3458], 'BRCA1/2-wild': [3429, 3460], 'type.': [3430], 'germline': [3439, 3478], 'heterozygosity': [3446], 'found': [3447], 'lower': [3453], 'score': [3457], 'subclonal': [3465], 'heterozygosity,': [3468], 'correlating': [3469], 'reduced': [3471], 'immunohistochemical': [3475], '[54.Kraya': [3482], 'A.A.': [3483], 'predict': [3487], 'BRCA-deficient': [3491], 'cancer.Clin.': [3493], '4363-4374Crossref': [3498], '(33)': [3501], 'add': [3506], 'granularity': [3507], 'association': [3510, 3555], 'infiltration,': [3516], 'indicating': [3517], 'detailed': [3519], 'needed': [3523], 'relationship.': [3529], 'intratumoral': [3531], 'plays': [3533], 'enabling': [3537], 'evasion': [3539], 'Using': [3543], 'digital': [3544], 'pathology': [3545], 'define': [3547], 'morphological': [3548, 3575, 3587, 3632], 'diversity': [3549], 'significant': [3554], 'low': [3557], 'diversification': [3562], 'noted': [3564], '[55.Heindl': [3565, 3622], 'al.Microenvironmental': [3568, 3625], 'niche': [3569, 3626], 'divergence': [3570, 3627], 'shapes': [3571, 3628], 'BRCA1-dysregulated': [3572, 3629], 'plasticity.Nat.': [3576, 3633], '3917Crossref': [3580, 3637], '(23)': [3583, 3640], 'Further': [3586], 'examination': [3588], 'lack': [3591], 'invasion': [3594], 'morphologically': [3600], 'regions,': [3602], 'suggestion': [3605], 'active': [3607], 'exclusion': [3608], 'nests': [3614], 'upregulation': [3616], 'galectin-3': [3621], 'relationship': [3644], 'environment': [3652], 'far': [3654], 'straightforward,': [3656], 'spatial': [3660], 'contributing': [3662], 'spectrum': [3665], 'almost': [3674], 'invariably': [3675], 'harbor': [3676], 'inactivating': [3677], '[19.Curtis': [3680], 'therefore,': [3703], 'incomplete': [3707, 3810], 'control': [3710], 'frequently': [3712, 3923], 'transmit': [3713], 'into': [3716], 'mitosis': [3717, 3723, 3782, 3839], '[56.Schoonen': [3718, 3777, 3834], 'P.M.': [3719, 3778, 3835], 'al.Progression': [3721, 3780, 3837], 'inhibitor-induced': [3726, 3785, 3842], 'cytotoxicity': [3727, 3786, 3843], 'recombination-deficient': [3730, 3789, 3846], 'cells.Nat.': [3732, 3791, 3848], '8:': [3735, 3758, 3794, 3851, 3912], '15981Crossref': [3736, 3795, 3852], 'Scholar,57.Feng': [3741], 'W.': [3742, 3896], 'Jasin': [3743, 3897], 'suppresses': [3746, 3900], 'stress-induced': [3748, 3902], 'G1': [3751, 3893, 3905], 'recombination.Nat.': [3755, 3909], '525Crossref': [3759, 3913], '(79)': [3762, 3916], 'positive': [3770], 'marker': [3775], 'represent': [3803], "'joint": [3804], "molecules',": [3806], 'either': [3807], 'unresolved': [3814], 'intermediates': [3815], 'attempts.': [3818], 'Consequently,': [3819], 'numbers': [3825], 'bridges': [3829, 3833], 'ultrafine': [3831], 'Scholar,58.Laulier': [3857], 'relative': [3861], 'efficiency': [3862], 'homology-directed': [3864], 'proper': [3870], 'anaphase': [3871], 'separation.Nucleic': [3873], '39:': [3877], '5935-5944Crossref': [3878], '(38)': [3881], '53BP1': [3887], 'nuclear': [3888], 'bodies': [3889], '[57.Feng': [3895], 'Unresolved': [3919], 'micronuclei': [3926, 3964], '[59.Löbrich': [3927], 'Jeggo': [3929], 'P.A.': [3930], 'impact': [3932], 'negligent': [3935], 'G2/M': [3936], 'induction.Nat.': [3943], '861-869Crossref': [3948], '(431)': [3951], 'Scholar,60.Lewis': [3953], 'C.W.': [3954], 'Golsteyn': [3955], 'adaptation': [3962], 'contain': [3963], 'ha': [3966]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4206381614', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 6}], 'updated_date': '2025-01-06T16:31:57.787438', 'created_date': '2022-01-26'}
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