Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4206315232', 'doi': 'https://doi.org/10.1093/nar/gkab1280', 'title': 'Systematic characterization of short intronic splicing-regulatory elements in <i>SMN2</i> pre-mRNA', 'display_name': 'Systematic characterization of short intronic splicing-regulatory elements in <i>SMN2</i> pre-mRNA', 'publication_year': 2022, 'publication_date': '2022-01-08', 'ids': {'openalex': 'https://openalex.org/W4206315232', 'doi': 'https://doi.org/10.1093/nar/gkab1280', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35018432'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/nar/gkab1280', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789036', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103861258', 'display_name': 'Yuan Gao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210124971', 'display_name': 'Second Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/02xjrkt08', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuan Gao', 'raw_affiliation_strings': ['Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou\xa0215004, China', 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou\xa0215004, China', 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210124971']}, {'raw_affiliation_string': 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002057869', 'display_name': 'Kuan‐Ting Lin', 'orcid': 'https://orcid.org/0000-0003-1294-1142'}, 'institutions': [{'id': 'https://openalex.org/I2750212522', 'display_name': 'Cold Spring Harbor Laboratory', 'ror': 'https://ror.org/02qz8b764', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2750212522']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kuan-Ting Lin', 'raw_affiliation_strings': ['Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY\xa011724, USA'], 'affiliations': [{'raw_affiliation_string': 'Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY\xa011724, USA', 'institution_ids': ['https://openalex.org/I2750212522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013422241', 'display_name': 'Tao Jiang', 'orcid': 'https://orcid.org/0000-0002-4487-299X'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Jiang', 'raw_affiliation_strings': ['Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100397483', 'display_name': 'Yang Yang', 'orcid': 'https://orcid.org/0000-0002-0273-9242'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210124971', 'display_name': 'Second Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/02xjrkt08', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Yang', 'raw_affiliation_strings': ['Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou\xa0215004, China', 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China', 'institution_ids': ['https://openalex.org/I3923682']}, {'raw_affiliation_string': 'Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou\xa0215004, China', 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210124971']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041483643', 'display_name': 'Mohammad Alinoor Rahman', 'orcid': 'https://orcid.org/0000-0003-1553-8316'}, 'institutions': [{'id': 'https://openalex.org/I2750212522', 'display_name': 'Cold Spring Harbor Laboratory', 'ror': 'https://ror.org/02qz8b764', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2750212522']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mohammad\xa0A Rahman', 'raw_affiliation_strings': ['Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY\xa011724, USA'], 'affiliations': [{'raw_affiliation_string': 'Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY\xa011724, USA', 'institution_ids': ['https://openalex.org/I2750212522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103111307', 'display_name': 'Shuaishuai Gong', 'orcid': 'https://orcid.org/0000-0002-4563-0204'}, 'institutions': [{'id': 'https://openalex.org/I152031979', 'display_name': 'Nanjing Normal University', 'ror': 'https://ror.org/036trcv74', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I152031979']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuaishuai Gong', 'raw_affiliation_strings': ['Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China', 'institution_ids': ['https://openalex.org/I152031979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027975050', 'display_name': 'Jialin Bai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I152031979', 'display_name': 'Nanjing Normal University', 'ror': 'https://ror.org/036trcv74', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I152031979']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jialin Bai', 'raw_affiliation_strings': ['Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China', 'institution_ids': ['https://openalex.org/I152031979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100335850', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0000-0001-7415-5599'}, 'institutions': [{'id': 'https://openalex.org/I152031979', 'display_name': 'Nanjing Normal University', 'ror': 'https://ror.org/036trcv74', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I152031979']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Wang', 'raw_affiliation_strings': ['Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China', 'institution_ids': ['https://openalex.org/I152031979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101875809', 'display_name': 'Junjie Sun', 'orcid': 'https://orcid.org/0000-0001-8710-7318'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junjie Sun', 'raw_affiliation_strings': ['Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085466214', 'display_name': 'Lei Sheng', 'orcid': 'https://orcid.org/0000-0001-7729-9248'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210124971', 'display_name': 'Second Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/02xjrkt08', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Sheng', 'raw_affiliation_strings': ['Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou\xa0215004, China', 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou\xa0215004, China', 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210124971']}, {'raw_affiliation_string': 'Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077163665', 'display_name': 'Adrian R. Krainer', 'orcid': 'https://orcid.org/0000-0001-9024-9501'}, 'institutions': [{'id': 'https://openalex.org/I2750212522', 'display_name': 'Cold Spring Harbor Laboratory', 'ror': 'https://ror.org/02qz8b764', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2750212522']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Adrian\xa0R Krainer', 'raw_affiliation_strings': ['Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY\xa011724, USA'], 'affiliations': [{'raw_affiliation_string': 'Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY\xa011724, USA', 'institution_ids': ['https://openalex.org/I2750212522']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082344505', 'display_name': 'Yimin Hua', 'orcid': 'https://orcid.org/0000-0003-0905-7989'}, 'institutions': [{'id': 'https://openalex.org/I152031979', 'display_name': 'Nanjing Normal University', 'ror': 'https://ror.org/036trcv74', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I152031979']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yimin Hua', 'raw_affiliation_strings': ['Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China', 'institution_ids': ['https://openalex.org/I152031979']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5077163665', 'https://openalex.org/A5082344505'], 'corresponding_institution_ids': ['https://openalex.org/I2750212522', 'https://openalex.org/I152031979'], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.088, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.615055, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '50', 'issue': '2', 'first_page': '731', 'last_page': '749'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/minigene', 'display_name': 'Minigene', 'score': 0.9899396}, {'id': 'https://openalex.org/keywords/exonic-splicing-enhancer', 'display_name': 'Exonic splicing enhancer', 'score': 0.7642262}, {'id': 'https://openalex.org/keywords/splice-site-mutation', 'display_name': 'Splice site mutation', 'score': 0.65312797}, {'id': 'https://openalex.org/keywords/exon-skipping', 'display_name': 'Exon skipping', 'score': 0.519986}, {'id': 'https://openalex.org/keywords/alternative-splicing', 'display_name': 'Alternative Splicing', 'score': 0.496462}, {'id': 'https://openalex.org/keywords/polypyrimidine-tract', 'display_name': 'Polypyrimidine tract', 'score': 0.47346583}, {'id': 'https://openalex.org/keywords/splicing-factor', 'display_name': 'Splicing factor', 'score': 0.45518017}, {'id': 'https://openalex.org/keywords/splice', 'display_name': 'splice', 'score': 0.4167146}], 'concepts': [{'id': 'https://openalex.org/C166342232', 'wikidata': 'https://www.wikidata.org/wiki/Q11936831', 'display_name': 'Minigene', 'level': 5, 'score': 0.9899396}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.9018923}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8329109}, {'id': 'https://openalex.org/C42576000', 'wikidata': 'https://www.wikidata.org/wiki/Q5420618', 'display_name': 'Exonic splicing enhancer', 'level': 5, 'score': 0.7642262}, {'id': 'https://openalex.org/C94671646', 'wikidata': 'https://www.wikidata.org/wiki/Q207551', 'display_name': 'Intron', 'level': 3, 'score': 0.75603455}, {'id': 'https://openalex.org/C36823959', 'wikidata': 'https://www.wikidata.org/wiki/Q373027', 'display_name': 'Exon', 'level': 3, 'score': 0.73288786}, {'id': 'https://openalex.org/C62257209', 'wikidata': 'https://www.wikidata.org/wiki/Q5487490', 'display_name': 'Splice site mutation', 'level': 5, 'score': 0.65312797}, {'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.6119098}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.60531974}, {'id': 'https://openalex.org/C2778776201', 'wikidata': 'https://www.wikidata.org/wiki/Q3474283', 'display_name': 'Exon skipping', 'level': 5, 'score': 0.519986}, {'id': 'https://openalex.org/C194583182', 'wikidata': 'https://www.wikidata.org/wiki/Q21114084', 'display_name': 'Alternative splicing', 'level': 4, 'score': 0.51210594}, {'id': 'https://openalex.org/C72994624', 'wikidata': 'https://www.wikidata.org/wiki/Q7226900', 'display_name': 'Polypyrimidine tract', 'level': 5, 'score': 0.47346583}, {'id': 'https://openalex.org/C73758832', 'wikidata': 'https://www.wikidata.org/wiki/Q7578564', 'display_name': 'Splicing factor', 'level': 5, 'score': 0.45518017}, {'id': 'https://openalex.org/C2780989783', 'wikidata': 'https://www.wikidata.org/wiki/Q7578557', 'display_name': 'splice', 'level': 3, 'score': 0.4167146}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3525548}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.34485722}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23466364}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.118777424}], 'mesh': [{'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012326', 'descriptor_name': 'RNA Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D038621', 'descriptor_name': 'Regulatory Sequences, Ribonucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017398', 'descriptor_name': 'Alternative Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001482', 'descriptor_name': 'Base Composition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015723', 'descriptor_name': 'Gene Library', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059372', 'descriptor_name': 'Nucleotide Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056510', 'descriptor_name': 'Position-Specific Scoring Matrices', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022821', 'descriptor_name': 'RNA Splice Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017423', 'descriptor_name': 'Sequence Analysis, RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055540', 'descriptor_name': 'Survival of Motor Neuron 2 Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055540', 'descriptor_name': 'Survival of Motor Neuron 2 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/nar/gkab1280', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://repository.cshl.edu/id/eprint/40498/1/2022.Gao.intronic_splicing.pdf', 'pdf_url': 'http://repository.cshl.edu/id/eprint/40498/1/2022.Gao.intronic_splicing.pdf', 'source': {'id': 'https://openalex.org/S4306402288', 'display_name': 'Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.05.17.444464', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/05/18/2021.05.17.444464.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35018432', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R37-GM42699'}, {'funder': 'https://openalex.org/F4320333688', 'funder_display_name': 'National Outstanding Youth Science Fund Project of National Natural Science Foundation of China', 'award_id': '82073753'}, {'funder': 'https://openalex.org/F4320333688', 'funder_display_name': 'National Outstanding Youth Science Fund Project of National Natural Science Foundation of China', 'award_id': '81471298'}, {'funder': 'https://openalex.org/F4320333688', 'funder_display_name': 'National Outstanding Youth Science Fund Project of National Natural Science Foundation of China', 'award_id': '81530035'}], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1511517753', 'https://openalex.org/W1699218328', 'https://openalex.org/W1829229016', 'https://openalex.org/W1829675031', 'https://openalex.org/W1836860525', 'https://openalex.org/W1967554461', 'https://openalex.org/W1974760231', 'https://openalex.org/W1977846760', 'https://openalex.org/W1982169734', 'https://openalex.org/W1985217779', 'https://openalex.org/W1990210083', 'https://openalex.org/W1997535872', 'https://openalex.org/W2008807546', 'https://openalex.org/W2019518393', 'https://openalex.org/W2023648355', 'https://openalex.org/W2025722577', 'https://openalex.org/W2028920559', 'https://openalex.org/W2029979788', 'https://openalex.org/W2038921819', 'https://openalex.org/W2053998703', 'https://openalex.org/W2071987213', 'https://openalex.org/W2074860825', 'https://openalex.org/W2079321730', 'https://openalex.org/W2079725644', 'https://openalex.org/W2082127202', 'https://openalex.org/W2082429191', 'https://openalex.org/W2091898769', 'https://openalex.org/W2092696079', 'https://openalex.org/W2094395530', 'https://openalex.org/W2102046311', 'https://openalex.org/W2103534177', 'https://openalex.org/W2105694586', 'https://openalex.org/W2108665093', 'https://openalex.org/W2113714682', 'https://openalex.org/W2117784725', 'https://openalex.org/W2118994793', 'https://openalex.org/W2121635864', 'https://openalex.org/W2124182320', 'https://openalex.org/W2129682060', 'https://openalex.org/W2130410032', 'https://openalex.org/W2152766938', 'https://openalex.org/W2152941241', 'https://openalex.org/W2158433767', 'https://openalex.org/W2159864549', 'https://openalex.org/W2164194877', 'https://openalex.org/W2166900174', 'https://openalex.org/W2167164394', 'https://openalex.org/W2167256464', 'https://openalex.org/W2170702502', 'https://openalex.org/W2278102309', 'https://openalex.org/W2492339642', 'https://openalex.org/W2663297928', 'https://openalex.org/W2889059385', 'https://openalex.org/W2909194804', 'https://openalex.org/W2951539817', 'https://openalex.org/W2980949872'], 'related_works': ['https://openalex.org/W4206315232', 'https://openalex.org/W2796118888', 'https://openalex.org/W2587382015', 'https://openalex.org/W2530844403', 'https://openalex.org/W2136785685', 'https://openalex.org/W2121144555', 'https://openalex.org/W2120243182', 'https://openalex.org/W2089450225', 'https://openalex.org/W1992555226', 'https://openalex.org/W1974440868'], 'abstract_inverted_index': {'Abstract': [0], 'Intronic': [1], 'splicing': [2, 47, 63], 'enhancers': [3], 'and': [4, 7, 48, 59, 139, 162, 174], 'silencers': [5], '(ISEs': [6], 'ISSs)': [8], 'are': [9, 32, 137, 141], 'two': [10], 'groups': [11, 159], 'of': [12, 40, 82, 93, 103, 127, 135, 160, 203], 'splicing-regulatory': [13], 'elements': [14], '(SREs)': [15], 'that': [16, 77, 124], 'play': [17], 'critical': [18], 'roles': [19], 'in': [20, 50, 85, 112, 118, 172], 'determining': [21], 'splice-site': [22], 'selection,': [23], 'particularly': [24], 'for': [25, 184], 'alternatively': [26], 'spliced': [27], 'introns': [28], 'or': [29, 38], 'exons.': [30], 'SREs': [31, 171, 194], 'often': [33], 'short': [34, 187], 'motifs;': [35], 'their': [36, 41, 201], 'mutation': [37], 'dysregulation': [39], 'cognate': [42], 'proteins': [43], 'frequently': [44], 'causes': [45], 'aberrant': [46], 'results': [49, 179], 'disease.': [51], 'To': [52, 143], 'date,': [53], 'however,': [54], 'knowledge': [55], 'about': [56], 'SRE': [57, 164], 'sequences': [58, 189], 'how': [60, 186], 'they': [61], 'regulate': [62, 190], 'remains': [64], 'limited.': [65], 'Here,': [66], 'using': [67], 'an': [68], 'SMN2': [69], 'minigene,': [70, 117], 'we': [71, 147, 157], 'generated': [72], 'a': [73, 89, 149, 181], 'complete': [74], 'pentamer-sequence': [75], 'library': [76], 'comprises': [78], 'all': [79, 104], 'possible': [80], 'combinations': [81], '5': [83], 'nucleotides': [84], 'intron': [86], '7,': [87], 'at': [88], 'fixed': [90], 'site': [91], 'downstream': [92], 'the': [94, 101, 115, 125], '5′': [95], 'splice': [96], 'site.': [97], 'We': [98, 166], 'systematically': [99], 'analyzed': [100], 'effects': [102], '1023': [105], 'mutant': [106], 'pentamers': [107, 128], 'on': [108], 'exon': [109, 131], '7': [110, 132], 'splicing,': [111], 'comparison': [113], 'to': [114, 199], 'wild-type': [116], 'HEK293': [119], 'cells.': [120], 'Our': [121, 178], 'data': [122], 'show': [123], 'majority': [126], 'significantly': [129], 'affect': [130], 'splicing:': [133], '584': [134], 'them': [136], 'stimulatory': [138, 161], '230': [140], 'inhibitory.': [142], 'identify': [144], 'actual': [145], 'SREs,': [146], 'utilized': [148], 'motif': [150], 'set': [151], 'enrichment': [152], 'analysis': [153], '(MSEA),': [154], 'from': [155], 'which': [156], 'identified': [158], 'inhibitory': [163], 'motifs.': [165], 'experimentally': [167], 'validated': [168], 'several': [169], 'strong': [170], 'SMN1/2': [173], 'other': [175], 'minigene': [176], 'settings.': [177], 'provide': [180], 'valuable': [182], 'resource': [183], 'understanding': [185], 'RNA': [188], 'splicing.': [191], 'Many': [192], 'novel': [193], 'can': [195], 'be': [196], 'explored': [197], 'further': [198], 'elucidate': [200], 'mechanism': [202], 'action.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4206315232', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-09-12T08:09:19.756853', 'created_date': '2022-01-26'}