Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4205565352', 'doi': 'https://doi.org/10.1093/ejcts/ezs533', 'title': 'Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (VARC-2)', 'display_name': 'Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (VARC-2)', 'publication_year': 2012, 'publication_date': '2012-10-01', 'ids': {'openalex': 'https://openalex.org/W4205565352', 'doi': 'https://doi.org/10.1093/ejcts/ezs533', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23084102'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/ejcts/ezs533', 'pdf_url': 'https://academic.oup.com/ejcts/article-pdf/42/5/S45/1120750/ezs533.pdf', 'source': {'id': 'https://openalex.org/S10542796', 'display_name': 'European Journal of Cardio-Thoracic Surgery', 'issn_l': '1010-7940', 'issn': ['1010-7940', '1873-734X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/ejcts/article-pdf/42/5/S45/1120750/ezs533.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016707931', 'display_name': 'A. Pieter Kappetein', 'orcid': 'https://orcid.org/0000-0003-3545-2229'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'A. P. Kappetein', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014149576', 'display_name': 'Stuart J. Head', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'S. J. Head', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007377189', 'display_name': 'Philippe Généreux', 'orcid': 'https://orcid.org/0000-0002-5507-3712'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'P. Genereux', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033599517', 'display_name': 'Nicolò Piazza', 'orcid': 'https://orcid.org/0000-0003-2809-3408'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'N. Piazza', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001295240', 'display_name': 'Nicolas M. Van Mieghem', 'orcid': 'https://orcid.org/0000-0002-2732-1205'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'N. M. van Mieghem', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003737429', 'display_name': 'Eugene H. Blackstone', 'orcid': 'https://orcid.org/0000-0001-9839-3567'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'E. H. Blackstone', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112357723', 'display_name': 'Thomas Brott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'T. G. Brott', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100648517', 'display_name': 'David J. Cohen', 'orcid': 'https://orcid.org/0000-0001-9163-724X'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'D. J. Cohen', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057352435', 'display_name': 'Donald E. Cutlip', 'orcid': 'https://orcid.org/0000-0002-7583-9893'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'D. E. Cutlip', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111967069', 'display_name': 'G.-A. van Es', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'G.-A. van Es', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055613208', 'display_name': 'Rebecca T. Hahn', 'orcid': 'https://orcid.org/0000-0003-1342-9191'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'R. T. Hahn', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058875978', 'display_name': 'Ajay J. Kirtane', 'orcid': 'https://orcid.org/0000-0003-0061-1058'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'A. J. Kirtane', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113560264', 'display_name': 'Mitchell W. Krucoff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'M. W. Krucoff', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019475815', 'display_name': 'Susheel Kodali', 'orcid': 'https://orcid.org/0000-0003-0517-2074'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'S. Kodali', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019062163', 'display_name': 'Michael J. Mack', 'orcid': 'https://orcid.org/0000-0002-3148-9158'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'M. J. Mack', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016139987', 'display_name': 'Roxana Mehran', 'orcid': 'https://orcid.org/0000-0002-5546-262X'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'R. Mehran', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046485954', 'display_name': 'Josep Rodés‐Cabau', 'orcid': 'https://orcid.org/0000-0001-8237-7095'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'J. Rodes-Cabau', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059011787', 'display_name': 'Pascal Vranckx', 'orcid': 'https://orcid.org/0000-0002-1526-0652'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'P. Vranckx', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040339119', 'display_name': 'John G. Webb', 'orcid': 'https://orcid.org/0000-0001-7903-2870'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'J. G. Webb', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053194091', 'display_name': 'Stephan Windecker', 'orcid': 'https://orcid.org/0000-0003-2653-6762'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'S. Windecker', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063792624', 'display_name': 'Patrick W. Serruys', 'orcid': 'https://orcid.org/0000-0002-9636-1104'}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'P. W. Serruys', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108090626', 'display_name': 'M.B. Leon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'M. B. Leon', 'raw_affiliation_strings': ['Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2801952686']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5016707931'], 'corresponding_institution_ids': ['https://openalex.org/I2801952686'], 'apc_list': {'value': 3147, 'currency': 'EUR', 'value_usd': 3394, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 52.715, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3334, 'citation_normalized_percentile': {'value': 0.999298, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '42', 'issue': '5', 'first_page': 'S45', 'last_page': 'S60'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10172', 'display_name': 'Cardiac Valve Diseases and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10172', 'display_name': 'Cardiac Valve Diseases and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11551', 'display_name': 'Infective Endocarditis Diagnosis and Management', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10193', 'display_name': 'Coronary Interventions and Diagnostics', 'score': 0.9837, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/endpoint-determination', 'display_name': 'Endpoint Determination', 'score': 0.43489486}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.42013672}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.77809846}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.5551672}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.49892998}, {'id': 'https://openalex.org/C2909914741', 'wikidata': 'https://www.wikidata.org/wiki/Q256289', 'display_name': 'Endpoint Determination', 'level': 3, 'score': 0.43489486}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.42013672}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.39614096}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32747066}], 'mesh': [{'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D006328', 'descriptor_name': 'Cardiac Catheterization', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': True}, {'descriptor_ui': 'D023381', 'descriptor_name': 'Endpoint Determination', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': True}, {'descriptor_ui': 'D019918', 'descriptor_name': 'Heart Valve Prosthesis Implantation', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': True}, {'descriptor_ui': 'D009626', 'descriptor_name': 'Terminology as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D006328', 'descriptor_name': 'Cardiac Catheterization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006328', 'descriptor_name': 'Cardiac Catheterization', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D006328', 'descriptor_name': 'Cardiac Catheterization', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D015897', 'descriptor_name': 'Comorbidity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032882', 'descriptor_name': 'Comprehension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032921', 'descriptor_name': 'Consensus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023381', 'descriptor_name': 'Endpoint Determination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019918', 'descriptor_name': 'Heart Valve Prosthesis Implantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019918', 'descriptor_name': 'Heart Valve Prosthesis Implantation', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D019918', 'descriptor_name': 'Heart Valve Prosthesis Implantation', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D019918', 'descriptor_name': 'Heart Valve Prosthesis Implantation', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033181', 'descriptor_name': 'Information Dissemination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018579', 'descriptor_name': 'Patient Selection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011788', 'descriptor_name': 'Quality of Life', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018570', 'descriptor_name': 'Risk Assessment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/ejcts/ezs533', 'pdf_url': 'https://academic.oup.com/ejcts/article-pdf/42/5/S45/1120750/ezs533.pdf', 'source': {'id': 'https://openalex.org/S10542796', 'display_name': 'European Journal of Cardio-Thoracic Surgery', 'issn_l': '1010-7940', 'issn': ['1010-7940', '1873-734X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://boris.unibe.ch/15011/', 'pdf_url': 'https://boris.unibe.ch/15011/1/ezs533.pdf', 'source': {'id': 'https://openalex.org/S4306401086', 'display_name': 'Bern Open Repository and Information System (University of Bern)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I118564535', 'host_organization_name': 'University of Bern', 'host_organization_lineage': ['https://openalex.org/I118564535'], 'host_organization_lineage_names': ['University of Bern'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23084102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/ejcts/ezs533', 'pdf_url': 'https://academic.oup.com/ejcts/article-pdf/42/5/S45/1120750/ezs533.pdf', 'source': {'id': 'https://openalex.org/S10542796', 'display_name': 'European Journal of Cardio-Thoracic Surgery', 'issn_l': '1010-7940', 'issn': ['1010-7940', '1873-734X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1964078918', 'https://openalex.org/W1967300023', 'https://openalex.org/W1973925025', 'https://openalex.org/W1976605452', 'https://openalex.org/W1982135373', 'https://openalex.org/W1983427045', 'https://openalex.org/W1990033097', 'https://openalex.org/W1991952617', 'https://openalex.org/W1993257772', 'https://openalex.org/W1993630998', 'https://openalex.org/W1995365032', 'https://openalex.org/W1997705909', 'https://openalex.org/W1998207473', 'https://openalex.org/W2000967076', 'https://openalex.org/W2001905888', 'https://openalex.org/W2022123127', 'https://openalex.org/W2025056766', 'https://openalex.org/W2026900031', 'https://openalex.org/W2037447718', 'https://openalex.org/W2037764599', 'https://openalex.org/W2039524126', 'https://openalex.org/W2044591445', 'https://openalex.org/W2044763137', 'https://openalex.org/W2045527048', 'https://openalex.org/W2052402060', 'https://openalex.org/W2056068526', 'https://openalex.org/W2058991556', 'https://openalex.org/W2073186247', 'https://openalex.org/W2076997626', 'https://openalex.org/W2080205885', 'https://openalex.org/W2080504768', 'https://openalex.org/W2083650930', 'https://openalex.org/W2090123416', 'https://openalex.org/W2094265494', 'https://openalex.org/W2096782143', 'https://openalex.org/W2110226194', 'https://openalex.org/W2110884945', 'https://openalex.org/W2111638574', 'https://openalex.org/W2116274343', 'https://openalex.org/W2121842052', 'https://openalex.org/W2122473579', 'https://openalex.org/W2122779695', 'https://openalex.org/W2125473912', 'https://openalex.org/W2129975031', 'https://openalex.org/W2130508139', 'https://openalex.org/W2140991303', 'https://openalex.org/W2146437656', 'https://openalex.org/W2149609916', 'https://openalex.org/W2149820004', 'https://openalex.org/W2150047811', 'https://openalex.org/W2153820409', 'https://openalex.org/W2154863203', 'https://openalex.org/W2162396364', 'https://openalex.org/W2163556807', 'https://openalex.org/W2164861810', 'https://openalex.org/W2165258820', 'https://openalex.org/W2166973706', 'https://openalex.org/W2172151487', 'https://openalex.org/W2187630416', 'https://openalex.org/W2204942361', 'https://openalex.org/W2207356991', 'https://openalex.org/W2272962241', 'https://openalex.org/W2325310783', 'https://openalex.org/W2952762910', 'https://openalex.org/W4234844359', 'https://openalex.org/W4238238952', 'https://openalex.org/W4388823094', 'https://openalex.org/W53283354'], 'related_works': ['https://openalex.org/W4404703837', 'https://openalex.org/W4213444599', 'https://openalex.org/W2973734919', 'https://openalex.org/W2920703862', 'https://openalex.org/W2770732258', 'https://openalex.org/W2283203256', 'https://openalex.org/W2116969055', 'https://openalex.org/W2083883160', 'https://openalex.org/W2019856079', 'https://openalex.org/W1866325404'], 'abstract_inverted_index': {'The': [0], 'aim': [1], 'of': [2, 18, 37, 50, 84, 164, 181, 242, 250, 273, 281, 291, 300, 325], 'the': [3, 14, 32, 48, 96, 152, 165, 204, 240, 248, 259, 279, 292], 'current': [4, 323], 'Valve': [5], 'Academic': [6], 'Research': [7], 'Consortium': [8], '(VARC)-2': [9], 'initiative': [10, 312], 'was': [11, 174], 'to': [12, 26, 31, 46, 189, 202, 286, 304, 328], 'revisit': [13], 'selection': [15], 'and': [16, 34, 54, 70, 73, 104, 124, 141, 149, 155, 159, 184, 221, 223, 289, 313], 'definitions': [17, 63, 107, 275, 327], 'transcatheter': [19, 330], 'aortic': [20, 89, 308], 'valve': [21, 244, 309, 331, 336], 'implantation': [22], '(TAVI)': [23], 'clinical': [24, 38, 69, 82, 97, 150, 206], 'endpoints': [25, 257], 'make': [27], 'them': [28], 'more': [29], 'suitable': [30], 'present': [33], 'future': [35], 'needs': [36], 'trials.': [39], 'In': [40], 'addition,': [41], 'this': [42, 100, 170], 'document': [43, 177, 268, 314], 'is': [44], 'intended': [45], 'expand': [47], 'understanding': [49], 'patient': [51, 185, 194], 'risk': [52, 182], 'stratification': [53, 186], 'case': [55], 'selection.': [56], 'A': [57], 'recent': [58], 'study': [59, 133, 293], 'confirmed': [60], 'that': [61, 187], 'VARC': [62, 132], 'have': [64, 108], 'already': [65], 'been': [66], 'incorporated': [67], 'into': [68], 'research': [71], 'practice': [72], 'represent': [74], 'a': [75, 224, 320], 'new': [76], 'standard': [77], 'for': [78, 192, 239, 247, 261, 276], 'consistency': [79], 'in': [80, 117, 120, 125, 128, 196], 'reporting': [81], 'outcomes': [83], 'patients': [85], 'with': [86, 99, 302], 'symptomatic': [87], 'severe': [88], 'stenosis': [90], '(AS)': [91], 'undergoing': [92], 'TAVI.': [93], 'However,': [94], 'as': [95, 319], 'experience': [98], 'technology': [101], 'has': [102, 269], 'matured': [103], 'expanded,': [105], 'certain': [106], 'become': [109], 'unsuitable': [110], 'or': [111], 'ambiguous.': [112], 'Two': [113], 'in-person': [114], 'meetings': [115], '(held': [116], 'September': [118], '2011': [119], 'Washington,': [121], 'DC,': [122], 'USA,': [123], 'February': [126], '2012': [127], 'Rotterdam,': [129], 'Netherlands)': [130], 'involving': [131], 'group': [134], 'members,': [135], 'independent': [136], 'experts': [137], '(including': [138], 'surgeons,': [139], 'interventional': [140], 'non-interventional': [142], 'cardiologists,': [143], 'imaging': [144], 'specialists,': [145, 148], 'neurologists,': [146], 'geriatric': [147], 'trialists),': [151], 'US': [153], 'Food': [154], 'Drug': [156], 'Administration': [157], '(FDA),': [158], 'industry': [160], 'representatives,': [161], 'provided': [162, 238, 270], 'much': [163], 'substantive': [166], 'discussion': [167], 'from': [168], 'which': [169, 283], 'VARC-2': [171, 267], 'consensus': [172], 'manuscript': [173], 'derived.': [175], 'This': [176, 266, 311], 'provides': [178], 'an': [179, 296], 'overview': [180], 'assessment': [183], 'need': [188], 'be': [190, 317], 'considered': [191], 'accurate': [193], 'inclusion': [195], 'studies.': [197], 'Working': [198], 'groups': [199], 'were': [200], 'assigned': [201], 'define': [203], 'following': [205], 'endpoints:': [207], 'mortality,': [208], 'stroke,': [209], 'myocardial': [210], 'infarction,': [211], 'bleeding': [212], 'complications,': [213, 218], 'acute': [214], 'kidney': [215], 'injury,': [216], 'vascular': [217], 'conduction': [219], 'disturbances': [220], 'arrhythmias,': [222], 'miscellaneous': [225], 'category': [226], 'including': [227], 'relevant': [228], 'complications': [229], 'not': [230], 'previously': [231], 'categorized.': [232], 'Furthermore,': [233], 'comprehensive': [234], 'echocardiographic': [235], 'recommendations': [236], 'are': [237, 253], 'evaluation': [241], 'prosthetic': [243], '(dys)function.': [245], 'Definitions': [246], 'quality': [249], 'life': [251], 'assessments': [252], 'also': [254], 'reported.': [255], 'These': [256], 'formed': [258], 'basis': [260], 'several': [262], 'recommended': [263], 'composite': [264], 'endpoints.': [265], 'further': [271], 'standardization': [272], 'endpoint': [274], 'studies': [277], 'evaluating': [278], 'use': [280], 'TAVI,': [282], 'will': [284], 'lead': [285], 'improved': [287], 'comparability': [288], 'interpretability': [290], 'results,': [294], 'supplying': [295], 'increasingly': [297], 'growing': [298], 'body': [299], 'evidence': [301], 'respect': [303], 'TAVI': [305], 'and/or': [306], 'surgical': [307], 'replacement.': [310], 'can': [315], 'furthermore': [316], 'used': [318], 'model': [321], 'during': [322], 'endeavours': [324], 'applying': [326], 'other': [329], 'therapies': [332], '(for': [333], 'example,': [334], 'mitral': [335], 'repair).': [337]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4205565352', 'counts_by_year': [{'year': 2024, 'cited_by_count': 29}, {'year': 2023, 'cited_by_count': 64}, {'year': 2022, 'cited_by_count': 67}, {'year': 2021, 'cited_by_count': 345}, {'year': 2020, 'cited_by_count': 440}, {'year': 2019, 'cited_by_count': 362}, {'year': 2018, 'cited_by_count': 350}, {'year': 2017, 'cited_by_count': 402}, {'year': 2016, 'cited_by_count': 367}, {'year': 2015, 'cited_by_count': 343}, {'year': 2014, 'cited_by_count': 222}, {'year': 2013, 'cited_by_count': 211}, {'year': 2012, 'cited_by_count': 94}], 'updated_date': '2024-12-30T20:52:10.822310', 'created_date': '2022-01-26'}