Title: Abstracts from the 4th Asian Conference in Pharmaceutical Sciences (Asia Pharm IV)
Abstract:PL1Breast cancer is the most common malignancy in Western women and grows under hormone-dependent control.Hence, the ability to reduce breast tumor growth through the administration of anti-estrogens ...PL1Breast cancer is the most common malignancy in Western women and grows under hormone-dependent control.Hence, the ability to reduce breast tumor growth through the administration of anti-estrogens has played a key role in the endocrine therapy of breast cancer.The non-steroidal anti-estrogen, tamoxifen (TAM), is the most widely used anti-estrogen in estrogen receptor-positive breast cancer patients.Although most patients are initially responsive, resistance to TAM is a critical problem for anti-estrogen therapy.To mimic this condition, we established an MCF-7 derived TAM-resistant cell line (TAMR-MCF-7 cells) by longterm culture of MCF-7 cells with 4-hydroxytamoxifen in 2007.RNA sequencing analysis using MCF-7 and TAMR-MCF-7 cells showed that many coding and non-coding RNAs regulating both estrogen signaling and epithelial mesenchymal transition were differentially expressed in both the cell types.In this presentation, I will briefly summarize our previous studies identifying potential targets to overcome TAM resistance and the related pharmacological approaches.Read More