Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4205370446', 'doi': 'https://doi.org/10.3389/fcell.2021.725114', 'title': 'Imaging Approaches for the Study of Metabolism in Real Time Using Genetically Encoded Reporters', 'display_name': 'Imaging Approaches for the Study of Metabolism in Real Time Using Genetically Encoded Reporters', 'publication_year': 2022, 'publication_date': '2022-01-18', 'ids': {'openalex': 'https://openalex.org/W4205370446', 'doi': 'https://doi.org/10.3389/fcell.2021.725114', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35118062'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fcell.2021.725114', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.725114/pdf', 'source': {'id': 'https://openalex.org/S2596924766', 'display_name': 'Frontiers in Cell and Developmental Biology', 'issn_l': '2296-634X', 'issn': ['2296-634X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.725114/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023989175', 'display_name': 'Panagiotis Chandris', 'orcid': 'https://orcid.org/0000-0002-6484-462X'}, 'institutions': [{'id': 'https://openalex.org/I6820528', 'display_name': 'Alexander Fleming Biomedical Sciences Research Center', 'ror': 'https://ror.org/013x0ky90', 'country_code': 'GR', 'type': 'facility', 'lineage': ['https://openalex.org/I6820528']}], 'countries': ['GR'], 'is_corresponding': True, 'raw_author_name': 'Panagiotis Chandris', 'raw_affiliation_strings': ['Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece'], 'affiliations': [{'raw_affiliation_string': 'Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece', 'institution_ids': ['https://openalex.org/I6820528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112742807', 'display_name': 'Christina Giannouli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I206127235', 'display_name': 'Academy of Athens', 'ror': 'https://ror.org/00qsdn986', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I206127235']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Christina C. Giannouli', 'raw_affiliation_strings': ['Biomedical Research Foundation Academy of Athens, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Biomedical Research Foundation Academy of Athens, Athens, Greece', 'institution_ids': ['https://openalex.org/I206127235']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040592899', 'display_name': 'George Panayotou', 'orcid': 'https://orcid.org/0009-0009-9538-1638'}, 'institutions': [{'id': 'https://openalex.org/I6820528', 'display_name': 'Alexander Fleming Biomedical Sciences Research Center', 'ror': 'https://ror.org/013x0ky90', 'country_code': 'GR', 'type': 'facility', 'lineage': ['https://openalex.org/I6820528']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'George Panayotou', 'raw_affiliation_strings': ['Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece'], 'affiliations': [{'raw_affiliation_string': 'Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece', 'institution_ids': ['https://openalex.org/I6820528']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5023989175'], 'corresponding_institution_ids': ['https://openalex.org/I6820528'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.588, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.998871, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '9', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10540', 'display_name': 'Advanced Fluorescence Microscopy Techniques', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12561', 'display_name': 'bioluminescence and chemiluminescence research', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/merge', 'display_name': 'Merge (version control)', 'score': 0.6383854}, {'id': 'https://openalex.org/keywords/catabolism', 'display_name': 'Catabolism', 'score': 0.44651568}, {'id': 'https://openalex.org/keywords/metabolic-network', 'display_name': 'Metabolic network', 'score': 0.424166}], 'concepts': [{'id': 'https://openalex.org/C197129107', 'wikidata': 'https://www.wikidata.org/wiki/Q1921621', 'display_name': 'Merge (version control)', 'level': 2, 'score': 0.6383854}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5854386}, {'id': 'https://openalex.org/C152662350', 'wikidata': 'https://www.wikidata.org/wiki/Q815297', 'display_name': 'Systems biology', 'level': 2, 'score': 0.4987595}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.4822348}, {'id': 'https://openalex.org/C21565614', 'wikidata': 'https://www.wikidata.org/wiki/Q12149006', 'display_name': 'Metabolomics', 'level': 2, 'score': 0.4552958}, {'id': 'https://openalex.org/C96942376', 'wikidata': 'https://www.wikidata.org/wiki/Q21130714', 'display_name': 'Catabolism', 'level': 3, 'score': 0.44651568}, {'id': 'https://openalex.org/C101810790', 'wikidata': 'https://www.wikidata.org/wiki/Q2263094', 'display_name': 'Metabolic network', 'level': 2, 'score': 0.424166}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.41361478}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40109503}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.37479293}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.31252056}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21913671}, {'id': 'https://openalex.org/C23123220', 'wikidata': 'https://www.wikidata.org/wiki/Q816826', 'display_name': 'Information retrieval', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fcell.2021.725114', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.725114/pdf', 'source': {'id': 'https://openalex.org/S2596924766', 'display_name': 'Frontiers in Cell and Developmental Biology', 'issn_l': '2296-634X', 'issn': ['2296-634X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/2bad0a2883624dae8ae9d914857f9a2a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804523', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35118062', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fcell.2021.725114', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.725114/pdf', 'source': {'id': 'https://openalex.org/S2596924766', 'display_name': 'Frontiers in Cell and Developmental Biology', 'issn_l': '2296-634X', 'issn': ['2296-634X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 139, 'referenced_works': ['https://openalex.org/W1542263802', 'https://openalex.org/W1542691236', 'https://openalex.org/W1589551917', 'https://openalex.org/W1928389510', 'https://openalex.org/W1935974026', 'https://openalex.org/W1965163468', 'https://openalex.org/W1967100281', 'https://openalex.org/W1968655038', 'https://openalex.org/W1969120829', 'https://openalex.org/W1969540020', 'https://openalex.org/W1976135176', 'https://openalex.org/W1977850703', 'https://openalex.org/W1977938101', 'https://openalex.org/W1990076574', 'https://openalex.org/W1996880521', 'https://openalex.org/W1998337135', 'https://openalex.org/W2013334588', 'https://openalex.org/W2013381253', 'https://openalex.org/W2019750161', 'https://openalex.org/W2021067645', 'https://openalex.org/W2025176940', 'https://openalex.org/W2027785297', 'https://openalex.org/W2029378794', 'https://openalex.org/W2031022790', 'https://openalex.org/W2033896109', 'https://openalex.org/W2034011015', 'https://openalex.org/W2034201925', 'https://openalex.org/W2039409076', 'https://openalex.org/W2052323992', 'https://openalex.org/W2055255976', 'https://openalex.org/W2055755990', 'https://openalex.org/W2057210916', 'https://openalex.org/W2067213531', 'https://openalex.org/W2070653651', 'https://openalex.org/W2072451938', 'https://openalex.org/W2081251375', 'https://openalex.org/W2081886031', 'https://openalex.org/W2083972083', 'https://openalex.org/W2086310064', 'https://openalex.org/W2087814592', 'https://openalex.org/W2088744527', 'https://openalex.org/W2091041795', 'https://openalex.org/W2093154482', 'https://openalex.org/W2095780210', 'https://openalex.org/W2095987251', 'https://openalex.org/W2104522961', 'https://openalex.org/W2105738527', 'https://openalex.org/W2112994046', 'https://openalex.org/W2117002197', 'https://openalex.org/W2118902684', 'https://openalex.org/W2135509527', 'https://openalex.org/W2135897043', 'https://openalex.org/W2140578228', 'https://openalex.org/W2141857874', 'https://openalex.org/W2143094150', 'https://openalex.org/W2144575277', 'https://openalex.org/W2147044753', 'https://openalex.org/W2147800368', 'https://openalex.org/W2168854431', 'https://openalex.org/W2170621766', 'https://openalex.org/W2202641067', 'https://openalex.org/W2223535266', 'https://openalex.org/W2224116510', 'https://openalex.org/W2234115940', 'https://openalex.org/W2271740119', 'https://openalex.org/W2343650972', 'https://openalex.org/W2472122738', 'https://openalex.org/W2517430769', 'https://openalex.org/W2519425563', 'https://openalex.org/W2523309591', 'https://openalex.org/W2536126966', 'https://openalex.org/W2557121453', 'https://openalex.org/W2567698536', 'https://openalex.org/W2592593165', 'https://openalex.org/W2594683400', 'https://openalex.org/W2606441315', 'https://openalex.org/W2609327219', 'https://openalex.org/W2617151789', 'https://openalex.org/W2734520622', 'https://openalex.org/W2739924689', 'https://openalex.org/W2744395348', 'https://openalex.org/W2746891430', 'https://openalex.org/W2752919824', 'https://openalex.org/W2759158289', 'https://openalex.org/W2765242536', 'https://openalex.org/W2765934351', 'https://openalex.org/W2766477555', 'https://openalex.org/W2779346725', 'https://openalex.org/W2779423373', 'https://openalex.org/W2783214188', 'https://openalex.org/W2783867527', 'https://openalex.org/W2784810610', 'https://openalex.org/W2792575173', 'https://openalex.org/W2803365362', 'https://openalex.org/W2811334205', 'https://openalex.org/W2890631306', 'https://openalex.org/W2898411802', 'https://openalex.org/W2905704278', 'https://openalex.org/W2914579308', 'https://openalex.org/W2922487097', 'https://openalex.org/W2924273050', 'https://openalex.org/W2936259264', 'https://openalex.org/W2942228202', 'https://openalex.org/W2942430710', 'https://openalex.org/W2945774263', 'https://openalex.org/W2946231429', 'https://openalex.org/W2961122344', 'https://openalex.org/W2971164558', 'https://openalex.org/W2980251061', 'https://openalex.org/W2981059853', 'https://openalex.org/W2990123204', 'https://openalex.org/W2994102487', 'https://openalex.org/W2996369394', 'https://openalex.org/W3008592960', 'https://openalex.org/W3010402261', 'https://openalex.org/W3012090404', 'https://openalex.org/W3020890244', 'https://openalex.org/W3025520212', 'https://openalex.org/W3038041948', 'https://openalex.org/W3040550067', 'https://openalex.org/W3040993782', 'https://openalex.org/W3042082711', 'https://openalex.org/W3044867500', 'https://openalex.org/W3080619725', 'https://openalex.org/W3087165503', 'https://openalex.org/W3088913508', 'https://openalex.org/W3097746752', 'https://openalex.org/W3105424763', 'https://openalex.org/W3106577951', 'https://openalex.org/W3119677602', 'https://openalex.org/W3121371466', 'https://openalex.org/W3134853307', 'https://openalex.org/W3148679421', 'https://openalex.org/W3162499857', 'https://openalex.org/W3165015553', 'https://openalex.org/W3173236620', 'https://openalex.org/W4211067149', 'https://openalex.org/W4211241312', 'https://openalex.org/W4225471014'], 'related_works': ['https://openalex.org/W3033588432', 'https://openalex.org/W2799517538', 'https://openalex.org/W235738631', 'https://openalex.org/W2166430819', 'https://openalex.org/W2147102947', 'https://openalex.org/W2075919068', 'https://openalex.org/W2072067873', 'https://openalex.org/W2047632644', 'https://openalex.org/W2031492751', 'https://openalex.org/W1989168955'], 'abstract_inverted_index': {'Metabolism': [0], 'comprises': [1], 'of': [2, 22, 28, 56, 70, 86, 101, 106, 129, 158, 168], 'two': [3], 'axes': [4, 14], 'in': [5, 37, 50, 60, 83, 171], 'order': [6], 'to': [7, 32, 45, 65, 90, 98, 116, 132, 149], 'serve': [8], 'homeostasis:': [9], 'anabolism': [10], 'and': [11, 35, 48, 63, 104], 'catabolism.': [12], 'Both': [13], 'are': [15, 74], 'interbranched': [16], 'with': [17, 160], 'the': [18, 53, 67, 77, 84, 142], 'so-called': [19], 'bioenergetics': [20], 'aspect': [21], 'metabolism.': [23], 'There': [24], 'is': [25, 41], 'a': [26, 42, 109, 126, 139, 166], 'plethora': [27], 'analytical': [29], 'biochemical': [30, 58, 102], 'methods': [31], 'monitor': [33, 99], 'metabolites': [34, 107], 'reactions': [36, 59, 103], 'lysates,': [38], 'yet': [39], 'there': [40], 'rising': [43], 'need': [44], 'monitor,': [46], 'quantify': [47], 'elucidate': [49], 'real': [51, 172], 'time': [52], 'spatiotemporal': [54], 'orchestration': [55], 'complex': [57], 'living': [61], 'systems': [62], 'furthermore': [64], 'analyze': [66], 'metabolic': [68], 'effect': [69], 'chemical': [71], 'compounds': [72], 'that': [73, 94, 111, 145, 153], 'destined': [75], 'for': [76, 119], 'clinic.': [78], 'The': [79], 'ongoing': [80], 'technological': [81], 'burst': [82], 'field': [85], 'imaging': [87], 'creates': [88], 'opportunities': [89], 'establish': [91], 'new': [92], 'tools': [93], 'will': [95, 154], 'allow': [96], 'investigators': [97], 'dynamics': [100], 'kinetics': [105], 'at': [108], 'resolution': [110], 'ranges': [112], 'from': [113], 'subcellular': [114], 'organelle': [115], 'whole': [117], 'system': [118], 'some': [120], 'key': [121], 'metabolites.': [122], 'This': [123], 'article': [124], 'provides': [125], 'mini': [127], 'review': [128], 'available': [130], 'toolkits': [131], 'achieve': [133], 'this': [134], 'goal': [135], 'but': [136], 'also': [137], 'presents': [138], 'perspective': [140, 167], 'on': [141], 'open': [143], 'space': [144], 'can': [146], 'be': [147], 'exploited': [148], 'develop': [150], 'novel': [151], 'methodologies': [152], 'merge': [155], 'classic': [156], 'biochemistry': [157], 'metabolism': [159, 170], 'advanced': [161], 'imaging.': [162], 'In': [163], 'other': [164], 'words,': [165], '“watching': [169], 'time.”': [173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4205370446', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-05T20:39:04.900857', 'created_date': '2022-01-25'}