DRP1 interacts directly with BAX to induce its activation and apoptosis

Name: Work Video:
Duration: 3 min 30 s
Andreas Jenner; Aida Peña‐Blanco; Raquel Salvador‐Gallego; Begoña Ugarte‐Uribe; Cristiana Zollo; Tariq Ganief; Jan Bierlmeier; Markus Mund; Jason E. Lee; Jonas Ries; Dirk Schwarzer; Boris Maček; Ana J. García‐Sáez
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'https://openalex.org/W2393048603', 'https://openalex.org/W2349064958', 'https://openalex.org/W2082860237', 'https://openalex.org/W2067513698', 'https://openalex.org/W2035768602', 'https://openalex.org/W1993015302', 'https://openalex.org/W1985332105'], 'abstract_inverted_index': {'Article13': [0], 'January': [1], '2022Open': [2], 'Access': [3], 'Source': [4], 'DataTransparent': [5], 'process': [6, 1027, 1732], 'DRP1': [7, 1059, 1089, 1105, 1131, 1144, 1175, 1201, 1220, 1235, 1262, 1275, 1769, 1808, 1833, 1860, 1888, 1907, 1941, 1957, 1980, 2004, 2020, 2029, 2075, 2093, 2119, 2160, 2178, 2229, 2306, 2325, 2349, 2375, 2390, 2434, 2451, 2481, 2658, 2845, 2866, 2939, 2963, 3001, 3116, 3276, 3305, 3466, 3518, 3545, 3561, 3606, 3721, 3747, 3768, 3820, 3846, 3984, 4041, 4073, 4125, 4144, 4171, 4224], 'interacts': [8], 'directly': [9, 1237, 3563, 3656, 3821], 'with': [10, 1190, 1327, 1526, 1582, 1657, 1835, 1913, 1965, 2003, 2019, 2099, 2136, 2206, 2220, 2224, 2237, 2308, 2313, 2340, 2403, 2406, 2413, 2453, 2462, 2504, 2521, 2534, 2550, 2665, 2716, 2794, 2835, 2904, 2928, 3174, 3373, 3403, 3493, 3499, 3530, 3614, 3726, 3740], 'BAX': [11, 1054, 1087, 1103, 1115, 1123, 1129, 1142, 1186, 1197, 1230, 1233, 1260, 1273, 1513, 1549, 1577, 1598, 1629, 1638, 1719, 1836, 1869, 1943, 1955, 1978, 1998, 2027, 2083, 2091, 2117, 2158, 2176, 2281, 2323, 2347, 2373, 2388, 2509, 2656, 2802, 2843, 2937, 2961, 3114, 3274, 3464, 3516, 3543, 3559, 3603, 3739, 3766, 3791, 3818, 3844, 3989, 4071, 4123], 'to': [12, 994, 1037, 1040, 1065, 1150, 1159, 1279, 1361, 1410, 1694, 1703, 1730, 1777, 1795, 1820, 1864, 1889, 2033, 2050, 2084, 2111, 2155, 2280, 2297, 2328, 2438, 2480, 2576, 2644, 2661, 2684, 2743, 2766, 2804, 2839, 2946, 2953, 3147, 3217, 3238, 3245, 3293, 3358, 3377, 3447, 3648, 3658, 3697, 3724, 3760, 3776, 3896, 4050, 4150, 4233], 'induce': [13, 1154, 1597], 'its': [14, 1191, 1527, 1758, 1815], 'activation': [15, 1147, 1372, 2043], 'and': [16, 249, 308, 696, 755, 939, 974, 1016, 1034, 1055, 1069, 1075, 1088, 1092, 1104, 1112, 1130, 1143, 1148, 1157, 1198, 1214, 1226, 1234, 1238, 1253, 1261, 1274, 1281, 1313, 1333, 1389, 1449, 1456, 1493, 1538, 1561, 1594, 1625, 1647, 1649, 1652, 1701, 1720, 1781, 1786, 1827, 1846, 1903, 1934, 1942, 1956, 1967, 1979, 1985, 2005, 2028, 2046, 2068, 2072, 2092, 2103, 2118, 2159, 2177, 2217, 2282, 2315, 2324, 2336, 2348, 2374, 2389, 2409, 2433, 2457, 2464, 2524, 2536, 2542, 2565, 2578, 2597, 2612, 2657, 2721, 2762, 2781, 2786, 2790, 2844, 2849, 2864, 2873, 2877, 2906, 2938, 2962, 2969, 2980, 2999, 3021, 3035, 3065, 3115, 3133, 3157, 3163, 3170, 3195, 3226, 3235, 3249, 3275, 3334, 3343, 3418, 3465, 3517, 3532, 3544, 3549, 3560, 3605, 3626, 3638, 3672, 3682, 3694, 3717, 3748, 3767, 3771, 3804, 3806, 3812, 3819, 3825, 3845, 3859, 3862, 3871, 3879, 3892, 3905, 3914, 3937, 4058, 4072, 4112, 4128, 4178], 'apoptosis': [17, 1064, 1161, 1178, 1283, 1323, 1439, 1544, 1575, 1890, 1945, 2066, 2215, 2381, 2421, 2539, 2601, 2792, 2890, 3045, 3075, 3118, 3168, 3230, 3279, 3301, 3406], 'Andreas': [18, 20, 465, 467, 914], 'Jenner': [19, 21, 466, 468], 'orcid.org/0000-0002-6388-3053': [22, 469], 'Institute': [23, 33, 69, 104, 124, 160, 191, 222, 343, 377, 417, 427, 470, 480, 516, 551, 571, 607, 638, 669, 790, 824, 864, 874, 954, 963], 'for': [24, 58, 92, 113, 149, 161, 180, 210, 236, 270, 295, 331, 365, 400, 418, 459, 471, 505, 539, 560, 596, 608, 627, 657, 683, 717, 742, 778, 812, 847, 865, 906, 945, 1533, 1688, 1760, 2016, 2044, 2058, 2065, 2069, 2214, 2796, 2801, 3086, 3097, 3315, 3338, 3570, 3799, 3836], 'Genetics,': [25, 162, 419, 472, 609, 866, 946], 'CECAD,': [26, 163, 420, 473, 610, 867, 947], 'University': [27, 36, 72, 107, 127, 164, 195, 225, 283, 346, 381, 421, 430, 474, 483, 519, 554, 574, 611, 642, 672, 730, 793, 828, 868, 877, 948, 957, 967], 'of': [28, 34, 37, 70, 73, 105, 108, 125, 128, 165, 192, 196, 223, 226, 284, 344, 347, 378, 382, 422, 428, 431, 475, 481, 484, 517, 520, 552, 555, 572, 575, 612, 639, 643, 670, 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615, 646, 676, 704, 763, 797, 832, 872, 881, 952, 961, 971, 982], 'Interfaculty': [32, 68, 103, 123, 190, 221, 342, 376, 426, 479, 515, 550, 570, 637, 668, 789, 823, 873], 'Biochemistry,': [35, 71, 106, 126, 224, 345, 429, 482, 518, 553, 573, 671, 792, 876, 956], 'Tübingen,': [38, 39, 74, 75, 109, 110, 129, 130, 197, 198, 227, 228, 348, 349, 383, 384, 432, 433, 485, 486, 521, 522, 556, 557, 576, 577, 644, 645, 674, 675, 795, 796, 830, 831, 879, 880, 959, 960, 969, 970], 'Contribution:': [41, 77, 132, 169, 200, 230, 258, 289, 317, 351, 386, 435, 488, 524, 579, 616, 647, 677, 705, 736, 764, 798, 833, 882], 'Formal': [42, 78, 133, 170, 489, 525, 580, 617], 'analysis': [43, 79, 134, 171, 490, 526, 581, 618], '(equal),': [44, 46, 48, 50, 80, 82, 84, 135, 137, 139, 141, 172, 174, 176, 202, 204, 206, 232, 260, 262, 291, 319, 321, 323, 353, 355, 357, 388, 390, 392, 437, 439, 442, 448, 451, 491, 493, 495, 497, 527, 529, 531, 582, 584, 586, 588, 619, 621, 623, 649, 651, 653, 679, 707, 709, 738, 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91, 112, 148, 179, 209, 235, 269, 294, 330, 364, 399, 458, 504, 538, 559, 595, 626, 656, 682, 716, 741, 777, 811, 846, 905], 'more': [59, 93, 114, 150, 181, 211, 237, 271, 296, 332, 366, 401, 460, 506, 540, 561, 597, 628, 658, 684, 718, 743, 779, 813, 848, 907], 'papers': [60, 94, 115, 151, 182, 212, 238, 272, 297, 333, 367, 402, 461, 507, 541, 562, 598, 629, 659, 685, 719, 744, 780, 814, 849, 908], 'by': [61, 95, 116, 152, 183, 213, 239, 273, 298, 334, 368, 403, 462, 508, 542, 563, 599, 630, 660, 686, 720, 745, 781, 815, 850, 909, 1179, 1343, 1351, 1502, 1580, 1616, 1875, 2163, 2190, 2580, 2632, 2676, 3436, 3746, 3751, 3874, 3945, 3992, 4027, 4135, 4183], 'this': [62, 96, 117, 153, 184, 214, 240, 274, 299, 335, 369, 404, 463, 509, 543, 564, 600, 631, 661, 687, 721, 746, 782, 816, 851, 910, 995, 1079, 1094, 1731, 2693, 2708, 2955, 3246], 'author': [63, 97, 118, 154, 185, 215, 241, 275, 300, 336, 370, 405, 464, 510, 544, 565, 601, 632, 662, 688, 722, 747, 783, 817, 852, 911, 1035], 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'European': [252, 311, 699, 758, 977], 'Molecular': [253, 312, 700, 759, 978], 'Laboratory,': [255, 314, 702, 761, 980], 'Heidelberg,': [256, 315, 703, 762, 981], 'Jason': [276, 279, 723, 726, 930], 'E': [277, 280, 724, 727, 931], 'Lee': [278, 281, 725, 728], 'orcid.org/0000-0001-5757-5954': [282, 729], 'Colorado,': [285, 732, 985], 'Boulder,': [286, 733, 986], 'CO,': [287, 734, 987], 'USA': [288, 735, 988], 'Jonas': [301, 303, 748, 750, 933], 'Ries': [302, 304, 749, 751], 'orcid.org/0000-0002-6640-9250': [305, 752], 'Supervision': [320, 354, 389, 438, 767, 801, 836, 885], 'Dirk': [337, 339, 784, 786, 935], 'Schwarzer': [338, 340, 785, 787], 'orcid.org/0000-0002-7477-3319': [341, 788], 'Boris': [371, 373, 818, 820, 937], 'Macek': [372, 374, 819, 821], 'orcid.org/0000-0002-1206-2458': [375, 822], 'Ana': [406, 411, 853, 858, 940], 'J': [407, 412, 854, 859, 941], 'Garcia-Saez': [408, 413, 855, 860, 942], 'Corresponding': [409, 856], 'Author': [410, 857, 912], '[email': [414, 861, 1005], 'protected]': [415, 862, 1006], 'orcid.org/0000-0002-3894-5945': [416, 863], 'Conceptualization': [436, 883], 'Funding': [440, 887], 'acquisition': [441, 888], 'Project': [449, 896], 'administration': [450, 897], 'Information': [913], 'Jenner1,2,': [915], 'Peña-Blanco2,†,': [917], 'Salvador-Gallego2,†,': [919], 'Ugarte-Uribe2,†,': [921], 'Zollo1,†,': [923], 'Ganief3,': [925], 'Bierlmeier2,': [927], 'Mund4,': [929], 'Lee5,': [932], 'Ries4,': [934], 'Schwarzer2,': [936], 'Macek3': [938], '*,1,2': [943], '1Institute': [944], '2Interfaculty': [953], '3Interfaculty': [962], '4Cell': [972], '5University': [983], '†': [989], 'These': [990, 1684, 2851, 3814], 'authors': [991], 'contributed': [992], 'equally': [993], 'work': [996], '*Corresponding': [997], 'author.': [998], 'Tel:': [999], '+49': [1000], '221': [1001], '478': [1002], '84263;': [1003], 'E-mail:': [1004], 'The': [1007, 1050, 1766, 1975, 2291], 'EMBO': [1008], 'Journal': [1009], '(2022)41:e108587https://doi.org/10.15252/embj.2021108587': [1010], 'PDFDownload': [1011], 'PDF': [1012], 'article': [1014], 'text': [1015], 'main': [1017], 'figures.': [1018], 'Peer': [1019], 'ReviewDownload': [1020], 'a': [1021, 1293, 1301, 1353, 1515, 1929, 2055, 2079, 2233, 2249, 2272, 2329, 2399, 2414, 2505, 2836, 2880, 3140, 3188, 3253, 3327, 3469, 3494, 3612, 3705, 3727, 3758, 4106, 4184], 'summary': [1022], 'the': [1024, 1056, 1072, 1109, 1114, 1126, 1133, 1164, 1250, 1255, 1285, 1314, 1318, 1344, 1362, 1366, 1374, 1392, 1401, 1407, 1423, 1466, 1473, 1482, 1488, 1519, 1534, 1539, 1583, 1587, 1604, 1662, 1668, 1689, 1695, 1714, 1724, 1855, 1866, 1885, 1931, 1938, 1970, 1973, 1982, 1987, 2001, 2008, 2012, 2017, 2059, 2063, 2144, 2172, 2185, 2238, 2253, 2257, 2276, 2300, 2344, 2351, 2355, 2367, 2392, 2454, 2476, 2486, 2607, 2668, 2671, 2688, 2697, 2710, 2717, 2735, 2746, 2750, 2759, 2768, 2816, 2895, 2898, 2925, 2934, 3109, 3148, 3159, 3178, 3191, 3196, 3208, 3221, 3265, 3285, 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1600, 1603, 1661, 1818, 1837, 1960, 2129, 2378, 2391, 2485, 2687, 3207, 3524, 3753, 4018], 'mitochondria': [1062, 1204, 1280, 1416, 1434, 1562, 1819, 1828, 1841, 2379, 2548], 'during': [1063, 1098, 1205, 1243, 1438, 1475, 1811, 2179, 2380, 2441, 2538, 3117, 3229, 3278, 3300, 3388, 3514], 'mediate': [1066], 'mitochondrial': [1067, 1155, 1212, 1378, 1454, 1469, 1483, 1489, 1541, 1692, 1728, 1771, 1784, 1894, 2047, 2070, 2805, 3141, 3395, 3733], 'permeabilization': [1068, 1158, 1213, 1381], 'fragmentation.': [1070], 'However,': [1071, 1884, 2143], 'molecular': [1073, 1932, 2056], 'basis': [1074, 2057], 'functional': [1076, 1935, 2060], 'consequences': [1077], 'interplay': [1080, 1209, 1853], 'remain': [1081, 1946], 'unknown.': [1082], 'Here,': [1083, 1219], 'we': [1084, 1172, 1949, 2102, 2181, 2265, 2678, 2695, 2856, 3120, 3186, 3251, 3257, 3482, 3573, 3674, 3689, 3702], 'show': [1085, 1950, 2587], 'that': [1086, 1093, 1174, 1299, 1359, 1556, 1619, 1664, 1748, 1951, 2007, 2074, 2270, 2298, 2319, 2354, 2586, 2680, 2752, 2840, 2933, 3144, 3218, 3260, 3460, 3484, 3522, 3618, 3762, 3817, 3826], 'physically': [1090, 2686], 'interact,': [1091], 'interaction': [1095, 1246, 1581, 1953, 2002, 2025, 2114, 2574, 2884, 2935, 3160, 3277, 3370, 3462, 3541, 3576, 3711, 3764, 3842], 'is': [1096, 1221, 1241, 1292, 1341, 1399, 1514, 1531, 1550, 1578, 1614, 1739, 1763, 1809, 1891, 1958, 2014, 2964, 3139, 3145, 3215, 3611, 3634, 3655, 3769, 3830], 'enhanced': [1097, 1242, 2941, 3166], 'apoptosis.': [1099, 1232, 1244, 1859, 2051, 2086, 2442], 'Complex': [1100], 'formation': [1101, 3222], 'between': [1102, 1128, 1559, 1825, 1854, 1940, 1954, 1977, 2026, 2062, 2115, 2275, 2346, 2357, 2674, 2758, 2936, 3113, 3161, 3190, 3220, 3463, 3542, 3663, 3680, 3712, 3765, 3802, 3903], 'occurs': [1106], 'exclusively': [1107], 'in': [1108, 1163, 1210, 1249, 1284, 1304, 1406, 1422, 1446, 1543, 1552, 1563, 1667, 1674, 1722, 1741, 1746, 1773, 1788, 1791, 1840, 1858, 1870, 1871, 1906, 1944, 1963, 2000, 2021, 2036, 2094, 2097, 2132, 2256, 2286, 2320, 2350, 2363, 2466, 2527, 2546, 2552, 2592, 2667, 2783, 2813, 2823, 2832, 2846, 2889, 2915, 2918, 2942, 2983, 2993, 3039, 3069, 3154, 3172, 3211, 3287, 3291, 3303, 3326, 3331, 3528, 3577, 3669, 3684, 3781, 3823, 3847, 3876, 3880, 3907, 3910, 3915, 3918, 3961, 3969, 3977, 4064, 4105, 4154, 4165, 4191, 4193], 'membrane': [1110, 1134, 1251, 1267, 1380, 1485, 1491, 1622, 1659, 1822, 1878, 1988, 3548, 3742, 3828, 3849, 3882, 3912, 3917, 3971, 4126, 4180], 'environment': [1111, 1252, 1984, 3829], 'requires': [1113, 1254, 1377, 1981, 3546], 'N-terminal': [1116, 1192, 1256, 2009], 'region,': [1117], 'but': [1118, 1207, 2826], 'also': [1119, 1421, 1908, 2887, 3641], 'involves': [1120], 'several': [1121, 1847, 1995], 'other': [1122, 3266], 'surfaces.': [1124], 'Furthermore,': [1125, 1462], 'association': [1127, 1240, 1976, 2018, 2757, 3112, 3662, 3737, 3801], 'enhances': [1132], 'activity': [1135, 1427, 1504, 1989, 3474, 3552], 'both': [1137, 1650, 1991, 2655, 3212, 3554, 3779], 'proteins.': [1138, 1992, 3666], 'Forced': [1139, 1270], 'dimerization': [1140, 1271], 'triggers': [1145, 1276, 2871], 'their': [1146, 1208, 1239, 1277, 2031, 2042, 3239, 3571, 3575, 3851], 'translocation': [1149, 1278, 2032, 2803], 'mitochondria,': [1151, 2034], 'where': [1152, 1414], 'they': [1153, 2681, 2731], 'remodeling': [1156, 1268, 1790, 2048], 'cause': [1160], 'even': [1162, 1745], 'absence': [1165, 1286, 1424, 4066, 4156, 4195], 'triggers.': [1168, 1289], 'Based': [1169], 'on': [1170, 2248, 2305, 3692, 3985, 4042, 4124], 'this,': [1171, 2341], 'propose': [1173], 'can': [1176, 1896, 2076, 2763], 'promote': [1177, 1865, 2085], 'acting': [1180], 'as': [1181, 1223, 1412, 1644, 2039, 2041, 2078, 2829, 2991, 3052, 4005, 4075, 4080, 4206], 'noncanonical': [1182, 1227], 'direct': [1183, 1224, 1588, 1952, 2113, 2164, 3710], 'activator': [1184, 1228, 1589, 2081], 'through': [1187, 1487], 'physical': [1188, 2165], 'contacts': [1189, 1823], 'region.': [1193], 'Synopsis': [1194], 'Apoptotic': [1195], 'colocalize': [1202], 'apoptosis,': [1206, 1476, 1812, 2180, 3515], 'mediating': [1211], 'fragmentation': [1215, 1738, 1785], 'remains': [1216, 1733], 'incompletely': [1217], 'understood.': [1218, 1765], 'found': [1222], 'interactor': [1225, 3792], 'promoting': [1231, 1876], 'interact': [1236, 2377, 2685, 3562, 3822], 'BAX/DRP1': [1245, 2573, 2645, 3199, 3369], 'takes': [1247], 'place': [1248], 'region': [1257, 2010, 3328], 'BAX.': [1259, 4160, 4202, 4226], 'mutually': [1263], 'enhance': [1264, 2756], 'each': [1265, 2489], "other's": [1266], 'activity.': [1269], 'induces': [1282, 2030], 'Introduction': [1290], 'Apoptosis': [1291, 1339, 2088], 'form': [1294, 1555, 1640, 1817, 2662], 'programmed': [1296], 'cell': [1297, 1349, 1743, 1761, 1910, 2401, 2859, 2967, 3123, 3182], 'death': [1298, 1350, 1762, 1911, 1971, 3536], 'plays': [1300], 'key': [1302], 'role': [1303, 1717], 'fundamental': [1305], 'biological': [1306], 'processes': [1307], 'like': [1308, 1592], 'embryo': [1309], 'development,': [1310], 'tissue': [1311], 'homeostasis,': [1312, 1780], 'correct': [1315], 'functioning': [1316], 'immune': [1319], 'system.': [1320], 'Dysregulation': [1321], 'has': [1324, 1861], 'been': [1325, 1655, 1862, 2109], 'related': [1326, 3237], 'human': [1328, 1775, 1793], 'pathology,': [1329], 'neurodegenerative': [1331], 'diseases': [1332], 'cancer': [1334], '(Strasser': [1335], 'et': [1336, 1429, 1506, 1510, 1567, 1571, 1610, 1635, 1677, 1681, 1706, 1710, 1801, 1805, 1830, 1843, 1881, 1917, 1925, 2121, 2140, 2196, 2262, 2704, 2774, 2808, 3232, 3592, 3596, 3794], 'al,': [1337, 1430, 1507, 1511, 1568, 1572, 1611, 1636, 1678, 1682, 1707, 1711, 1802, 1806, 1831, 1844, 1882, 1918, 1926, 2122, 2141, 2197, 2263, 2705, 2775, 2809, 3233, 3593, 3597, 3795], '2011).': [1338], 'execution': [1340, 1535, 2067], 'mediated': [1342], 'caspases,': [1346], 'which': [1347, 1383, 1477, 1596, 1813, 2284, 2724, 3201, 3630, 3654], 'accelerate': [1348], 'cleaving': [1352], 'defined': [1354], 'set': [1355], 'target': [1357], 'proteins': [1358, 1523, 1729, 1857, 2126, 2711, 2719, 2761, 3555, 3714, 3780], 'leads': [1360], 'organized': [1363], 'dismantling': [1364], 'cellular': [1367, 1779], 'components.': [1368], 'In': [1369, 2338, 2707, 2893, 3686], 'most': [1370], 'cells,': [1371, 2825, 3381], 'caspase': [1375, 1426, 1503, 3473], 'cascade': [1376], 'outer': [1379, 1490], '(MOMP),': [1382], 'releases': [1384], 'cytochrome': [1385], 'c': [1386, 1700, 1798, 1901, 4110], '(cyt': [1387], 'c)': [1388], 'Smac/DIABLO': [1390], 'into': [1391, 1472, 1630, 2171, 3177, 3520], 'cytosol': [1393, 1474, 1560, 3149, 3333], '(Bock': [1394], 'Tait,': [1396], '2020).': [1397], 'MOMP': [1398, 1418, 1537, 1752, 1966, 2100], 'considered': [1400], 'point': [1402, 3361], 'no': [1404], 'return': [1405], "cell's": [1408], 'commitment': [1409], 'death,': [1411, 1744], 'cells': [1413, 1565, 1776, 1794, 1904, 2134, 2203, 2322, 2519, 2585, 2594, 2625, 2785, 2788, 2834, 2920, 2927, 2944, 2948, 3043, 3073, 3128, 3340, 3348, 3372, 3385, 3434, 3490], 'all': [1415, 3347], 'underwent': [1417], 'ultimately': [1419], 'die': [1420], '(Tait': [1428], '2010).': [1431, 1883], 'Besides': [1432], 'MOMP,': [1433, 1723, 2045, 3531], 'undergo': [1435, 1909], 'multiple': [1436, 1631], 'alterations': [1437, 1542, 4131], 'cristae': [1441, 1789], 'remodeling,': [1442], 'extensive': [1443, 1621], 'fragmentation,': [1444], 'changes': [1445, 1618], 'lipid': [1447, 1983, 3729, 3734], 'composition': [1448, 3730], 'calcium': [1450], 'signaling,': [1451], 'loss': [1452], 'potential,': [1455], 'swelling': [1457], '(Cosentino': [1458], 'Garcia-Saez,': [1460, 1547], '2014).': [1461], 'recent': [1463], 'studies': [1464], 'reported': [1465], 'release': [1467, 1690, 1799, 1902, 3176, 3228], 'DNA': [1470], '(mtDNA)': [1471], 'happens': [1478, 3263], 'via': [1479], 'extrusion': [1480], 'inner': [1484], '(MIM)': [1486], '(MOM)': [1492], 'initiates': [1494], 'type': [1495, 2968], 'I': [1496], 'interferon': [1497], 'inflammatory': [1498], 'normally': [1500], 'blocked': [1501], '(McArthur': [1505, 1705], '2018;': [1508, 1708], 'Riley': [1509, 1709], '2018).': [1512, 1548, 1712], 'pro-apoptotic': [1516, 3142], 'member': [1517], 'BCL-2': [1520, 2900], 'family': [1521], 'that,': [1524, 3512], 'together': [1525], 'homolog': [1528], 'BAK,': [1530], 'necessary': [1532], 'additional': [1540, 1727, 3566, 3833], '(Pena-Blanco': [1545], 'kept': [1551], 'an': [1553, 1734, 1852, 3773, 3784], 'inactive': [1554], 'constantly': [1557], 'retrotranslocates': [1558], 'healthy': [1564, 1774], '(Edlich': [1566], '2011;': [1569], 'Schellenberg': [1570], '2013).': [1573], 'Upon': [1574], 'induction,': [1576], 'activated': [1579, 3991], 'BH3': [1584], 'domain': [1585], 'BH3-only': [1590], 'proteins,': [1591], 'tBID': [1593], 'BIM,': [1595], 'accumulation': [1599, 2035, 3777], 'discrete': [1601, 2130, 2287, 2830, 3525], 'puncta': [1602], 'MOM,': [1605], 'called': [1606], 'foci': [1608, 1839, 1962, 2131, 2288, 2352, 2831, 3225, 3337, 3364, 3375], '(Karbowski': [1609, 1842, 2139], '2002).': [1612, 2142], 'This': [1613, 3214], 'accompanied': [1615], 'conformational': [1617], 'allow': [1620, 2154], 'interactions,': [1623], 'dimerization,': [1624], 'further': [1626, 2169], 'self-assembly': [1627], 'oligomeric': [1632, 1816], 'species': [1633], '(Subburaj': [1634], '2015).': [1637, 1832, 2706, 2776], 'oligomers': [1639, 2664], 'supramolecular': [1641], 'structures': [1642, 2482], 'shaped': [1643], 'lines,': [1645, 3350], 'arcs,': [1646], 'rings,': [1648], 'arcs': [1651], 'rings': [1653], 'have': [1654, 2105], 'associated': [1656], 'growing': [1658], 'pores': [1660, 1685], 'MOM': [1663], 'reach': [1665], 'sizes': [1666, 2666], 'order': [1669, 2669], 'hundreds': [1671], 'nanometers': [1673], 'diameter': [1675], '(Große': [1676], '2016;': [1679], '2016).': [1683, 1807, 2198, 2810], 'are': [1686, 2161, 2496, 2560, 2659, 2714, 2732, 3005, 3016, 3084, 3095, 3313, 3568, 4003, 4078, 4204], 'responsible': [1687], 'contents': [1693], 'cytosol,': [1696, 3179], 'ranging': [1697], 'from': [1698, 1899, 2478, 2491, 2498, 3267, 3424, 3629, 3956], 'cyt': [1699, 1797, 1900], 'Smac': [1702, 3138, 3227], 'mtDNA': [1704], 'Despite': [1713], 'clear': [1715, 3254], 'paramount': [1716], 'BAK': [1721], 'contribution': [1725, 1886], 'open': [1735], 'question.': [1736], 'Mitochondrial': [1737], 'conserved': [1740], 'organisms': [1747], 'do': [1749], 'not': [1750, 2108, 2153, 2755, 2909, 3468, 3676, 3744, 3772], 'involve': [1751], '(Martinou': [1753], 'Youle,': [1755], '2011),': [1756], 'yet': [1757], 'relevance': [1759], 'poorly': [1764], 'promotes': [1770], 'fission': [1772, 1895], 'maintain': [1778], 'it': [1782, 2753], 'mediates': [1783], 'participates': [1787], 'facilitate': [1796], '(Frank': [1800], '2001;': [1803], 'Otera': [1804], 'SUMOylated': [1810], 'stabilizes': [1814], 'stabilize': [1821], 'sites': [1824], 'ER': [1826], '(Prudent': [1829], 'co-localizes': [1834], '2002)': [1845], 'lines': [1848, 2860, 3894], 'evidence': [1850], 'support': [1851], 'two': [1856, 2125, 2309, 3665], 'shown': [1863, 2545, 2812, 3153, 3668], 'oligomerization': [1867], 'vitro': [1872, 3824], 'reconstituted': [1873], 'systems': [1874, 3579], 'negative': [1877], 'curvature': [1879], '(Montessuit': [1880, 2120], 'controversial,': [1892], 'because': [1893], 'be': [1897, 2764], 'uncoupled': [1898], 'deficient': [1905], 'albeit': [1912], 'altered': [1914], 'kinetics': [1915], '(Parone': [1916], '2006;': [1919], 'Estaquier': [1920], 'Arnoult,': [1922], '2007;': [1923], 'Sheridan': [1924], '2008).': [1927], 'As': [1928, 2811, 2879, 3152, 3667, 3757], 'result,': [1930], 'mechanisms': [1933], 'significance': [1936, 2629, 3942], 'connection': [1939], 'unclear.': [1947], 'Here': [1948], 'induced': [1959, 2888, 3745], 'correlation': [1964, 2098], 'maintained': [1968, 3488], 'until': [1969, 3181, 3534], 'cell.': [1974, 3539], 'affects': [1986, 3550, 3850], 'We': [1993, 2199, 2777, 3584], 'identify': [1994], 'surfaces': [1996], 'involved': [1999], 'determine': [2006], 'required': [2015, 3569, 3835], 'cells.': [2022, 2468, 3003, 3307], 'Interestingly,': [2023], 'forced': [2024], 'foci,': [2038, 3526], 'well': [2040], 'leading': [2049], 'Our': [2052], 'findings': [2053, 3510], 'provide': [2054], 'link': [2061], 'machineries': [2064], 'dynamics': [2071, 2769, 3110], 'reveal': [2073], 'act': [2077], 'non-BH3': [2080], 'Results': [2087], 'induction': [2089, 2216, 2602, 2648, 2793, 3046, 3076, 3169, 3302, 3407, 3452], 'brings': [2090], 'close': [2095, 2273], 'proximity': [2096], 'While': [2101], 'others': [2104], 'so': [2106], 'far': [2107], 'able': [2110], 'detect': [2112, 3677], 'endogenous': [2116], '2010),': [2123], 'these': [2124, 3268, 3509], 'clearly': [2127, 3703], 'visualized': [2135, 3006], 'confocal': [2137, 2514, 2973, 3029, 3059, 3124, 4099], 'microscopy': [2138, 2193, 2515, 2974, 3030, 3060, 3281, 4100], 'spatial': [2145, 2187], 'resolution': [2146, 2188, 2330], 'limit': [2147], 'around': [2149], '200': [2150], 'nm': [2151, 2333, 2362, 2440, 2740], 'does': [2152, 2754], 'discern': [2156], 'whether': [2157, 3558, 3565], 'connected': [2162], 'interactions.': [2166], 'To': [2167, 2691, 3107, 3458, 3556], 'gain': [2168], 'insight': [2170], 'structural': [2173], 'organization': [2174], 'took': [2182], 'advantage': [2183, 2751], 'high': [2186], 'offered': [2189], 'single-molecule': [2191], 'localization': [2192], '(SMLM)': [2194], '(Salvador-Gallego': [2195, 2807, 3231], 'imaged': [2200, 2787], 'fixed': [2201], 'HeLa': [2202, 2400, 2467, 2518, 2593, 2784, 2988, 3127], 'transiently': [2204, 2778, 3129], 'transfected': [2205, 2402, 2520, 2584], 'GFP-BAX': [2207, 2404, 2432, 2479, 3224], '3': [2208, 2418, 2598, 2618, 2797, 3089, 3100, 3318, 3427, 4012, 4213], 'h': [2209, 2419, 2599, 2798], 'after': [2210, 2420, 2600, 2646, 2791, 3044, 3074, 3450], 'staurosporine': [2211], '(STS)': [2212, 2531, 2987], 'treatment': [2213, 2800], 'stained': [2218, 2405], 'them': [2219, 2358, 2675], 'anti-GFP': [2221, 2407], 'nanobodies': [2222], 'labeled': [2223, 2236, 2312, 2549, 3602], 'Alexa': [2225], 'Fluor': [2226, 4146], '(AF)647.': [2227], 'Endogenous': [2228], 'was': [2230, 2295, 2359, 2590, 2821, 2886, 2940, 3165, 3202, 3422, 3467, 3487, 3743, 3749, 3990, 4016], 'immunostained': [2231], 'using': [2232, 3007, 3047, 3077, 3599], 'secondary': [2234, 2310, 2416, 2459], 'antibody': [2235, 2411], 'cyanine-based': [2239], 'fluorescent': [2240, 2277, 2699, 2912], '(CF)': [2241], 'dye': [2242], 'CF680.': [2243], 'Using': [2244], 'spectral': [2245], 'unmixing': [2246], 'based': [2247, 2304], 'ratiometric': [2250], 'classification': [2251], 'individual': [2254, 2258, 2564, 3020, 3339, 4013], 'localizations': [2255], 'emission': [2259], 'channels': [2260], '(Winterflood': [2261], '2015),': [2264], 'built': [2266], 'two-color': [2267], 'super-resolved': [2268], 'images': [2269, 2430, 2516, 2975, 2990, 3031, 3283, 4101], 'revealed': [2271, 2353, 2932], 'apposition': [2274], 'signals': [2278], 'corresponding': [2279], 'DRP1,': [2283], 'appeared': [2285], '(Fig': [2289, 2334, 2369, 2875, 2891, 2921, 2949, 3506, 3608, 3636, 3715], '1A).': [2290], 'degree': [2292], 'overlap': [2294], 'comparable': [2296, 3216], 'positive': [2301, 2881, 2929, 3380, 3706], 'co-localization': [2302], 'control': [2303, 2449, 3401, 3449, 3759], 'immunostaining': [2307, 2452], 'antibodies': [2311, 2460], 'AF647': [2314, 2463], 'CF680': [2316], 'dyes,': [2317], 'indicating': [2318, 3442], 'up': [2327, 2437], '30': [2332, 2361, 2439], '1B': [2335], 'C).': [2337, 3718], 'agreement': [2339], 'quantification': [2342], 'distance': [2345, 2356, 2477], '<': [2360, 2638, 2641, 3951, 3954, 4033, 4036, 4091, 4217], '>': [2364, 3444, 4187], '80%': [2365], 'cases': [2368], '1D).': [2370], 'Figure': [2371, 2957, 3270, 3839], '1.': [2372], 'specifically': [2376, 3513], 'A–D.': [2382], 'Dual-color': [2383], 'SMLM': [2384, 2396, 2429, 2493], 'shows': [2385], 'colocalization': [2386], 'nanoscale.': [2393], '(A)': [2394, 3878], 'Overview': [2395], 'image': [2397, 3061], 'nanobody-AF647': [2408], 'anti-DRP1': [2410], 'probed': [2412], 'CF680-labeled': [2415], 'antibody,': [2417], 'induction.': [2422], 'Scale': [2423, 2443, 2469, 2554, 2568, 3010, 3024, 3054, 3079, 3308, 4115], 'bar': [2424, 2444, 2470, 2555, 2569, 3011, 3025, 3055, 3080, 3309, 4116], '2': [2425], 'μm.': [2426, 2557, 2571, 3013, 3027, 3057, 3082, 3311], '(B)': [2427], 'Magnified': [2428], 'assemblies': [2435], 'colocalizing': [2436], '100': [2445, 2471, 2624, 3384, 3433], 'nm.': [2446, 2472], '(C)': [2447], 'Colocalization': [2448], 'same': [2455, 2736], 'primary': [2456], 'different': [2458, 2858, 2869, 4199], '(labelled': [2461], 'CF680)': [2465], '(D)': [2473], 'Quantification': [2474, 2923, 3367, 3900], '(distance': [2483], 'measured': [2484, 2672, 3690, 3873, 3967, 4134], 'center': [2487], 'structure)': [2490], 'dual-color': [2492], 'images.': [2494], 'Data': [2495, 3092, 4002, 4077, 4203], 'quantified': [2497, 2591, 3574], 'n': [2499, 2616, 2622, 3087, 3098, 3316, 3351, 3382, 3425, 3431, 3957, 3963, 3973, 4010, 4085, 4211], '=': [2500, 2617, 2623, 3088, 3099, 3317, 3352, 3383, 3426, 3432, 3958, 3964, 3974, 4011, 4086, 4212], '4': [2501, 4087], 'independent': [2502, 2619, 2965, 3090, 3101, 3319, 3428, 4088, 4214], 'experiments': [2503, 2620, 3429], 'total': [2506], '720': [2508], 'structure.': [2510], 'E,': [2511], 'F.': [2512], 'Representative': [2513, 2972, 3028, 3058, 3856, 4139], 'ddFP': [2522, 2747, 2977], 'RA-BAX': [2523, 2535, 2780, 2979, 3162], 'GB-DRP1': [2525, 2782, 2907, 3164], '(E)': [2526], 'untreated': [2528, 2595, 2824, 2916, 2947, 2984], 'or': [2529, 2533, 2868, 2985, 3050, 3404, 3475, 3498, 3564, 3972, 3996, 4067, 4157, 4196], 'conditions,': [2532], 'GB-BAX': [2537], '(F).': [2540], 'RA-BAX/GB-DRP1': [2541, 2819, 3033, 3297, 3336, 3363, 3374], 'RA-BAX/GB-BAX': [2543, 2883], 'complexes': [2544, 2820, 3298, 3521], 'green,': [2547], 'mito-BFP': [2551, 2583, 3008, 3036, 3066, 3379], 'magenta.': [2553], '10': [2556, 2739, 3012, 3056, 3081, 3205, 3310, 4117], 'Right': [2558, 3014], 'panels': [2559, 3015], 'zoomed': [2561, 3017], 'areas': [2562, 3018], 'representing': [2563, 3019], 'merged': [2566, 3022], 'channels.': [2567, 3023], '5': [2570, 3026], 'G.': [2572, 4120], 'compared': [2575, 2643, 2945, 3446], 'BAX/BAX': [2577], 'BCL-xL/DRP1': [2579], 'ddFP.': [2581], '%': [2582, 2926, 4047, 4161], 'RA/GB': [2588, 2930], 'signal': [2589, 2885, 2913, 2931, 3486, 3646], '(untr.)': [2596], '(STS).': [2603, 2649, 3453], 'Box': [2604, 3410, 3925], 'plots': [2605, 3411, 3926, 4142], 'represent': [2606, 3412, 3927], 'interquartile': [2608, 3414, 3929], '(box),': [2609, 3415], 'median': [2610, 3416, 3935], '(line)': [2611, 3417, 3936], 'SD': [2613, 3419, 4008, 4083, 4209], '(whiskers)': [2614], '(with': [2621, 3430], 'each).': [2626], 'Levels': [2627, 3940], 'were': [2630, 2682, 2853, 3365, 3491, 3943], 'determined': [2631, 3423, 3944, 4017], 'paired': [2633, 3437, 3946, 4028], 'two-tailed': [2634, 3438, 3947, 4029, 4094, 4220], "Student's": [2635, 3439, 3948, 4030, 4095, 4221], 't-test': [2636, 3440, 3949, 4031], '(*P': [2637, 3950, 4032], '0.05,': [2639, 3952, 4034], '***P': [2640, 4035], '0.001)': [2642], 'Download': [2650, 2652, 3103, 3105, 3454, 3456, 4227, 4229], 'figure': [2651, 3104, 3455, 4228], 'PowerPoint': [2653, 3106, 3457, 4230], 'Since': [2654], 'known': [2660, 3790], 'large': [2663], 'distances': [2673], 'SMLM,': [2677], 'reasoned': [2679], 'likely': [2683, 3236], 'foci.': [2690], 'test': [2692], 'hypothesis,': [2694], 'used': [2696, 2765, 2857, 2992], 'dimerization-dependent': [2698], '(ddFP)': [2701], 'technique': [2702, 3613], '(Ding': [2703, 2773], 'method,': [2709], 'interest': [2713, 3330], 'tagged': [2715, 2760, 2903], 'fusion': [2718], 'RA': [2720, 2905], 'GB,': [2722], 'respectively,': [2723], 'emit': [2725], 'significant': [2726], 'measurable': [2727], 'fluorescence': [2728, 2817, 3322, 4173], 'only': [2729, 3832], 'when': [2730, 2855, 3362, 3489, 3688], 'part': [2733], 'complex': [2737], '(<': [2738], 'apart).': [2741], 'Compared': [2742], 'similar': [2744, 2838], 'approaches,': [2745], 'pair': [2748], 'offers': [2749], 'follow': [2767], 'reversible': [2771], 'interactions': [2772], 'expressed': [2779], 'before': [2789, 3264], 'STS': [2795, 3136], '(optimal': [2799], 'foci)': [2806], 'Fig': [2814, 2847, 2994, 3155, 3670], '1E,': [2815], 'negligible': [2822], 'became': [2827], 'apparent': [2828], 'distribution': [2837], 'colocalized': [2842], '1A': [2848], 'B.': [2850, 3855], 'results': [2852, 3815], 'consistent': [2854], '(U2OS': [2861], 'BAX/BAK': [2862, 2997, 3041, 3071], 'DKO': [2863, 3042, 3072], 'MEFs': [2865], 'KO)': [2867], '(paclitaxel': [2872], 'etoposide)': [2874], 'EV1A': [2876], 'B).': [2878, 3639], 'control,': [2882], '1F).': [2892], 'contrast,': [2894, 3687], 'combination': [2896], 'anti-apoptotic': [2899], 'BCL-xL': [2902], 'did': [2908], 'give': [2910], 'any': [2911, 3678], 'neither': [2914], 'nor': [2917], 'treated': [2919, 3492], 'EV1C).': [2922], '1G).': [2950], 'Click': [2951, 4231], 'here': [2952, 4232], 'expand': [2954], 'figure.': [2956], 'EV1.': [2958], 'Interaction': [2959], 'stimuli': [2971], 'GB-DFP1': [2981], '(green)': [2982, 3034, 3064, 3299, 4111], '(same': [2989], '1E),': [2995], 'U2OS': [2996, 3040, 3070], 'DKO,': [2998], 'MEF': [3000, 3304], 'KO': [3002, 3306], 'Mitochondria': [3004], '(magenta).': [3009, 4114], '(magenta)': [3037, 3067, 3290], 'overexpressed': [3038, 3068], 'STS,': [3048], 'Paclitaxel': [3049], 'Etoposide': [3051], 'indicated.': [3053, 4076], 'RA-BCL-xL/GB-DRP1': [3063], 'STS.': [3078], 'Images': [3083, 3094, 3312], 'representative': [3085, 3096, 3314, 4098], 'experiments.': [3091, 3102, 3269, 3320, 4014, 4089, 4215], 'information:': [3093], 'examine': [3108], 'progression,': [3119], 'performed': [3121, 3585], 'live': [3122], 'imaging': [3125], 'expressing': [3130], 'RA-BAX,': [3131], 'GB-DRP1,': [3132], 'Smac-GFP': [3134, 3175, 3194, 3289, 3325], 'following': [3135], 'treatment.': [3137], 'factor': [3143], 'released': [3146], 'upon': [3150, 3167], 'MOMP.': [3151], '2A': [3156], 'B,': [3158], 'correlated': [3171], 'time': [3173, 3360, 3529], 'persisting': [3180], 'death.': [3183], 'Of': [3184, 3719], 'note,': [3185, 3720], 'observed': [3187, 3219], 'delay': [3189], 'redistribution': [3192], 'appearance': [3197], 'complexes,': [3200, 3653], 'about': [3204], 'min': [3206, 3356], '50%': [3209], 'increase': [3210, 3286], 'signals.': [3213], '2016)': [3234], 'relative': [3240], 'efficiency': [3241], 'detection.': [3243], 'Due': [3244], 'technical': [3247], 'limitation,': [3248], 'although': [3250], 'observe': [3252], 'temporal': [3255, 3621], 'correlation,': [3256], 'cannot': [3258], 'exclude': [3259], 'one': [3261], 'event': [3262], '2.': [3271], 'Dynamics': [3272], 'Confocal': [3280], 'time-series': [3282], 'cytosolic': [3288], 'relation': [3292], 'detection': [3295], 'Normalized': [3321], 'intensity': [3323], '(thin': [3341], 'lines)': [3342], 'average': [3345], '(thick': [3349], '5).': [3353], 'Time': [3354], '0': [3355], 'corresponds': [3357], 'detected.': [3366], '(%': [3371], 'normalized': [3376], 'per': [3386], 'experiment)': [3387], 'inhibition': [3389], 'effector': [3391], 'caspases': [3392], '(Q-VD-OPh),': [3393], 'permeability': [3396, 3478], 'transition': [3397, 3479], 'pore': [3398, 3480], '(CsA)': [3399, 3505], 'versus': [3400], '(DMSO),': [3402], 'without': [3405, 4225], '(+/−': [3408], 'STS).': [3409], '(whiskers).': [3420, 3939], 'Significance': [3421, 4015], 'each)': [3435], '(n.s.': [3441], 'P': [3443], '0.05)': [3445], 'DMSO': [3448], 'discard': [3459], 'product': [3470], 'downstream': [3472], '(PTP),': [3481], 'confirmed': [3483], 'pan-caspase': [3495], 'inhibitor': [3496], '(Q-VD-OPh)': [3497], 'PTP': [3501], 'blocker': [3502], 'cyclosporine': [3503], 'A': [3504], '2C).': [3507], 'Together,': [3508], 'demonstrate': [3511, 3816], 'associate': [3519], 'accumulate': [3523], 'correlate': [3527], 'persist': [3533], 'Direct': [3540, 3841], 'investigate': [3557], 'components': [3567], 'association,': [3572], 'minimal': [3578], 'chemically': [3581], 'controlled': [3582], 'composition.': [3583], 'Fluorescence': [3586], 'Cross-Correlation': [3587], 'Spectroscopy': [3588], '(FCCS)': [3589], 'measurements': [3590, 3960], '(Garcia-Saez': [3591], '2009;': [3594], 'Bleicken': [3595], '2017)': [3598], 'recombinant,': [3600], 'fluorescently': [3601], '(BAX-AF633)': [3604], '(DRP1-AF488)': [3607], '3A–C).': [3609], 'FCCS': [3610, 3691, 3875], 'single': [3615], 'molecule': [3616], 'sensitivity': [3617], 'calculates': [3619], 'auto-correlation': [3622], 'diffusing': [3624], 'BAX-AF633': [3625, 3681, 3693, 3803, 3872, 3906], 'DRP1-AF488': [3627, 3683, 3695, 3805, 3870, 3904], 'particles,': [3628], 'diffusion': [3632], 'coefficient': [3633], 'calculated': [3635], 'EV2A': [3637], 'It': [3640], 'quantifies': [3642], 'cross-correlation': [3644, 3863], '(CC)': [3645], 'due': [3647, 3775], 'codiffusion': [3650], 'BAX-AF633/DRP1-AF488': [3652], 'proportional': [3657], 'extent': [3660], '3A': [3671], 'C,': [3673], 'could': [3675], 'CC': [3679, 3707], 'solution.': [3685], 'bound': [3696, 3722], 'Giant': [3698], 'Unilamellar': [3699], 'Vesicles': [3700], '(GUVs),': [3701], 'detected': [3704], 'indicative': [3708], '3B': [3716], 'spontaneously': [3723], 'GUVs': [3725, 3884, 3968, 3976, 4048, 4103], 'simple': [3728], 'containing': [3731], 'cardiolipin,': [3735], 'while': [3736], 'promoted': [3750], 'incubation': [3752], '42°C': [3754], '(heat': [3755], 'activation).': [3756], 'confirm': [3761], 'specific': [3770], 'artifact': [3774], 'membrane,': [3783], 'excess': [3785, 3921], 'unlabeled': [3787, 3922], 'cBID': [3788, 3923, 3993], '(a': [3789], '(Czabotar': [3793], '2013))': [3796], 'successfully': [3797], 'competed': [3798], 'decreased': [3807], '%CC': [3809, 3902], '(Figs': [3810], '3C': [3811], 'EV2C).': [3813], 'component': [3834], 'such': [3837], 'interaction.': [3838], '3.': [3840], 'respective': [3852], 'activities': [3853], 'A,': [3854], 'auto-': [3857], '(green': [3858], 'violet': [3860], 'curves)': [3861, 3867], '(CC,': [3864], 'BAX-DRP1,': [3865], 'grey': [3866, 4000], 'curves': [3868], 'solution': [3877, 3908, 4107], '(B).': [3885], 'Dash': [3886], 'gray': [3887], 'line': [3888], 'depicts': [3889], 'raw': [3890], 'data': [3891, 3897], 'solid': [3893], 'correspond': [3895], 'fitting.': [3898], 'C.': [3899], '(grey),': [3909], '(violet),': [3913], 'presence': [3919, 3978, 4068, 4158, 4197], '(beige).': [3924], '(outer': [3930], 'box),': [3931, 3934], 'mean': [3932, 4006, 4081, 4207], '(inner': [3933], 'range': [3938], '**P': [3953], '0.01)': [3955], '9': [3959], 'solution,': [3962], '46': [3965], 'individually': [3966], '17': [3975], 'cBID.': [3980], 'D.': [3981], 'Effect': [3982, 4039, 4121], 'BAX-induced': [3986, 4043], 'LUV': [3987], 'permeabilization.': [3988, 4045], '(blue': [3994], 'lines),': [3995], 'mild': [3997], 'heat': [3998], '(42°C,': [3999], 'lines).': [4001], 'presented': [4004, 4079, 4205], '±': [4007, 4082, 4208], 'end-point': [4020], 'kinetic': [4023], 'measurement': [4024], '(180': [4025], 'min)': [4026], '0.001).': [4037], 'E.': [4038], 'GUV': [4044], 'Left:': [4046], 'permeabilized': [4049], 'Cytochrome': [4051], 'c488': [4052], '(Cyt': [4053], 'c,': [4054], '12': [4055], 'kDa,': [4056, 4062], 'beige)': [4057], 'allophycocianin': [4059], '(APC,': [4060], '104': [4061], 'blue)': [4063], 'cBID,': [4070], 'combined': [4074], '*P': [4090, 4216], '0.05': [4092, 4218], '(paired': [4093, 4219], 't-test).': [4096], 'Right:': [4097], 'showing': [4102], '(grey)': [4104], 'Cyt': [4109], 'APC': [4113], 'µm.': [4118], 'F,': [4119], 'density': [4127, 4169], 'DRP1-induced': [4129, 4179], 'shape': [4130, 4185], 'liposomes': [4133], 'flow': [4136, 4140], 'cytometry.': [4137], '(F)': [4138], 'cytometry': [4141], 'outlining': [4143], '(Alexa': [4145], '488': [4147], 'signal)': [4148, 4153], 'binding': [4149], 'LUVs': [4151, 4163, 4192], '(Rhodamine': [4152], 'DRP1-positive': [4162], 'indicated': [4164], 'green.': [4166], '(G)': [4167], 'Membrane': [4168], '(corrected': [4172], 'units,': [4174], 'cFU,': [4175], 'left': [4176], 'graph)': [4177, 4190], 'tethering': [4181], '(indicated': [4182], 'index': [4186], '1,': [4188], 'right': [4189], 'concentrations': [4200], 't-test)': [4222], 'vs.': [4223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4205280413', 'counts_by_year': [{'year': 2024, 'cited_by_count': 27}, {'year': 2023, 'cited_by_count': 39}, {'year': 2022, 'cited_by_count': 17}], 'updated_date': '2024-12-14T06:21:20.348382', 'created_date': '2022-01-25'}
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