Title: A C–H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (−)-Aflatoxin B<sub>2</sub>
Abstract:An enantioselective formal synthesis of (−)-aflatoxin B2 from 4-methoxyphenylacetic acid has been achieved by an approach that produces a key carbon–carbon bond, a benzylic stereocenter, and two arene...An enantioselective formal synthesis of (−)-aflatoxin B2 from 4-methoxyphenylacetic acid has been achieved by an approach that produces a key carbon–carbon bond, a benzylic stereocenter, and two arene carbon–oxygen bonds in the course of three site-selective C–H functionalizations. The carbonyl-directed acetoxylation of two arene C–H bonds described herein is unprecedented in natural product synthesis and occurs under mild conditions that preserve the configuration of a sensitive benzylic stereocenter.Read More
Publication Year: 2021
Publication Date: 2021-12-05
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 11
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